Pathways to gene therapy in rheumatoid arthritis

Current Opinion in Rheumatology

Volumn 8, Issue 3, 1996, Pages 230-234

  Evans, Christopher H ^a   Robbins, Paul D ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

EXPRESSION VECTOR; GENE THERAPY; GENE TRANSFER; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; TARGET ORGAN;

EID: 0029984847     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-199605000-00011     Document Type: Review

References (28)

1. Bandara G, Robbins PD, Georgescu HI, Mueller GM, Glorioso JC, Evans CH: Gene transfer to synoviocytes: prospects for gene treatment for arthritis. DNA Cell Biol 1992, 11:227-231.
2. Evans CH, Robbins PD: Prospects for treating arthritis by gene therapy. J Rheumatol 1994, 21:779-782.
3. Evans CH, Robbins PD: Gene therapy for arthritis. In Gene Therapeutics: Methods and Applications of Direct Gene Transfer. Edited by Wolff JA. Boston: Birkhauser; 1994:320-343.
4. Evans CH, Robbins PD: Possible orthopaedic applications of gene therapy. J Bone Joint Surg Am 1995, 77:1103-1114. A simply written, comprehensive review covering all aspects of gene therapy for arthritis and other disorders of the musculoskeletal system.
5. Roessler BJ, Alolen ED, Wilson JM, Hartman JW, Davidson BL: Adenoviral-mediated gene transfer to rabbit synovium in vivo. J Clin Invest 1993, 92:1085-1092.
6. Nita I, Ghivizzani SC, Galea-Lauri J, Bandara G, Georgescu HI, Robins PD, Evans CH: Direct gene delivery to synovium: an evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 1996, 39:in press. The authors directly compare the abilities of several different vectors to introduce genes into synoviocytes.
7. Roessler BJ, Hartman JW, Vallance DK, Latta JM, Janich SL, Davidson BL: Inhibition of interleukin-1-induced effects in synoviocytes transduced with the human IL-1 receptor antagonist cDNA using an adenoviral vector. Hum Gene Ther 1995, 6:307-316. This paper demonstrates that adenovirus can be used to deliver biologically active IL-1Ra into joints. Expression, although high initially, is transient.
8. Sawchuk SJ, Boivin GP, Duwel LE, Ball W, Bove K, Trapnell B, Hirsch R: Anti-T cell receptor monoclonal antibody prolongs transgene expression following adenovirus-mediated in vivo gene transfer to mouse synovium. Hum Gene Ther 1996, 7:499-506.
9. Yang Y, Nunes EA, Berencsi K, Furth EE, Gonczol E, Wilson JM: Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci U S A 1994, 91:4407-4411.
10. Yovandich J, O'Malley B, Sikes M, Ledley FD: Gene transfer to synovial cells by intraarticular administration of plasmid DNA. Hum Gene Ther 1995, 6:603-610. This paper reports that synoviocytes can take up and intra-articularly express naked DNA that is injected into the joint.
11. Bandara G, Mueller GM, Galea-Lauri J, Tindal MH, Georgescu HI, Suchanek MK, Hung GL, Glorioso JC, Robbins PD, Evans CH: Intraarticular expression of biologically active interleukin-1-receptor antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci U S A 1993, 90:10764-10768.
12. Hung G, Galea-Lauri J, Mueller GM, Georgescu HI, Larkin LA, Tindal M, Robbins PD, Evans CH: Suppression of the intraarticular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonists gene to synovium. Gene Ther 1994, 1:64-69. This paper describes how ex vivo transfer of the IL-1Ra gene is able to block the intra-articular activities of IL-1.
13. Markarov SS, Olsen JC, Johnston WN, Schwab JH, Anderle SK, Brown RR, Haskill JS: Retrovirus-mediated ex vivo gene transfer to synovium in bacterial cell wall-induced arthritis in rats. Gene Ther 1995, 2:424-428. Independent confirmation that successful ex vivo gene transfer is not restricted to the knee joints of rabbits.
