Hypoxia inhibits cyclic nucleotide-stimulated epithelial ion transport: Role for nucleotide cyclases as oxygen sensors

Journal of Pharmacology and Experimental Therapeutics

Volumn 284, Issue 2, 1998, Pages 568-575

  Taylor, Cormac T ^a   Lisco, Steven J ^a   Awtrey, Christopher S ^a   Colgan, Sean P ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 ANILINO 5,8 QUINOLINEQUINONE; 8 BROMOGUANOSINE PHOSPHATE; COBALT; GUANYLATE CYCLASE; HEMOPROTEIN; MANGANESE; NICKEL; NUCLEOTIDE;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL CULTURE; CELL HYPOXIA; ENZYME ACTIVITY; FLUID TRANSPORT; INTESTINE EPITHELIUM CELL; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL; REOXYGENATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ADENYLATE CYCLASE; ANOXIA; BIOLOGICAL TRANSPORT; CELL LINE; CYCLIC AMP; CYCLIC GMP; DOWN-REGULATION; EPITHELIAL CELLS; GUANYLATE CYCLASE; HEME; HUMANS; INTESTINAL MUCOSA; NUCLEOTIDES, CYCLIC; OXYGEN; WATER-ELECTROLYTE BALANCE;

EID: 0031933947     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Acker H (1994) Cellular oxygen sensors. Ann NY Acad Sci 718:3-12.
2. Barrett KE (1993) Positive and negative regulation of chloride secretion in T84 cells. Am J Physiol 265:C859-C868.
3. Beru N, McDonald J, Lacombe C and Goldwasser E (1986) Expression of the eryth-ropoietin gene. Mol Cell Biol 6:2571-2575.
4. Bradford M (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Clark ET, Desai TR, Hynes KL and Gewertz BL (1995) Endothelial cell response to hypoxia-reoxygenation is mediated by IL-1. J Surg Res 58:675-681.
6. Colgan SP, Dzus AL and Parkos CA (1996) Epithelial exposure to hypoxia modulates neutrophil transepithelial migration. J Exp Med 184:1003-1015.
7. Colgan SP, Hull-Thrall MA, Gasper PW, Rose BJ, Fulton R, Gould DH, Blancquaert A-MB and Bruyninckx WJ (1991) Restoration of neutrophil motility and platelet function in feline Chediak-Higashi syndrome with bone marrow transplantation. Bone Marrow Transplantation 7:365-374.
8. Colgan SP, Parkos CA, Matthews JB, D'Andrea L, Awtrey CS, Lichtman A, Delp C and Madara JL (1994) Interferon-γ induces a surface phenotype switch in intestinal epithelia: Downregulation of ion transport and upregulation of immune accessory ligands. Am J Physiol 267:C402-C410.
9. Currie MG, Fok KF, Kato J, Moore RJ, Hamra FK, Duffin KL and Smith CE (1992) Guanylin: An endogenous activator of intestinal guanylate cyclase. Proc Natl Acad Sci USA 89:947-951.
10. Dharmsathaphorn K and Madara JL (1990) Established intestinal cell lines as model systems for electrolyte transport studies. Meth Enzymol 192:354-389.
11. Forte LR, Thorne PK, Eber SL, Krause WJ, Freeman RH, Francis SH and Corbin JD (1992) Stimulation of intestinal Cl transport by heat-stable enterotoxin: Activation of cAMP-dependent protein kinase by cGMP. Am J Physiol (Cell Physiol) 263: C607-C615.
12. Goldberg MA, Dunning SP and Bunn HF (1988) Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein. Science (Wash DC) 242:1412-1415.
13. Gregory RJ, Cheng SH, Rich DP, Marshall J, Paul S, Hehir K, Ostedgaard L, Klinger KW, Welsh MJ and Smith AE (1990) Expression and characterization of the cystic fibrosis transmembrane conductance regulator. Nature (Lond) 347:382-386.
14. Hochachka PW (1986) Defense strategies against hypoxia and hypothermia. Science (Wash DC) 231:234-242.
15. Huott PA, Liu W, McRoberts GA, Gianella RA and Dharmsathaphorn K (1988) The mechanism of E. coli heat stable enterotoxin in a human colonic cell. J Clin Invest 82:514-523.
16. Madara JL, Colgan SP, Nusrat A, Delp C and Parkos CA (1992a) A simple approach to measurement of electrical parameters of cultured epithelial monolayers: Use in assessing neutrophil epithelial interactions. J Tiss Cult Res 14:209-216.
17. - secretion in a model intestinal epithelium induced by a neutrophil-derived secretagogue. J Clin Invest 89:1938-1944.
18. - cotransport by cAMP in intestinal epithelial monolayers. J Clin Invest 90:1608-1613.
19. Matthews JB, Tally KJ, Smith JA, Zeind J and Hrnjez BJ (1995) Activation of Cl secretion during chemical hypoxia by endogenous release of adenosine in intestinal epithelial monolayers. J Clin Invest 96:117-125.
20. Mertens S, Noll T, Spahr R, Krutzfeldt A and Piper HM (1990) Energetic response of coronary endothelial cells to hypoxia. Am J Physiol 258:H689-H694.
