Glycoprotein Ib-V-IX, a receptor for von Willebrand factor, couples physically and functionally to the Fc receptor γ-chain, Fyn, and Lyn to activate human platelets

Blood

Volumn 94, Issue 5, 1999, Pages 1648-1656

  Falati, Shahrokh ^a   Edmead, Christine E ^a   Poole, Alastair W ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGIN; CALCIUM ION; CELL SURFACE RECEPTOR; FC RECEPTOR; GLYCOPROTEIN IB; LECTIN; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; SEROTONIN; SNAKE VENOM; VON WILLEBRAND FACTOR;

ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SEROTONIN RELEASE; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

EID: 0033199050     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.5.1648     Document Type: Article

References (75)

1. Ruggeri ZM: Mechanisms initiating platelet thrombus formation. Thromb Haemost 78:611, 1997
2. Ruggeri ZM, Ware J: von Willebrand factor. FASEB J 7:308, 1993
3. Fressinaud E, Meyer D: von Willebrand factor and platelet interactions with the vessel wall. Blood Coagul Fibrinol 2:333, 1991
4. Ikeda Y, Handa M, Kawano K, Kamata T, Murata M, Araki Y, Anbo H, Kawai Y, Watanabe K, Itagaki I, Sakai K, Ruggeri ZM: The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest 87:1234, 1991
5. Kroll MH, Harris TS, Moake JL, Handin RI, Schafer AI: von Willebrand factor binding to platelet GPIb initiates signals for platelet activation. J Clin Invest 88:1568, 1991
6. Chow TW, Hellums JD, Moake JL, Kroll MH: Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation. Blood 80:113, 1992
7. Kroll MH, Hellums JD, Guo Z, Durante W, Razdan K, Hrbolich JK, Schafer AI: Protein kinase C is activated in platelets subjected to pathological shear stress. J Biol Chem 268:3520, 1993
8. Cunningham JG, Meyer SC, Fox JE: The cytoplasmic domain of the α-subunit of glycoprotein (GP) Ib mediates attachment of the entire GP Ib-IX complex to the cytoskeleton and regulates von Willebrand factor-induced changes in cell morphology. J Biol Chem 271:11581, 1996
9. 3) in von Willebrand factor-induced signal transduction. J Biol Chem 272:21847, 1997
10. 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J Biol Chem 267:11300, 1992
11. Asazuma N, Ozaki Y, Satoh K, Yatomi Y, Handa M, Fujimura Y, Miura S, Kume S: Glycoprotein Ib-von Willebrand factor interactions activate tyrosine kinases in human platelets. Blood 90:4789, 1997
12. Yanabu M, Ozaki Y, Nomura S, Miyake T, Miyazaki Y, Kagawa H, Yamanaka Y, Asazuma N, Satoh K, Kume S, Komiyama Y, Fukuhara S: Tyrosine phosphorylation and p72syk activation by an anti-glycoprotein Ib monoclonal antibody. Blood 89:1590, 1997
13. 1. Blood 89:1235, 1997
14. Ezumi Y, Shindoh K, Tsuji M, Takayama H: Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets. J Exp Med 188:267, 1998
15. Gibbins JM, Okuma M, Farndale R, Barnes M, Watson SP: Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor γ-chain. FEBS Lett 413:255, 1997
16. Ichinohe T, Takayama H, Ezumi Y, Arai M, Yamamoto N, Takahashi H, Okuma M: Collagen-stimulated activation of Syk but not c-Src is severely compromised in human platelets lacking membrane glycoprotein VI. J Biol Chem 272:63, 1997
17. Kralisz U, Cierniewski CS: Tyrosine phosphorylation events during different stages of collagen-induced platelet activation. Biochim Biophys Acta 1405:128, 1998
18. Polgar J, Clemetson JM, Kehrel BE, Wiedemann M, Magnenat EM, Wells TNC, Clemetson KJ: Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor. J Biol Chem 272:13576, 1997
19. Poole A, Gibbins JM, Turner M, van Vugt MJ, van de Winkel JG, Saito T, Tybulewicz VL, Watson SP: The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen. EMBO J 16:2333, 1997
20. Yanaga F, Poole A, Asselin J, Blake R, Schieven GL, Clark EA, Law CL, Watson SP: Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fcγ-IIA receptor. Biochem J 311:471, 1995
21. Cambier JC: Antigen and Fc receptor signaling. The awesome power of the immunoreceptor tyrosine-based activation motif (ITAM). J Immunol 155:3281, 1995
22. Chacko GW, Brandt JT, Coggeshall KM, Anderson CL: Phosphoinositide 3-kinase and p72(syk) noncovalently associate with the low affinity Fcγ receptor on human platelets through an immunoreceptor tyrosine-based activation motif: Reconstitution with synthetic phosphopeptides. J Biol Chem 271:10775, 1996
