Inhibition of cyclooxygenase-2 decreases DNA synthesis induced by platelet-derived growth factor in Swiss 3T3 fibroblasts

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 2, 2000, Pages 509-513

  Castaño, Esther ^a   Bartrons, Ramon ^a   Joan, Gil ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CYCLOOXYGENASE 2; KETOROLAC; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PLATELET DERIVED GROWTH FACTOR; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; SALICYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DRUG EFFECT; DRUG MECHANISM; DRUG SAFETY; ENZYME INHIBITION; FIBROBLAST; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ANIMALS; BLOTTING, WESTERN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DINOPROSTONE; DNA; FIBROBLASTS; ISOENZYMES; MICE; NITROBENZENES; PLATELET-DERIVED GROWTH FACTOR; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZOLES; SULFONAMIDES; THYMIDINE;

EID: 0034055374     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Bhattacharyya DK, LecomteM, Dunn J, Morgans DJ and Smith WL (1995) Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valeryl salicylic acid. Arch Biochem Biophys 317:19-24.
2. Castaño E, Dalmau M, Martí M, Berrocal F, Bartrons R and Gil J (1997) Inhibition of DNA synthesis by aspirin in Swiss 3T3 fibroblasts. J Pharmacol Exp Ther 280:366-372.
3. Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL and Morrow JD (1997) Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci USA 94:657-662.
4. Cohn SM, Schloemann S, Tessner T, Seibert K and Stenson WF (1997) Crypt stem cell survival in the mouse intestinal epithelium is regulated by prostaglandins synthesized through cyclooxygenase-1. J Clin Invest 99:1367-1379.
5. Domin J and Rozengurt E (1993) Platelet-derived growth factor stimulates a biphasic mobilization of arachidonic acid in Swiss 3T3 cells. The role of phospholipase A2. J Biol Chem 268:8927-8934.
6. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S and DuBois RN (1994) Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastrotnterology 107:1183-1188.
7. Elder DJ and Paraskeva C (1998) COX-2 inhibitors for colorectal cancer. Nat Med 4:392-393.
8. Erickson BA, Longo WE, Panesar N. Mazuski JE and Kaminski DL (1999) Theeflect of selective cyclooxygenase inhibitors on intestinal epithelial cell mitogenesis. J Surg Res 81:101-107.
9. Futaki N, Yoshikawa K, Hamasaka Y, Arai I, Higuchi S, Iizuka H and Otomo S (1993) NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol 24:105-110.
10. Gierse JK, McDonald JJ, Hauser SD, Rangwala SH, Koboldt CM and Seibert K (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J Biol Chem 271: 15810-15814.
11. Gil J, Higgins T and Rozengurt E (1991) Mastoparan, a novel mitogen for Swiss 3T3 cells, stimulates pertussis toxin-sensitive arachidonic acid release without inositol phosphate accumulation. J Cell Biol 113:943-950.
12. Hanke B, Furstenberger G and Marks F (1996) Relationship between TGF alpha-induced DNA synthesis and prostaglandin synthesis in human HaCaT keratinocytes. Biochim Biophys Acts 1310:137-144.
13. Herschman HR (1994) Regulation of prostaglandin synthase-1 and prostaglandin synthase-2. Cancer Metastasis Rev 13:241-256.
14. Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnstvorth NR, Kinghorn AD, Mehta RG, Moon RC and Pezzuto JM (1997) Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science (Wash DC) 275:218-220.
15. Kopp E and Ghosh S (1994) Inhibition of NF-kappa B by sodium salicylate and aspirin. Science (Wash DC) 265:956-959.
16. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685.
17. Levy GN (1997) Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer. FASEB J 11:234-247.
18. Martinez J, Sanchez T and Moreno JJ (1997) Role of prostaglandin H synthase-2-mediated conversion of arachidonic acid in controlling 3T6 fibroblast growth. Am J Physiol 273:C1466-C1471.
19. Masferrer JL, Zweifel BS, Manning PT, Hauser SD, Leahy KM, Smith WG, Isakson PC and Seitiert K (1994) Inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic. Proc Natl Acad Sci USA 91:3228-3232.
20. Olashaw NE, Kowalik TF, Huang ES and Pledger WJ (1992) Induction of NF-kappa B-like activity by platelet-derived growth factor in mouse fibroblasts. Mol Biol Cell 3:1131-1139.
21. Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF and Taketo MM (1996) Suppression of intestinal polyposis in Ape delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87:803-809.
22. Patrignani P, Panara MR, Sciulli MG, Santini G, Renda G and Patrono C (1997) Differential inhibition of human prostaglandin endoperoxide synthase-1 and -2 by nonsteroidal anti-inflammatory drugs. J Physiol Pharmacol 48:623-631.
23. Reddy ST and Herschman HR (1994) Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J Biol Chem 269:15473-15480.
24. Rozengurt E (1986) Early signals in the mitogenic response. Science (Wash DC) 234:161-166.
25. Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD and DuBois RN (1997) Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99:2254-2259.
26. Sheng H, Williams CS, Shao J, Liang P, DuBois RN and Beauchamp RD (1998) Induction of cyclooxygenase-2 by activated Ha-ras oncogene in Rat-1 fibroblasts and the role of mitogen-activated protein kinase pathway. J Biol Chem 273: 22120-22127.
27. Sniff SJ and Rigas B (1997) Nonsteroidal anti-inflammatory drugs and colorectal cancer: Evolving concepts of their chemopreventive actions. Gastroenterology 113: 1992-1998.
28. Smalley WE and DuBois RN (1997) Colorectal cancer and nonsteroidal anti-inflammatory drugs. Adv Pharmacol 39:1-20.
29. Smith WL (1989) The eicosanoids and their biochemical mechanisms of action. Biochem J 259:315-324.
30. Subbaramaiah K, Altorki N, Chung WJ, Mestre JR, Sampat A and Dannenberg AJ (1999) Inhibition of cyclooxygenase-2 gene expression by p53. J Biol Chem 274: 10911-10915.
31. Taketo MM (1998) Cyclooxygenase-2 inhibitors in tumorigenesis (part II). J Natl Cancer Inst 90:1609-1620.
32. Tsuji S, Kawano S, Sawaoka H, Takei Y, Kobayashi I, Nagano K, Fusamoto H and Kamada T (1996) Evidences for involvement of cyclooxygenase-2 in proliferation of two gastrointestinal cancer cell lines. Prostaglandins Leukot Essent Fatty Acids 55:179-183.
33. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M and DuBois RN (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer. Cell 93:705-716.
34. Vadlamudi R, Mandai M, Adam L, Steinbach G, Mendelsohn J and Kumar R (1999) Regulation of cyclooxygenase-2 pathway by HER2 receptor. Oncogene 18:305-314.
35. Vane JR (1971) Inhibition of prostaglandin synthesis as mechanism of action for aspirin-like drugs. Nat New Biol 231:232-235.
36. Vane JR, Bakhle YS and Botting RM (1998) Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol 38:97-120.
37. Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA and Vane J (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with gastrointestinal toxicity: A full in vitro analysis. Proc Natl Acad Sci USA 96:7563-7568.
38. Williams CS and DuBois RN (1996) Prostaglandin endoperoxide synthase: Why two isoforms? Am J Physiol 270:G393-G400.
39. Xie W and Herschman HR (1995) v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J Biol Chem 270:27622-27628.
40. Yin MJ, Yamamoto Y and Gaynor RB (1998) The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature (Lond) 396: 77-80.