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Volumn 7, Issue 4, 2000, Pages 211-216

The effects of free fatty acids on glucose transport and phosphorylation in human skeletal muscle

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE 6 PHOSPHATE;

EID: 0033910341     PISSN: 10683097     EISSN: None     Source Type: Journal    
DOI: 10.1097/00060793-200008000-00006     Document Type: Review
Times cited : (15)

References (75)
  • 1
    • 0019987653 scopus 로고
    • Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic type 2 (non-insulin-dependent) diabetes mellitus
    • 1 Waldhäusl W, Bratusch-Marrain P, Gasic S, et al.: Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1982, 23:6-15.
    • (1982) Diabetologia , vol.23 , pp. 6-15
    • Waldhäusl, W.1    Bratusch-Marrain, P.2    Gasic, S.3
  • 2
    • 0029933670 scopus 로고    scopus 로고
    • Abnormalities of insulin pulsatility and glucose oscillations during meals in obese non-insulin-dependent diabetic patients: Effects of weight reduction
    • 2 Gumbiner B, VanCauter E, Beltz WF, et al.: Abnormalities of insulin pulsatility and glucose oscillations during meals in obese non-insulin-dependent diabetic patients: effects of weight reduction. J Clin Endocrinol Metab 1996, 81:2061-2068.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2061-2068
    • Gumbiner, B.1    VanCauter, E.2    Beltz, W.F.3
  • 3
    • 0032742992 scopus 로고    scopus 로고
    • The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus
    • 3 Weyer Ch, Bogardus C, Mott DM, Pratley RE: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 1999, 104:787-794. This longitudinal study demonstrates early parallelism of metabolic change, indicating simultaneous damage of both insulin secretion and action in a prediabetic state.
    • (1999) J Clin Invest , vol.104 , pp. 787-794
    • Weyer, Ch.1    Bogardus, C.2    Mott, D.M.3    Pratley, R.E.4
  • 4
    • 0025077462 scopus 로고
    • Quantitative and qualitative differences in basal and glucose-and arginine-stimulated insulin secretion in healthy subjects and different stages of NIDDM
    • 4 Ratheiser K, Reitgruber W, Komjati M, et al.: Quantitative and qualitative differences in basal and glucose-and arginine-stimulated insulin secretion in healthy subjects and different stages of NIDDM. Acta Diabetol Latina 1990, 27:197-213.
    • (1990) Acta Diabetol Latina , vol.27 , pp. 197-213
    • Ratheiser, K.1    Reitgruber, W.2    Komjati, M.3
  • 5
    • 0028175908 scopus 로고
    • Insulin production following i.v. glucose, arginine and valine: Different pattern in patients with impaired glucose tolerance and in NIDDM
    • 5 Fasching P, Ratheiser K, Nowotny P, et al.: Insulin production following i.v. glucose, arginine and valine: different pattern in patients with impaired glucose tolerance and in NIDDM. Metabolism 1994, 43:385-389.
    • (1994) Metabolism , vol.43 , pp. 385-389
    • Fasching, P.1    Ratheiser, K.2    Nowotny, P.3
  • 6
    • 0030955017 scopus 로고    scopus 로고
    • Disorderly and non-stationary insulin secretion in relatives of patients with NIDDM
    • 6 Schmitz O, Porksen N, Nyholm B, et al.: Disorderly and non-stationary insulin secretion in relatives of patients with NIDDM. Am J Physiol 1997, 272:E218-E226.
    • (1997) Am J Physiol , vol.272
    • Schmitz, O.1    Porksen, N.2    Nyholm, B.3
  • 7
    • 0032999920 scopus 로고    scopus 로고
    • Glucose entrainment of high-frequency plasma insulin oscillations in control and type 2 diabetic subjects
    • 7 Mao CS, Herman N, Roberts K, Ipp E: Glucose entrainment of high-frequency plasma insulin oscillations in control and type 2 diabetic subjects. Diabetes 1997, 48:714-721.
