메뉴 건너뛰기




Volumn 7, Issue 1, 2000, Pages 44-48

Chronic exposure to high glucose impairs multiple β-cell functions in cultured human pancreatic islets

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; GLUCOSE; INSULIN; MESSENGER RNA; PROINSULIN; TRANSCRIPTION FACTOR;

EID: 0034050838     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-200002000-00007     Document Type: Article
Times cited : (2)

References (34)
  • 1
  • 2
    • 0028912883 scopus 로고
    • Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus
    • 2 Alarcon C, Leahy JL, Schuppin GT, Rhodes CJ: Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest 1995, 95:1032-1039.
    • (1995) J Clin Invest , vol.95 , pp. 1032-1039
    • Alarcon, C.1    Leahy, J.L.2    Schuppin, G.T.3    Rhodes, C.J.4
  • 3
    • 0029091212 scopus 로고
    • Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the B-cell
    • 3 Gadot M, Ariav Y, Cerasi E, Kaiser N, Gross D: Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the B-cell. Endocrinology 1995, 136:4218-4223.
    • (1995) Endocrinology , vol.136 , pp. 4218-4223
    • Gadot, M.1    Ariav, Y.2    Cerasi, E.3    Kaiser, N.4    Gross, D.5
  • 4
    • 0033347050 scopus 로고    scopus 로고
    • Prolonged exposure of human beta-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine
    • 4 Hostens K, Ling Z, Van Schravendijk C, Pipeleers D: Prolonged exposure of human beta-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine. J Clin Endocrinol Metab 1999, 84:1386-1390. Human islets cultured at 20 mM glucose for 10 to 13 days lost the intracellular hormone stores and increased the proinsulin fraction; β-cells were hyperstimulated, since the response to arginine was exaggerated.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 1386-1390
    • Hostens, K.1    Ling, Z.2    Van Schravendijk, C.3    Pipeleers, D.4
  • 5
    • 17144458294 scopus 로고    scopus 로고
    • Long-term in vitro exposure to high glucose increases proinsulin-like-molecules released by isolated human islets
    • 5 Bertuzzi F, Saccomanno K, Socci C, Davalli AM, Taglietti MV, Berra C, et al.: Long-term in vitro exposure to high glucose increases proinsulin-like-molecules released by isolated human islets. J Endocrinol 1998, 158:205-211.
    • (1998) J Endocrinol , vol.158 , pp. 205-211
    • Bertuzzi, F.1    Saccomanno, K.2    Socci, C.3    Davalli, A.M.4    Taglietti, M.V.5    Berra, C.6
  • 6
    • 0032921702 scopus 로고    scopus 로고
    • The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose
    • 6 Lupi R, Del Guerra S, Tellini C, Giannareli R, Coppelli A, Lorenzetti M, et al.: The biguanide compound metformin prevents desensitization of human pancreatic islets induced by high glucose. Eur J Pharmacol 1999, 364:205-209. Addition of metformin, but not glyburide, to human islets cultured for 24 hours at 22 mM glucose prevented the impairment of the acute insulin release.
    • (1999) Eur J Pharmacol , vol.364 , pp. 205-209
    • Lupi, R.1    Del Guerra, S.2    Tellini, C.3    Giannareli, R.4    Coppelli, A.5    Lorenzetti, M.6
  • 7
    • 0040503709 scopus 로고    scopus 로고
    • Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets
    • 7 Björklund A, Grill V: Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets. Diabetes 1999, 48:1409-1414. This article provides experimental evidence indicating that the increased proinsulin-to-insulin ratio under conditions of in vitro long-term stimulation of human islets is secondary to depletion of islet insulin stores, since this is preventable by diazoxide.
