-
1
-
-
0032544181
-
Cilostazol has beneficial effects in treatment of intermittent claudication: Results from a multicenter, randomized, prospective, double-blind trial
-
Dawson, D. L., B. S. Cutler, M. H. Meissner, and D. E. J. Strandness. 1998. Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trial. Circulation 98:678.
-
(1998)
Circulation
, vol.98
, pp. 678
-
-
Dawson, D.L.1
Cutler, B.S.2
Meissner, M.H.3
Strandness, D.E.J.4
-
2
-
-
0032246995
-
Anliasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig
-
Underwood, D., S. Bochnowicz, R. Osborn, C. Kotzer, M. Luttmann, D. Hay, P. Gorycki, S. Christensen, and T. Torphy, 1998. Anliasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig. Journal of Pharmacology & Experimental Therapeutics. 287:988.
-
(1998)
Journal of Pharmacology & Experimental Therapeutics.
, vol.287
, pp. 988
-
-
Underwood, D.1
Bochnowicz, S.2
Osborn, R.3
Kotzer, C.4
Luttmann, M.5
Hay, D.6
Gorycki, P.7
Christensen, S.8
Torphy, T.9
-
3
-
-
0032516296
-
Oral sildenafil in the treatment of erectile dysfunction
-
Sildenafil Study Group
-
Goldstein, I., T. Lue, H. Padma-Nathan, R. Rosen, W. Steers, and P. Wicker. 1998. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. N Engl J Med 338:1397.
-
(1998)
N Engl J Med
, vol.338
, pp. 1397
-
-
Goldstein, I.1
Lue, T.2
Padma-Nathan, H.3
Rosen, R.4
Steers, W.5
Wicker, P.6
-
4
-
-
0015539983
-
Induction of cytolysis of cultured lymphoma cells by adenosine 3′:5′-cyclic monophosphate and isolation of resistant variants
-
Daniel, V., G. Litwack, and G. M. Tompkins. 1973. Induction of cytolysis of cultured lymphoma cells by adenosine 3′:5′-cyclic monophosphate and isolation of resistant variants. Proc. Natl. Acad Sci. USA 70:76.
-
(1973)
Proc. Natl. Acad Sci. USA
, vol.70
, pp. 76
-
-
Daniel, V.1
Litwack, G.2
Tompkins, G.M.3
-
5
-
-
0016816003
-
Mechanism of lymphoma cell death induced by cyclic AMP
-
Coffino, P., H. R. Bourne, and G. M. Tomkins. 1975. Mechanism of lymphoma cell death induced by cyclic AMP. Am. J. Pathol. 81:199.
-
(1975)
Am. J. Pathol.
, vol.81
, pp. 199
-
-
Coffino, P.1
Bourne, H.R.2
Tomkins, G.M.3
-
6
-
-
0025024913
-
Agents that elevate cAMP stimulate DNA fragmentation in thymocytes
-
McConkey, D. J., S. Orrenius, and M. Jondal. 1990. Agents that elevate cAMP stimulate DNA fragmentation in thymocytes. J. Immunol. 145:1227.
-
(1990)
J. Immunol.
, vol.145
, pp. 1227
-
-
McConkey, D.J.1
Orrenius, S.2
Jondal, M.3
-
7
-
-
0027426206
-
Distribution of cAMP in secondary follicles and its expression in B cell apoptosis and CD40-mediated survival
-
Knox, K. A., G. D. Johnson, and J. Gordon. 1993. Distribution of cAMP in secondary follicles and its expression in B cell apoptosis and CD40-mediated survival. Int. Immunol. 5:1085.
-
(1993)
Int. Immunol.
, vol.5
, pp. 1085
-
-
Knox, K.A.1
Johnson, G.D.2
Gordon, J.3
-
8
-
-
0028980745
-
TGF-B1 and cyclic AMP promote apoptosis in resting human B lymphocytes
-
Lomo, J., H. K. Blomhoff, K. Beiske, T. Stokke, and E. B. Smeland. 1995. TGF-B1 and cyclic AMP promote apoptosis in resting human B lymphocytes. J. Immunol. 154:1634.
-
(1995)
J. Immunol.
, vol.154
, pp. 1634
-
-
Lomo, J.1
Blomhoff, H.K.2
Beiske, K.3
Stokke, T.4
Smeland, E.B.5
-
10
-
-
0032480888
-
Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
-
de Rooij, J., F. J. T. Zwartkruis, M. H. G. Verheijen, R. H. Cool, S. M. B. Nijman, A. Wittinghofer, and J. L. Bos. 1998. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cAMP. Nature 396:474.
-
(1998)
Nature
, vol.396
, pp. 474
-
-
De Rooij, J.1
Zwartkruis, F.J.T.2
Verheijen, M.H.G.3
Cool, R.H.4
Nijman, S.M.B.5
Wittinghofer, A.6
Bos, J.L.7
-
11
-
-
0029050664
-
A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth
-
Nesterova, M., and Y. S. Cho-Chung. 1995. A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth. Nat Med 1:528.