    • (1997) Diabetes , vol.48 , pp. 714-721
    • Mao, C.S.1    Herman, N.2    Roberts, K.3    Ipp, E.4
  • 8
    • 0028849148 scopus 로고
    • Opposite effects of short-and long-term fatty acid infusion on insulin secretion in healthy subjects
    • 8 Paolisso G, Gambardella A, Amato L, et al.: Opposite effects of short-and long-term fatty acid infusion on insulin secretion in healthy subjects. Diabetologia 1995, 38:1295-1299.
    • (1995) Diabetologia , vol.38 , pp. 1295-1299
    • Paolisso, G.1    Gambardella, A.2    Amato, L.3
  • 9
    • 0032999260 scopus 로고    scopus 로고
    • Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation
    • 9 Carpentier A, Mittelman SD, Lamarche B, et al.: Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. Am J Physiol 1999, 276:E1055-E1066. This important study demonstrates that in healthy men, a doubling in plasma FFA concentration suffices to disable the beta cell to sufficiently counteract FFA-induced insulin resistance.
    • (1999) Am J Physiol , vol.276
    • Carpentier, A.1    Mittelman, S.D.2    Lamarche, B.3
  • 10
    • 0027499271 scopus 로고
    • Acute and chronic near-normoglycaemia are required to improve insulin resistance in insulin-dependent (type 1) diabetes
    • 10 Fasching P, Ratheiser K, Damjancic D, et al.: Acute and chronic near-normoglycaemia are required to improve insulin resistance in insulin-dependent (type 1) diabetes. Diabetologia 1993, 36:346-351.
    • (1993) Diabetologia , vol.36 , pp. 346-351
    • Fasching, P.1    Ratheiser, K.2    Damjancic, D.3
  • 11
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • 11 DeFronzo RA: Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 1997, 5:177-269.
    • (1997) Diabetes Rev , vol.5 , pp. 177-269
    • DeFronzo, R.A.1
  • 12
    • 0001795590 scopus 로고
    • Epidemiology and natural history of NIDDM: Non-obese and obese
    • Edited by Alberti KGMM, Zimmet P, DeFronzo RA, Keen H. Chichester, UK: John Wiley & Sons, Ltd.
    • 12 Bennett PH, Bogardus C, Tuomilehto J, Zimmet P: Epidemiology and natural history of NIDDM: non-obese and obese. In: International Textbook of Diabetes Mellitus, ed. 2. Edited by Alberti KGMM, Zimmet P, DeFronzo RA, Keen H. Chichester, UK: John Wiley & Sons, Ltd., 1987:147-176.
    • (1987) International Textbook of Diabetes Mellitus, Ed. 2 , pp. 147-176
    • Bennett, P.H.1    Bogardus, C.2    Tuomilehto, J.3    Zimmet, P.4
  • 13
    • 0028091753 scopus 로고
    • Metabolic and genetic characterisation of prediabetic states
    • 13 Beck-Nielsen H, Groop LC: Metabolic and genetic characterisation of prediabetic states. J Clin Invest 1994, 93:1714-1721.
    • (1994) J Clin Invest , vol.93 , pp. 1714-1721
    • Beck-Nielsen, H.1    Groop, L.C.2
  • 14
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinaemia precede the development of type II diabetes in the offspring of diabetic parents
    • 14 Warram JH, Martin BC, Krolewski AS, et al.: Slow glucose removal rate and hyperinsulinaemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 1990, 113:909-915.
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3
  • 15
    • 0024160877 scopus 로고
    • Role of insulin resistance in human disease
    • 15 Reaven GM: Role of insulin resistance in human disease. Diabetes 1988, 37:1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 16
    • 0025945012 scopus 로고
    • Insulin resistance: Mechanisms, syndromes and implications
    • 16 Moller DE, Fliers JS: Insulin resistance: mechanisms, syndromes and implications. N Engl J Med 1992, 325:938-948.
    • (1992) N Engl J Med , vol.325 , pp. 938-948
    • Moller, D.E.1    Fliers, J.S.2
  • 17
    • 0345711540 scopus 로고    scopus 로고
    • Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency
    • 17 Mingrone G, Henriksen FL, Greco AV, et al.: Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency. Diabetes 1999, 48:1258-1263. This manuscript describes the potential metabolic toxicity of extremely high plasma triglyceride concentration to induce a severely insulin resistant state, which only could be overcome by surgically induced lipid malabsorption.
