Exploring the functional robustness of an enzyme by in vitro evolution

EMBO Journal

Volumn 15, Issue 6, 1996, Pages 1203-1210

  Martinez, Miguel Angel ^a,b   Pezo, Valérie ^a   Marlière, Philippe ^a   Wain Hobson, Simon ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Dihydrofolate reductase; Hypermutagenesis; In vitro protein evolution; Protein robustness; Reverse transcriptase

Indexed keywords

COMPLEMENTARY DNA; DIHYDROFOLATE REDUCTASE; MUTANT PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME SYNTHESIS; ESCHERICHIA COLI; GENE MUTATION; MUTAGENESIS; MUTATION RATE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ESCHERICHIA COLI;

EID: 0029989171     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00461.x     Document Type: Article

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