Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts

Journal of Clinical Investigation

Volumn 104, Issue 2, 1999, Pages 137-146

  Takayanagi, Hiroshi ^a   Juji, Takuo ^a   Miyazaki, Tsuyoshi ^a   Iizuka, Hideharu ^a   Takahashi, Tokiharu ^a   Isshiki, Masashi ^a   Okada, Masato ^b   Tanaka, Yoshiya ^c   Koshihara, Yasuko ^d   Oda, Hiromi ^a   Kurokawa, Takahide ^a   Nakamura, Kozo ^a   Tanaka, Sakae ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; INTERLEUKIN 6;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENE TRANSFER; GROWTH REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTIC INFILTRATION; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; REACTION ANALYSIS; RHEUMATOID ARTHRITIS; SYNOVIUM;

EID: 0032739075     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI6093     Document Type: Article

References (52)

1. Firestein, G.S. 1996. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum. 39:1781-1790.
2. Müller-Ladner, U., Gay, R.E., and Gay, S. 1997. Cellular pathways of joint destruction. Curr. Opin. Rheumatol. 9:213-220.
3. Fassbender, H.G. 1983. Histomorphological basis of articular cartilage destruction in rheumatoid arthritis. Coll. Relat. Res. 3:141-155.
4. Hamilton, J.A. 1983. Hypothesis: in vitro evidence for the invasive and tumor-like properties of the rheumatoid pannus. J. Rheumatol. 10:845-851.
5. Yocum, D.E., Lafyatis, R., Remmers, E.F., Schumacher, H.R., and Wilder, R.L. 1988. Hyperplastic synoviocytes from rats with streptococcal cell wall-induced arthritis exhibit a transformed phenotype that is thymic-dependent and retinoid inhibitable. Am. J. Pathol. 132:38-48.
6. Isomaki, P., and Punnonen, J. 1997. Pro- and anti-inflammatory cytokines in rheumatoid arthritis. Ann. Med. 29:499-507.
7. Cawston, T.E. 1995. Proteinases and connective tissue breakdown. In Mechanisms and models in rheumatoid arthritis. B. Henderson, J.C.W. Edwards, and E.R. Pettipher, editors. Academic Press. London, United Kingdom. 333-359.
8. Takayanagi, H., et al. 1997. A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis Biochem. Biophys. Res. Commun. 240:279-286.
9. Gravallese, E.M., et al. 1998. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am. J. Pathol. 152:943-951.
10. Müller-Ladner, U., Kriegsmann, J., Gay, R.E., and Gay, S. 1995. Oncogenes in rheumatoid arthritis. Rheum. Dis. Clin. North Am. 21:675-690.
11. Bromley, M., and Woolley, D.E. 1984. Chondroclasts and osteoclasts at subchondral sites of erosion in the rheumatoid joint. Arthritis Rheum. 27:968-975.
12. Parsons, J.T., and Parsons, S.J. 1997. Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways. Curr. Opin. Cell Biol. 9:187-192.
13. Thomas, S.M., and Brugge, J.S. 1997. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 13:513-609.
14. Soriano, P., Montgomery, C., Geske, R., and Bradley, A. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 64:693-702.
15. c-src. Nature. 351:69-72.
16. Okada, M., Nada, S., Yamanashi, Y., Yamamoto, T., and Nakagawa, H. 1991. CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J. Biol. Chem. 266:24249-24252.
17. Arnett, F.C., et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315-324.
18. Burmester, G.R., Dimitriu-Bona, A., Waters, S.J., and Winchester, R.J. 1983. Identification of three major synovial lining cell populations by monoclonal antibodies directed to Ia antigens and antigens associated with monocytes/macrophages and fibroblasts. Scand. J. Immunol. 17:69-82.
19. Miyake, S., et al. 1996. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc. Natl. Acad. Sci. USA. 93:1320-1324.
20. Tanaka, S., et al. 1998. Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor. J. Bone Miner. Res. 13:1714-1720.
21. Sanes, J.R., Rubenstein, J.L., and Nicolas, J.F. 1986. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos. EMBO J. 5:3133-3142.
22. 2+ waves preferentially originate at specific loci in caveolin-rich cell edges. Proc. Natl Acad. Sci. USA. 95:5009-5014.
23. c-src, preferentially on ruffled border membranes. FEBS Lett. 313:85-89.