    • (1999) Diabetes , vol.48 , pp. 1409-1414
    • Björklund, A.1    Grill, V.2
  • 8
    • 0344258475 scopus 로고    scopus 로고
    • Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose
    • 8 Marshak S, Leibowitz G, Bertuzzi F, Socci C, Kaiser N, Gross DJ, et al.: Impaired beta-cell functions induced by chronic exposure of cultured human pancreatic islets to high glucose. Diabetes 1999, 48:1230-1236. Human islets were cultured as monolayers on extracellular matrix; 4-to 9-day exposure to 33 mM glucose reduced islet insulin stores, insulin mRNA, insulin gene transcription, and the DNA-binding and mRNA levels of PDX-1, with no or minor changes in RIPE3b1 Act or IEF1. It is suggested that downregulation of PDX-1 plays a key role in glucose toxicity.
    • (1999) Diabetes , vol.48 , pp. 1230-1236
    • Marshak, S.1    Leibowitz, G.2    Bertuzzi, F.3    Socci, C.4    Kaiser, N.5    Gross, D.J.6
  • 9
    • 0023758721 scopus 로고
    • Monolayer culture of adult pancreatic islets on extracellular matrix: Long-term maintenance of differentiated B-cell function
    • 9 Kaiser N, Corcos AP, Tur-Sinai A, Ariav Y, Cerasi E: Monolayer culture of adult pancreatic islets on extracellular matrix: long-term maintenance of differentiated B-cell function. Endocrinology 1988, 123:834-840.
    • (1988) Endocrinology , vol.123 , pp. 834-840
    • Kaiser, N.1    Corcos, A.P.2    Tur-Sinai, A.3    Ariav, Y.4    Cerasi, E.5
  • 10
    • 0026091234 scopus 로고
    • Monolayer culture of adult rat pancreatic islets on extracellular matrix: Modulation of B-cell function by chronic exposure to high glucose
    • 10 Kaiser N, Corcos AP, Sarel I, Cerasi E: Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of B-cell function by chronic exposure to high glucose. Endocrinology 1991, 129:2067-2076.
    • (1991) Endocrinology , vol.129 , pp. 2067-2076
    • Kaiser, N.1    Corcos, A.P.2    Sarel, I.3    Cerasi, E.4
  • 11
    • 0032896436 scopus 로고    scopus 로고
    • Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors
    • 11 Hou X, Ling Z, Quartier E, Foriers A, Schuit F, Pipeleers D, Van Schravendijk C: Prolonged exposure of pancreatic beta cells to raised glucose concentrations results in increased cellular content of islet amyloid polypeptide precursors. Diabetologia 1999, 42:188-194. This study shows that 6-day stimulation with high glucose reduces the insulin, but not islet amyloid polypeptide (IAPP) content of human islets; yet the proportion of IAPP precursors increases in a fashion similar to proinsulin.
    • (1999) Diabetologia , vol.42 , pp. 188-194
    • Hou, X.1    Ling, Z.2    Quartier, E.3    Foriers, A.4    Schuit, F.5    Pipeleers, D.6    Van Schravendijk, C.7
  • 12
    • 0032499902 scopus 로고    scopus 로고
    • Effect of high glucose concentration on proinsulin biosynthesis and conversion by human islets
    • 12 Usac EF, Nadal B, Gasa R, Fernandez-Alvarez J, Gomis R: Effect of high glucose concentration on proinsulin biosynthesis and conversion by human islets. Biochem Biophys Res Commun 1998, 248:186-189.
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 186-189
    • Usac, E.F.1    Nadal, B.2    Gasa, R.3    Fernandez-Alvarez, J.4    Gomis, R.5
  • 15
    • 0030001136 scopus 로고    scopus 로고
    • Insulin gene: Organisation, expression and regulation
    • 15 Dumonteil E, Philippe J: Insulin gene: organisation, expression and regulation. Diabetes Metab 1996, 22:164-173.
    • (1996) Diabetes Metab , vol.22 , pp. 164-173
    • Dumonteil, E.1    Philippe, J.2
  • 16
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • 16 Jonsson J, Carlsson L, Edlund T, Edlund H: Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994, 371:606-609.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 17
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • 17 Ohlsson H, Karlsson K, Edlund T: IPF1, a homeodomain-containing transactivator of the insulin gene. Embo J 1993, 12:4251-4259.
