Transforming growth factor-β signaling in epithelial cells

Pharmacology and Therapeutics

Volumn 75, Issue 1, 1997, Pages 21-41

  Hartsough, Melanie T ^a   Mulder, Kathleen M ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Cancer; Cell cycle; Cell signaling; Epithelial cells; Kinases; Ras; SMADs; TGF

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

CANCER INHIBITION; CARCINOGENESIS; CELL GROWTH; CELL PROLIFERATION; EPITHELIUM CELL; GENE ACTIVATION; GROWTH INHIBITION; HUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TUMOR GROWTH;

ALKYL AND ARYL TRANSFERASES; CARRIER PROTEINS; CELL NUCLEUS; CYTOPLASM; DNA-BINDING PROTEINS; DROSOPHILA PROTEINS; EPITHELIAL CELLS; HEAT-SHOCK PROTEINS; HUMANS; INSECT PROTEINS; NEOPLASMS; PROTEIN SORTING SIGNALS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TACROLIMUS BINDING PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0030751329     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(97)00020-X     Document Type: Review

References (250)

1. 1) reduces cellular levels of p34cdc2, and this effect is abrogated by adenovirus independently of the E1A-associated pRb binding activity. Mol. Biol. Cell 3: 655-665.
2. Alexandrow, M. G. and Moses, H. L. (1995) Transforming growth factor β and cell cycle regulation. Cancer Res. 55: 1452-1457.
3. Alexandrow, M. G., Kawabata, M., Aarke, M. and Moses, H. L. (1995) Overexpression of the c-myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor β1. Proc. Natl. Acad. Sci. USA 92: 3239-3243.
4. Arrick, B. A., Lopez, A. R., Elfman, F., Ebner, R., Damsky, C. H. and Derynck, R. (1992) Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor β1. J. Cell Biol. 118: 715-726.
5. Arteaga, C., Tandon, A. K., von Hoff, D. D. and Osborne, C. K. (1988) Transforming growth factor β: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res. 48: 3898-3904.
6. Assoian, R. K., Komoriya, A., Meyers, C. A., Miller, D. M. and Sporn, M. B. (1983) Transforming growth factor-β in human platelets. J. Biol. Chem. 258: 7155-7160.
7. Attisano, L., Cárcamo, J., Ventura, F., Weis, F. M. B., Massagué, J. and Wrana, J. L. (1993) Identification of human activin and TGFβ type I receptors that form heteromeric kinase complexes with type II receptors. Cell 75: 671-680.
8. Baker, J. C. and Harland, R. M. (1996) A novel mesoderm inducer Madr2, functions in the activin signal tranduction pathway. Genes Dev. 10: 1880-1889.
9. Bang, O.-S., Ruscetti, F. W., Lee, M.-H., Kim, S.-J. and Birchenall-Roberts, M. C. (1996) Transforming growth factor-β1 modulates p107 function in myeloid cells. J. Biol. Chem. 271: 7811-7818.
10. Barnard, J. A., Beauchamp, R. D., Coffey, R. J. and Moses H. L. (1989) Regulation of intestinal epithelial cell growth by transforming growth factor type β. Proc. Natl. Acad. Sci. USA 86: 1578-1582.
11. Bassing, C. H., Howe, D. J., Segarini, P. R., Donahoe, P. K. and Wang, X.-F. (1994a) A single heteromeric receptor complex is sufficient to mediate biological effects of transforming growth factor-β ligands. J. Biol. Chem. 269: 14861-14864.
12. Bassing, C. H., Yingling, J. M., Howe, D. J., Wang, T., He, W. W., Gustafson, M. L., Shah, P., Donahoe, P. K. and Wang, X.-F. (1994b) A transforming growth factor β type I receptor that signals to activate gene expression. Science 263: 87-89.
13. Boyd, F. T. and Massagué, J. (1989) Transforming growth factor-β inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. J. Biol. Chem. 264: 2272-2278.
14. Brand, T. and Schneider, M. D. (1995) Inactive type II and type I receptors for TGFβ are dominant inhibitors of TGFβ-dependent transcription. J. Biol. Chem. 270: 8274-8284.
15. Brand, T., MacLellan, W. R. and Schnieder, M. D. (1993) A dominant-negative receptor for type β transforming growth factors created by deletion of the kinase domain. J. Biol. Chem. 268: 11500-11503.
16. Buard, A., Zipfel, P. A., Frey, R. S. and Mulder, K. M. (1996) Maintenance of growth factor signaling through Ras in human colon carcinoma cells containing K-ras mutations. Int. J. Cancer 67: 539-546.
17. Burt, D. W. and Paton, I. R. (1991) Molecular cloning and primary structure of the chicken transforming growth factor-β2 gene. DNA Cell Biol. 10: 723-734.
18. Cárcamo, J., Zentella, A. and Massagué, J. (1995) Disruption of transforming growth factor β signaling by a mutation that prevents transphosphorylation within the receptor complex. Mol. Cell. Biol. 15: 1573-1581.
19. Carr, B. I., Hayashi, I., Branum, E. L. and Moses, H. L. (1986) Inhibition of DNA synthesis in rat hepatocytes to platelet-derived type β transforming growth factor. Cancer Res. 46: 2330-2334.
20. 1 induces an epithelial-mesenchymal transdifferentiation and spindle tumoral phenotype. Cell Growth Differ. 6: 1027-1035.
21. Centrella, M., McCarthy, T. L. and Canalis, E. (1987) Transforming growth factor β is a bifunctional regulator of replication and collagen synthesis in osteoblast-enriched cell cultures of fetal rat bone. J. Biol. Chem. 262: 2869-2874.
22. Chang, H.-L., Gillett, N., Figari, I., Lopez, A. R., Palladino, M. A. and Derynck, R. (1993) Increased transforming growth factor-β expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. Cancer Res. 53: 4391-4398.
23. Chaouchi, N., Arvanitakis, L., Auffredou, M. T., Blanchard, D. A., Vazquez, A. and Sharma, S. (1995) Characterization of transforming growth factor-β1 induced apoptosis in normal human B cells and lymphoma B cell lines. Oncogene 11: 1615-1622.
24. Charng, M.-J., Kinnunen, P., Hawker, J., Brand, T. and Schneider, M. D. (1996) FKBP-12 recognition is dispensible for signal generation by type I transforming growth factor-β receptors. J. Biol. Chem. 271: 22941-22944.
25. Cheifetz, S., Like, B. and Massagué, J. (1986) Cellular distribution of type I and type II receptors for transforming growth factor-β. J. Biol. Chem. 261: 9972-9978.
26. Cheifetz, S., Weatherbee, J. A., Tsang, M. L.-S., Anderson, J. K., Mole, J. E., Lucas, R. and Massagué, J. (1987) The transforming growth factor-β system, a complex pattern of cross-reactive ligands and receptors. Cell 48: 409-415.