-
(1995)
Nat Med
, vol.1
, pp. 528
-
-
Nesterova, M.1
Cho-Chung, Y.S.2
-
12
-
-
0032527802
-
Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide
-
Ciardiello, F., R. Caputo, R. Bianco, V. Damiano, G. Pomatico, S. Pepe, A. R. Bianco, S. Agrawal, J. Mendelsohn, and G. Tortora. 1998. Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide. JNCI 90:1087.
-
(1998)
JNCI
, vol.90
, pp. 1087
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Pomatico, G.5
Pepe, S.6
Bianco, A.R.7
Agrawal, S.8
Mendelsohn, J.9
Tortora, G.10
-
13
-
-
0023864503
-
Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic and acute lymphocytic human leukemia cell lines
-
Tortora, G., P. Tagliaferri, T. Clair, O. Colamonici, L. M. Neekers, R. K. Robins, and Y. S. Cho-Chung. 1988. Site-selective cAMP analogs at micromolar concentrations induce growth arrest and differentiation of acute promyelocytic, chronic myelocytic and acute lymphocytic human leukemia cell lines. Blood 71:230.
-
(1988)
Blood
, vol.71
, pp. 230
-
-
Tortora, G.1
Tagliaferri, P.2
Clair, T.3
Colamonici, O.4
Neekers, L.M.5
Robins, R.K.6
Cho-Chung, Y.S.7
-
14
-
-
0025753771
-
8-Chloroadenosine 3′,5′-monophosphate inhibits the growth of chinese hamster ovary and molt 4 cells through its adenosine metabolite
-
Van Lookeren Campagne, M. M., F. V. Diaz, B. Jastorff, and R. H. Kessin. 1991. 8-chloroadenosine 3′,5′-monophosphate inhibits the growth of chinese hamster ovary and Molt 4 cells through its adenosine metabolite. Cancer Res 51:1600.
-
(1991)
Cancer Res
, vol.51
, pp. 1600
-
-
Van Lookeren Campagne, M.M.1
Diaz, F.V.2
Jastorff, B.3
Kessin, R.H.4
-
15
-
-
0027490967
-
Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parenteral 8-Cl-cAMP
-
Han, Z., D. Chatterjee, and J. H. Wyche. 1993. Proliferation of nontransformed cells is inhibited by adenosine metabolite of but not by parenteral 8-Cl-cAMP. J Pharm Exper Therap 265:790.
-
(1993)
J Pharm Exper Therap
, vol.265
, pp. 790
-
-
Han, Z.1
Chatterjee, D.2
Wyche, J.H.3
-
16
-
-
0029123371
-
Theophylline, a new inducer of apoptosis in B-CLL: Role of cylic nucleotides
-
Mentz, F., H. Merle-Beral, F. Ouaaz, and J.-L. Binet. 1995. Theophylline, a new inducer of apoptosis in B-CLL: role of cylic nucleotides. Br. J. Hematol. 90:957.
-
(1995)
Br. J. Hematol.
, vol.90
, pp. 957
-
-
Mentz, F.1
Merle-Beral, H.2
Ouaaz, F.3
Binet, J.-L.4
-
17
-
-
0029815706
-
Theophylline synergizes with chlorambucil in inducing apoptosis of B-chronic lymphocytic leukemia cells
-
Mentz, F., M. D. Mossalayi, F. Ouaaz, S. Baudet, F. Issaly, S. Ktorza, M. Semichon, J.-L. Binet, and H. Merle-Beral. 1996. Theophylline synergizes with chlorambucil in inducing apoptosis of B-chronic lymphocytic leukemia cells. Blood 88:2172.
-
(1996)
Blood
, vol.88
, pp. 2172
-
-
Mentz, F.1
Mossalayi, M.D.2
Ouaaz, F.3
Baudet, S.4
Issaly, F.5
Ktorza, S.6
Semichon, M.7
Binet, J.-L.8
Merle-Beral, H.9
-
18
-
-
0032954675
-
Theophyl-line-induced B-CLL apoptosis is partly dependent on cyclic AMP production but independent of CD38 expression and endogenous IL-10 production
-
Mentz, F., H. Merle-Beral, and A. Dalloul. 1999. Theophyl-line-induced B-CLL apoptosis is partly dependent on cyclic AMP production but independent of CD38 expression and endogenous IL-10 production. Leukemia 13:78.
-
(1999)
Leukemia
, vol.13
, pp. 78
-
-
Mentz, F.1
Merle-Beral, H.2
Dalloul, A.3
-
19
-
-
0029797436
-
In vitro and in vivo anti-leukemic efficacy of cyclic AMP modulating agents against human leukemic B cell precursors
-
Myers, D., M. Chandun-Langlie, L. Chelstrom, and F. Uckun. 1996. In vitro and in vivo anti-leukemic efficacy of cyclic AMP modulating agents against human leukemic B cell precursors. Leukemia and Lymphoma 22:259.
