메뉴 건너뛰기




Volumn 83, Issue 4, 1998, Pages 1234-1238

Effect of glucose on production and release of proinsulin conversion products by cultured human islets

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; PROINSULIN;

EID: 0031763798     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.4.1234     Document Type: Article
Times cited : (11)

References (28)
  • 1
    • 0023655547 scopus 로고
    • The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing
    • Davidson HW, Hutton JC. 1987 The insulin-secretory-granule carboxypeptidase H. Purification and demonstration of involvement in proinsulin processing. Biochem J. 245:575-582.
    • (1987) Biochem J , vol.245 , pp. 575-582
    • Davidson, H.W.1    Hutton, J.C.2
  • 2
    • 0026693483 scopus 로고
    • A member of the eukaryoric subtilisin family (PC3) has the enzymatic properties of the type 1 proinsulin-converting endopeptidase
    • Bailyes EM, Shennan KIJ, Seal AJ, et al. 1992 A member of the eukaryoric subtilisin family (PC3) has the enzymatic properties of the type 1 proinsulin-converting endopeptidase. Biochem J. 285:391-394.
    • (1992) Biochem J , vol.285 , pp. 391-394
    • Bailyes, E.M.1    Shennan, K.I.J.2    Seal, A.J.3
  • 3
    • 0026741798 scopus 로고
    • Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family
    • Bennett DL, Bailyes EM, Nielsen E, et al. 1992 Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family. J Biol Chem. 267:15229-15236.
    • (1992) J Biol Chem , vol.267 , pp. 15229-15236
    • Bennett, D.L.1    Bailyes, E.M.2    Nielsen, E.3
  • 5
    • 0025784819 scopus 로고
    • Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II
    • Sizonenko SV, Halban PA. 1991 Differential rates of conversion of rat proinsulins I and II. Evidence for slow cleavage at the B-chain/C-peptide junction of proinsulin II. Biochem J. 278:621-625.
    • (1991) Biochem J , vol.278 , pp. 621-625
    • Sizonenko, S.V.1    Halban, P.A.2
  • 6
    • 0027380787 scopus 로고
    • Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells
    • Vollenweider F, Irminger J-C, Halban PA. 1993 Substrate specificity of proinsulin conversion in the constitutive pathway of transfected FAO (hepatoma) cells. Diabetologia. 36:1322-1325.
    • (1993) Diabetologia , vol.36 , pp. 1322-1325
    • Vollenweider, F.1    Irminger, J.-C.2    Halban, P.A.3
  • 7
    • 0027957282 scopus 로고
    • Human proinsuin conversion in the regulated and the constitutive pathways of transfected At20 cells
    • Irminger JC, Vollenweider FM, Neerman-Arbez M, Halban PA. 1994 Human proinsuin conversion in the regulated and the constitutive pathways of transfected At20 cells. J Biol Chem. 269:1756-1762.
    • (1994) J Biol Chem , vol.269 , pp. 1756-1762
    • Irminger, J.C.1    Vollenweider, F.M.2    Neerman-Arbez, M.3    Halban, P.A.4
  • 8
    • 0027317264 scopus 로고
    • Slow cleavage at the proinsulin B-chain/connecting pepride junction associated with low levels of endoprotease PC1/3 in transformed β cells
    • Neerman-Arbez M, Sizonenko SV, Halban PA. 1993 Slow cleavage at the proinsulin B-chain/connecting pepride junction associated with low levels of endoprotease PC1/3 in transformed β cells. J Biol Chem. 268:16098-16100.
    • (1993) J Biol Chem , vol.268 , pp. 16098-16100
    • Neerman-Arbez, M.1    Sizonenko, S.V.2    Halban, P.A.3
  • 10
    • 0026726773 scopus 로고
    • Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3
    • Smeekens SP, Montag AG, Thomas G. 1992 Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3. Proc Natl Acad Sci USA. 89:8822-8826.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8822-8826
    • Smeekens, S.P.1    Montag, A.G.2    Thomas, G.3
  • 11
    • 0029040210 scopus 로고
    • Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity
    • Naggert JK, Fricker LD, Varlamov O, et al. 1995 Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. Nat Genet. 10:135-142.
    • (1995) Nat Genet , vol.10 , pp. 135-142
    • Naggert, J.K.1    Fricker, L.D.2    Varlamov, O.3
  • 12
    • 0028230040 scopus 로고
    • What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism
    • Rhodes CJ, Alarcònn C. 1994 What β-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism. Diabetes. 43:511-517.
    • (1994) Diabetes , vol.43 , pp. 511-517
    • Rhodes, C.J.1    Alarcònn, C.2
  • 13
    • 0030065077 scopus 로고    scopus 로고
    • Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing β TC3 cells
    • Schuppin GT, Rhodes CJ. 1996 Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing β TC3 cells. Biochem J. 313:259-268.
    • (1996) Biochem J , vol.313 , pp. 259-268
    • Schuppin, G.T.1    Rhodes, C.J.2
  • 14
    • 0013551552 scopus 로고
    • Treatment of diabetes by islet cell transplantation
    • Baya C, ed. IOS Press Amsterdam
    • Pipeleers D. 1994 Treatment of diabetes by islet cell transplantation. In: Baya C, ed. Biomedical and health research. Advances in Medical Biology. IOS Press Amsterdam: vol 3:185-197.
    • (1994) Biomedical and Health Research. Advances in Medical Biology , vol.3 , pp. 185-197
    • Pipeleers, D.1
  • 15
    • 0030467497 scopus 로고    scopus 로고
    • Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