27. Cheifetz, S., Hernandez, H., Laiho, M., ten Dijke, P., Iwata, K. K. and Massagué, J. (1990) Distinct transforming growth factor-β (TGF-β) subsets as determinants of cellular responsiveness to three TGF-β isoforms. J. Biol. Chem. 265: 20533-20538.
28. Chen, F. and Weinberg, R. A. (1995) Biochemical evidence for the autophosphorylation and transphosphorylation of transforming growth factor-β receptor kinases. Proc. Natl. Acad. Sci. USA 92: 1565-1569.
29. Chen, R.-H. and Derynck, R. (1994) Homomeric interaction between type II transforming growth factor-β receptors. J. Biol. Chem. 269: 22868-22874.
30. Chen, R.-H., Ebner, R. and Derynck, R. (1993) Inactivation of the type II receptor reveals two receptor pathways for the diverse TGFβ receptor. Science 260: 1335-1338.
31. Chen, R.-H., Miettinen, P. J., Maruoka, E. M., Choy, L. and Derynck, R. (1995a) AWD-domain protein associated with and phosphorylated by the type II TGF-β receptor. Nature 377: 548-552.
32. Chen, R.-H., Moses, H. L., Maruoka, E. M., Derynck, R. and Kawabata, M. (1995b) Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-β receptors. J. Biol. Chem. 270: 12235-12241.
33. Chen, X., Rubock, M. J. and Whitman, M. (1996) A transcriptional partner for MAD proteins in TGF-β signaling. Nature 383: 691-696.
34. Chen, Y., Lebrun, J.-J. and Vale, W. (1996) Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins. Proc. Natl. Acad. Sci. USA 93: 12992-12997.
35. Chiang, C. P. and Nilsen-Hamilton, M. (1986) Opposite and select effects of epidermal growth factor-β on the production of secreted proteins by murine 3T3 cells and human fibroblasts. J. Biol. Chem. 261: 10478-10481.
36. Choi, M. E. and Ballermann, B. J. (1995) Inhibition of capillary morphogenesis and associated apoptosis by dominant negative mutant transforming growth factor-β receptors. J. Biol. Chem. 270: 21144-21150.
37. Coffey, R. J., Bascom, C. C., Sipes, N. J., Graves-Deal, R., Weissman, B. E. and Moses, H. L. (1988) Selective inhibition of growth-related gene expression in murine keratinocytes by transforming growth factor β. Mol. Cell. Biol. 8: 3088-3093.
38. Cui, W., Fowlis, D. J., Bryson, S., Duffie, E., Ireland, H., Balman, A. and Akhurst, R. J. (1996) TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86: 531-542.
39. Datto, M. B., Li, Y., Panus, J. F., Howe, D. J., Xiong, Y. and Wang, X.-F. (1995) Transforming growth factor β induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92: 5545-5549.
40. 1 mediated by the dyad symmetry element (DSE) and the TPA responsive element. Biochem. Biophys. Res. Commun. 168: 1074-1081.
41. de Martin, R., Haendler, B., Hofer-Warbinek, R., Gaugitsch, H., Wrann, M., Schlüsener, H., Seifert, J. M., Bodmer, S., Fontana, A. and Hofer, E. (1987) Complementary DNA for human glioblastoma-derived T cell suppressor factor, a novel member of the transforming growth factor-β gene family. EMBO J. 6: 3673-3677.
42. Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R. J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-jun activation domain. Cell 76: 1025-1037.
43. Derynck, R. (1994) TGF-β-receptor mediated signaling. Trends Biochem. Sci. 19: 548-553.
44. Derynck, R. and Rhee, L. (1987) Sequence of the porcine transforming growth factor-beta precursor. Nucl. Acids Res. 15: 3187.
45. Derynck, R., Jarrett, J. A., Chen, E. Y., Eaton, D. H., Bell, J. R., Assoian, R. K., Roberts, A. B., Sporn, M. B. and Goeddel, D. V. (1985) Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells. Nature 316: 701-704.
46. Derynck, R., Jarrett, J. A., Chen, E. Y. and Goeddel, D. V. (1986) The murine transforming growth factor-β precursor. J. Biol. Chem. 261: 4377-4379.
47. Derynck, R., Lindquist, P. B., Lee, A., Wen, D., Tamm, J., Graycar, J. L., Rhee, L., Mason, A. J., Miller, D. A., Coffey, R. J., Moses, H. L. and Chen, E. Y. (1988) A new type of transforming growth factor-β, TGF-β3. EMBO J. 12: 3737-3743.
48. Derynck, R., Gelbhart, W. M., Harland, R. M., Massagué, J., Melton, D. A., Modzik, M., Padgett, R. W., Roberts, A. B., Smith, J., Thomsen, G. H., Volgelstein, B. and Wang, X.-F. (1996) Nomenclature: vetebrate mediators of TGFβ family signals. Cell 87: 173.
49. 1 inhibitory signals. Mol. Cell. Biol. 12: 302-308.
50. 1 in cycling epithelial cells. Cell Growth Differ. 5: 109-116.
51. Ebner, R., Chen, R.-H., Shum, L., Lawler, S., Zioncheck, T. F., Lee, A., Lopez, A. R. and Derynck, R. (1993) Cloning of a type I TGFβ receptor and its effect on TGFβ-binding to the type II receptor. Science 260: 1344-1348.
52. Edwards, D. R., Murphy, G., Reynolds, J., Whitman, S. E., Docherty, A. J. P., Angel, P. and Heath, J. K. (1987) Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J. 6: 1899-1904.
53. Elbendary, A., Berchuck, A., Davis, P., Harvrilesky, L., Bast, R. C., Jr., Iglehart, D. and Marks, R. (1994) Transforming growth factor β1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells. Cell Growth Differ. 5: 1301-1307.
54. Ellingsworth, L. R., Brennan, J. E., Fok, K., Rosen, D. M., Bentz, H., Piez, K. A. and Seyedin, S. M. (1986) Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor-β. J. Biol. Chem. 261: 12362-12367.
55. Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L.-C., Bapat, B., Gallinger, S., Andrulis, I. L., Thomsen, G. H., Wrana, J. L. and Attisano, L. (1996) MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell 86: 543-552.
56. Estevez, M., Attisano, L., Wrana, J. L., Albert, P. S., Riddle, D. J. and Massagué, J. (1993) The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development. Nature 365: 644-649.
57. Ewen, M. E., Sluss, H. K., Whitehouse, L. L. and Livingston, D. M. (1993) TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest. Cell 74: 1009-1020.
58. cdk2 by transforming growth factor-β1 in murine mammary epithelial cells. J. Cell. Biochem. 58: 517-526.
59. Feng, X.-H., Filvaroff, E. H. and Derynck, R. (1995) Transforming growth factor-β (TGF-β)-induced down-regulation of cyclin A expression requires a functional TGFβ receptor complex. J. Biol. Chem. 270: 24237-24245.
60. Franzén, P., ten Dijke, P., Ichijo, H., Yamashita, H., Schulz, P., Heldin, C.-H. and Miyazono, K. (1993) Cloning of a TGFβ type I receptor that forms a heteromeric complex with the TGFβ type II receptor. Cell 75: 681-692.