    • (1999) Diabetes , vol.48 , pp. 1258-1263
    • Mingrone, G.1    Henriksen, F.L.2    Greco, A.V.3
  • 18
    • 0028809238 scopus 로고
    • Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin dependent diabetes mellitus
    • 18 Rothman DL, Magnusson I, Cline GW, et al.: Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin dependent diabetes mellitus. Proc Natl Acad Sci USA 1995, 92:983-987.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 983-987
    • Rothman, D.L.1    Magnusson, I.2    Cline, G.W.3
  • 19
    • 0033595120 scopus 로고    scopus 로고
    • Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
    • 19 Cline GW, Petersen KF, Krssak M, et al.: Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N Engl J Med 1999, 341:240-246. This study identifies defective glucose transport as a major cause of insulin resistance and impaired glycogen synthesis in type 2 diabetes. From this it appears that the very early steps of glucose metabolism might be impaired in the diabetic state.
    • (1999) N Engl J Med , vol.341 , pp. 240-246
    • Cline, G.W.1    Petersen, K.F.2    Krssak, M.3
  • 20
    • 0031594368 scopus 로고    scopus 로고
    • 13C/31P NMR studies on the mechanism of insulin resistance in obesity
    • 20 Petersen KF, Hendler R, Price T, et al.: 13C/31P NMR studies on the mechanism of insulin resistance in obesity. Diabetes 1998, 47:381-386.
    • (1998) Diabetes , vol.47 , pp. 381-386
    • Petersen, K.F.1    Hendler, R.2    Price, T.3
  • 21
    • 0026624835 scopus 로고
    • Facilitative glucose transported regulatory mechanisms and dysregulation in diabetes
    • 21 Kahn BB: Facilitative glucose transported regulatory mechanisms and dysregulation in diabetes. J Clin Invest 1992, 89:1367-1374.
    • (1992) J Clin Invest , vol.89 , pp. 1367-1374
    • Kahn, B.B.1
  • 22
    • 0025125772 scopus 로고
    • Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity and body-fat distribution
    • 22 Haffner SM, Stern MP, Mitchell BD, et al.: Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity and body-fat distribution. Diabetes 1990, 39:283-288.
    • (1990) Diabetes , vol.39 , pp. 283-288
    • Haffner, S.M.1    Stern, M.P.2    Mitchell, B.D.3
  • 23
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
    • 23 Lillioja S, Mott DM, Spraul M, et al.: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 1993, 27:1988-1992.
    • (1993) N Engl J Med , vol.27 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3
  • 24
    • 0032953097 scopus 로고    scopus 로고
    • Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance: A population-based twin study
    • 24 Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H: Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance: a population-based twin study. Diabetologia 1999, 42:139-145. This population-based twin study (n = 606) strongly suggests that nongenetic factors might play the predominant role in the development of type 2 diabetes in predisposed individuals (estimated heritability for type 2 diabetes: 26%).
    • (1999) Diabetologia , vol.42 , pp. 139-145
    • Poulsen, P.1    Kyvik, K.O.2    Vaag, A.3    Beck-Nielsen, H.4
  • 25
    • 0025847593 scopus 로고
    • Molecular defects in diabetes mellitus
    • 25 Bell GI: Molecular defects in diabetes mellitus. Diabetes 1991, 40:413-422.
    • (1991) Diabetes , vol.40 , pp. 413-422
    • Bell, G.I.1
  • 27
    • 0025800354 scopus 로고
    • Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects
    • 27 Arner P, Pollare T, Lithell H: Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia 1991, 34:483-487.
    • (1991) Diabetologia , vol.34 , pp. 483-487
    • Arner, P.1    Pollare, T.2    Lithell, H.3
  • 28
    • 0028919252 scopus 로고
    • Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive?
    • 28 Banerji M, Chaiken R, Gordon D, et al.: Does intra-abdominal adipose tissue in black men determine whether NIDDM is insulin-resistant or insulin-sensitive? Diabetes 1995, 44:141-146.