-
(1996)
Leukemia and Lymphoma
, vol.22
, pp. 259
-
-
Myers, D.1
Chandun-Langlie, M.2
Chelstrom, L.3
Uckun, F.4
-
20
-
-
0026669254
-
A simple fluorescence method for surface antigen phe-notyping of lymphocytes undergoing DNA fragmentation
-
Hardin, J. A., D. H. Sherr, M. DeMaria, and P. A. Lopez. 1992. A simple fluorescence method for surface antigen phe-notyping of lymphocytes undergoing DNA fragmentation. J. Immunol. Methods 154:99.
-
(1992)
J. Immunol. Methods
, vol.154
, pp. 99
-
-
Hardin, J.A.1
Sherr, D.H.2
DeMaria, M.3
Lopez, P.A.4
-
21
-
-
0029591322
-
Synergistic action of alkylating agents and methylxanthine derivatives in the treatment of chronic lymphocytic leukemia
-
Binet, J.-L., F. Mentz, V. Leblond, and H. Merle-Beral. 1995. Synergistic action of alkylating agents and methylxanthine derivatives in the treatment of chronic lymphocytic leukemia. Leukemia 9:2159.
-
(1995)
Leukemia
, vol.9
, pp. 2159
-
-
Binet, J.-L.1
Mentz, F.2
Leblond, V.3
Merle-Beral, H.4
-
22
-
-
0033005763
-
Therapeutic efficacy of theophylline in chronic lymphocytic leukemia
-
Makower, D., U. Malik, Y. Novik, and P. Wiernik. 1999. Therapeutic efficacy of theophylline in chronic lymphocytic leukemia. Med Oncol 16:69.
-
(1999)
Med Oncol
, vol.16
, pp. 69
-
-
Makower, D.1
Malik, U.2
Novik, Y.3
Wiernik, P.4
-
23
-
-
0030974622
-
Tailoring cAMP-signalling responses through isoform multiplicity
-
Houslay, M. D., and G. Milligan. 1997. Tailoring cAMP-signalling responses through isoform multiplicity. Trends Biochem. Sci.:217.
-
(1997)
Trends Biochem. Sci.
, pp. 217
-
-
Houslay, M.D.1
Milligan, G.2
-
24
-
-
0003226768
-
Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia
-
Kim, D. H., and A. Lerner. 1998. Type 4 cyclic adenosine monophosphate phosphodiesterase as a therapeutic target in chronic lymphocytic leukemia. Blood 92:2484.
-
(1998)
Blood
, vol.92
, pp. 2484
-
-
Kim, D.H.1
Lerner, A.2
-
25
-
-
0024331946
-
Chemotactic peptide induces cAMP elevation in human neutrophils by amplification of the adenylate cyclase response to endogenously produced adenosine
-
Iannone, M. A., G. Wolberg, and T. P. Zimmerman. 1989. Chemotactic peptide induces cAMP elevation in human neutrophils by amplification of the adenylate cyclase response to endogenously produced adenosine. J Biol Chem 264:20177.
-
(1989)
J Biol Chem
, vol.264
, pp. 20177
-
-
Iannone, M.A.1
Wolberg, G.2
Zimmerman, T.P.3
-
26
-
-
0023162087
-
Identification and characterization of Ca2+-calmodulin-sensitive cyclic nucleotide phosphodiesterase in a human lymphoblastoid cell line
-
Epstein, P. M., S. Moraski, and R. Hachisu. 1987. Identification and characterization of Ca2+-calmodulin-sensitive cyclic nucleotide phosphodiesterase in a human lymphoblastoid cell line. Biochem. J. 243:533.
-
(1987)
Biochem. J.
, vol.243
, pp. 533
-
-
Epstein, P.M.1
Moraski, S.2
Hachisu, R.3
-
27
-
-
0017726762
-
Increased cyclic nucleotide phosphodiesterase activity associated with proliferation and cancer in human and murine lymphoid cells
-
Epstein, P. M., J. S. Mills, C. P. Ross, S. J. Strada, E. M. Hersh, and W. J. Thompson. 1977. Increased cyclic nucleotide phosphodiesterase activity associated with proliferation and cancer in human and murine lymphoid cells. Cancer Res. 37:4016.
-
(1977)
Cancer Res.