61. Franzén, P., Heldin, C.-H. and Miyazono, K. (1995) The GS domain of the transforming growth factor-β type I receptor is important in signal transduction. Biochem. Biophys. Res. Commun. 207: 682-689.
62. Frater-Schröder, M., Muller, G., Birchmeier, W. and Bohlen, P. (1986) Transforming growth factor-β inhibits endothelial cell proliferation. Biochem. Biophys. Res. Commun. 137: 295-302.
63. Frey, R. S. and Mulder, K. M. (1997) Involvement of ERK2 and SAPK/JNK activation by TGFβ by transforming growth factor β in the negative growth control of breast cancer cells. Cancer Res. 57: 628-633.
64. Frolik, C. A., Dart, L. L., Meyers, C. A., Smith, D. M. and Sporn, M. B. (1983) Purification and initial characterization of a type β transforming growth factor from human placenta. Proc. Natl. Acad. Sci. USA 80: 3676-3680.
65. Geng, Y. and Weinberg, R. A. (1993) Transforming growth factor β effects on expression of G1 cyclins and cyclin-dependent protein kinases. Proc. Natl. Acad. Sci. USA 90: 10315-10319.
66. Georgi, L. L., Albert, P. S. and Riddle, D. L. (1990) Daf-1, a C. elegans gene controlling dauer larva development, encodes a novel receptor protein kinase. Cell 61: 635-645.
67. Gille, H., Sharrocks, A. D. and Shaw, P. E. (1992) Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 58: 414-417.
68. Graff, J. M., Bansal, A. and Melton, D. A. (1996) Xenopus Mad protein transduce distinct subsets of signals for the TGFβ superfamily. Cell 85: 479-487.
69. Graycar, J. L., Miller, D. A., Arrick B. A., Lyons, R. M. and Moses, H. L. (1989) Human transforming growth factor-beta 3: recombinant expression, purification, and biological activities in comparison with transforming growth factor-beta 1 and -beta 2. Mol. Endocrinol. 3: 1977-1986.
70. Gruppuso, P. A., Mikumo, R., Brautigan, D. L. and Braun, L. (1991) Growth arrest induced by transforming growth factor β1 is accompanied by protein phosphatase activation in human keratinocytes. J. Biol. Chem. 266: 3444-3448.
71. Gupta, S., Campbell, D., Derijard, B. and Davis, R. J. (1995) Transcription factor ATF-2 regulation by the JNK signal transduction pathway. Science 267: 389-393.
72. Hahn, S. A., Schutte, M., Hoque, A. T. M. S., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H. and Kern, S. E. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271: 350-353.
73. Halstead, J., Kemp, K. and Ignotz, R. A. (1995) Evidence for involvement of phosphatidyl-choline-phospholipase C and protein kinase C in transforming growth factor-β signaling. J. Biol. Chem. 270: 13600-13603.
74. Hanks, S. K., Armour, R., Baldwin, J. H., Maldonado, F., Spiess, J. and Holley, R. W. (1988) Amino acid sequence of the BSC-1 cell growth inhibitor (polyergin) deduced from the nucleotide sequence of the cDNA. Proc. Natl. Acad. Sci. USA 85: 79-82.
75. Hannon, G. J. and Beach, D. (1994) p15INK4B is a potential effector of TGFβ-induced cell cycle arrest. Nature 371: 257-260.
76. mapk in proliferating cultures of epithelial cells. J. Biol. Chem. 270: 7117-7124.
77. Hartsough, M. T., Frey, R. S., Zipfel, P. A., Buard, A., Cook, S. J., McCormick, F. and Mulder, K. M. (1996) Altered transforming growth factor β signaling in epithelial cells when Ras activation is blocked. J. Biol. Chem. 271: 22368-22375.
78. Heino, J., Ignotz, R. A., Hemler, M. E., Crouse, C. and Massagué, J. (1989) Regulation of cell adhesion receptors by transforming growth factor-β. Concomitant regulation of integrins that share a common β1 subunit. J. Biol. Chem. 264: 380-388.
79. Henis, Y. I., Moustakas, A., Lin, H. Y. and Lodish, H. F. (1994) The types II and III transforming growth factor-β receptors form homo-oligomers. J. Cell Biol. 126: 139-154.
80. Herskowitz, I. (1995) MAP kinase pathways in yeast: for mating and more. Cell 80: 187-197.
81. Herzinger, T., Wolf, D. A., Eick, D. and Kind, P. (1995) The pRb-related protein p130 is a possible effector of transforming growth factor β1 induced cell cycle arrest in ratinocytes. Oncogene 10: 2079-2084.
82. Hibi, M., Lin, A., Smeal, T., Minden, A. and Karin, M. (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7: 2135-2148.
83. Hill, D. J., Strain, A. J., Elstow, S. F., Swenne, I. and Milner, R. D. G. (1986) Regulation of cell-adhesion receptors by transforming growth factor-β on DNA synthesis in early passage human fetal fibroblasts. J. Cell. Physiol. 128: 322-328.
84. Holley, R. W., Bohlen, P., Fava, R., Baldwin, J. H., Kleeman, G. and Armour, R. (1980) Purification of kidney epithelial cell growth inhibitors. Proc. Natl. Acad. Sci. USA 77: 5989-5992.
85. Hoodless, P. A., Haerry, T., Abdollah, S., Stapleton, M., O'Conner, M. B., Attisano, L. and Wrana, J. L. (1996) MADR1, a mad-related protein that functions in BMP2 signaling pathways. Cell 85: 489-500.
86. Hoosein, N. M., McKnight, M. K., Levine, A. E., Mulder, K. M., Childress, K. E., Brattain, D. E. and Brattain, M. G. (1989) Differential sensitivity of subclasses of human colon carcinoma cell lines to the growth inhibitory effects of transforming growth factor β1. Exp. Cell Res. 181: 442-453.
87. cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol. Cell. Biol. 11: 1185-1194.
88. Hsu, S., Huang, F., Hafez, M., Winawer, S. and Friedman, E. (1994) Colon carcinoma cells switch their response to transforming growth factor β1 with tumor progression. Cell Growth Differ. 5: 267-275.
89. Ignotz, R. A. and Massagué, J. (1986) Transforming growth factor-β stimulates the expression of fibronentin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 261: 4337-4345.
90. Ignotz, R. A. and Massagué, J. (1987) Cell adhesion receptors as targets for transforming growth factor-β action. Cell 52: 189-197.
91. Ignotz, R. A., Endo, T. and Massagué, J. (1987) Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-β. J. Biol. Chem. 262: 6443-6446.
92. Ikeda, T., Lioubin, M. N. and Marquardt, H. (1987) Human transforming growth factor type β2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization. Biochemistry 26: 2406-2410.