    • (1995) Diabetes , vol.44 , pp. 141-146
    • Banerji, M.1    Chaiken, R.2    Gordon, D.3
  • 29
    • 0022450553 scopus 로고
    • Beta cell dysfunction rather than insulin insensitivlty is the primary defect in familial type II diabetes
    • 29 O'Rahilly S, Rudenski A, Burnett M, et al.: Beta cell dysfunction rather than insulin insensitivlty is the primary defect in familial type II diabetes. Lancet 1986, 2:360-364.
    • (1986) Lancet , vol.2 , pp. 360-364
    • O'Rahilly, S.1    Rudenski, A.2    Burnett, M.3
  • 30
    • 17344388503 scopus 로고    scopus 로고
    • Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: The insulin resistance atherosclerosis study
    • 30 Haffner SM, Howard G, Mayer E, et al.: Insulin sensitivity and acute insulin response in African-Americans, non-Hispanic whites, and Hispanics with NIDDM: the insulin resistance atherosclerosis study. Diabetes 1997, 46:63-69.
    • (1997) Diabetes , vol.46 , pp. 63-69
    • Haffner, S.M.1    Howard, G.2    Mayer, E.3
  • 31
    • 0023546342 scopus 로고
    • Effect of stress hormones on splanchnic substrate and insulin disposal following glucose ingestion in healthy man
    • 31 Waldhäusl W, Gasic S, Bratusch-Marrain P, et al.: Effect of stress hormones on splanchnic substrate and insulin disposal following glucose ingestion in healthy man. Diabetes 1987, 36:127-135.
    • (1987) Diabetes , vol.36 , pp. 127-135
    • Waldhäusl, W.1    Gasic, S.2    Bratusch-Marrain, P.3
  • 33
    • 0032925340 scopus 로고    scopus 로고
    • Mechanisms of TNF-α induces insulin resistance
    • 33 Hotamisligil GS: Mechanisms of TNF-α induces insulin resistance. Endocrinol Diabetes 1999, 107:119-125.
    • (1999) Endocrinol Diabetes , vol.107 , pp. 119-125
    • Hotamisligil, G.S.1
  • 34
    • 0030771331 scopus 로고    scopus 로고
    • Effects of non-esterified fatty acids on glucose metabolism after glucose ingestion
    • 34 Kruszynksa YT, Mulford MI, Yu JG, et al.: Effects of non-esterified fatty acids on glucose metabolism after glucose ingestion. Diabetes 1997, 46:1586-1593.
    • (1997) Diabetes , vol.46 , pp. 1586-1593
    • Kruszynksa, Y.T.1    Mulford, M.I.2    Yu, J.G.3
  • 35
    • 50549202600 scopus 로고
    • The glucose fatty acids cycle: Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus
    • 35 Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty acids cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963, 1:785-789.
    • (1963) Lancet , vol.1 , pp. 785-789
    • Randle, P.J.1    Garland, P.B.2    Hales, C.N.3    Newsholme, E.A.4
  • 36
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid induced insulin resistance in humans
    • 36 Roden M, Price TB, Perseghin G, et al.: Mechanism of free fatty acid induced insulin resistance in humans. J Clin Invest 1996, 97:2859-2865.
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3
  • 37
    • 0002697987 scopus 로고    scopus 로고
    • Cross-talk mechanisms in the development on insulin resistance of skeletal muscle cells
    • 37 Storz P, Döppler H, Wernig A, et al.: Cross-talk mechanisms in the development on insulin resistance of skeletal muscle cells. Eur J Biochem 1999, 266:17-25.
    • (1999) Eur J Biochem , vol.266 , pp. 17-25
    • Storz, P.1    Döppler, H.2    Wernig, A.3
  • 38
    • 0002031490 scopus 로고    scopus 로고
    • Insulin resistance, lipid and fatty acid concentrations in 867 healthy Europeans. European group for the study of insulin resistance (EGIR)
    • 38 Baldeweg SE, Golay A, Natali A, et al.: Insulin resistance, lipid and fatty acid concentrations in 867 healthy Europeans. European group for the study of insulin resistance (EGIR). Eur J Clin Invest 2000, 30:45-52.