    • (1993) Embo J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 18
    • 0027154077 scopus 로고
    • Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat i and the human insulin promoters
    • 18 Melloul D, Ben-Neriah Y, Cerasi E: Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci USA 1993, 90:3865-3869.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3865-3869
    • Melloul, D.1    Ben-Neriah, Y.2    Cerasi, E.3
  • 19
    • 0030447883 scopus 로고    scopus 로고
    • Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells
    • 19 Marshak S, Totary H, Cerasi E, Melloul D: Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells. Proc Natl Acad Sci USA 1996, 93:15057-15062.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15057-15062
    • Marshak, S.1    Totary, H.2    Cerasi, E.3    Melloul, D.4
  • 20
    • 0025246260 scopus 로고
    • Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene
    • 20 Hwung YP, Gu YZ, Tsai MJ: Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene. Mol Cell Biol 1990, 10:1784-1788.
    • (1990) Mol Cell Biol , vol.10 , pp. 1784-1788
    • Hwung, Y.P.1    Gu, Y.Z.2    Tsai, M.J.3
  • 21
    • 0028808719 scopus 로고
    • The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene
    • 21 Sharma A, Fusco-DeMane D, Henderson E, Efrat S, Stein R: The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene. Mol Endocrinol 1995, 9:1468-1476.
    • (1995) Mol Endocrinol , vol.9 , pp. 1468-1476
    • Sharma, A.1    Fusco-DeMane, D.2    Henderson, E.3    Efrat, S.4    Stein, R.5
  • 22
    • 0025213351 scopus 로고
    • A cDNA from a mouse pancreatic beta cell encoding a putative transcription factor of the insulin gene
    • 22 Walker MD, Park CW, Rosen A, Aronheim A: A cDNA from a mouse pancreatic beta cell encoding a putative transcription factor of the insulin gene. Nucleic Acids Res 1990, 18:1159-1166.
    • (1990) Nucleic Acids Res , vol.18 , pp. 1159-1166
    • Walker, M.D.1    Park, C.W.2    Rosen, A.3    Aronheim, A.4
  • 23
    • 0026016780 scopus 로고
    • Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer
    • 23 German MS, Blanar MA, Nelson C, Moss LG, Rutter WJ: Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. Mol Endocrinol 1991, 5:292-299.
    • (1991) Mol Endocrinol , vol.5 , pp. 292-299
    • German, M.S.1    Blanar, M.A.2    Nelson, C.3    Moss, L.G.4    Rutter, W.J.5
  • 24
    • 0030886674 scopus 로고    scopus 로고
    • Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
    • 24 Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ: Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 1997, 11:2323-2334.
    • (1997) Genes Dev , vol.11 , pp. 2323-2334
    • Naya, F.J.1    Huang, H.P.2    Qiu, Y.3    Mutoh, H.4    DeMayo, F.J.5    Leiter, A.B.6    Tsai, M.J.7
  • 25
    • 0028941181 scopus 로고
    • Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
    • 25 Naya FJ, Stellrecht CM, Tsai MJ: Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 1995, 9:1009-1019.
    • (1995) Genes Dev , vol.9 , pp. 1009-1019
    • Naya, F.J.1    Stellrecht, C.M.2    Tsai, M.J.3
  • 26
    • 0033044994 scopus 로고    scopus 로고
    • Leptin suppression of insulin secretion and gene expression in human pancreatic islets: Implications for the development of adipogenic diabetes mellius
    • 26 Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF: Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellius. J Clin Endocrinol Metab 1999, 84:670-676.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 670-676
    • Seufert, J.1    Kieffer, T.J.2    Leech, C.A.3    Holz, G.G.4    Moritz, W.5    Ricordi, C.6    Habener, J.F.7
  • 27
    • 0029664752 scopus 로고    scopus 로고
    • Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator
    • 27 Poitout V, Olson LK, Robertson RP: Chronic exposure of βTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. J Clin Invest 1996, 97:1041-1046.