93. Inagaki, M., Moustakas, A., Lin, H. Y., Lodish, H. F. and Carr, B. I. (1993) Growth inhibition by transforming growth factor β (TGFβ) type I is restored in TGF-β-resistant hepatoma cells after expression of TGFβ receptor type II cDNA. Proc. Natl. Acad. Sci. USA 90: 5359-5363.
94. Janknecht, R., Ernst, W. H., Pingoud, V. and Nordheim, A. (1993) Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J. 12: 5097-5104.
95. Jennings, J. C., Mohan, S., Linkhart, T. A., Widstrom, R. and Baylink, D. J. (1988) Comparison of the biological actions of TGF beta-1 and TGF beta-2: differential activity in endothelial cells. J. Cell. Physiol. 137: 167-172.
96. Kawabata, M., Chytil, A. and Moses, H. L. (1995a) Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor. J. Biol. Chem. 270: 5625-5630.
97. Kawabata, M., Imamura, T., Miyazono, K., Engel, M. E. and Moses, H. L. (1995b) Interaction of the transforming growth factor-β type I receptor with farnesyl-protein transferase-α. J. Biol. Chem. 270: 29628-29631.
98. Kehrl, J. H., Wakefield, L. M., Roberts, A. B., Jakowlew, S., Alvarez-Mon, M., Derynck, R., Sporn, M. B. and Fauci, A. S. (1986) Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 163: 1037-1050.
99. Kehrl, J. H., Taylor, A. S., Delsing, G. A., Roberts, A. B., Sporn, M. B. and Fauci, A. S. (1989) Further studies of the role of transforming growth factor-β in human B cell function. J. Immunol. 143: 1868-1874.
100. Keller, J. R., Sing, G. K., Ellingsworth, L. R. and Ruscetti, F. W. (1989) Transforming growth factor-β: possible roles for the regulation of normal and leukemic hematopoietic cell growth. J. Cell. Biochem. 39: 175-184.
101. Kim, I.-Y., Ahn, H.-J., Zelner, D. J., Shae, J. W., Sensibar, J., Kim, J.-H., Kato, M. and Lee, C. (1996) Genetic changes in transforming growth factor β (TGFβ) receptor type I gene correlates with insensitivty to TGF-β1 in human prostate cancer cells. Cancer Res. 56: 44-48.
102. 1 is mediated by the AP-1 complex. Mol. Cell. Biol. 10: 1492-1497.
103. Kim, S.-J., Wagner, S., Liu, F., O'Reilly, M. A., Robbins, P. D. and Green, M. R. (1992) Retinoblastoma gene product activates expression of the human TGF-β2 gene through TF ATF-2. Nature 358: 331-334.
104. Kimchi, A., Wang, X.-F., Weinberg, R. A., Cheifetz, S. and Massagué, J. (1988) Absence of TGF-β receptors and growth inhibitory responses in retinoblastoma cells. Science 240: 196-198.
105. Knaus, P. I., Lindemann, D., De Coteau, J. F., Perlman, R., Yankelev, H., Hille, M., Kadin, M. E. and Lodish, H. F. (1996) A dominant inhibitory mutant type II transforming growth factor β receptor in the malignant progression of a cutaneous T-cell lymphoma. Mol. Cell. Biol. 16: 3480-3489.
106. Ko, T. C., Beauchamp, R. D., Townsend, C. M., Thompson, E. A. and Thompson, J. C. (1994) Transforming growth factor-β inhibits rat intestinal epithelial cell growth by regulating cell cycle specific gene expression. Am. J. Surg. 167: 14-19.
107. Ko, T. C., Sheng, H. M., Reisman, D., Thompson, E. A. and Beauchamp, R. D. (1995) Transforming growth factor-β1 inhibits cyclin D1 expression in intestinal epithelial cells. Oncogene 10: 177-184.
108. Koff, A., Ohtsuki, M., Polyak, K., Roberts, J. M. and Massagué, J. (1993) Negative regulation of Gl in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science 260: 536-539.
109. Koike, M., Ishino, K., Huh, N. and Kuroki, T. (1994) Growth inhibition of SV40-transformed human keratinocytes by TGF-βs is not linked to dephosphorylation of the Rb gene product. Biochem. Biophys. Res. Commun. 201: 673-681.
110. Kondaiah, P., van Obberghen-Schilling, E., Ludwig, R. L., Dehar, R., Sporn, M. B. and Roberts, A. B. (1988) cDNA cloning of porcine TGF-β1 mRNAs. J. Biol. Chem. 263: 18313-18317.
111. Kramer, I. M., Koornneef, I., de Laat, S. W. and van den Eijn denvan Raaij, A. J. M. (1991) TGF-β1 induces phosphorylation of the cyclic AMP responsive element binding protein in ML-CCl 64 cells. EMBO J. 10: 1083-1089.
112. 1 in rat alveolar epithelial cell. Exp. Cell Res. 221: 385-394.
113. Kurokowa, M., Lynch, K. and Podolsky, D. K. (1987) Effects of growth factors on an intestinal epithelial cell line: transforming growth factor-β inhibits proliferation and stimulates differentiation. Biochem. Biophys. Res. Commun. 142: 775-782.
114. Kyriakis, J. M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J. and Woodgett, J. R. (1994) The stress-activated protein kinase subfamily of c-jun kinases. Nature 369: 156-160.
115. 3 promoter. J. Biol. Chem. 265: 19128-19136.
116. Lagna, G., Hata, A., Hemmati-Brivanlou, A. and Massagué, J. (1996) Partnership between DPC4 and SMAD proteins in TGFβ signaling pathways. Nature 383: 832-836.
117. Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M. and Massagué, J. (1990a) Growth inhibition by TGFβ linked to suppression of retinoblastoma protein phosphorylation. Cell 62: 175-185.
118. Laiho, M., Weis, F. M. B. and Massagué, J. (1990b) Concomitant loss of transforming growth factor (TGF)-β receptor types I and II in TGF-β-resistant cell mutants implicates both receptor types in signal transduction. J. Biol. Chem. 265: 18518-18524.
119. Laiho, M., Rönnstrand, L., Heino, J., Decaprio, J. A., Ludlow, J. W., Livingston, D. M. and Massagué, J. (1991a) Control of JunB and extracellular matrix protein expression by transforming growth factor-β1 is independent of simian virus 40 T antigen-sensitive growth-inhibitory events. Mol. Cell. Biol. 11: 972-978.
120. Laiho, M., Weis, F. M. B., Boyd, F. T., Ignotz, R. A. and Massagué, J. (1991b) Responsiveness to transforming growth factor-β (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II. J. Biol. Chem. 266: 9108-9112.
121. Lechleider, R. J., de Caestecker, M. P., Dehejia, A., Polymeropoulos, M. H. and Roberts, A. B. (1996) Serine phosphorylation, chromosomal localization, and transforming growth factor-β signal transduction by human bsp-1. J. Biol. Chem. 271: 17617-17620.
