Intra-articular delivery of a herpes simplex virus IL-1Ra gene vector reduces inflammation in a rabbit model of arthritis

Gene Therapy

Volumn 6, Issue 10, 1999, Pages 1713-1720

  Oligino, T ^a   Ghivizzani, S C ^a   Wolfe, D ^a   Lechman, E R ^a   Krisky, D ^a   Mi, Z ^a   Evans, C H ^a   Robbins, P D ^a   Glorioso, J C ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Arthritis; HSV; IL 1Ra; sTNFR

Indexed keywords

INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR RECEPTOR; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CLONING VECTOR; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; FIBROBLAST; GENE OVEREXPRESSION; GENE TARGETING; GENE THERAPY; HERPES SIMPLEX VIRUS; HISTOLOGY; IMMEDIATE EARLY GENE; KNEE; LAVAGE; LEUKOCYTOSIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; RETROVIRUS; SYNOVIAL FLUID; SYNOVIOCYTE; SYNOVITIS; TRANSGENE;

ADOPTIVE TRANSFER; ANIMALS; ARTHRITIS, EXPERIMENTAL; CELL LINE; FIBROBLASTS; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENETIC VECTORS; HINDLIMB; INFLAMMATION; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; KNEE JOINT; RABBITS; RECEPTORS, TUMOR NECROSIS FACTOR; SIALOGLYCOPROTEINS; SIMPLEXVIRUS; SYNOVIAL MEMBRANE;

EID: 0032845120     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301014     Document Type: Article

References (28)

1. Evans CH et al. Gene therapy in autoimmune diseases. Ann Rheum Dis 1998; 57: 125-127.
2. Evans CH et al. Gene therapy for rheumatic diseases. Arthritis Rheum 1999; 42: 1-16.
3. Bandara G et al. Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer. Proc Natl Acad Sci USA 1993; 90: 10764-10768.
4. Hung G et al. Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium. Gene Therapy 1994; 1: 64-69.
5. Otani K et al. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy. J Immunol 1996; 156: 3558-3562.
6. Evans CH et al. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis. Hum Gene Ther 1996; 7: 1261-1280.
7. Ghivizzani SC et al. Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy. Gene Therapy 1997; 4: 977-982.
8. Nita I et al. Direct gene delivery to synovium. An evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 1996; 39: 820-828.
9. Roessler BJ et al. Adenoviral-mediated gene transfer to rabbit synovium in vivo. J Clin Invest 1993; 92: 1085-1092.
10. Yovandich J et al. Gene transfer to synovial cells by intra-articular administration of plasmid DNA. Hum Gene Ther 1995; 6: 603-610.
11. Tomita T et al. In vivo direct gene transfer into articular cartilage by intraarticular injection mediated by HVJ (Sendai virus) and liposomes. Arthritis Rheum. 1997; 40: 901-906.
12. Ghivizzani SC et al. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects. Proc Natl Acad Sci USA 1998; 95: 4613-4618.
13. Evans CH, Ghivizzani SC, Robbins PD. Blocking cytokines with genes. J Leukocyte Biol 1998; 64: 55-61.
14. Glorioso JC et al. Progress in the development of herpes simplex virus gene vectors for treatment of rheumatoid arthritis. Adv Drug Del Rev 1997; 27: 41-57.
15. Campbell MEM, Palfeyman JW, Preston CM. Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription. J Mol Biol 1984; 180: 1-19.
16. Mackem S, Roizman B. Differentiation between alpha promoter and regulatory regions of herpes simplex virus type 1: the functional domains and sequence of a movable alpha regulator. Proc Natl Acad Sci USA 1982; 79: 4917-4921.
17. DeLuca NA, McCarthy AM, Schaffer PA. Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. J Virol 1985; 56: 558-570.
18. DeLuca NA, Schaffer PA. Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4. Mol Cell Biol 1985; 5: 1997-2008.
19. Krisky DM et al. Deletion of multiple immediate-early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons. Gene Therapy 1998, 5: 1593-1603.
20. Georgescu HI, Mendelow D, Evans CH. An established cell line from rabbit periarticular soft tissue which retains the 'activatable' phenotype. In Vitro 1988; 24: 1015-1022.
21. Ghivizzani SC et al. Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis. J Immunol 1997; 159: 3604-3612.
22. Roessler B et al. Inhibition of interleukin-1 induced effects in synoviocytes transduced with human IL-1 receptor antagonist cDNA using an adenviral vector. Hum Gene Ther 1995; 6: 307-316.
23. Samaniego LA, Neiderhiser L, DeLuca NA. Persistence and expression of the herpes simplex virus genome in the absence of immediate-early proteins. J Virol 1998; 72: 3307-3320.
24. Fisher KJ et al. Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology 1996; 217: 11-22.
25. Kochanek S et al. A new adenoviral vector: replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length Dystrophin and β-galactosidase. Proc Natl Acad Sci USA 1996; 93: 5731-5736.
26. Krisky DM et al. Rapid method for construction of recombinant HSV gene transfer vectors. Gene Therapy 1997; 4: 1120-1125.
27. Peppel K, Crawford D, Beutler B. A tumor necrosis factor (TNF) receptor-Ig heavy chain chimeric protein as a bivalent antagonist of TNF activity. J Exp Med 1991; 174: 1483-1489.
28. McGeoch DJ et al. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1. J Gen Virol 1988; 69: 1531-1574.