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1 Evans CH, Robbins PD, Ghivizzani SC, Herndon JH, Kang R, Bahnson AB, Barranger JA, Elders EM, Gay S, Tomaino MM, Wasko MC, Watkins SC, Whiteside TL, Glorioso JC, Lotze MT, Wright TM: Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 1996, 7:1261-1280.
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2 Ghivizzani SC, Lechman ER, Tio C, Mulé KM, Chada S, McCormack JE, Evans CH, Robbins PD: Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Ther 1997, 4:977-982.
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This paper reports the us of both first-and second-generation herpes simplex virus (HSV) vectors for gene transfer in arthritis. It is suggested that HSV vector systems could be used for therapeutic applications in patients with RA
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8 Oligino T, Ghivizzani SC, Wolfe D, Lechman ER, Krisky D, Mi Z, Evans CH, Robbins PD, Glorioso JC: Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis. Gene Ther 1999, 6:1713-1720. This paper reports the us of both first-and second-generation herpes simplex virus (HSV) vectors for gene transfer in arthritis. It is suggested that HSV vector systems could be used for therapeutic applications in patients with RA.
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9 Kaneda Y, Saeki Y, Morishita R: Gene therapy using HVJ-liposomes: the best of both worlds? Mol Med Today 1999, 5:298-303.
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10 Tomita T, Hashimoto H, Tomita N, Morishita R, Lee SB, Hayashida K, Nakamura N, Yonenobu K, Kaneda Y, Ochi T: In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes. Arthritis Rheum 1997, 40:901-906.
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Tagreted gene expression in human articular cartilage by direct in vivo gene transfer into SCID-HuRAg mouse
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11 Katayama R, Tomita T, Tsumaki N, Ochi T, Matsuno H, Morita Y, Yudoh K, Nakazawa F, Kimura T: Tagreted gene expression in human articular cartilage by direct in vivo gene transfer into SCID-HuRAg mouse. Arthritis Rheum 1999, 42 (suppl 9):S107.
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12 Evans CH, Robbins PD: Pathways to gene therapy in rheumatoid arthritis. Curr Opin Rheumatol 1996, 8:230-234.
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This article reviews the results from the First Workshop of the European Study Group of Gene Therapy in Osteoarticular Diseases, and summarizes potential targets for gene therapy in RA based on recent advances in understanding the pathogenesis of disease
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14 Jorgensen C, Gay S: Gene therapy in osteoarticular diseases: where are we? Immunol Today 1998, 19:387-391. This article reviews the results from the First Workshop of the European Study Group of Gene Therapy in Osteoarticular Diseases, and summarizes potential targets for gene therapy in RA based on recent advances in understanding the pathogenesis of disease.
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17 Kuiper S, Joosten LA, Bendele AM, Edwards CK, Arntz OJ, Helsen MM, Van de Loo FA, Van den Berg WB: Different roles of tumour necrosis factor alpha and interleukin 1 in murine streptococcal cell wall arthritis. Cytokine 1998, 10:690-702.
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18 Van de Loo FA, Joosten LA, van Lent PL, Arntz OJ, Van den Berg WB: Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen-and zymosan-induced arthritis. Arthritis Rheum 1995, 38:164-172.
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23 Woods JM, Katschke KJ, Volin MV, Ruth JH, Woodruff DC, Amin MA, Connors MA, Kurata H, Arai K, Koch AE: Adenoviral interleukin(IL)-4 gene therapy improves rat adjuvant-induced arthritis. Arthritis Rheum 1999, 42 (suppl 9):S106.
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25 Kawakami A, Eguchi K, Matsuoka N, Tsuboi M, Urayama S, Kawabe Y, Aoyagi T, Maeda K, Nagataki S: Inhibitory effects of interleukin-10 on synovial cells of rheumatoid arthritis. Immunology 1997, 91:252-259.
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28 Joosten LA, Lubberts E, Durez P, Helsen MM, Jacobs MJ, Goldman M, Van den Berg WB: Role of interleukin-4 and interleukin-10 in murine collagen-induced arthritis: protective effect of interleukin-4 and interleukin-10 treatment on cartilage destruction. Arthritis Rheum 1997, 40:249-260.