, vol.37
, pp. 4016
-
-
Epstein, P.M.1
Mills, J.S.2
Ross, C.P.3
Strada, S.J.4
Hersh, E.M.5
Thompson, W.J.6
-
28
-
-
0025284702
-
Induction of a calcium/calmodulin-dependent phosphodiesterase during PHA-stimulated lymphocyte mitogenesis
-
Hurwitz, R. L., K. M. Hirsch, D. J. Clark, V. N. Holcombe, and M. Y. Hurwitz. 1990. Induction of a calcium/calmodulin-dependent phosphodiesterase during PHA-stimulated lymphocyte mitogenesis. J. Biol. Chem. 265:8901.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 8901
-
-
Hurwitz, R.L.1
Hirsch, K.M.2
Clark, D.J.3
Holcombe, V.N.4
Hurwitz, M.Y.5
-
29
-
-
0029148807
-
Cyclic nucleotide phosphodiesterases from purified human CD4+ and CDs+ T lymphocytes
-
Tenor, H., L. Staniciu, C. Schudt, A. Hatzelmann, A. Wendel, R. Djukanovic, M. K. Church, and J. K. Shute. 1995. Cyclic nucleotide phosphodiesterases from purified human CD4+ and CDS+ T lymphocytes. Clin Exper Aller 25:616.
-
(1995)
Clin Exper Aller
, vol.25
, pp. 616
-
-
Tenor, H.1
Staniciu, L.2
Schudt, C.3
Hatzelmann, A.4
Wendel, A.5
Djukanovic, R.6
Church, M.K.7
Shute, J.K.8
-
30
-
-
0031887507
-
Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation
-
Gantner, F., C. Gotz, V. Gekeler, C. Schudt, A. Wendel, and A. Hatzelmann. 1998. Phosphodiesterase profile of human B lymphocytes from normal and atopic donors and the effects of PDE inhibition on B cell proliferation. Br J Pharmacol 123:1031.
-
(1998)
Br J Pharmacol
, vol.123
, pp. 1031
-
-
Gantner, F.1
Gotz, C.2
Gekeler, V.3
Schudt, C.4
Wendel, A.5
Hatzelmann, A.6
-
31
-
-
0029745055
-
Inhibition of calmodulin dependent phosphodiesterase induces apoptosis in human leukemic cells
-
Jiang, X., J. Li, M. Paskind, and P. M. Epstein. 1996. Inhibition of calmodulin dependent phosphodiesterase induces apoptosis in human leukemic cells. Proc. Natl. Acad. Sci. USA 93:11236.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 11236
-
-
Jiang, X.1
Li, J.2
Paskind, M.3
Epstein, P.M.4
-
32
-
-
85011468695
-
Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: Possible role for protein kinase b but not mitogen-activated protein kinase or p70 S6 kinase
-
Wijkander, J., T. R. Landstrom, V. Manganiello, P. Belfrage, and E. Degerman. 1998. Insulin-induced phosphorylation and activation of phosphodiesterase 3B in rat adipocytes: possible role for protein kinase B but not mitogen-activated protein kinase or p70 S6 kinase. Endocrinology 139:219.
-
(1998)
Endocrinology
, vol.139
, pp. 219
-
-
Wijkander, J.1
Landstrom, T.R.2
Manganiello, V.3
Belfrage, P.4
Degerman, E.5
-
33
-
-
0025314048
-
Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: Inhibition of cyclic AMP breakdown by cyclic GMP
-
Maurice, D. H., and R. J. Haslam. 1990. Molecular basis of the synergistic inhibition of platelet function by nitrovasodilators and activators of adenylate cyclase: inhibition of cyclic AMP breakdown by cyclic GMP. Mol Pharmacol 37:671.
-
(1990)
Mol Pharmacol
, vol.37
, pp. 671
-
-
Maurice, D.H.1
Haslam, R.J.2
-
34
-
-
0031442533
-
Cyclic AMP phosphodiesterases in human lymphocytes
-
Sheth, S. B., K. Chaganti, M. Bastepe, J. Ajuria, K. Brennan, R. Biradovolu, and R. W. Colman. 1997. Cyclic AMP phosphodiesterases in human lymphocytes. Br. Journal of Haematology 99:784.
-
(1997)
Br. Journal of Haematology
, vol.99
, pp. 784
-
-
Sheth, S.B.1
Chaganti, K.2
Bastepe, M.3
Ajuria, J.4
Brennan, K.5
Biradovolu, R.6
Colman, R.W.7
-
35
-
-
0029833842
-
Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CDS+ T-lymphocytes: Role in regulating proliferation and the biosynthesis of interleukin-2
-
Giembycz, M. A., C. J. Corrigan, J. Seybold, R. Newton, and P. J. Barnes. 1996. Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CDS+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2. British Journal of Pharmacology 118:1945.
-
(1996)
British Journal of Pharmacology
, vol.118
, pp. 1945
-
-
Giembycz, M.A.1
Corrigan, C.J.2
Seybold, J.3
Newton, R.4
Barnes, P.J.5
-
36
-
-
0031028090
-
Challenge of human Jurkat T cells with the adenylate cyclase activator forskolin elicits major changes in cAMP PDE expression by up-regulating PDE3 and inducing PDE4DI and PDE4D2 splice variants as well as down regulating a novel PDE4A splice variant
-
Erdogan, S., and M. D. Houslay. 1997. Challenge of human Jurkat T cells with the adenylate cyclase activator forskolin elicits major changes in cAMP PDE expression by up-regulating PDE3 and inducing PDE4DI and PDE4D2 splice variants as well as down regulating a novel PDE4A splice variant. Biochem. J. 321:165.