24. Chomczynski, P., and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
25. Chandrasekar, B., Melby, P.C., Troyer, D.A., and Freeman, G.L. 1996. Induction of proinflammatory cytokine expression in experimental acute Chagasic cardiomyopathy. Biochem. Biophys. Res. Commun. 223:365-371.
26. Takahashi, N., et al. 1988. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology. 122:1373-1382.
27. Zhang, H., et al. 1997. Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. J. Clin. Invest. 100:1951-1957.
28. Ackerman, N.R., et al. 1979. Effects of naproxen on connective tissue changes in the adjuvant arthritic rat. Arthritis Rheum. 22:1365-1374.
29. Guerne, P.A., Zuraw, B.L., Vaughan, J.H., Carson, D.A., and Lotz, M. 1989. Synovium as a source of interleukin 6 in vitro. Contribution to local and systemic manifestations of arthritis. J Clin. Invest. 83:585-592.
30. Bandara, G., et al. 1993. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc. Natl. Acad. Sci. USA. 90:10764-10768.
31. Miller, D.G., Adam, M.A., and Miller, A.D. 1990. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol. 10:4239-4242.
32. Rubin, B.A., and Rorke, L.B. 1988. Adenovirus vaccines. In Vaccines. S.A. Plotkin and E.A.J. Mortimer, editors. W.B. Saunders. Philadelphia. PA. 492-512.
33. Nita, I., et al. 1996. Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum. 39:820-828.
34. Le, C.H., Nicolson, A.G., Morales, A., and Sewell, K.L. 1997. Suppression of collagen-induced arthritis through adenovirus-mediated transfer of a modified tumor necrosis factor α receptor gene. Arthritis Rheum. 40:1662-1669.
35. Ghivizzani, S.C., et al. 1998. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor α soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc. Natl. Acad. Sci. USA. 95:4613-4618.
36. Apparailly, F., et al. 1998. Adenovirus-mediated transfer of viral IL-10 gene inhibits murine collagen-induced arthritis. J. Immunol. 160:5213-5220.
37. Parks, E., et al. 1998. Transient gene transfer of IL-12 regulates chemokine expression and disease severity in experimental arthritis. J. Immunol. 160:4615-4619.
38. Brown, M.T., and Cooper, J.A. 1996. Regulation, substrates and functions of src. Biochim. Biophys Acta. 1287:121-149.
39. Sabe, H., Okada, M., Nakagawa, H., and Hanafusa, H. 1992. Activation of c-Src in cells bearing v-Crk and its suppression by Csk. Mol. Cell. Biol. 12:4706-4713.
40. csk. Nature. 365:156-160.
41. 2 production in response to lipopolysaccharide in the macrophage cell line J774A.1. Eur. J. Immunol. 27:742-749.
42. Kaplan, K.B., et al. 1994. Association of the amino-terminal half of c-Src with focal adhesions alters their properties and is regulated by phosphorylarion of tyrosine 527. EMBO J. 13:4745-4756.
43. 5 integrin, and interferes with HeLa cell spreading. Mol. Cell. Biol. 15:711-722.
44. Houssiau, F.A., Devogelaer, J.P., Van Damme, J., de Deuxchaisnes, C.N., and Van Snick, J. 1988. Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 31:784-788.
45. Brozik, M., et al. 1992. Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production. J. Rheumatol. 19:63-68.
46. Mihara, M., Moriya, Y., Kishimoto, T., and Ohsugi, Y. 1995. Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor. Br. J. Rheumatol. 34:321-325.
47. Kotake, S., et al. 1996. Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J. Bone Miner. Res. 11:88-95.
48. Miyazawa, K., Mori, A., Yamamoto, K., and Okudaira, H. 1998. Constitutive transcription of the human interleukin-6 gene by rheumatoid synoviocytes: spontaneous activation of NF-κB and CBF1. Am. J. Pathol. 152:793-803.
49. Ohshima, S., et al. 1998. Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc. Natl. Acad. Sci. USA. 95:8222-8226.
50. Takagi, N., et al. 1998. Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum. 41:2117-2121.
51. Abu-Amer, Y., et al. 1998. Tumor necrosis factor-α activation of nuclear transcription factor-κB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of IκBα. J. Biol. Chem. 273:29417-29423.
52. Lowe, C., et al. 1993. Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc. Natl. Acad. Sci. USA. 90:4485-4489.