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Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model
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The authors demonstrate that the SCID mouse model of RA is a useful tool to study the effect of gene transfer on the aggressive behaviour of RA-SF. It is shown that gene transfer with the IL-10 gene inhibits the invasion of RA-SF into cartilage in this model
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29 Müller-Ladner U, Evans CH, Franklin BN, Roberts CR, Gay RE, Robbins PD, Gay S: Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCID mouse model. Arthritis Rheum 1999, 42:490-497. The authors demonstrate that the SCID mouse model of RA is a useful tool to study the effect of gene transfer on the aggressive behaviour of RA-SF. It is shown that gene transfer with the IL-10 gene inhibits the invasion of RA-SF into cartilage in this model.
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31 Apparailly F, Verwaerde C, Jacquet C, Auriault C, Sany J, Jorgensen C: Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J Immunol 1998, 160:5213-5220.
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32 Ma Y, Thornton S, Duwel LE, Boivin GP, Giannini EH, Leiden JM, Bluestone JA, Hirsch R: Inhibition of collagen-induced arthritis in mice by viral IL-10 gene transfer. J Immunol 1998, 161:1516-1524.
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Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees
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It is demonstrated that direct delivery of the viral IL-10 gene not only affects the treated joints by reducing the leukocytosis, cartilage matrix degradation, and levels of endogenous rabbit TNF-α but that an antiarthritic effect can be observed also in the contralateral control knee joints
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33 Lechman ER, Jaffurs D, Ghivizzani SC, Gambotto A, Kovesdi I, Mi Z, Evans CH, Robbins PD: Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees. J Immunol 1999, 163:2202-2208. It is demonstrated that direct delivery of the viral IL-10 gene not only affects the treated joints by reducing the leukocytosis, cartilage matrix degradation, and levels of endogenous rabbit TNF-α but that an antiarthritic effect can be observed also in the contralateral control knee joints.
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34 Whalen JD, Lechman EL, Carlos CA, Weiss K, Kovesdi I, Glorioso JC, Robbins PD, Evans CH: Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws. J Immunol 1999, 162:3625-3632.
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37 Pap T, Kuchen S, Parak W, Kunzler P, Gay RE, Gay S, Aicher WK: SV40 immortalized rheumatoid arthritis synovial fibroblasts (RA-SF) maintain their cytokine expression pattern and aggressive behavior in the SCID mouse model despite an altered TNF-alpha and IL-1 response. Arthritis Rheum 1999, 42 (suppl 9):S251.
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45 Makarov SS, Johnston WN, Olsen JC, Watson JM, Mondal K, Rinehart C, Haskill JS: NF-kappa B as a target for anti-inflammatory gene therapy: suppression of inflammatory responses in monocytic and stromal cells by stable gene transfer of I kappa B alpha cDNA. Gene Ther 1997, 4:846-852.
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46 Franz JK, Pap T, Hummel KM, Nawrath M, Aicher WK, Shigeyama Y, Müller-Ladner U, Gay RE, Gay S: Expression of sentrin, a novel anti-apoptotic molecule at sites of synovial invasion in rheumatoid arthritis. Arthritis Rheum 2000, in press.
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47
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47 Taniguchi K, Kohsaka H, Inoue N, Terada Y, Ito H, Hirokawa K, Miyasaka N: Induction of the p16INK4a senescence gene as a new therapeutic strategy for the treatment of rheumatoid arthritis. Nat Med 1999, 5:760-767. The authors report that synovial cells derived from RA synovial tissue expressed p16INK4a when they were growth-inhibited, whereas this was not seen in other fibroblasts, including those derived from normal and osteoarthritis-affected synovial tissues. It is demonstrated that in vivo adenoviral gene therapy with the p16INK4a gene efficiently inhibited the pathology in an animal model of arthritis.
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48 Asahara H, Hasumuna T, Kobata T, Yagita H, Okumura K, Inoue H, Gay S, Sumida T, Nishioka K: Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue. Clin Immunol Immunopathol 1996, 81:27-34.
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This article explores the effect of cells transfected with human Fas ligand (hFasL) gene on proliferating human rheumatoid synovium engrafted in SCID mice and suggests that ex vivo gene transfer of FasL may represent a novel therapeutic strategy for RA
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50 Okamoto K, Asahara H, Kobayashi T, Matsuno H, Hasunuma T, Kobata T, Sumida T, Nishioka K: Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer. Gene Ther 1998, 5:331-338. This article explores the effect of cells transfected with human Fas ligand (hFasL) gene on proliferating human rheumatoid synovium engrafted in SCID mice and suggests that ex vivo gene transfer of FasL may represent a novel therapeutic strategy for RA.
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