122. Leof, E. B., Proper, J. A., Goustin, A. S., Shipley, G. D., Dicorletto, P. E. and Moses, H. L. (1986) Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth facctor β: a proposed model for indirect mitogenesis involving autocrine activity. Proc. Natl. Acad. Sci. USA 83: 2453-2457.
123. Li, C.-Y., Suardet, L. and Little, J. B. (1995) Potential role of WAF1/Cip1/p21 as a mediator of TGF-β cytoinhibitory effect. J. Biol. Chem. 70: 4971-4974.
124. Lin, A., Minden, A., Martinetto, H., Claret, F-X., Lange-Carter, C., Mercurio, F., Johnson, G. L. and Karin, M. (1995) Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268: 286-290.
125. Lin, H. Y., Wang, X.-F., Ng-Eaton, E., Weinberg, R. A. and Lodish, H. F. (1992) Expression cloning of the TGF-β type II receptor, a funtional transmembrane serine/threonine kinase. Cell 68: 775-785.
126. Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S. and Collins, F. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132.
127. Liu, F., Hata, A., Baker, J. C., Doody, J., Cárcamo, J., Harland, R. M. and Massagué, J. (1996) A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381: 620-623.
128. Livingstone, C., Patel, G. and Jones, N. (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14:1785-1797.
129. 1)-induced growth arrest and p34cdc2 regulation in ras-transfected epithelial cells. Oncogene 7:1549-1556.
130. Lund, L. R., Riccio, A., Andreasen, P. A., Nielsen, L. S. and Kristensen, P. (1987) Transforming growth factor-β is a strong and fast acting positive regulator of the level of type 1 plasminogen activator mRNA in WI-38 human lung fibroblasts. EMBO J. 6: 1281-1286.
131. Macías-Silva, M., Abdollah, S., Hoodless, P. A., Pirone, R., Attisano, L. and Wrana, J. L. (1996) MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87: 1215-1224.
132. Madisen, L., Webb, N. R., Rose, T. M., Marquardt, H., Ikeda, T., Twardzik, D., Seyedin, S. and Purchio, A. F. (1988) Transforming growth factor-β2: cDNA cloning and sequence analysis. DNA 7: 1-8.
133. Markowitz, S., Wang, J., Myerofff, L., Parsons, R., Sun, L., Lutterbaugh, J., Fan, R. S., Zboroska, E., Kinzler, K., Volgelstein, B., Brattain, M. and Willson, J. K. (1995) Inactivation of the Type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338.
134. 1 on proliferation and death of rat prostatic cells. Endocrinology 127: 2963-2969.
135. Massagué, J. (1990) The transforming growth factor-β family. Annu. Rev. Cell. Biol. 6: 597-641.
136. Massagué, J. and Like, B. (1985) Cellular receptors for type transforming growth factor: ligand binding and affinity labeling in human and rodent cell lines. J. Biol. Chem. 260: 2636-2645.
137. Massagué, J., Cheifetz, S., Laiho, M., Ralph, D. A., Weis, F. M. B. and Zentella, A. (1992) Transforming growth factor-β. Cancer Surv. 12: 81-103.
138. Mathieu, C., Jozan, S., Mazars, P., Come, M. G., Moisand, A. and Valette, A. (1995) Density-dependent induction of apoptosis by transforming growth factor-β1 in a human ovarian carcinoma cell line. Exp. Cell Res. 216: 13-20.
139. Matrisian, L. M., Leroy, P., Ruhlmann, C., Gesnel M.-C. and Breathnach, R. (1986) Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts. Mol. Cell. Biol. 6: 1679-1686.
140. Mazars, P., Barboule, N., Baldin, V., Vidal, S., Ducommun, B. and Valette, A. (1995) Effects of TGF-β1 (transforming growth factor-β1) on the cell cycle regulation of human breast adenocarcinoma (MCF-7) cells. FEBS Lett. 362: 295-300.
141. Meno, C., Saijoh, Y., Fuji, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y. and Hamada, H. (1996) Left-right asymmetric expression of the TGFβ-family member lefty in mouse embryos. Nature 381: 151-155.
142. Miettinen, P. J., Ebner, R., Lopez, A. R. and Derynck, R. (1994) TGF-β induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J. Cell Biol. 127: 2021-2036.
143. 3) precursor and the comparative expression of TGF-β3 and TGF-β1 messenger RNA in murine embryos and adult tissues. Mol. Endocrinol. 3: 1926-1934.
144. Miller, D. A., Lee, A., Pelton, R. W., Chen, E. Y., Moses, H. L. and Derynck, R. (1989b) Murine transforming growth factor-β2 cDNA sequence and expression in adult tissues and embryos. Mol. Endocrinol. 3: 1108-1114.
145. Minden, A., Lin, A., McMahon, M., Lange-Carter, C., Dérijard, B., Davis, R. J., Johnson, G. L. and Karin, M. (1994a) Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266: 1719-1723.
146. Minden, A., Lin, A., Smeal, T., Derijard, B., B., Cobb, M., Davis, R. and Karin, M. (1994b) c-Jun terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14: 6683-6688.
147. Moses, H. L., Branum, E. L., Proper, J. A. and Robinson, R. A. (1981) Transforming growth factor production by chemically transformed cells. Cancer Res. 41: 2842-2848.
148. Moses, H. L., Tucker, R. F., Leof, E. B., Coffey, R. J., Jr., Halper, J. and Shipley, G. D. (1985) Type β transforming growth factor is a growth stimulator and a growth inhibitor. In: Cancer Cells, Vol. 3, pp. 65-75, Feramisco, J., Ozane, B. and Stiles, C. (eds.) Cold Spring Harbor Press, New York.
149. Moustakas, A., Lin, H. Y., Henis, Y. I., Plamondon, J., O'Connor-McCourt, M. D. and Lodish, H. F. (1993) The transforming growth factor β receptor types I, II, and III form hetero-oligomeric complexes in the presence of ligand. J. Biol. Chem. 268: 22215-22218.
150. Mulder, K. M. and Brattain, M. G. (1988) Alteration in c-myc expression in relation to maturational status of human colon carcinoma cells. Int. J. Cancer 42: 64-70.
151. Mulder, K. M. and Brattain, M. G. (1989) Growth factor expression and response in human colon carcinoma cells. In: The Cell and Molecular Biology of Colon Cancer, pp. 45-67, Augenlicht, L. (ed.) CRC Press, Boca Raton.
152. ras by transforming growth factor β in epithelial cells. J. Biol. Chem. 267: 5029-5031.
153. Mulder, K. M., Levine, A. E., Hernandez, X., McKnight, M. K., Brattain,
154. Mulder, K. M., Ramey, M. K., Hoosein, N. M., Levine, A. E. Hinshaw, X. H., Brattain, D. E. and Brattain, M. G. (1988b) Characterization of transforming growth factor-β resistant subclones isolated from a transforming growth factor-β-sensitive human colon carcinoma cell line. Cancer Res. 48: 7120-7125.