    • (2000) Eur J Clin Invest , vol.30 , pp. 45-52
    • Baldeweg, S.E.1    Golay, A.2    Natali, A.3
  • 39
    • 0030941820 scopus 로고    scopus 로고
    • Metabolic defects in lean non-diabetic offspring of NIDDM parents: A cross-sectional study
    • 39 Perseghin G, Ghosh S, Gerow K, Shulman GI: Metabolic defects in lean non-diabetic offspring of NIDDM parents: a cross-sectional study. Diabetes 1997, 46:1001-1009.
    • (1997) Diabetes , vol.46 , pp. 1001-1009
    • Perseghin, G.1    Ghosh, S.2    Gerow, K.3    Shulman, G.I.4
  • 40
    • 0026539663 scopus 로고
    • The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents
    • 40 Gully G, Ferrannini E, Stern S, et al.: The metabolic profile of NIDDM is fully established in glucose-tolerant offspring of two Mexican-American NIDDM parents. Diabetes 1992, 41:1575-1586.
    • (1992) Diabetes , vol.41 , pp. 1575-1586
    • Gully, G.1    Ferrannini, E.2    Stern, S.3
  • 41
    • 0030664299 scopus 로고    scopus 로고
    • Insulin resistance of muscle glucose transport in rats fed a high-fat diet: A reevaluation
    • 41 Han DH, Hansen PA, Host HH, Holloszy JO: Insulin resistance of muscle glucose transport in rats fed a high-fat diet: a reevaluation. Diabetes 1997, 46:1761-1767.
    • (1997) Diabetes , vol.46 , pp. 1761-1767
    • Han, D.H.1    Hansen, P.A.2    Host, H.H.3    Holloszy, J.O.4
  • 42
    • 0022977709 scopus 로고
    • Fat feeding causes widespread in vivo insulin resistance, decrease energy expenditure and obesity in rats
    • Endocr Metab 14
    • 42 Storlien LH, James DE, Burleigh KM, et al.: Fat feeding causes widespread in vivo insulin resistance, decrease energy expenditure and obesity in rats. Am J Physiol 1986, 251 (Endocr Metab 14):E576-E583.
    • (1986) Am J Physiol , vol.251
    • Storlien, L.H.1    James, D.E.2    Burleigh, K.M.3
  • 43
    • 0034012439 scopus 로고    scopus 로고
    • Control of glycogen synthesis is shared between glucose transport and glycogen synthase in skeletal muscle fibers
    • 43 Azpiazu I, Manchester J, Skurat AV, et al.: Control of glycogen synthesis is shared between glucose transport and glycogen synthase in skeletal muscle fibers. Am J Physiol Endocrinol Metab 2000, 278:E234-E243. This interesting study in lean and obese volunteers reminds us of the interdependence of insulin sensitivity and FFA availability by analysis of the leg balance of glucose and FFA uptake. A story long known, but neglected as to its clinical importance by the medical community.
    • (2000) Am J Physiol Endocrinol Metab , vol.278
    • Azpiazu, I.1    Manchester, J.2    Skurat, A.V.3
  • 44
    • 0025949939 scopus 로고
    • Level of skeletal muscle glucose transporter protein correlates with insulin stimulated whole body glucose disposal in man
    • 44 Koranyi LI, Bourey RE, Vuorinen-Markkola H, et al.: Level of skeletal muscle glucose transporter protein correlates with insulin stimulated whole body glucose disposal in man. Diabetologia 1991, 34:763-765.
    • (1991) Diabetologia , vol.34 , pp. 763-765
    • Koranyi, L.I.1    Bourey, R.E.2    Vuorinen-Markkola, H.3
  • 45
    • 0024325405 scopus 로고
    • The cell biology of the insulin receptor
    • 45 Carpentier JL: The cell biology of the insulin receptor. Diabetologia 1989, 32:627-635.
    • (1989) Diabetologia , vol.32 , pp. 627-635
    • Carpentier, J.L.1
  • 46
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • 46 Cheatham B, Kahn CR: Insulin action and the insulin signaling network. Endcr Rev 1995, 16:117-142.