23. Gibbins J, Asselin J, Farndale R, Barnes M, Law CL, Watson SP: Tyrosine phosphorylation of the Fc receptor γ-chain in collagen-stimulated platelets. J Biol Chem 271:18095, 1996
24. Moore A, Ross GD, Nachman RL: Interaction of platelet membrane receptors with von Willebrand factor, ristocetin, and the Fc region of immunoglobulin G. J Clin Invest 62:1053, 1978
25. Sullam PM, Hyun WC, Szollosi J, Dong J, Foss WM, Lopez JA: Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcγRIIA on the platelet plasma membrane. J Biol Chem 273:5331, 1998
26. Tsuji M, Ezumi Y, Arai M, Takayama H: A novel association of Fc receptor γ-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets. J Biol Chem 272:23528, 1997
27. Clemetson KJ, Polgar J, Clemetson JM: Snake venom C-type lectins as tools in platelet research. Platelets 9:165, 1998
28. Kowalska MA, Tan L, Holt JC, Peng M, Karczewski J, Calvete JJ, Niewiarowski S: Alboaggregins A and B. Structure and interaction with human platelets. Thromb Haemost 79:609, 1998
29. Peng M, Lu W, Kirby EP: Alboaggregin-B: A new platelet agonist that binds to platelet membrane glycoprotein Ib. Biochemistry 30:11529, 1991
30. Peng M, Lu W, Kirby EP: Characterization of three alboaggregins purified from Trimeresurus albolabris venom. Thromb Haemost 67:702, 1992
31. Fujimura Y, Kawasaki T, Titani K: Snake venom proteins modulating the interaction between von Willebrand factor and platelet glycoprotein Ib. Thromb Haemost 76:633, 1996
32. Andrews RK, Kroll MH, Ward CM, Rose JW, Scarborough RM, Smith AI, Lopez JA, Berndt MC: Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-K-V complex. Effect on platelet aggregation and glycoprotein Ib-mediated platelet activation. Biochemistry 35:12629, 1996
33. Sixma JJ, Schiphorst ME, Verweij CL, Pannekoek H: Effect of deletion of the A1 domain of von Willebrand factor on its binding to heparin, collagen and platelets in the presence of ristocetin. Eur J Biochem 196:369, 1991
34. Lankhof H, Wu YP, Vink T, Schiphorst ME, Zerwes HG, de Groot PG, Sixma JJ: Role of the glycoprotein Ib-binding A1 repeat and the RGD sequence in platelet adhesion to human recombinant von Willebrand factor. Blood 86:1035, 1995
35. Born GVR: Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 194:927, 1962
36. Poole AW, Watson SP: Regulation of cytosolic calcium by collagen in single human platelets. Br J Pharmacol 115:101, 1995
37. Wang X, Yanagi S, Yang C, Inatome R, Yamamura H: Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets. J Biochem 121:325, 1997
38. Blake RA, Schieven GL, Watson SP: Collagen stimulates tyrosine phosphorylation of phospholipase Cγ2 but not phospholipase Cγ1 in human platelets. FEBS Lett 353:212, 1994
39. Yanaga F, Asselin J, Schieven GL, Watson SP: Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase Cγ2 in human platelets and phospholipase Cγ1 in NIH-3T3 fibroblasts. FEBS Lett 368:377, 1995
40. Briddon SJ, Watson SP: Evidence for the involvement of a Src-like kinase in signalling by collagen-related peptide in washed human platelets. Br J Pharmacol 122:102P, 1997
41. Ikeda Y, Handa M, Kamata T, Kawano K, Kawai Y, Watanabe K, Kawakami K, Sakai K, Fukuyama M, Itagaki I, Yoshioka A, Ruggeri ZM: Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation. Thromb Haemost 69:496, 1993
42. Ruggeri ZM: von Willebrand factor. J Clin Invest 99:559, 1997
43. Oda A, Yokoyama K, Murata M, Tokuhira M, Nakamura K, Handa M, Watanabe K, Ikeda Y: Protein tyrosine phosphorylation in human platelets during shear stress-induced platelet aggregation (SIPA) is regulated by glycoprotein (GP) Ib/IX as well as GP IIb/IIIa and requires intact cytoskeleton and endogenous ADP. Thromb Haemost 74:736, 1995
44. Ozaki Y, Satoh K, Yatomi Y, Miura S, Fujimura Y, Kume S: Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein Ib and von Willebrand factor. Biochim Biophys Acta 1243:482, 1995
45. Razdan K, Hellums JD, Kroll MH: Shear-stress-induced von Willebrand factor binding to platelets causes the activation of tyrosine kinase(s). Biochem J 302:681, 1994
46. 3. EMBO J 16:6414, 1997
47. Taniguchi T, Kitagawa H, Yasue S, Yanagi S, Sakai K, Asahi M, Ohta S, Takeuchi F, Nakamura S, Yamamura H: Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets. J Biol Chem 268:2277, 1993
48. Reth M: Antigen receptor tail clue. Nature 338:383, 1989