155. Mulder, K. M., Humphrey, L. E., Choi, H. G., Childress-Fields, K. E. and Brattain, M. G. (1990a) Evidence for c-myc in the signaling pathway for TGF-β in well-differentiated human colon carcinoma cells. J. Cell. Physiol. 145: 501-507.
156. 1 on mitogenic response, transforming growth factor α, and c-myc in quiescent, well-differentiated colon carcinoma cells. Cancer Res. 50: 7581-7586.
157. Mulder, K. M., Segarini, P. R., Morris, S. L., Ziman, J. M. and Choi, H. G. (1993) Role of receptor complexes in resistance or sensitivity to growth inhibition by TGFβ in intestinal epithelial cell clones. J. Cell. Physiol. 154: 162-174.
158. Nakamura, T., Tomita, Y., Hirai, R., Yamaoka, K., Kaji, K. and Ichihara, A. (1985) Inhibitory effect of transforming growth factor-β on DNA synthesis of adult hepatocytes in primary culture. Biochem. Biophys. Res. Commun. 133: 1042-1050.
159. Nakao, A., Röijer, E., Imamura, T., Souchelnytsky, S., Stenman, G., Heldin, C.-H. and ten Dijke, P. (1997) Identification of Smad2, a human Mad-related protein in the transforming growth factor ßsignaling pathway. J. Biol. Chem. 272: 2896-2900.
160. Newfeld, S. J., Chartoff, E. H., Graff, J. M., Melton, D. A. and Gelbart, W. M. (1996) Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGFβ responsive cells. Development 122: 2099-2108.
161. 1. Proc. Natl. Acad. Sci. USA 89: 5408-5412.
162. Ohta, M., Greenberger, J. S., Anklesaria, P., Bassols, A. and Massagué, J. (1987) Two forms of transforming growth factor-β distinguished by multipotential hematopoietic progenitor cells. Nature 329: 539-541.
163. Ohtsuki, M. and Massagué, J. (1992) Evidence for the involvement of protein kinase activity in transforming growth factor-β signal transduction. Mol. Cell. Biol. 12: 261-265.
164. Okadome, T., Yamashita, H., Franzen, P., Moren, A., Heldin, C.-H. and Miyazono, K. (1994) Distinct roles of the intracellular domains of transforming growth factor-β type I and II receptors in signal transduction. J. Biol. Chem. 169: 30753-30756.
165. Okadome, T., Oeda, E., Saitoh, M., Ichijo, H., Moses, H. L., Miyazono, K. and Kawabata, M. (1996) Characterization of the interaction of FKBP12 with the transforming growth factor-β type I receptor in vivo. J. Biol. Chem. 271: 21687-21690.
166. Ong, G., Sikora, K. and Gullick, W. J. (1991) Inactivation of the retinoblastoma gene does not lead to loss of TGF-β receptors or response to TGF-β in breast cancer cell lines. Oncogene 6: 761-763.
167. Ottmann, O. G. and Pelus, L. M. (1988) Differential proliferative effects of transforming growth factor-β on human hematopoietic progenitor cells. J. Immunol. 140: 2661-2665.
168. Peter, M. and Herskowitz, I. (1994) Joining the complex: cyclindependent kinase inhibitory proteins and the cell cycle. Cell 79: 181-184.
169. Petrovaara, L., Sistonen, L., Bos, T. J., Vogt, P. K., Keski-Oja, J. and Alitalo, K. (1989) Enhanced jun gene expression in an early genomic response to transforming factor β stimulation. Mol. Cell. Biol. 9: 1255-1262.
170. Pierce, D. F., Jr., Gorska, A. E., Chytil, A., Meise, K. S., Page, D. L., Coffey, R. J., Jr. and Moses, H. L. (1995) Mammary tumor suppression by transforming growth factor β1 transgene expression. Proc. Natl. Acad. Sci. USA 92: 4254-4258.
171. 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc. Natl. Acad. Sci. USA 87: 3758-3762.
172. 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell 61: 777-785.
173. kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev. 8: 9-22.
174. Proper, J. A., Bjornson, C. L. and Moses, H. L. (1982) Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture. J. Cell. Physiol. 11: 169-174.
175. Qian, S. W., Kondaiah, P., Roberts, A. B. and Sporn, M. B. (1990) cDNA cloning by PCR of rat transforming growth factor β-1. Nucl. Acids Res. 18: 3059.
176. Rafferty, L. A., Twombly, V., Wharton, K. and Gelbhart, W. M. (1995) Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila. Genetics 139: 241-254.
177. Raghow, R., Postlethwaite, A. E., Keski-Oja, J., Moses, H. L. and Kang, A. H. (1987) Transforming growth factor-β increases steady state levels of type I procollagen and fibronectin messenger RNAs post-transcriptionally in cultured dermal fibroblasts. J. Clin. Invest. 79: 1285-1288.
178. Reynisdóttir, I., Polyak, K., lavarone, A. and Massagué, J. (1995) Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev. 9: 1831-1845.
179. Riggins, G. J., Thiagalingam, S., Rozenblum, E., Weinstein, C. L., Kern, S. E., Hamilton, S. R., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W. and Vogelstein, B. (1996) Mad-related genes in the human. Nat. Genet. 13: 347-349.
180. Roberts, A. B. and Sporn, M. B. (1990) The transforming growth factor βs. In: Peptides, Growth Factors and Their Receptors, Part I, pp. 419-472, Sporn, M. B. and Roberts, A. B. (eds.) Springer-Verlag, Berlin.
181. Roberts, A. B., Anzano, M. A., Lamb, L. C., Smith, J. M. and Sporn, M. B. (1981) New class of transforming growth factors potentiated by epidermal growth factor: isolation from nonneoplastic tissues. Proc. Natl. Acad. Sci. USA 78: 5339-5343.
182. Roberts, A. B., Anzano, M. A., Lamb, L. C., Smith, J. M., Frolik, C. A., Marquardt, H., Todaro, G. J. and Sporn, M. B. (1982) Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGRNature 295: 417-419.
183. Roberts, A. B., Anzano, M. A., Meyers, C. A., Wideman, J., Blacher, R., Pan, Y.-C. E., Stein, S., Lehrman, S. R., Smith, J. M., Lamb, L. C. and Sporn, M. B. (1983) Purification and properties of a type β transforming growth factor from bovine kidney. Biochemistry 22: 5692-5698.
184. Roberts, A. B., Anzano, M. A., Wakefield, L. M., Roche, N. S., Stern, D. F. and Sporn, M. B. (1985) Type ßtransforming growth factor: a bifunctional regulator of cellular growth. Proc. Natl. Acad. Sci. USA 82: 119-123.
185. Roberts, A. B., Sporn, M. B., Assoian, R. K., Smith, J. M., Roche, N. S., Wakefield, L. M., Heine, U. I., Liotta, L. A., Falanga, V., Kehrl, J. H. and Fauci, A. S. (1986) Transforming growth factor type β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc. Natl. Acad. Sci. USA 83: 4167-4171.
186. 1) enhances apoptosis in human papillomavirus type 16-immortalized human cytocervical epithelial cells. Exp. Cell Res. 216: 65-72.