    • (1995) Endcr Rev , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 47
    • 0023798487 scopus 로고
    • Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effects of weight loss
    • 47 Freidenberg GR, Reichart D, Olefsky JM, Henry RR: Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effects of weight loss. J Clin Invest 1988, 82:1398-1406.
    • (1988) J Clin Invest , vol.82 , pp. 1398-1406
    • Freidenberg, G.R.1    Reichart, D.2    Olefsky, J.M.3    Henry, R.R.4
  • 48
    • 0023683874 scopus 로고
    • An in vitro human muscle preparation suitable for metabolic studies: Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
    • 48 Dohm GL, Tapscott EB, Pories WJ, et al.: An in vitro human muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J Clin Invest 1988, 82:486-494.
    • (1988) J Clin Invest , vol.82 , pp. 486-494
    • Dohm, G.L.1    Tapscott, E.B.2    Pories, W.J.3
  • 49
    • 0025302915 scopus 로고
    • Evidence against altered expression of GLUT-1 and GLUT-4 in skeletal muscle of patients with obesity or NIDDM
    • 49 Pedersen O, Bak JF, Andersen PH, et al.: Evidence against altered expression of GLUT-1 and GLUT-4 in skeletal muscle of patients with obesity or NIDDM. Diabetes 1990, 39:865-870.
    • (1990) Diabetes , vol.39 , pp. 865-870
    • Pedersen, O.1    Bak, J.F.2    Andersen, P.H.3
  • 50
    • 0019415752 scopus 로고
    • Receptor and postreceptor defects contribute to the insulin resistance in non-insulin-dependent diabetes mellitus
    • 50 Kolterman OG, Gray RS, Griffin J, et al.: Receptor and postreceptor defects contribute to the insulin resistance in non-insulin-dependent diabetes mellitus. J Clin Invest 1981, 68:957-969.
    • (1981) J Clin Invest , vol.68 , pp. 957-969
    • Kolterman, O.G.1    Gray, R.S.2    Griffin, J.3
  • 51
    • 0033050848 scopus 로고    scopus 로고
    • Applications of NMR spectroscopy to study muscle glycogen metabolism in man
    • 51 Roden M, Shulman GI: Applications of NMR spectroscopy to study muscle glycogen metabolism in man. Annu Rev Med 1999, 50:277-290.
    • (1999) Annu Rev Med , vol.50 , pp. 277-290
    • Roden, M.1    Shulman, G.I.2
  • 52
    • 0026611962 scopus 로고
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate: Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus
    • 52 Rothman DL, Shulman RG, Shulman GI: 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate: evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest 1992, 89:1069-1075.
    • (1992) J Clin Invest , vol.89 , pp. 1069-1075
    • Rothman, D.L.1    Shulman, R.G.2    Shulman, G.I.3
  • 53
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • 53 Boden G, Chen X, Ruiz J, et al.: Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 1994, 93:2438-2446.
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3
  • 54
    • 0033007561 scopus 로고    scopus 로고
    • Rapid impairment of skeletal muscle glucose transport/ phosphorylation by free fatty acids in man
    • 54 Roden M, Krssak M, Stingl H, et al.: Rapid impairment of skeletal muscle glucose transport/ phosphorylation by free fatty acids in man. Diabetes 1999, 48:358-364. This study shows even small physiologic increases in plasma FFA concentration to markedly inhibit glucose transport and phosphorylation in human skeletal muscle.
    • (1999) Diabetes , vol.48 , pp. 358-364
    • Roden, M.1    Krssak, M.2    Stingl, H.3
  • 55
    • 0030045492 scopus 로고    scopus 로고
    • Effects of an acute decrease in non-esterified fatty acids levels on muscle glucose utilisation and forearm indirect calorimetry in lean NIDDM patients
    • 55 Piatti PM, Monti LD, Davis SD, et al.: Effects of an acute decrease in non-esterified fatty acids levels on muscle glucose utilisation and forearm indirect calorimetry in lean NIDDM patients. Diabetologia 1996, 39:103-112.
