Activation of synovial fibroblasts in rheumatoid arthritis: Lack of expression of the tumour suppressor PTEN at sites of invasive growth and destruction

Arthritis Research

Volumn 2, Issue 1, 2000, Pages 59-64

  Pap, T ^a   Franz, J K ^a   Hummel, K M ^a   Jeisy, E ^a   Gay, R ^a   Gay, S ^a  

^a WORLD HEALTH ORGANIZATION   (Switzerland)

Author keywords

Cartilage destruction; Fibroblasts; In situ hybridization; PTEN tumour suppressor; Rheumatoid arthritis; Severe combined immunodeficiency (SCID) mouse model; Synovial membrane

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOMATION; CARTILAGE; CARTILAGE DEGENERATION; CELL ACTIVATION; CELL INVASION; CONTROLLED STUDY; FIBROBLAST; FIBROBLAST CULTURE; GENE SEQUENCE; GENETICS; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SCID MOUSE; STAINING; SYNOVIUM;

ANIMALS; ARTHRITIS, RHEUMATOID; CARTILAGE; CELLS, CULTURED; FIBROBLASTS; GENES, TUMOR SUPPRESSOR; HUMANS; IN SITU HYBRIDIZATION; MICE; MICE, SCID; MODELS, ANIMAL; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; POLYMERASE CHAIN REACTION; PTEN PHOSPHOHYDROLASE; RNA, MESSENGER; SYNOVIAL MEMBRANE; TUMOR SUPPRESSOR PROTEINS;

EID: 0034467058     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar69     Document Type: Article

References (16)

1. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
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4. Cellular pathways of joint destruction
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7. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
8. Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
9. Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues
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11. Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry
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14. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
15. Transforming growth factor-beta production by synovial tissues from rheumatoid patients and streptococcal cell wall arthritic rats. Studies on secretion by synovial fibroblast-like cells and immunohistologic localization
16. Expression of sentrin, a novel anti-apoptotic molecule at sites of synovial invasion in rheumatoid arthritis