21. Michiels C, Arnould T, Knott I, Dieu M and Remade J (1993) Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia. Am J Physiol 264:C866-C874.
22. Ogawa S, Koga S, Kuwabara K, Brett J, Morrow B, Morris SA, Bilezikian JP, Silverstein SC and Stern D (1992) Hypoxia-induced increased permeability of endothelial monolayers occurs through lowering of cellular cAMP levels. Am J Physiol 262:0546-C554.
23. Owen NE and Prastein ML (1985) Na/K/Cl cotransporter in cultured human fibroblasts. J Biol Chem 260:1445-1451.
24. Parkos CA, Colgan SP, Liang A, Nusrat A, Bacarra AE, Carnes DK and Madara JL (1996) CD 47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol 132:437-450.
25. Pinsky DJ, Naka Y, Chowdhury NC, Liao H, Oz MC, Michler RE, Kubaszewski E, Malinski T and Stern DM (1994) The nitric oxide/cyclic GMP pathway in organ transplantation: Critical role in successful lung preservation. Proc Natl Acad Sci USA 91:12086-12090.
26. Pinsky DJ, Oz MC, Liao H, Morris S, Brett J, Morales A, Karakurum M, Campagne MMVL, Nowygrod R and Stern DM (1993) Restoration of the cAMP second messenger pathway enhances cardiac preservation for transplantation in a heterotopic rat model. J Clin Invest 92:2994-3002.
27. Powell D (1981) Barrier function of epithelia. Am J Physiol 241:G275-G288.
28. Powell DW (1987) Intestinal water and electrolyte transport, in Physiology of the Gastrointestinal Tract (Johnstone LR ed) pp 1267-1291, Raven Press, New York.
29. Schmidt MJ, Sawyer BD, Truex LL, Marshall WS and Fleisch JH (1985) LY83583: An agent that lowers intracellular levels of cyclic guanosine 3′,5′-monophosphate. J Pharmacol Exp Ther 232:764-769.
30. Schulz S, Green CK, Yuen PS and Garbers DL (1990) Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell 63:941-948.
31. Schuster SJ, Badiavas EV, Costa-Giomi P, Weinmann R, Erslev AJ and Caro J (1989) Stimulation of erythropoietin gene transcription during bypoxia and cobalt exposure. Blood 73:13-16.
32. Shreeniwas R, Koga S, Karakurum M, Pinsky D, Kaiser E, Brett J, Wolitzky BA, Norton C, Plocinski J, Benjamin W, Burns DK, Goldstein A and Stern D (1992) Hypoxia-mediated induction of endothelial cell interleukin-1-α: An autocrine mechanism promoting expression of leukocyte adhesion molecules on the vessel surface. J Clin Invest 90:2333-2339.
33. Smith JJ and Welsh MJ (1993) Fluid and electrolyte transport by cultured human airway epithelia. J Clin Invest 91:1590-1597.
34. Stevens T and Rodman DM (1995) The effect of hypoxia on endothelial cell function. Endothelium 3:1-11.
35. Stone JR and Marletta MA (1994) Soluble guanylate cyclase from bovine lung: Activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry 33:5636-5640.
36. Stone JR and Marletta MA (1995) Heme stoichiometry of heterodimeric soluble guanylate cyclase. Biochemistry 34:14668-14674.
37. Taussig R and Gilman AF (1995) Mammalian membrane-bound adenylyl cyclases. J Biol Chem 270:1-4.
38. Tretyakov AV and Farber HW (1995) Endothelial cell tolerance to hypoxia: Potential role of purine nucleotide phosphates. J Clin Invest 95:738-744.
39. Tsuchiya T, Ueda M, Ochiai H, Imajoh-Ohmi S and Kanegasaki S (1993) Erythropoietin 5′-flanking sequence-binding protein induced during hypoxia and cobalt exposure. J Biochem 113:395-400.
40. Venglarik CJ, Bridges RJ and Frizzell RA (1990) A simple assay for agonist-regulated Cl and K conductances in salt-secreting epithelial cells. Am J Physiol 259:C358-C362.
41. Waldman SA, Sinacore MS, Lewicki JA, Chang LY and Murad F (1984) Selective activation of particulate guanylate cyclase by a specific class of porphyrins. J Biol Chem 259:4038-4042.
42. Waxman K (1996) Shock: Ischemia, reperfusion and inflammation. New Horizons 4:153-160.
43. Zimmerman LH, Levine RA and Farber HW (1991) Hypoxia induces a specific set of stress proteins in cultured endothelial cells. J Clin Invest 87:908-914.
44. Zünd G, M JL, Dzus AL, Awtrey CS and Colgan SP (1996a) Interleukin 4 and interleukin 13 differentially regulate epithelial chloride secretion. J Biol Chem 271:7460-7464.
45. Zünd G, Nelson DP, Neufeld EJ, Dzus AL, Bischoff J, Mayer JE and Colgan SP (1996b) Hypoxia enhances stimulus-dependent induction of E-selectin on aortic endothelial cells. Proc Natl Acad Sci USA 93:7075-7080.