    • (1996) Diabetologia , vol.39 , pp. 103-112
    • Piatti, P.M.1    Monti, L.D.2    Davis, S.D.3
  • 56
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss
    • 56 Kelley DE, Goodpaster B, Wing RR, Simoneau JA: Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss. Am J Physiol 1999, 277:E1130-E1141.
    • (1999) Am J Physiol , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 57
    • 0030926433 scopus 로고    scopus 로고
    • Role of the glucosamine pathway in fat-induced insulin resistance
    • 57 Hawkins M, Barzilai N, Lui R, et al.: Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest 1997, 99:2173-2182.
    • (1997) J Clin Invest , vol.99 , pp. 2173-2182
    • Hawkins, M.1    Barzilai, N.2    Lui, R.3
  • 58
    • 0034072554 scopus 로고    scopus 로고
    • Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in man
    • 58 Roden M, Stingl H, Chandramouli V, et al.: Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in man. Diabetes 2000, 49:701-707.
    • (2000) Diabetes , vol.49 , pp. 701-707
    • Roden, M.1    Stingl, H.2    Chandramouli, V.3
  • 59
    • 0029067962 scopus 로고
    • The mitochondrial carnitine palmitoyltransferase system: Its broadening role in fuel homoestasis and new insights into its molecular feature
    • 59 McGarry JD: The mitochondrial carnitine palmitoyltransferase system: its broadening role in fuel homoestasis and new insights into its molecular feature. Biochem Soc Trans 1995, 23:321-324.
    • (1995) Biochem Soc Trans , vol.23 , pp. 321-324
    • McGarry, J.D.1
  • 61
    • 0030969532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride levels are inversely related to insulin action
    • 61 Pan DA, Lillioja S, Kriketos AD, et al.: Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 1997, 46:983-988.
    • (1997) Diabetes , vol.46 , pp. 983-988
    • Pan, D.A.1    Lillioja, S.2    Kriketos, A.D.3
  • 62
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in man: A 1H NMR spectroscopy study
    • 62 Krssak M, Falk Petersen K, Dresner A, et al.: Intramyocellular lipid concentrations are correlated with insulin sensitivity in man: a 1H NMR spectroscopy study. Diabetologia 1999, 42:113-116. The is the first study to show noninvasively a direct linear correlation between intramyocellular triglyceride concentration and insulin sensitivity independently of FFA concentation.
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3
  • 63
    • 0027395358 scopus 로고
    • The relationship between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids
    • 63 Bjorkman M, Storlien LH, Pan DA, et al.: The relationship between insulin sensitivity and the fatty acid composition of skeletal muscle phospholipids. N Engl J Med 1993, 328:238-244.
    • (1993) N Engl J Med , vol.328 , pp. 238-244
    • Bjorkman, M.1    Storlien, L.H.2    Pan, D.A.3
  • 64
    • 0032896651 scopus 로고    scopus 로고
    • Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet
    • 64 Kim JY, Nolte LA, Hansen PA, et al.: Insulin resistance of muscle glucose transport in male and female rats fed a high-sucrose diet. Am J Physiol 1999, 276:R665-R672.
    • (1999) Am J Physiol , vol.276
    • Kim, J.Y.1    Nolte, L.A.2    Hansen, P.A.3
  • 65
    • 0001090974 scopus 로고    scopus 로고
    • A mechanism for fatty acid inhibition of glucose utilisation in liver: Role of xylulose-5-P
    • 65 Liu Y, Uyeda K: A mechanism for fatty acid inhibition of glucose utilisation in liver: role of xylulose-5-P. J Biol Chem 1996, 271:8824-8830.
    • (1996) J Biol Chem , vol.271 , pp. 8824-8830
    • Liu, Y.1    Uyeda, K.2
  • 66
    • 0029962286 scopus 로고    scopus 로고
    • Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats
    • 66 Kim JK, Wi JK, Youn JH: Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes 1996, 45:446-453.
    • (1996) Diabetes , vol.45 , pp. 446-453
    • Kim, J.K.1    Wi, J.K.2    Youn, J.H.3
  • 67
    • 0026002683 scopus 로고
    • Effects of fat on insulin-stimulated carbohydrate metabolism in normal men
    • 67 Boden G, Jadali F, White J, et al.: Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 1991, 88:960-966.