    • Ling Z, Pipeleers D. 1996 Prolonged exposure of human β cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest. 98:2805-2812.
    • (1996) J Clin Invest , vol.98 , pp. 2805-2812
    • Ling, Z.1    Pipeleers, D.2
  • 17
    • 0028318109 scopus 로고
    • Preservation of glucose-responsive islet β-cells during serum-free culture
    • Ling Z, Pipeleers D. 1994 Preservation of glucose-responsive islet β-cells during serum-free culture. Endocrinology. 134:2614-2621.
    • (1994) Endocrinology , vol.134 , pp. 2614-2621
    • Ling, Z.1    Pipeleers, D.2
  • 18
    • 0027225379 scopus 로고
    • Analysis of proinsulin and its conversion products by reversed-phase high-performance liquid chromatography
    • Linde S, Welinder BS, Nielsen JH. 1993 Analysis of proinsulin and its conversion products by reversed-phase high-performance liquid chromatography. J Chromatogr. 614:185-204.
    • (1993) J Chromatogr , vol.614 , pp. 185-204
    • Linde, S.1    Welinder, B.S.2    Nielsen, J.H.3
  • 19
    • 0025784369 scopus 로고
    • Influence of affinity of antibodies upon their detection by liquid phase radiobinding assay and solid phase enzyme linked immunosorbent assay. Demonstration using monoclonal antibodies raised against rDNA human proinsulin
    • Sodoyez JC, Koch M, Lemoir I, et al. 1991 Influence of affinity of antibodies upon their detection by liquid phase radiobinding assay and solid phase enzyme linked immunosorbent assay. Demonstration using monoclonal antibodies raised against rDNA human proinsulin. Diabetologia. 34:463-468.
    • (1991) Diabetologia , vol.34 , pp. 463-468
    • Sodoyez, J.C.1    Koch, M.2    Lemoir, I.3
  • 20
    • 0030844159 scopus 로고    scopus 로고
    • Proinsulin and its conversion intermediates in human pancreas and isolated islet tissue: Kinetics and steady state analysis
    • Hou X, Ling Z, Zambre Y, et al. 1997 Proinsulin and its conversion intermediates in human pancreas and isolated islet tissue: kinetics and steady state analysis. Pancreas. 15:113-121.
    • (1997) Pancreas , vol.15 , pp. 113-121
    • Hou, X.1    Ling, Z.2    Zambre, Y.3
  • 21
    • 0011857351 scopus 로고
    • A software package for the evaluation of peak parameters in an analytical signal based on a non-linear regression method
    • Scheeren PJH, Barna P, Smit H. 1985 A software package for the evaluation of peak parameters in an analytical signal based on a non-linear regression method. Anal Chim Acta. 167:65-80.
    • (1985) Anal Chim Acta , vol.167 , pp. 65-80
    • Scheeren, P.J.H.1    Barna, P.2    Smit, H.3
  • 22
    • 0028099196 scopus 로고
    • Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans
    • Martin SK, Carroll R, Benig M, Steiner DF. 1994 Regulation by glucose of the biosynthesis of PC2, PC3 and proinsulin in (ob/ob) mouse islets of Langerhans. FEBS Lett 356:279-282.
    • (1994) FEBS Lett , vol.356 , pp. 279-282
    • Martin, S.K.1    Carroll, R.2    Benig, M.3    Steiner, D.F.4
  • 23
    • 0030033858 scopus 로고    scopus 로고
    • Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin producing MIN6 cell line
    • Skelly RH, Schuppin GT, Ishihara H, Oka Y, Rhodes CJ. 1996 Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin producing MIN6 cell line. Diabetes. 45:37-43.
    • (1996) Diabetes , vol.45 , pp. 37-43
    • Skelly, R.H.1    Schuppin, G.T.2    Ishihara, H.3    Oka, Y.4    Rhodes, C.J.5
  • 24
    • 0024340494 scopus 로고
    • Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins
    • Sobey WJ, Beer SF, Carrington CA, et al. 1989 Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J. 260:535-541.
    • (1989) Biochem J , vol.260 , pp. 535-541
    • Sobey, W.J.1    Beer, S.F.2    Carrington, C.A.3
  • 25
    • 0026803423 scopus 로고
    • Pancreatic β cell heterogeneity in glucose-induced insulin secretion
    • Van Schravendijk CHF, Kiekens R, Pipeleers DG. 1992 Pancreatic β cell heterogeneity in glucose-induced insulin secretion. J Biol Chem. 267:21344-21348.
    • (1992) J Biol Chem , vol.267 , pp. 21344-21348
    • Van Schravendijk, C.H.F.1    Kiekens, R.2    Pipeleers, D.G.3
  • 26
    • 0026593276 scopus 로고
    • Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity
    • Kiekens R, In't Veld P, Schuit F, Van De Winkel M, Pipeleers D. 1991 Differences in glucose recognition by individual rat pancreatic B cells are associated with intercellular differences in glucose-induced biosynthetic activity. J Clin Invest. 89:117-125.
    • (1991) J Clin Invest , vol.89 , pp. 117-125
    • Kiekens, R.1    In't Veld, P.2    Schuit, F.3    Van De Winkel, M.4    Pipeleers, D.5
  • 27
    • 0028912883 scopus 로고
    • Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus
    • Alarcon C, Leahy JL, Schuppin GT, Rhodes CJ. 1995 Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J Clin Invest. 95:1032-1039.
    • (1995) J Clin Invest , vol.95 , pp. 1032-1039
    • Alarcon, C.1    Leahy, J.L.2    Schuppin, G.T.3    Rhodes, C.J.4
  • 28
    • 0027941219 scopus 로고
    • The pathogenesis of NIDDM
    • Hales CN. 1994 The pathogenesis of NIDDM. Diabetologia 37(Suppl 2):S162-S168.
    • (1994) Diabetologia , vol.37 , Issue.2 SUPPL.
    • Hales, C.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.