Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: Analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram

Cellular Signalling

Volumn 8, Issue 2, 1996, Pages 97-110

  Michie, Alison M ^a   Lobban, Margaret ^a   Müller, Thomas ^b   Harnett, Margaret M ^b   Houslay, Miles D ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

CD3; Cyclic CAMP phosphodiesterase; Cyclic GMP; EHNA; Phytohaemagglutinin; Rolipram; T cells; TCR; Thymocytes

Indexed keywords

9 (2 HYDROXY 3 NONYL)ADENINE; CELL SURFACE RECEPTOR; CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE; CYCLIC GMP; PHOSPHODIESTERASE; PHYTOHEMAGGLUTININ; ROLIPRAM; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME REGULATION; HUMAN; HUMAN CELL; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; 5'-GUANYLIC ACID; ADENINE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; BINDING, COMPETITIVE; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; ISOENZYMES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; PHOSPHODIESTERASE INHIBITORS; PHYTOHEMAGGLUTININS; PYRROLIDINONES; RABBITS; RECEPTORS, ANTIGEN, T-CELL; ROLIPRAM; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; THYMUS GLAND;

EID: 0029962380     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/0898-6568(95)02032-2     Document Type: Article

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