    • (1991) J Clin Invest , vol.88 , pp. 960-966
    • Boden, G.1    Jadali, F.2    White, J.3
  • 68
    • 0027475061 scopus 로고
    • Contribution of muscle and liver to glucose-fatty acid cycle in humans
    • 68 Saloranta C, Koivisto V, Widen E, et al.: Contribution of muscle and liver to glucose-fatty acid cycle in humans. Am J Physiol 1993, 264:E599-E605.
    • (1993) Am J Physiol , vol.264
    • Saloranta, C.1    Koivisto, V.2    Widen, E.3
  • 69
    • 0023908033 scopus 로고
    • Effect of elevated free fatty acids on glucose oxidation in normal humans
    • 69 Wolfe BM, Klein S, Peters EJ, et al.: Effect of elevated free fatty acids on glucose oxidation in normal humans. Metabolism 1988, 37:323-329.
    • (1988) Metabolism , vol.37 , pp. 323-329
    • Wolfe, B.M.1    Klein, S.2    Peters, E.J.3
  • 70
    • 0345086474 scopus 로고    scopus 로고
    • Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signalling cascade
    • 70 Griffin ME, Marcucci MJ, Cline GW, et al.: Free fatty acid-induced insulin resistance is associated with activation of protein kinase Cθ and alterations in the insulin signalling cascade. Diabetes 1999, 48:1270-1274.
    • (1999) Diabetes , vol.48 , pp. 1270-1274
    • Griffin, M.E.1    Marcucci, M.J.2    Cline, G.W.3
  • 71
    • 0031057526 scopus 로고    scopus 로고
    • Insulin receptor substrates I phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
    • 71 Bjornholm M, Kawano Y, Lehtihet M, Zierath JR: Insulin receptor substrates I phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 1997, 46:524-527.
    • (1997) Diabetes , vol.46 , pp. 524-527
    • Bjornholm, M.1    Kawano, Y.2    Lehtihet, M.3    Zierath, J.R.4
  • 72
    • 0032954778 scopus 로고    scopus 로고
    • Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
    • 72 Dresner A, Laurent D, Marucci M, et al.: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin invest 1999, 103:253-259. Evidence is provided that decreased glucose transport is responsible for FFA-induced insulin resistance. In addition, reduction in IRS-1-associated PI3-kinase activity during lipid infusion indicates that FFAs interfere with the insulin-signalling cascade.
    • (1999) J Clin Invest , vol.103 , pp. 253-259
    • Dresner, A.1    Laurent, D.2    Marucci, M.3
  • 73
    • 0032898667 scopus 로고    scopus 로고
    • Fatty acids, lipotoxicity and insulin secretion
    • 73 McGarry JD, Dobbins RL: Fatty acids, lipotoxicity and insulin secretion. Diabetologia 1999, 42:128-138. This review points at the "Jekyll and Hyde" character of fatty acids. In particular, it becomes apparent that at any given time insulin secretion will be governed not only by the prevailing concentration of plasma glucose but also by that of FFAs and their qualitative nature.
    • (1999) Diabetologia , vol.42 , pp. 128-138
    • McGarry, J.D.1    Dobbins, R.L.2
  • 74
    • 0031753344 scopus 로고    scopus 로고
    • Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes
    • 74 Paolisso G, Tagliamonte MR, Rizzo MR, et al.: Lowering fatty acids potentiates acute insulin response in first degree relatives of people with type II diabetes. Diabetologia 1998, 41:1127-1132.
    • (1998) Diabetologia , vol.41 , pp. 1127-1132
    • Paolisso, G.1    Tagliamonte, M.R.2    Rizzo, M.R.3
  • 75
    • 0030731946 scopus 로고    scopus 로고
    • Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT-2, glukokinase, insulin, and somatostatin levels
    • 75 Gremlich S, Bonny C, Waeber G, Thorens B: Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT-2, glukokinase, insulin, and somatostatin levels. J Biol Chem 1997, 48:30261-30269.
    • (1997) J Biol Chem , vol.48 , pp. 30261-30269
    • Gremlich, S.1    Bonny, C.2    Waeber, G.3    Thorens, B.4


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