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Volumn 48, Issue 7, 1999, Pages 1409-1414

Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets

Author keywords

[No Author keywords available]

Indexed keywords

DIAZOXIDE; GLUCOSE; INSULIN; PALMITIC ACID; PROINSULIN;

EID: 0040503709     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.7.1409     Document Type: Article
Times cited : (44)

References (31)
  • 1
    • 0017761172 scopus 로고
    • Circulating proinsulin in patients with maturity onset diabetes
    • Mako ME, Starr JI, Rubenstein AH: Circulating proinsulin in patients with maturity onset diabetes. Am J Med 63:865-869, 1977
    • (1977) Am J Med , vol.63 , pp. 865-869
    • Mako, M.E.1    Starr, J.I.2    Rubenstein, A.H.3
  • 2
    • 0023634652 scopus 로고
    • Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance
    • Ward WK, LaCava EC, Paquette TL, Beard JC, Wallum BJ, Porte DJ: Disproportionate elevation of immunoreactive proinsulin in type 2 (non-insulin-dependent) diabetes mellitus and in experimental insulin resistance. Diabetologia 30:698-702, 1987
    • (1987) Diabetologia , vol.30 , pp. 698-702
    • Ward, W.K.1    LaCava, E.C.2    Paquette, T.L.3    Beard, J.C.4    Wallum, B.J.5    Porte, D.J.6
  • 3
    • 0023759449 scopus 로고
    • Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Yoshioka N, Kuzuya T, Matsuda A, Taniguchi M, Iwamoto Y: Serum proinsulin levels at fasting and after oral glucose load in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 31:355-360, 1988
    • (1988) Diabetologia , vol.31 , pp. 355-360
    • Yoshioka, N.1    Kuzuya, T.2    Matsuda, A.3    Taniguchi, M.4    Iwamoto, Y.5
  • 5
    • 0024493106 scopus 로고
    • Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM
    • Yoshioka N, Kuzuya T, Matsuda A, Iwamoto Y: Effects of dietary treatment on serum insulin and proinsulin response in newly diagnosed NIDDM. Diabetes 38:262-266, 1989
    • (1989) Diabetes , vol.38 , pp. 262-266
    • Yoshioka, N.1    Kuzuya, T.2    Matsuda, A.3    Iwamoto, Y.4
  • 6
    • 0028137716 scopus 로고
    • Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus
    • Davies MJ, Metcalfe J, Day JL, Grenfell A, Hales CN, Gray IP: Improved beta cell function, with reduction in secretion of intact and 32/33 split proinsulin, after dietary intervention in subjects with type 2 diabetes mellitus. Diabet Med 11:71-78, 1994
    • (1994) Diabet Med , vol.11 , pp. 71-78
    • Davies, M.J.1    Metcalfe, J.2    Day, J.L.3    Grenfell, A.4    Hales, C.N.5    Gray, I.P.6
  • 7
    • 0030851920 scopus 로고    scopus 로고
    • Enhancement of β-cell secretion by blood glucose normalization relates to fasting c-peptides levels
    • Clausson P, Alvarsson M, Grill V: Enhancement of β-cell secretion by blood glucose normalization relates to fasting C-peptides levels. J Intern Med 241: 493-500, 1997
    • (1997) J Intern Med , vol.241 , pp. 493-500
    • Clausson, P.1    Alvarsson, M.2    Grill, V.3
  • 8
    • 0030845937 scopus 로고    scopus 로고
    • Relative hyperproinsulinemia of NIDDM persists despite the reduction of hyperglycemia with insulin or sulfonylurea therapy
    • Rachman J, Levy JC, Barrow BA, Manley SE, Turner RC: Relative hyperproinsulinemia of NIDDM persists despite the reduction of hyperglycemia with insulin or sulfonylurea therapy. Diabetes 46:1557-1562, 1997
    • (1997) Diabetes , vol.46 , pp. 1557-1562
    • Rachman, J.1    Levy, J.C.2    Barrow, B.A.3    Manley, S.E.4    Turner, R.C.5
  • 9
    • 0027389774 scopus 로고
    • Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats
    • Leahy JL: Increased proinsulin/insulin ratio in pancreas extracts of hyperglycemic rats. Diabetes 42:22-27, 1993
    • (1993) Diabetes , vol.42 , pp. 22-27
    • Leahy, J.L.1
  • 10
    • 0028912883 scopus 로고
    • Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus
    • Alacrón C, Leahy JL, Schuppin GT, Rhodes CJ: Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest 95:1032-1039, 1995
    • (1995) J Clin Invest , vol.95 , pp. 1032-1039
    • Alacrón, C.1    Leahy, J.L.2    Schuppin, G.T.3    Rhodes, C.J.4
  • 11
    • 0029091212 scopus 로고
    • Hyperproinsulinemia in the diabetic psammomys obesus is a result of increased secretory demand on the β-cell
    • Gadot M, Ariav Y, Cerasi E, Kaiser N, Gross DJ: Hyperproinsulinemia in the diabetic Psammomys obesus is a result of increased secretory demand on the β-cell. Endocrinology 136:4218-4223, 1995
    • (1995) Endocrinology , vol.136 , pp. 4218-4223
    • Gadot, M.1    Ariav, Y.2    Cerasi, E.3    Kaiser, N.4    Gross, D.J.5
  • 12
    • 0025736943 scopus 로고
    • Relative hypersecretion of proinsulin in a rat model of NIDDM
    • Leahy JL, Halban PA, Weir GC: Relative hypersecretion of proinsulin in a rat model of NIDDM. Diabetes 40:985-989, 1991
    • (1991) Diabetes , vol.40 , pp. 985-989
