The CDK9-associated cyclins T1 and T2 exert opposite effects on HIV-1 Tat activity

AIDS

Volumn 13, Issue 12, 1999, Pages 1453-1459

  Napolitano, Giuliana ^a   Licciardo, Paolo ^a   Gallo, Pasquale ^a   Majello, Barbara ^a   Giordano, Antonio ^b   Lania, Luigi ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

CDK9 kinase; Cyclin T1; Cyclin T2; Tat; Transcription

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLINE; TRANSACTIVATOR PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIN-DEPENDENT KINASE 9; CYCLIN-DEPENDENT KINASES; CYCLINS; GENE PRODUCTS, TAT; HIV-1; HUMANS; PLASMIDS; RECOMBINANT PROTEINS; TERMINAL REPEAT SEQUENCES; TRANSCRIPTION, GENETIC;

EID: 0032858138     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199908200-00003     Document Type: Article

References (26)

1. Jones KA. Taking a new TAK on tat transactivation. Genes Dev 1997, 11:2593-2599.
2. Emerman M, Malin M. HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. Science 1998, 280:1880-1884.
3. Cullen BR. HIV-1 auxiliary proteins: making connections in a dying cell. Cell 1998, 93:685-692.
4. Jones KA, Peterlin BM. Control of RNA initiation and elongation at the HIV-1 promoter. Annu Rev Biochem 1994, 63:717-743.
5. Alonso A, Derse D, Peterlin BM. Human chromosome 12 is required for optimal interactions between Tat and TAR of human immunodeficiency virus type 1 in rodent cells. J Virol 1992, 66:4617-4621.
6. Hart CE, Galphin JC, Westhafer MA, Schochetman G. TAR loop-dependent human immunodeficiency virus trans activation requires factors encoded on human chromosome 12. J Virol 1993, 67:5020-5024.
7. Chun RF, Jeang K-T. Requirements for RNA polymerase II carboxy-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1. J Biol Chem 1996, 271:27888-27894.
8. Okamoto H, Sheline C, Corden J, Jones K, Peterlin B. Transactivation by human immunodeficiency virus Tat requires the C-terminal domain of RNA polymerase II. Proc Natl Acad Sci USA 1996, 93:11575-11579.
9. Parada C, Roeder R. Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain. Nature 1996, 384:376-378.
10. Herrmann CH, Rice AP. Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor. J Virol 1995, 69:1612-1620.
11. Grana X, De Luca A, Sang N, et al. PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro. Proc Natl Acad Sci USA 1994, 91:3834-3848.
12. De Falco G, Giordano A. CDK9 (PITALRE): A multifuntional cdc2-related kinase. J Cell Physiol 1999, 177:501-506.
13. Peng J, Zhu Y, Milton JT, Price DH. Identification of multiple cyclin subunits of human P-TEFb. Genes Dev 1998, 12:755-762.
14. Wei P, Garber ME, Fang SM, Fischer WH, Jones KA. A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA. Cell 1998, 92:451-462.
15. Zhou Q, Chen D, Pierstorff E, Luo K. Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages. EMBO J 1998, 17: 3681-3691.
16. Garber ME, Wei P, Kewal Ramani VN, et al. The interaction beween HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the rodent CycT1 protein. Genes Dev 1998, 12:3512-3527.
17. Bieniasz PD, Grdina TA, Bogerd HP, Cullen BR. Recruitment of a protein complex containing Tat and cyclin T1 to TAR governs the species specifity of HIV-1 Tat. EMBO J. 1998, 17:7056-7065.
18. Fujinaga K, Taube R, Wimmer J, Cujec, TP, Peterlin BM. Interactions between human T, Tat, and the transactivation response elemnt (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T. Proc Natl Acad Sci USA 1999, 96:1285-1290.
19. Winner J, Fujinaga K, Taube R, et al. Interactions between Tat and TAR and immunodeficiency virus replication are facilitated by human cyclin T1 but not cyclins T2a or T2b. Virology 1999, 255:182-189.
20. Garriga J, Segura E, Mayol X, Grubmeyer C, Grana X. Phosphorylation site specificity of the CDC2-related kinase PITALRE. Biochem J 1996, 320: 983-989.
21. Majello B, Napolitano G, Lania L. Recruitment of the TATA-binding protein to the HIV-1 promoter is a limiting step for Tat transactivation. AIDS 1998, 12: 1957-1964.
22. Marzio G, Tyagy M, Gutierrez MI, Giacca M. HIV-1 Tat transactivator recruits p300 and CREB-binding protein histone acetyltransferase to the viral promoter. Proc Natl Acad Sci USA 1998, 95:13519-13524.
23. Zhu Y, Pe'ery T, Peng J, et al. Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro. Genes Dev 1997, 11:2622-2632.
24. Mancebo HS, Lee G, Flygare I, et al. P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro. Genes Dev 1997, 11:2633-2644.
25. Herrmann CH, Carroll RG, Wei P, Jones KA, Rice, AP. Tat-associated kinase, TAK, activity is regulated by distinct mechanisms in peripheral blood lymphocytes and promonocytic cell lines. J Virol 1998, 72:9881-9888.
26. Garriga J, Peng J, Parreno M, Price DH, Henderson EE, Grana X. Upregulation of cyclin T1/CDK9 complexes during T cell activation. Oncogene 1998, 17:1093-3102.