Prolonged exposure of human β-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginine

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 4, 1999, Pages 1386-1390

  Hostens, Katleen ^a   Ling, Zhidong ^a   Van Schravendijk, Christiaan ^a   Pipeleers, Daniel ^a  

^a DIABETES RESEARCH CENTER   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; GLUCOSE; PROINSULIN;

ARTICLE; CELL FUNCTION; CELL ISOLATION; CELL POPULATION; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HORMONAL REGULATION; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS FUNCTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

EID: 0033347050     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.84.4.5621     Document Type: Article

References (26)

1. Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin dependent) diabetes mellitus and in experimental insulin resistance
2. Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
3. Insulin deficiency in non-insulin-dependent diabetes
4. Disproportionately elevated pro-insulin in Pima Indians with non-insulin-dependent diabetes mellitus
5. Proinsulin and specific insulin concentration in high- and low-risk populations for NIDDM
6. Proinsulin immunoreactivity in identical twins discordant for non-insulin-dependent diabetes mellitus
7. Proinsulin as a marker for the development of NIDDM in Japanese-American men
8. Serum proinsulin levels are disproportionately increased in elderly prediabetic subjects
9. Impaired β-cell function with chronic hyperglycerma: 'Overworked β-cell' hypothesis
10. Regulation of β-cell function in vivo
11. Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM
12. Disproportionately elevated proinsulin levels reflect the degree of impaired β cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
13. Hyperproinsulinemia and amyloid in NIDDM. Clues to etiology of islet β-cell dysfunction?
14. Relative hyperproinsulinemia of NIDDM persists despite the reduction of hyperglycemia with insulin or sulfonylurea therapy
15. Relative hypersecretion of proinsulin in a rat model of NIDDM
16. Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats
17. Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus
18. Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the β-cell
19. Hyperproinsulinemia is associated with increased β cell demand after hemipancreatectomy in humans
20. Effects of chronically elevated glucose levels on the functional properties of rat pancreatic β cells
21. Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
22. Implantation of standardized β-cell grafts in a liver segment of IDDM patients: Graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft
23. Pancreatic β-cell heterogeneity in glucose-induced insulin secretion
24. A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum
25. An integrated view of β cell dysfunction in type II diabetes
26. Effect of glucose on production and release of proinsulin conversion products by cultured human islets