49. Watson SP, Gibbins J: Collagen receptor signalling in platelets: Extending the role of the ITAM. Immunol Today 19:260, 1998
50. Ichinohe T, Takayama H, Ezumi Y, Yanagi S, Yamamura H, Okuma M: Cyclic AMP-insensitive activation of c-Src and Syk protein-tyrosine kinases through platelet membrane glycoprotein VI. J Biol Chem 270:28029, 1995
51. Sada K, Yanagi S, Yamamura H: Activation of p72syk by thrombin in a cell-free system. Biochem Biophys Res Commun 200:1, 1994
52. Cheng AM, Rowley B, Pao W, Hayday A, Bolen JB, Pawson T: Syk tyrosine kinase required for mouse viability and B-cell development. Nature 378:303, 1995
53. Turner M, Mee PJ, Costello PS, Williams O, Price AA, Duddy LP, Furlong MT, Geahlen RL, Tybulewicz VL: Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378:298, 1995
54. Ravetch JV, Kinet JP: Fc receptors. Annu Rev Immunol 9:457, 1991
55. Amoui M, Draber P, Draberova L: Src-family selective tyrosine kinase inhibitor, PP1, inhibits both Fc∈RI- and Thy-1-mediated activation of rat basophilic leukaemia cells. Eur J Immunol 27:1881, 1997
56. Daeron M: Fc receptor biology. Annu Rev Immunol 15:203, 1997
57. Stenberg PE, Pestina TI, Barrie RJ, Jackson CW: The Src family kinases, Fgr, Fyn, Lck and Lyn, colocalise with coated membranes in platelets. Blood 89:2384, 1997
58. Zhao Y-H, Krueger JG, Sudol M: Expression of cellular-yes protein in mammalian tissues. Oncogene 5:1629, 1990
59. Horak ID, Corcoran ML, Thompson PA, Wahl LM, Bolen JB: Expression of pp60fyn in human platelets. Oncogene 5:597, 1990
60. Golden A, Nemeth SP, Brugge JS: Blood platelets express high levels of the pp60c-crc-specific tyrosine kinase activity. Proc Natl Acad Sci USA 83:852, 1986
61. Jackson SP, Schoenwaelder SM, Yuan Y, Rabinowitz I, Salem HH, Mitchell CA: Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets. J Biol Chem 269:27093, 1994
62. Duchemin AM, Anderson CL: Association of non-receptor protein tyrosine kinases with the Fc gamma RI/gamma-chain complex in monocytic cells. J Immunol 158:865, 1997
63. 1 integrin is a necessary co-receptor for collagen-induced activation of Syk and the subsequent phosphorylation of phospholipase Cγ2 in platelets. J Biol Chem 271:26668, 1996
64. Dibirdik I, Kristupaitis D, Kurosaki T, Tuel-Ahlgren L, Chu A, Pond D, Tuong D, Luben R, Uckun FM: Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for Syk kinase-dependent phospholipase Cγ2 activation in lymphoma B cells exposed to low energy electromagnetic fields. J Biol Chem 273:4035, 1998
65. Law CL, Chandran KA, Sidorenko SP, Clark EA: Phospholipase Cγ1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol 16:1305, 1996
66. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA: Discovery of a novel, potent, and Src-family-selective tyrosine kinase inhibitor. Study of Lck- and Fyn-dependent T cell activation. J Biol Chem 271:695, 1996
67. Falasca M, Logan SK, Lento VP, Baccante G, Lammon MA, Schlessinger J: Activation of phospholipase Cγ by PI 3-kinase-induced PH domain-mediated membrane targetting. EMBO J 17:414, 1998
68. Rhee SG, Bae YS: Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem 272:15045, 1997
69. Gratacap M, Payrastre B, Viala C, Mauco G, Plantavid M, Chap H: Phosphatidylinositol 3,4,5-triphosphate-dependent stimulation of phospholipase Cγ2 is an early key event in FcγRIIA-mediated activation of human platelets. J Biol Chem 273:24314, 1998
70. Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC, Cantley LG: Phosphoinositide 3-kinase regulates phospholipase Cγ-mediated calcium signaling. J Biol Chem 273:23750, 1998
71. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG: Activation of phospholipase Cγ by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 273:4465, 1998
72. Andrews RK, Harris SJ, McNally T, Berndt MC: Binding of purified 14-3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. Biochemistry 37:638, 1998
73. Calverley DC, Kavanagh TJ, Roth GJ: Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib subunits Ibalpha and Ibbeta. Blood 91:1295, 1998
74. Du X, Harris SJ, Tetaz TJ, Ginsberg MH, Berndt MC: Association of a phospholipase A2 (14-3-3 protein) with the platelet glycoprotein Ib-IX complex. J Biol Chem 269:18287, 1994
75. Du X, Fox JE, Pei S: Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ib alpha. J Biol Chem 271:7362, 1996