Zn2+ inhibition of recombinant GABA(A) receptors: An allosteric, state-dependent mechanism determined by the γ-subunit

Journal of Physiology

Volumn 506, Issue 3, 1998, Pages 609-625

  Gingrich, K J ^a   Burkat, P M ^a  

^a UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CHLORIDE ION; RECEPTOR SUBUNIT; RECOMBINANT PROTEIN; ZINC ION; ZINC; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA2; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2;

ALLOSTERISM; ARTICLE; CHLORIDE CURRENT; CONTROLLED STUDY; HUMAN; HUMAN CELL; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION; CELL LINE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; GENETICS; KINETICS; PHYSIOLOGY; BINDING AFFINITY; CHEMOSENSITIVITY; MEMBRANE CURRENT; MEMBRANE POTENTIAL; PROTEIN SUBUNIT;

CELL LINE; ELECTROPHYSIOLOGY; HUMANS; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MOLECULAR CONFORMATION; PATCH-CLAMP TECHNIQUES; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; TRANSFECTION; ZINC;

EID: 0032008230     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1998.609bv.x     Document Type: Article

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