-
(1997)
Biochem. J.
, vol.321
, pp. 165
-
-
Erdogan, S.1
Houslay, M.D.2
-
37
-
-
0032493818
-
Induction of phosphodiesterases 3A, 4A4, 4D1, 4D2 and 4D3 in Jurkat T cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor antagonists
-
Seybold, J., R. Newton, L. Wright, P. A. Finney, N. Suttorp, P. J. Barnes, I. M. Adcock, and M. A. Giembycz. 1998. Induction of phosphodiesterases 3A, 4A4, 4D1, 4D2 and 4D3 in Jurkat T cells and in human peripheral blood T-lymphocytes by 8-bromo-cAMP and Gs-coupled receptor antagonists. J Biol Chem 273:20575.
-
(1998)
J Biol Chem
, vol.273
, pp. 20575
-
-
Seybold, J.1
Newton, R.2
Wright, L.3
Finney, P.A.4
Suttorp, N.5
Barnes, P.J.6
Adcock, I.M.7
Giembycz, M.A.8
-
38
-
-
0031601339
-
The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: Intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions
-
Houslay, M. D., M. Sullivan, and G. B. Bolger. 1998. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions. Advances in Pharmacology 44:225.
-
(1998)
Advances in Pharmacology
, vol.44
, pp. 225
-
-
Houslay, M.D.1
Sullivan, M.2
Bolger, G.B.3
-
39
-
-
0025994414
-
Hormonal regulation of cyclic nucleotide phosphodiesterases
-
Conti, M., S. C. Jin, L. Monaco, D. R. Repaske, and J. V. Swinnen. 1991. Hormonal regulation of cyclic nucleotide phosphodiesterases. Endocrin. Rev. 12:218.
-
(1991)
Endocrin. Rev.
, vol.12
, pp. 218
-
-
Conti, M.1
Jin, S.C.2
Monaco, L.3
Repaske, D.R.4
Swinnen, J.V.5
-
40
-
-
0026996701
-
Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity
-
Torphy, T. J., H. L. Zhou, and L. B. Cieslinski. 1992. Stimulation of beta adrenoceptors in a human monocyte cell line (U937) up-regulates cyclic AMP-specific phosphodiesterase activity. J. Pharmacol. Exper. Ther. 263:1195.
-
(1992)
J. Pharmacol. Exper. Ther.
, vol.263
, pp. 1195
-
-
Torphy, T.J.1
Zhou, H.L.2
Cieslinski, L.B.3
-
41
-
-
0028231180
-
Effects of rolipram on responses to acute and chronic antigen exposure in monkeys
-
Turner, C. R., C. J. Andresen, W. B. Smith, and J. W. Watson. 1994. Effects of rolipram on responses to acute and chronic antigen exposure in monkeys. Am J Res Crit Care Med 14:1153.
-
(1994)
Am J Res Crit Care Med
, vol.14
, pp. 1153
-
-
Turner, C.R.1
Andresen, C.J.2
Smith, W.B.3
Watson, J.W.4
-
42
-
-
0028912608
-
Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor
-
Genain, C. P., T. Roberts, R. L. Davis, M. H. Nguyen, A. Uccelli, D. Faulds, Y. Li, J. Hedgpeth, and S. L. Hauser. 1995. Prevention of autoimmune demyelination in non-human primates by a cAMP-specific phosphodiesterase inhibitor. Proc. Natl. Acad. Sci. USA. 92:3601.
-
(1995)
Proc. Natl. Acad. Sci. USA.
, vol.92
, pp. 3601
-
-
Genain, C.P.1
Roberts, T.2
Davis, R.L.3
Nguyen, M.H.4
Uccelli, A.5
Faulds, D.6
Li, Y.7
Hedgpeth, J.8
Hauser, S.L.9
-
43
-
-
0027315234
-
The specific type IV PDE inhibitor rolipram suppresses tumor necrosis factor alpha production by human mononuclear cells
-
Semmler, J., H. Wachtel, and S. Endres. 1993. The specific type IV PDE inhibitor rolipram suppresses tumor necrosis factor alpha production by human mononuclear cells. Int. J. Immunopharmacol. 15:409.
-
(1993)
Int. J. Immunopharmacol.
, vol.15
, pp. 409
-
-
Semmler, J.1
Wachtel, H.2
Endres, S.3
-
44
-
-
0028957419
-
Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs
-
Platzer, C., C. Meisel, K. Vogt, M. Platzer, and H. D. Volk. 1995. Up-regulation of monocytic IL-10 by tumor necrosis factor-alpha and cAMP elevating drugs. Int Immunol 7:517.