14. Otani K, Nita I, Macaulay W, Georgescu HI, Robbins PD, Evans CH: Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996, 156:in press. These authors and Makarov et al. (Proc Natl Acad Sci U S A 1996, 93:402-406) are the first to show an antiarthritic effect of gene therapy in an animal model of RA.
15. Otani K, Nita I, Macaulay W, Georgescu HI, Robbins PD, Evans CH: Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996, 156:in press. These authors and Makarov et al. (Proc Natl Acad Sci U S A 1996, 93:402-406) are the first to show an antiarthritic effect of gene therapy in an animal model of RA.
16. Makarov SS, Olsen JC, Johnston WN, Anderle SK, Brown RR, Baldwin AS, Haskill JS, Schwab JH: Suppression of experimental arthritis by gene transfer of interleukin-1 receptor antagonist cDNA. Proc Natl Acad Sci U S A 1996, 93:402-406. These authors and Otani et al. (J Immunol 1996, 156:in press) are the first to show an antiarthritic effect of gene therapy in an animal model of RA.
17. Makarov SS, Olsen JC, Johnston WN, Anderle SK, Brown RR, Baldwin AS, Haskill JS, Schwab JH: Suppression of experimental arthritis by gene transfer of interleukin-1 receptor antagonist cDNA. Proc Natl Acad Sci U S A 1996, 93:402-406. These authors and Otani et al. (J Immunol 1996, 156:in press) are the first to show an antiarthritic effect of gene therapy in an animal model of RA.
18. Lewthwaite J, Blake SM, Hardingham TE, Warden PJ, Henderson B: The effect of recombinant human interleukin 1 receptor antagonist on the induction phase of antigen induced arthritis in the rabbit. J Rheumatol 1994, 21:467-472.
19. Schwab JH, Anderle SK, Brown RR, Dalldorf FG, Thompson RC: Pro- and anti-inflammatory effects of interleukin-1 in recurrence of bacterial wall-induced arthritis in rats. Infect Immunol 1991, 59:4436-4442.
20. Kang R, Georgescu HI, Nita I, Robbins PD, Evans CH: Susceptibility of human synovial fibroblasts to retroviral transduction and retransduction with MFG-IRAP. Arthritis Rheum 1995, 38(suppl):S281.
21. Muller-Ladner U, Roberts CR, Franklin BN, Gay RE, Robbins PD, Evans CH, Gay S: Gene transfer of interleukin-1 receptor antagonist protein (IRAP) into human synovial fibroblasts and implantation into SCID mouse. Arthritis Rheum 1995, 38(suppl):S398.
22. Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, Lotz M, Kipps TJ, Carson DA: Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sci U S A 1993, 90:4523-4537.
23. Boggs SS, Patrene KD, Mueller GM, Evans CH, Doughty LA, Robbins PD: Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic cells transduced with a retrovirus carrying the hIL-1ra cDNA. Gene Ther 1995, 2:632-638. Demonstration that lifelong high systemic levels of biologically active IL-1Ra can be achieved by gene transfer to hematopoietic stem cells.
24. Van de Loo FAJ, Joosten LAB, Van Lent PLEM, Arntz OJ, Van den Berg WB: Role of interleukin-1, tumor necrosis factor α, and interleukin-6 in cartilage proteoglycan metabolism and destruction: effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum 1995, 38:164-172.
25. Chernajovsky Y, Adans G, Podhajcer O, Mueller G, Robbins PD, Feldmann M: Inhibition of transfer of collagen induced arthritis into SCID mice by gene transfer of spleen cells with retrovirus expressing soluble human tumor necrosis factor receptor. Gene Ther 1995, 2:731-735. Further demonstration that systemic gene delivery has the potential to suppress the development of arthritis in experimental animals.
26. Evans CH, Robbins PD: Progress toward the treatment of arthritis by gene therapy. Ann Med 1995, 27:543-546.
27. Recombinant DNA Advisory Committee: Minutes of meeting June 9-10, 1994. Hum Gene Ther 1995, 6:239-241.
28. Evans CH, Robbins PD: Gene therapy as a treatment for rheumatoid arthritis. Exp Opin Invest Drugs 1995, 4:843-852.