    • (1996) J Clin Invest , vol.97 , pp. 1041-1046
    • Poitout, V.1    Olson, L.K.2    Robertson, R.P.3
  • 29
    • 0032852505 scopus 로고    scopus 로고
    • In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression
    • 29 Harmon JS, Gleason CE, Tanaka Y, Oseid EA, Hunter-Berger KK, Robertson RP: In vivo prevention of hyperglycemia also prevents glucotoxic effects on PDX-1 and insulin gene expression. Diabetes 1999, 48:1995-2000. Chronic hyperglycemia in ZDF rats is associated with loss of insulin and PDX-1 mRNAs and loss of glucose-stimulated insulin secretion. Prevention of hyperglycemia with troglitazone prevented these defects.
    • (1999) Diabetes , vol.48 , pp. 1995-2000
    • Harmon, J.S.1    Gleason, C.E.2    Tanaka, Y.3    Oseid, E.A.4    Hunter-Berger, K.K.5    Robertson, R.P.6
  • 30
    • 0033553462 scopus 로고    scopus 로고
    • Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
    • 30 Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patane G, Laybutt R, et al.: Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem 1999, 274:14112-14121. In 90% pancreatectomized hyperglycemic rats, the expression of many genes important for glucose-induced insulin release decreased with increasing hyperglycemia, in parallel with reduction in several islet transcription factors involved in β-cell development and differentiation.
    • (1999) J Biol Chem , vol.274 , pp. 14112-14121
    • Jonas, J.C.1    Sharma, A.2    Hasenkamp, W.3    Ilkova, H.4    Patane, G.5    Laybutt, R.6
  • 31
    • 0031025828 scopus 로고    scopus 로고
    • Long-term effects of aminoguanidine on insulin release and biosynthesis: Evidence that the formation of advanced glycosylation end products inhibits B cell function
    • 31 Tajiri Y, Moller C, Grill V: Long-term effects of aminoguanidine on insulin release and biosynthesis: evidence that the formation of advanced glycosylation end products inhibits B cell function. Endocrinology 1997, 138:273-280.
    • (1997) Endocrinology , vol.138 , pp. 273-280
    • Tajiri, Y.1    Moller, C.2    Grill, V.3
  • 32
    • 0031020374 scopus 로고    scopus 로고
    • Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells
    • 32 Matsuoka T, Kajimoto Y, Watada H, Kaneto H, Kishimoto M, Umayahara Y, et al.: Glycation-dependent, reactive oxygen species-mediated suppression of the insulin gene promoter activity in HIT cells. J Clin Invest 1997, 99:144-150.
    • (1997) J Clin Invest , vol.99 , pp. 144-150
    • Matsuoka, T.1    Kajimoto, Y.2    Watada, H.3    Kaneto, H.4    Kishimoto, M.5    Umayahara, Y.6
  • 33
    • 0032998220 scopus 로고    scopus 로고
    • Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes
    • 33 Ihara Y, Toyokuni S, Uchida K, Odaka H, Tanaka T, Ikeda H, et al.: Hyperglycemia causes oxidative stress in pancreatic beta-cells of GK rats, a model of type 2 diabetes. Diabetes 1999, 48:927-932. The level of 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress, was increased in the β-cells of GK rats, a model of nonobese type 2 diabetes.
    • (1999) Diabetes , vol.48 , pp. 927-932
    • Ihara, Y.1    Toyokuni, S.2    Uchida, K.3    Odaka, H.4    Tanaka, T.5    Ikeda, H.6
  • 34
    • 0032863183 scopus 로고    scopus 로고
    • Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
    • 34 Tanaka Y, Gleason CE, Tran PO, Harmon JS, Robertson RP: Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci USA 1999, 96:10857-10862. Administration of the antioxidants N-acetyl-L-cysterine or aminoguanidine to Zucker diabetic fatty rats prevented rise in blood oxidative stress markers, and partially prevented hyperglycemia and the associated defects in insulin secretion and biosynthesis.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10857-10862
    • Tanaka, Y.1    Gleason, C.E.2    Tran, P.O.3    Harmon, J.S.4    Robertson, R.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.