187. 1 in cultured uterine epithelial cells. Proc. Natl. Acad. Sci. USA 88: 3412-3415.
188. Saitoh, M., Nishitoh, H., Amagasa, T., Miyazono, K., Takagi, M. and Ichijo, H. (1996) Identification of important regions in the cytoplasmic juxtamembrane domain of Type I receptor that separate pathways of transforming growth factor-β. J. Biol. Chem. 271: 2768-2775.
189. Sanchez, I., Hughes, R. T., Mayer, B. J., Yee, K., Woodgett, J. R., Avruch, J., Kyriakis, J. M. and Zon, L. I. (1994) Role of SAPK/ ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (Lond.) 372: 794-798.
190. 1 is associated with inhibition of B-myb and cyclin A in both BALB/MK and MvlLu cells. Cell Growth Differ. 5: 789-799.
191. Savage, C., Das, P., Finelli, A. L., Townsend, S. R., Sun, C.-Y., Baird, S. E. and Padgett, R. W. (1996) Canorhabditis elegans gene sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor β pathway components. Proc. Natl. Acad. Sci. USA 93: 790-794.
192. Schwartz, J. K., Bassing, C. H., Kovesdi, I., Datto, M. B., Blazing, M., George, S., Wang, X.-F. and Nevins, J. R. (1995) Expression of the E2F1 transcription factor overcomes type β transforming growth factor-mediated growth suppression. Proc. Natl. Acad. Sci. USA 92: 483-487.
193. Segarini, P. R. (1993) TGF-β receptors: a complicated system of multiple binding proteins. Biochim. Biophys. Acta 1155: 269-275.
194. Segarini, P. R., Rose, D. M. and Seyedin, S. M. (1989) Binding of TGF-β to cell surface proteins varies with cell type. Mol. Endocrinol. 3: 261-272.
195. Sekelsky, J. L., Newfeld, S. J., Raftery, L. A., Chartoff, E. H. and Gelbart, W. M. (1995) Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics 139: 1347-1358.
196. Seyedin, S. M., Thomas, T. C., Thompson, A. Y., Rosen, D. M. and Piez, K. A. (1985) Purification and charaterization of two cartilage-inducing factors from bovine demineralized bone. Proc. Natl. Acad. Sci. USA 82: 2267-2271.
197. Seyedin, S. M., Segarini, P. R., Rose, D. M., Thompson, A. Y., Bentz, H. and Graycar, J. (1987) Cartilage-inducing factor-β is a unique protein structurally and functionally related to trans-forming growth factor-β. J. Biol. Chem. 262: 1946-1949.
198. Sharples, K., Powman, G. D., Rose, T. M., Twardzik, D. R. and Purchio, A. F. (1987) Cloning and sequence analysis of Simian transforming growth factor-β cDNA. DNA 6: 239-244.
199. Shibuya, H., Yamaguchi, K., Shirakabe, K., Tonegawa, A., Gotoh, Y., Ueno, N., Irie, K., Nishida, E. and Matsumoto, K. (1996) An activator of the TAK1 MAPKKK in TGF-β signal transduction. Science 272: 1179-1182.
200. Shipley, G. D., Tucker, R. F. and Mose, H. L. (1985) Type β transforming growth factor/growth inhibitor stimulates entry of monolayer cultures of AKR-2B cells into S phase after a prolonged prereplicative interval. Proc. Natl. Acad. Sci. USA 82: 4147-4151.
201. Shipley, G. D., Pittelkow, M. R., Wille, J. J., Scott, R. E. and Moses, H. L. (1986) Reversible inhibition of normal human prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium. Cancer Res. 46: 2068-2071.
202. Simon, K. E., Cha, H. H. and Firestone, G. L. (1995) Transforming growth factor β down-regulation of CKShs1 transcripts in growth-inhibited epithelial cells. Cell Growth Differ. 6: 1261-1269.
203. Slingerland, J. M., Hengst, L., Pan, C.-H., Alexander, D., Stampfer, M. R. and Reed. S. I. (1994) A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor β-arrested epithelial cells. Mol. Cell. Biol. 14: 3683-3694.
204. Souchelnytskyi, S., ten Dijke, P., Miyazono, K. and Heldin, C.-H. (1996) Phosphorylation of Serl65 in TGF-β type I receptor modulates TGF-β1-induced cellular responses. EMBO J. 15: 6231-6240.
205. Sporn, M. B., Roberts, A. B., Wakefield, L. M. and de Crombrugghe, B. (1987) Some recent advances in the chemistry and biology of transforming growth factor-beta. J. Cell Biol. 105: 1039-1045.
206. 1 overproduction in prostate cancer: effects on growth in vivo and in vitro. Mol. Endocrinol. 6: 15-25.
207. Sun, L., Wu, G., Willson, J. K., Zborowska, E., Yang, J., Rajkarunanayake, I., Wang, J., Gentry, L. E., Wang, X.-F. and Brattain, M. G. (1994) Expression of transforming growth factor-β type II receptor leads to reduced malignancy in human cancer MCF-7 cells. J. Biol. Chem. 269: 26449-26455.
208. 3 maps to human chromosome 14 region q23-q24. Oncogene 3: 721-724.
209. ten Dijke, P., Hansen, P., Iwata, K. K., Pieler, C. and Foulkes, G. (1988b) Identification of another member of the transforming growth factor type β gene family. Proc. Natl. Acad. Sci. USA 85: 4715-4719.
210. ten Dijke, P., Yamashita, H., Ichijo, H., Franzén, P., Laiho, M., Miyazono, K. and Heldin, C.-H. (1994) Characterization of type I receptors for transforming growth factor-β and activin. Science 264: 101-104.
211. Thalacker, F. W. and Nilsen-Hamilton, M. (1992) Opposite and independent actions of cyclic AMP and transforming growth factor β in the regulation of type 1 plasminogen activator inhibitor expression. Biochem. J. 287: 855-862.
212. Thomsen, G. H. (1996) Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor. Development 122: 2359-2366.
213. Tucker, R. F., Shipley, G. D. and Moses, H. L. (1984) Growth inhibitor from BSC-1 cells closely related to platelet type β transforming growth factor. Science 226: 705-707.
214. van Dam, H., Wilhelm, D., Herr, I., Steffen, A., Herrlich, P. and Angel, P. (1995) ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14: 1798-1811.
215. 1. Mol. Endocrinol. 1: 693-698.
216. Ventura, F., Doody, J., Liu, F., Wrana, J. L. and Massagué, J. (1994) Reconstitution and transphosphorylation of TGF-β receptor complexes. EMBO J. 13: 5581-5589.
217. Ventura, F., Liu, F., Doody, J. and Massagué, J. (1996) Interaction of transforming growth factor-β receptor I with farnesyl-protein transferase-α in yeast and mammalian cells. J. Biol. Chem. 271: 13931-13934.