-
(1995)
Int Immunol
, vol.7
, pp. 517
-
-
Platzer, C.1
Meisel, C.2
Vogt, K.3
Platzer, M.4
Volk, H.D.5
-
45
-
-
0029962380
-
Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine(EHNA) and rolipram
-
Michie, A. M., M. Lobban, T. Muller, M. M. Harnett, and M. D. Houslay. 1996. Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine(EHNA) and rolipram. Cellular Signalling 8:97.
-
(1996)
Cellular Signalling
, vol.8
, pp. 97
-
-
Michie, A.M.1
Lobban, M.2
Muller, T.3
Harnett, M.M.4
Houslay, M.D.5
-
46
-
-
0033556705
-
Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation
-
Baroja, M. L., L. B. Cieslinski, T. J. Torphy, R. L. Wange, and J. Madrenas. 1999. Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation. J Immunol 162:2016.
-
(1999)
J Immunol
, vol.162
, pp. 2016
-
-
Baroja, M.L.1
Cieslinski, L.B.2
Torphy, T.J.3
Wange, R.L.4
Madrenas, J.5
-
47
-
-
0027164208
-
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient saccharomyces cerevisiae
-
Michaeli, T., T. J. Bloom, T. Martins, K. Loughney, K. Ferguson, M. Riggs, L. Rodgers, J. A. Beavo, and M. Wigler. 1993. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J Biol Chem 268:12925.
-
(1993)
J Biol Chem
, vol.268
, pp. 12925
-
-
Michaeli, T.1
Bloom, T.J.2
Martins, T.3
Loughney, K.4
Ferguson, K.5
Riggs, M.6
Rodgers, L.7
Beavo, J.A.8
Wigler, M.9
-
48
-
-
0030459832
-
Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants
-
Bloom, T. J., and J. A. Beavo. 1996. Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc. Natl. Acad. USA 93:14188.
-
(1996)
Proc. Natl. Acad. USA
, vol.93
, pp. 14188
-
-
Bloom, T.J.1
Beavo, J.A.2
-
49
-
-
0033524977
-
CD3 and CD28-dependent induction of PDE7 required for T cell activation
-
Li, L., C. Yee, and J. A. Beavo. 1999. CD3 and CD28-dependent induction of PDE7 required for T cell activation. Science 283:848.
-
(1999)
Science
, vol.283
, pp. 848
-
-
Li, L.1
Yee, C.2
Beavo, J.A.3
-
50
-
-
0343095111
-
Catalytic and kinetic properties of purified high affin-ity cAMP phosphodiesterase from dog kidney
-
Epstein, P. M., S. J. Strada, K. Sarada, and W. J. Thompson. 1982. Catalytic and kinetic properties of purified high affin-ity cAMP phosphodiesterase from dog kidney. Arch Biochem Biophys 215:183.
-
(1982)
Arch Biochem Biophys
, vol.215
, pp. 183
-
-
Epstein, P.M.1
Strada, S.J.2
Sarada, K.3
Thompson, W.J.4
-
51
-
-
0024319477
-
Rolipram in major depressive disorder: Results of a double-blind comparative study with imipramine
-
Hebenstreit, G., K. Fellerer, K. Fichte, G. Fischer, N. Geyer, U. Meya, M. Sastre-y-Hernandez, W. Schony, M. Schratzer, W. Soukop, E. Trampitsch, S. Varosanec, E. Zawada, and R. Zochling. 1989. Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine. Pharmacopsychiatry 22:156.
-
(1989)
Pharmacopsychiatry
, vol.22
, pp. 156
-
-
Hebenstreit, G.1
Fellerer, K.2
Fichte, K.3
Fischer, G.4
Geyer, N.5
Meya, U.6
Sastre-Y-Hernandez, M.7
Schony, W.8
Schratzer, M.9
Soukop, W.10
Trampitsch, E.11
Varosanec, S.12
Zawada, E.13
Zochling, R.14
-
52
-
-
0026528829
-
Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast
-
Torphy, T. J., J. M. Stadel, M. Burman, L. B. Cieslinski, M. M. McLaughlin, J. R. White, and G. P. Livi. 1992. Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast. J Biol Chem 267:1798.
-
(1992)
J Biol Chem
, vol.267
, pp. 1798
-
-
Torphy, T.J.1
Stadel, J.M.2
Burman, M.3
Cieslinski, L.B.4
McLaughlin, M.M.5
White, J.R.6
Livi, G.P.7
-
53
-
-
0030925148
-
Proposal for pharmacologically distinct conformers of PDE4 cAMP phosphodiesterases
-
Souness, J. E., and S. Rao. 1997. Proposal for pharmacologically distinct conformers of PDE4 cAMP phosphodiesterases. Cell Signal 9:227.
-
(1997)
Cell Signal
, vol.9
, pp. 227
-
-
Souness, J.E.1
Rao, S.2
-
54
-
-
0031911575
-
Sb 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions
-
Barnette, M., S. Christensen, D. Essayen, D. Grous, U. Prabhakar, J. Rush, A. Kagey-Sobotka, and T. Torphy. 1998. SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: In vitro anti-inflammatory actions. J Pharmacol and Exper Ther 284:420.