    • Leahy, J.L.1    Halban, P.A.2    Weir, G.C.3
  • 15
    • 0024995157 scopus 로고
    • A 48 h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation
    • Sako Y, Grill V: A 48 h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127:1580-1589, 1990
    • (1990) Endocrinology , vol.127 , pp. 1580-1589
    • Sako, Y.1    Grill, V.2
  • 16
    • 0028268936 scopus 로고
    • Long term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
    • Zhou Y, Grill V: Long term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 93:870-876, 1994
    • (1994) J Clin Invest , vol.93 , pp. 870-876
    • Zhou, Y.1    Grill, V.2
  • 18
    • 26344453991 scopus 로고    scopus 로고
    • Glucose and palmitate enhance proinsulin/insulin release from human islets through an insulin depletion defect
    • Björklund A, Grill V: Glucose and palmitate enhance proinsulin/insulin release from human islets through an insulin depletion defect (Abstract). Diabetologia 41 (Suppl. 1):76A, 1998
    • (1998) Diabetologia , vol.41 , Issue.SUPPL. 1
    • Björklund, A.1    Grill, V.2
  • 19
    • 0026451942 scopus 로고
    • Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function
    • Eizirik DL, Korbutt GS, Hellerström C: Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the β-cell function. J Clin Invest 90:1263-1268, 1992
    • (1992) J Clin Invest , vol.90 , pp. 1263-1268
    • Eizirik, D.L.1    Korbutt, G.S.2    Hellerström, C.3
  • 21
    • 0030467497 scopus 로고    scopus 로고
    • Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to loss of glucose regulation
    • Ling Z, Pipeleers DG: Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to loss of glucose regulation. J Clin Invest 98:2805-2812, 1996
    • (1996) J Clin Invest , vol.98 , pp. 2805-2812
    • Ling, Z.1    Pipeleers, D.G.2
  • 23
    • 0026787567 scopus 로고
    • A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum
    • Bowsher RR, Wolney JD, Frank BH: A rapid and sensitive radioimmunoassay for the measurement of proinsulin in human serum. Diabetes 41:1084-1090, 1992
    • (1992) Diabetes , vol.41 , pp. 1084-1090
    • Bowsher, R.R.1    Wolney, J.D.2    Frank, B.H.3
  • 24
    • 0030662718 scopus 로고    scopus 로고
    • Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM
    • Kahn SE, Halban PA: Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 46:1725-1732, 1997
    • (1997) Diabetes , vol.46 , pp. 1725-1732
    • Kahn, S.E.1    Halban, P.A.2
  • 25
    • 0026555329 scopus 로고
    • Impact of uncoupling glucose stimulus from secretion on β-cell release and biosynthesis
    • Sako Y, Eizirik DL, Grill V: Impact of uncoupling glucose stimulus from secretion on β-cell release and biosynthesis. Am J Physiol 262:E150-E154, 1992
    • (1992) Am J Physiol , vol.262
    • Sako, Y.1    Eizirik, D.L.2    Grill, V.3
  • 26
    • 0026551285 scopus 로고
    • Expression of the 64 kDa/glutamatic acid decarboxylase rat islet cell autoantigen is influenced by the rate of insulin secretion
    • Björk E, Kämpe O, Andersson A, Karlsson FA: Expression of the 64 kDa/glutamatic acid decarboxylase rat islet cell autoantigen is influenced by the rate of insulin secretion. Diabetologia 32:490-493, 1992
    • (1992) Diabetologia , vol.32 , pp. 490-493
    • Björk, E.1    Kämpe, O.2    Andersson, A.3    Karlsson, F.A.4
  • 27
    • 0024263778 scopus 로고
    • Glucose-regulated proinsulin processing in isolated islets from rat pancreas
    • Nagamatsu S, Grodsky GM: Glucose-regulated proinsulin processing in isolated islets from rat pancreas. Diabetes 37:1426-1431, 1988
    • (1988) Diabetes , vol.37 , pp. 1426-1431
    • Nagamatsu, S.1    Grodsky, G.M.2
  • 28
    • 0029036835 scopus 로고
    • Long term exposure to fatty acids and ketones inhibits β-cell functions in human pancreatic islets of langerhans
    • Zhou Y, Grill V: Long term exposure to fatty acids and ketones inhibits β-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol Metab 80:1584-1590, 1995
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1584-1590
    • Zhou, Y.1    Grill, V.2
  • 29
    • 0032030866 scopus 로고    scopus 로고
    • Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
    • Bollheimer C, Skelly R, Chester M, McGarry D, Rhodes C: Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 101:1094-1101, 1998
    • (1998) J Clin Invest , vol.101 , pp. 1094-1101
    • Bollheimer, C.1    Skelly, R.2    Chester, M.3    McGarry, D.4    Rhodes, C.5
  • 30
    • 0345611200 scopus 로고    scopus 로고
    • Long term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta cell line MIN 6
    • Furukawa H, Caroll R, Steiner D: Long term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta cell line MIN 6 (Abstract). Diabetes 47:262A, 1998
    • (1998) Diabetes , vol.47
    • Furukawa, H.1    Caroll, R.2    Steiner, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.