218. Vivien, D., Attisano, L., Wrana, J. L. and Massagué, J. (1995) Signaling activity of homologous and heterologous transforming growth factor-β receptor kinase complex. J. Biol. Chem. 270: 7134-7141.
219. Wakefield, L. M., Smith, D. M., Masui, T., Harris, C. C. and Sporn, M. B. (1987) Distribution and modulation of the cellular receptor for transforming growth factor-beta. J. Cell Biol. 105: 965-975.
220. Wang, C-Y., Eshleman, J. R., Willson, J. K. V. and Markowitz, S. (1995) Both transforming growth factor-β and substrate release are inducers of apoptosis in a human colon adenoma cell line. Cancer Res. 55: 5101-5105.
221. Wang, J., Sun, L., Myeroff, L., Wang, X., Gentry, L. E., Yang, J., Liang, J., Zborowska, E., Markowitz, S., Willson, J. K. and Brattain, M. G. (1995) Demonstration that mutation of the type II transforming growth factor-β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J. Biol. Chem. 270: 22044-22049.
222. Wang, J., Han, W., Zborowska, E., Liang, J., Wang, X., Willson, J. K. V., Sun, L. and Brattain, M. G. (1996) Reduced expression of transforming growth factor β type I receptor contributes to the malignancy of human colon carcinoma cells. J. Biol. Chem. 271: 17366-17371.
223. Wang, T., Donahoe, P. K. and Zervos, A. S. (1994) Specific interaction of type I receptors of the TGF-β family with the immunophilin FKBP-12. Science 265: 674-676.
224. Ras farnesyltransferase a subunit in TGF-β and activin signaling. Science 271: 1120-1122.
225. Wang, T., Li, B.-Y., Danielson, P. D., Shah, P. C., Rockwell, S., Lechleider, R. J., Martin, J., Manganaro, T. and Donahoe, P. K. (1996b) The immunophilin FKBP-12 functions as a common inhibitor of the TGFβ family type I receptors. Cell 86: 435-444.
226. Wang, X.-F., Lin, H., Ng-Eaton, E., Downward, J., Lodish, H. and Weinberg, R. (1991) Expression cloning and characterization of the TGF-β type III receptor. Cell 67: 797-805.
227. Weis-Garcia, F. and Massagué, J. (1996) Complementation between kinase-defective and activation-defective TGF-β receptors reveals a novel form of receptor cooperativity essential for signaling. EMBO J. 15: 276-289.
228. Whitmarsh, A. J., Shore, P., Sharrocks, A. D. and Davis, R. J. (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science 269: 403-407.
229. Wieser, R., Attisano, L., Wrana, J. L. and Massagué, J. (1993) Signaling activity of transforming growth factor β type II receptors lacking specific domains in the cytoplasmic region. Mol. Cell. Biol. 13: 7239-7247.
230. Wieser, R., Wrana, J. L. and Massagué, J. (1995) GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-β receptor complex. EMBO J. 14: 2199-2208.
231. Wozney, J. M. (1988) Bone morphogenetic proteins. Prog. Growth Factor Res. 1: 267-280.
232. Wozney, J. M., Rosen, V., Celeste, A. J., Mistsock, L. M., Whitters, M. J., Kriz, R. W., Hewick, R. M. and Wang, E. A. (1989) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-1534.
233. Wrana, J. L., Attisano, L., Cárcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X.-F. and Massagué, J. (1992) TGFβ signals through a heteromeric protein kinase receptor complex. Cell 71: 1003-1014.
234. Wrana, J. L., Attisano, L., Wieser, R., Ventura, F. and Massagué, J. (1994) Mechanism of activation of the TGFβ-receptor. Nature 370: 341-346.
235. Wrann, M., Bodmer, S., de Martin, R., Siepl, C., Hofer-Warbinek, R., Frei, K., Hofer, E. and Fontana, A. (1987) T cell suppressor factor from human glioblastoma cells is a 12.5 Kd protein closely related to transforming growth factor-β. EMBO J. 6: 1633-1636.
236. 1 is an autocrine-negative growth regulator of human colon carcinoma FET cell in vivo as revealed by transfection of an antisense expression vector. J. Cell Biol. 116: 187-196.
237. 2 in quiescent CBS colon carcinoma cells leads to progression of tumorgenic properties. Cell Growth Differ. 4:115-123.
238. Yamaguchi, K., Shirakabe, K., Shibuya, H., Irie, K., Oishi, I., Ueno, N., Taniguchi, T., Nishida, E. and Matsumoto, K. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGFβ signal transduction. Science 270: 2008-2011.
239. Yamamoto, H., Ueno, H., Ooshima, A. and Takeshita, A. (1996) Adenovirus-mediated transfer of a truncated transforming growth factor-β (TGFβ) type II receptor completely and specifically abolishes diverse signaling by TGF-β in vascular wall cells in primary culture. J. Biol. Chem. 271: 16253-16259.
240. Yamashita, H., ten Dijke, P., Franzén, P., Miyazono, K. and Heldin, C.-H. (1994) Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-β. J. Biol. Chem. 269: 20172-20178.
241. 1 in epithelial cells. J. Biol. Chem. 269: 13231-13237.
242. 1 induces apoptotic cell death in cultured human gastric carcinoma cells. Cancer Res. 52: 4042-4045.
243. Yingling, J. M., Das, P., Savage, C., Zhang, M., Padgett, R. W. and Wang, X.-F. (1996) Mammalian dwarfins are phosphorylated in response to transforming growth factor β and are implicated in control of cell growth. Proc. Natl. Acad. Sci. USA 93: 8940-8944.
244. Cip1 by expression of RasN17 in intestinal epithelial cells. J. Cell. Biochem., in press.
245. Zentella, A., Weis, F. M. B., Ralph, D. A., Laiho, M. and Massagué, J. (1991) Early gene responses to transforming growth factor-β in cells lacking growth-suppressive RB function. Mol. Cell. Biol. 11: 4952-4958.
246. Zhang, Y., Feng, X.-H., Wu, R.-Y. and Derynck, R. (1996) Receptor-associated Mad homologues synergize as effectors of the TGFβ response. Nature 383: 168-172.
247. Zhou, G.-H. K., Sechrist, G. L., Brattain, M. G. and Mulder, K. M. (1995a) Clonal heterogeneity of the sensitivity of human colon carcinoma cell lines to TGFβ isoforms. J. Cell. Physiol 165: 512-520.
248. Zhou, G.-H. K., Sechrist, G. L., Periyasamy, S., Brattain, M. G. and Mulder, K. M. (1995b) Transforming growth factor β isoform-specific differences in interactions with type I and II transforming growth factor β receptors. Cancer Res. 55: 2056-2062.
249. Zhou, X., Sasaki, H., Lowe, L., Hogan, B. L. M. and Kuehn, M. R. (1993) Nodal is a novel TGFβ-like gene expressed in the mouse node during gastrulation. Nature 361: 543-547.
250. 1, EGF, and DMF in human colon carcinoma cells. Cell Growth Differ. 4: 637-645.