-
(1998)
J Pharmacol and Exper Ther
, vol.284
, pp. 420
-
-
Barnette, M.1
Christensen, S.2
Essayen, D.3
Grous, D.4
Prabhakar, U.5
Rush, J.6
Kagey-Sobotka, A.7
Torphy, T.8
-
56
-
-
0029812555
-
The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5)
-
O'Connell, J. C., J. F. McCallum, I. McPhee, J. Wakefield, E. S. Houslay, W. Wishart, G. Bolger, M. Frame, and M. D. Houslay. 1996. The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5). Biochem. J. 318:255.
-
(1996)
Biochem. J.
, vol.318
, pp. 255
-
-
O'Connell, J.C.1
McCallum, J.F.2
McPhee, I.3
Wakefield, J.4
Houslay, E.S.5
Wishart, W.6
Bolger, G.7
Frame, M.8
Houslay, M.D.9
-
57
-
-
0039181708
-
Selective activation of rolipram-sensitive, cAMP-specific phosphodiesterase isoforms by phosphatidic acid
-
Nemoz, G., C. Sette, and M. Conti. 1997. Selective activation of rolipram-sensitive, cAMP-specific phosphodiesterase isoforms by phosphatidic acid. Mol Pharmacol 51:242.
-
(1997)
Mol Pharmacol
, vol.51
, pp. 242
-
-
Nemoz, G.1
Sette, C.2
Conti, M.3
-
58
-
-
0030053525
-
Interleukin 10 mRNA expression in B cell chronic lymphocytic leukemia inversely correlates with progression of disease
-
Sjoberg, J., M. Aguilar-Santelises, A.-M. Sjogren, E. K. Pisa, A. Ljungdahl, M. Bjorkholm, M. Jondal, H. Mellstedt, and P. Pisa. 1996. Interleukin 10 mRNA expression in B cell chronic lymphocytic leukemia inversely correlates with progression of disease. Br J Haematol 92:393.
-
(1996)
Br J Haematol
, vol.92
, pp. 393
-
-
Sjoberg, J.1
Aguilar-Santelises, M.2
Sjogren, A.-M.3
Pisa, E.K.4
Ljungdahl, A.5
Bjorkholm, M.6
Jondal, M.7
Mellstedt, H.8
Pisa, P.9
-
59
-
-
0027955125
-
Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells
-
Fluckiger, A.-C., I. Durand, and J. Banchereau. 1994. Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells. J Exp Med 179:91.
-
(1994)
J Exp Med
, vol.179
, pp. 91
-
-
Fluckiger, A.-C.1
Durand, I.2
Banchereau, J.3
-
60
-
-
0030916742
-
Characterization of interleukin-10 receptor expression on B cell chronic lymphocytic leukemia cells
-
Jurlander, J., C.-F. Lai, J. Tan, C.-C. Chou, C. H. Geisler, J. Schriber, L. E. Blumenson, S. K. Narula, H. Baumann, and M. A. Caligiuri. 1997. Characterization of interleukin-10 receptor expression on B cell chronic lymphocytic leukemia cells. Blood 89:4146.
-
(1997)
Blood
, vol.89
, pp. 4146
-
-
Jurlander, J.1
Lai, C.-F.2
Tan, J.3
Chou, C.-C.4
Geisler, C.H.5
Schriber, J.6
Blumenson, L.E.7
Narula, S.K.8
Baumann, H.9
Caligiuri, M.A.10
-
61
-
-
0025361921
-
Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: A possible regulatory role of TNF in the progression of the disease
-
Foa, R., M. Massaia, S. Cardona, A. Tos, A. Bianchi, C. Attisano, A. Guarini, P. di Celle, and M. Fierro. 1990. Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease. Blood 76:393.
-
(1990)
Blood
, vol.76
, pp. 393
-
-
Foa, R.1
Massaia, M.2
Cardona, S.3
Tos, A.4
Bianchi, A.5
Attisano, C.6
Guarini, A.7
Di Celle, P.8
Fierro, M.9
-
62
-
-
0024593088
-
Tumor necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leukemia
-
Digel, W., M. Stefanic, W. Schoniger, C. Buck, A. Raghavachar, N. Frickhofen, H. Heimpel, and F. Porzsolt. 1989. Tumor necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leukemia. Blood 73:1242.
-
(1989)
Blood
, vol.73
, pp. 1242
-
-
Digel, W.1
Stefanic, M.2
Schoniger, W.3
Buck, C.4
Raghavachar, A.5
Frickhofen, N.6
Heimpel, H.7
Porzsolt, F.8
-
63
-
-
0029937459
-
Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia
-
Reittie, J., K. L. Yong, P. Panayiotidis, and A. V. Hoffbrand. 1996. Interleukin-6 inhibits apoptosis and tumour necrosis factor induced proliferation of B-chronic lymphocytic leukaemia. Leukemia in & Lymphoma 22:83.
