Maintenance of growth factor signaling through Ras in human colon carcinoma cells containing K-ras mutations

International Journal of Cancer

Volumn 67, Issue 4, 1996, Pages 539-546

  Buard, Annie ^a   Zipfel, Patricia A ^a   Frey, Randall S ^a   Mulder, Kathleen M ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; GROWTH FACTOR; INSULIN; TRANSFERRIN;

ARTICLE; CANCER CELL CULTURE; CANCER GENETICS; COLON CARCINOMA; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CODON; COLONIC NEOPLASMS; DNA PRIMERS; EPIDERMAL GROWTH FACTOR; EXONS; GENES, RAS; GROWTH SUBSTANCES; GUANOSINE TRIPHOSPHATE; HUMANS; INSULIN; KINETICS; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMERASE CHAIN REACTION; RAS PROTEINS; SIGNAL TRANSDUCTION; TRANSFERRIN; TUMOR CELLS, CULTURED;

EID: 0029812715     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19960807)67:4<539::AID-IJC13>3.0.CO;2-2     Document Type: Article

References (32)

1. AUGENLICHT, L.H., AUGERON, C., YANDER, G. and LABOISSE, C., Overexpression of ras in mucus-secreting human colon carcinoma cells of low tumorigenicity. Cancer Res., 47, 3763-3765 (1987).
2. BASU, T.N., GUTMANN, D.H., FLETCHER, J.A., GLOVER, T.W., COLLINS, F.S. and DOWNWARD, J., Aberrant regulation of ras proteins in malignant tumour cells from type I neurofibromatosis patients. Nature (Lond.), 356, 713-715 (1992).
3. BOS, J.L., ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-1689. Erratum in Cancer Res., 50, 1352 (1989).
4. BOS, J.L., FEARON, E.R., HAMILTON, S.R., VERLAAN-DE VRIES, M., VAN BOOM, J.H., VAN DER EB, A.J. and VOGELSTEIN, B., Prevalence of ras gene mutations in human colorectal cancers. Nature (Lond.), 327, 293-297 (1987).
5. BRATTAIN, M.G., LEVINE, A.E., CHAKRABARTY, S., YEOMAN, L.C., WILLSON, J.K.V. and LONG, B., Heterogeneity of human colon carcinoma. Cancer Metastasis Rev., 3, 177-191 (1984).
6. ras activation. EMBOJ., 10, 1103-1109 (1991).
7. CAPELLA, G., CHRONAUER-MITRA, S., PEINADO, M.A. and PERUCHO, M., Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ. Health Perspect., 93, 125-131 (1991).
8. CARBONE, A., GUSELLA, G.L., RADZIOCH, D. and VARESIO, L., Human Harvey-ras is biochemically different from Kirsten- or N-ras. Oncogene, 6, 731-737 (1991).
9. FEARON, E.R. and VOGELSTEIN, B., A genetic model for colorectal tumorigenesis. Cell, 61, 759-767 (1990).
10. FEIG, L.A. and SCHAFFHAUSEN, B., The hunt for Ras targets. Nature (Lond.), 370, 508-509 (1994).
11. FORRESTER, K., ALMOGUERA, C., HAN, K., GRIZZLE, W.E. and PERUCHO, M., Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature (Lond.), 327, 298-303 (1987).
12. ras in fresh primary and metastatic human colorectal tumors. Proc. nut. Acad. Sci. (Wash.), 82, 1795-1799 (1985).
13. GIBBS, J.B., MARSHALL, M.S., SCOLNICK, E.M., DIXON, R.A.F. and VOGEL, U.S., Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP). J. biol. Chem., 265, 20437-20442 (1990).
14. maPk in proliferating cultures of epithelial cells. 7. biol. Chem., 270, 7117-7124 (1995).
15. HUANG, F., HSU, S., YAN, Z., WINAWER, S. and FRIEDMAN, E., The capacity for growth stimulation by TGFβ1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53, or ras. Oncogene, 9, 3701-3706 (1994).
16. JIANG, W., KAHN, S.M., GUILLEM, J.G., LU, S-H. and WEINSTEIN, I.B., Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal and gastric cancer. Oncogene, 4, 923-928 (1989).
