Induction of apoptosis in the rheumatoid synovium by Fas ligand gene transfer

Gene Therapy

Volumn 5, Issue 3, 1998, Pages 331-338

  Okamoto, K ^a   Asahara, H ^a   Kobayashi, T ^a   Matsuno, H ^b   Hasunuma, T ^a   Kobata, T ^a,c   Sumida, T ^a   Nishioka, K ^a  

^a ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Fas FasL; Gene therapy; Rheumatoid arthritis

Indexed keywords

FAS LIGAND;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMBINED IMMUNODEFICIENCY; CYTOTOXICITY; GENE TRANSFER; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOHISTOCHEMISTRY; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 0031932949     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300597     Document Type: Article

References (39)

1. Harris EDJ. Rheumatoid arthritis. Pathophysiology and implications for therapy. New Engl J Med 1990; 322: 1277-1289.
2. Zvaifler NJ. Rheumatoid arthritis. The multiple pathways to chronic rheumatoid synovitis. lab Invest 1995; 73: 307-310.
3. Nakajima T et al. Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis Rheum 1995; 38: 485-491.
4. Firestein GS, Yeo M, Zvaifler NJ. Apoptosis in rheumatoid synovium. J Clin Invest 1995; 96: 1631-1638.
5. Hoa TTM et al. Novel mechanisms of selective apoptosis in synovial T cells of patients with rheumatoid arthritis. J Rheumatol 1996; 23: 1332-1337.
6. Itoh N et al. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 1991; 66: 233-243.
7. Leithäuser F et al. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest 1993; 69: 415-429.
8. Nagata S. Fas and Fas ligand: a death factor and its receptor. Adv Immunol 1994; 57: 129-144.
9. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993; 75: 1169-1178.
10. Hanabuchi S et al. Fas and its ligand in a general mechanism of T cell-mediated cytotoxicity. Proc Natl Acad Sci USA 1994; 91: 4930-4934.
11. Suda T et al Expression of the Fas ligand in cells of T cell lineage. J lmmunol 1995; 154: 3806-3813.
12. Arase H, Arase N, Saito T. Fas-mediated cytotoxicity by freshly isolated natural killer cells. J Exp Med 1995, 181: 1235-1238.
13. Iwakura Y et al. Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-1. Science 1991; 253: 1026-1028.
14. Fujisawa K et al. Therapeutic effect of the anti-Fas antibody on arthritis in HTLY-1 tax transgenic mice. J Clin Invest 1996; 98: 271-278.
15. Ogasawara J et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993: 364. 806-809.
16. Rensing-Ehl A et al. Local Fas/APO-1 (CD95) ligand-mediated tumor cell killing in vivo. Ear J Immunol 1995; 25: 2253-2258.
17. Kayagaki N et al. Metalloproteinase-mediated release of human Fas ligand. J Exp Med 1995; 182: 1777-1783.
18. Matsuno H et al. Etiology and treatment effects of apoptosis in RA patients - using animal model study. Arthritis Rheum 1997; 40 (Suppl 9): S1579 (Abstr.).
19. Karasuyama H, Tohyama N, Tada T. Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene. J Exp Med 1989; 169: 13-25.
20. Beer JZ et al. Loss of tumorigenicity with simultaneous changes in radiosensitivity and photosensitivity during in vitro growth of L5178Y murine lymphoma cells. Cancer Res 1983; 43: 4736-4742.
21. Okamoto K et al. Selective activation of JNK/AP-1 pathway in Fas-mediated apoptosis of rheumatoid arthritis synoviocytes. Arthritis Rheum 1997; 40: 919-926.
22. Mima T et al. Transfer of rheumatoid arthritis into severe combined immunodeficient mice: the pathogenetic implications of T cell populations oligoclonally expanding in the rheumatoid joints. J Clin Invest 1995; 96: 1746-1758.
23. McCune JM et al. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 1988; 241: 1632-1639.
24. Mosier DE, Gulizia RJ, Baird SM, Wilson DB. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 1988; 335: 256-259.
25. Kamel-Reid S, Dick JE. Engraftment of immune-deficient mice with human hematopoietic stem cells Science 1988; 242: 1706-1709.
26. Kamel-Reid S et al. A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. Science 1989; 246: 1597-1600.
27. Barry TS, Jones DM, Richter CB, Haynes BF. Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thy- mic components with irradiation versus anti-asialo GM-1 immunosuppressive regimens. J Exp Med 1991; 173: 167-180.
28. Sack U et al. Synovial tissue implants from patients with rheumatoid arthritis cause cartilage destruction in knee joints of SCID. bg mice. J Rheumatol 1994; 21: 10-16.
29. Geiler T et al. A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum 1994; 37: 1664-1671.
30. Bandara G et al. Gene transfer to synoviocytes: prospects for gene treatment for arthritis. DNA CM Biol 1992; 11: 227-231.
31. Bandara G et al. Intra-articular expression of biologically active interleukin-1-receptor-antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci USA 1993; 90: 10764-10768.
32. Nita I et al. Direct gene delivery to synovium. An evaluation of potential vector in vitro and in vivo. Arthritis Rheum 1996; 39: 820-828.
33. Roessler BJ et al. Adenovirus-mediated gene transfer to rabbit synovium in vivo. J Clin Invest 1993; 92: 1085-1092.
34. Asahara H et al. Expression of Fas antigen and Fas ligand in the rheumatoid synovial tissue. Clin Immunol Immunopathol 1996; 81: 27-34.
35. Hasunuma T et al. Accumulation of soluble Fas in inflamed joints of patients with rheumatoid arthritis. Arthritis Rheum 1997; 40: 80-86.
36. Seino K, Kayagaki N, Okumura K, Yagita H. Antitumor effect of locally produced CD95 ligand. Nature Med 1997; 3: 165-170.
37. Arnett FC et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988, 31: 315-324.
38. Hasunuma T et al. Establishment and characterization of synovial cell clones with integrated human T-cell leukemia virus type-1. Clin Immunol Immunopathol 1994; 72: 90-97.
39. Gavrich Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.