-
(1996)
Leukemia in & Lymphoma
, vol.22
, pp. 83
-
-
Reittie, J.1
Yong, K.L.2
Panayiotidis, P.3
Hoffbrand, A.V.4
-
64
-
-
0031022361
-
Endogenous adenosine curtails lipopolysaccharide-stimulated TNF synthesis
-
Eigler, A., T. F. Greten, B. Sinha, C. Hasleberger, G. W. Sullivan, and S. Endres. 1997. Endogenous adenosine curtails lipopolysaccharide-stimulated TNF synthesis. Scand. J. Immunol. 45:132.
-
(1997)
Scand. J. Immunol.
, vol.45
, pp. 132
-
-
Eigler, A.1
Greten, T.F.2
Sinha, B.3
Hasleberger, C.4
Sullivan, G.W.5
Endres, S.6
-
65
-
-
0027448876
-
Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents
-
Marcoz, P., A. F. Prigent, M. Lagarde, and G. Nemoz. 1993. Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents. Mol. Pharmacol. 44:1027.
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 1027
-
-
Marcoz, P.1
Prigent, A.F.2
Lagarde, M.3
Nemoz, G.4
-
66
-
-
0031611368
-
Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 in mitogen-stimulated and leukemic human lymphocytes
-
Jiang, X., M. Paskind, R. Weltzien, and P. M. Epstein. 1998. Expression and regulation of mRNA for distinct isoforms of cAMP-specific PDE-4 in mitogen-stimulated and leukemic human lymphocytes. Cell Biochem Biophys. 28:135.
-
(1998)
Cell Biochem Biophys.
, vol.28
, pp. 135
-
-
Jiang, X.1
Paskind, M.2
Weltzien, R.3
Epstein, P.M.4
-
67
-
-
0032541484
-
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase
-
Loughney, K., T. R. Hill, V. A. Florio, L. Uher, G. J. Rosman, S. L. Wolda, B. A. Jones, M. L. Howard, L. M. McAllister-Lucas, W. K. Sonnenburg, S. H. Francis, J. D. Corbin, J. A. Beavo, and K. Ferguson. 1998. Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase. Gene 216:139.
-
(1998)
Gene
, vol.216
, pp. 139
-
-
Loughney, K.1
Hill, T.R.2
Florio, V.A.3
Uher, L.4
Rosman, G.J.5
Wolda, S.L.6
Jones, B.A.7
Howard, M.L.8
McAllister-Lucas, L.M.9
Sonnenburg, W.K.10
Francis, S.H.11
Corbin, J.D.12
Beavo, J.A.13
Ferguson, K.14
-
68
-
-
0027280561
-
Interactions of a G-protein with its effector: Transducin and cGMP phosphodiesterase in retinal rods
-
Pfister, C., N. Bennett, F. Bruckert, P. Catty, A. Clerc, F. Pages, and P. Deterre. 1993. Interactions of a G-protein with its effector: transducin and cGMP phosphodiesterase in retinal rods. Cell Signal 5:235.
-
(1993)
Cell Signal
, vol.5
, pp. 235
-
-
Pfister, C.1
Bennett, N.2
Bruckert, F.3
Catty, P.4
Clerc, A.5
Pages, F.6
Deterre, P.7
-
69
-
-
0032555138
-
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
-
Soderling, S. H., S. J. Bayuga, and J. A. Beavo. 1998. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc. Natl. Acad. Sci. USA 95:8991.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8991
-
-
Soderling, S.H.1
Bayuga, S.J.2
Beavo, J.A.3
-
70
-
-
0032546779
-
Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase
-
Fisher, D. A., J. F. Smith, J. S. Pillar, S. H. St. Denis, and J. B. Cheng. 1998. Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J. Biol. Chem. 273:15559.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 15559
-
-
Fisher, D.A.1
Smith, J.F.2
Pillar, J.S.3
St. Denis, S.H.4
Cheng, J.B.5
-
71
-
-
0033603598
-
Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)
-
Fujishige, K., J. Kotera, H. Michibata, K. Yuasa, S. Takebayashi, K. Okumura, and K. Omori. 1999. Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J Biol Chem 274:18438.
-
(1999)
J Biol Chem
, vol.274
, pp. 18438
-
-
Fujishige, K.1
Kotera, J.2
Michibata, H.3
Yuasa, K.4
Takebayashi, S.5
Okumura, K.6
Omori, K.7
-
72
-
-
0033536020
-
Isolation and characterization of a dual substrate phosphodiesterase gene family: PDE10A
-
Soderling, S. H., S. J. Bayuga, and J. A. Beavo. 1999. Isolation and characterization of a dual substrate phosphodiesterase gene family: PDE10A. Proc. Natl. Acad. Sci. USA. 96:7071.
-
(1999)
Proc. Natl. Acad. Sci. USA.
, vol.96
, pp. 7071
-
-
Soderling, S.H.1
Bayuga, S.J.2
Beavo, J.A.3
|