17. LAURENT-PUIG, P., OLSCHWANG, S., DELATTRE, O., VALIDIRE, P., MELOT, T., MOSSERI, V., SALMON, R.J, and THOMAS, G., Association of Ki-ras mutation with differentiation and tumor-formation pathways in colorectal carcinoma. Int. J. Cancer, 49, 220-223 (1991).
18. LOWY, D.R. and WILLUMSEN, B.M., Function and regulation of Ras. Annu. Rev. Biochem., 62, 851-891 (1993).
19. MAHER, J., BAKER, D.A., MANNING, M., DIBB, N.J. and ROBERTS, I.A.G., Evidence for cell-specific differences in transformation by N-, H-, and K-ras. Oncogene, 11, 1639-1647 (1995).
20. MARKOWITZ, S.D., MYEROFF, L., COOPER, M.J., TRAICOFF, J., KOCHERA, M., LUTTERBAUCH, J., SWIRIDUK, M. and WILLSON, J.K.V., A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene. J. clin. Invest., 93, 1005-1013 (1994).
21. MIYAHARA, M., SAITO, T., KAKETANI, K., SATO, K., KUWAHARA, A., SHIMODA, K. and KOBAYASHI, M., Clinical significance of ras p21 overexpression for patients with an advanced colorectal cancer. Dis. Colon Rectum, 34, 1097-1102 (1991).
22. MULDER, K.M. and BRATTAIN, M.G., Effects of growth stimulatory factors on mitogenicity and c-myc expression in poorly differentiated and well differentiated human colon carcinoma cells. Mol. Endocrinol., 3, 1215-1222 (1989a).
23. MULDER, K.M. and BRATTAIN, M.G., Growth factor expression and response in human colon carcinoma cells. In: L. Augenlicht (ed.), Cell and molecular biology of colon cancer, pp. 45-67, CRC Press, Boca Raton, FL (1989b).
24. MULDER, K.M., HUMPHREY, L.E., CHOI, H.G., CHILDRESS-FIELDS, K.E. and BRATTAIN, M.G., Evidence for c-myc in the signaling pathway for TGFβ in well-differentiated human colon carcinoma cells. J. cell. Physiol., 145, 501-507 (1990).
25. ras by transforming growth factor βin epithelial cells. J. biol. Chem., 267, 5029-5031 (1992).
26. MULDER, K.M., SEGARINI, P.R., MORRIS, S.L., ZIMAN, J.M. and CHOI, H.G., Role of receptor complexes in resistance or sensitivity to growth inhibition by TGFβ in intestinal epithelial cell clones. J. cell. Physiol., 154, 162-174 (1993).
27. PORIES, S., GREATHEAD, P., STEELE, G. and SUMMERHAYES, I.C., Expression of individual RAS proteins in normal and neoplastic colon. Int. J. Oncol., 1, 581-585 (1992).
28. ras · GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc. nat. Acad. Sci. (Wash.), 87, 7926-7929 (1990).
29. SATOH, T., NAKAFUKU, M. and KAZIRO, Y., Function of Ras as a molecular switch in signal transduction. J. biol. Chem., 267, 24149-24152 (1992).
30. VOGELSTEIN, B., FEARON, E.R., HAMILTON, S.R., KERN, S.E., PREISINGER, A.C., LEPPERT, M., NAKAMURA, Y., WHITE, R., SMITS, A.M.M. and BOS, J.L., Genetic alterations during colorectal-tumor development. New Engl. J. Med., 319, 525-532 (1988).
31. WILLIAMS, A.C., BROWNE, S.J., MANNING, A.M., DAFFADA, P., COLLARD, T.J. and PARASKEVA, C., Transfection and expression of mutant p53 protein does not alter the in vivo or in vitro growth characteristics of the AA/C1 human adenoma derived cell line, including sensitivity to transforming growth factor-β1. Oncogene, 9, 1479-1485 (1994).
32. WILLIAMS, A.C., HAGUE, A., MANNING, A.M., VAN DER STAPPEN, J.W.J. and PARASKEVA, C., In vitro models of human colorectal cancer. Cancer Surv., 16, 15-29 (1993).