Signaling of immune system cells by glycosylphosphatidylinositol (GPI) anchor and related structures derived from parasitic protozoa

Current Opinion in Microbiology

Volumn 3, Issue 4, 2000, Pages 395-403

  Ropert, Catherine ^a   Gazzinelli, Ricardo T ^b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLPHOSPHATIDYLINOSITOL; LIPOPHOSPHOGLYCAN; NITRIC OXIDE;

B LYMPHOCYTE; CELL MEMBRANE; CYTOKINE PRODUCTION; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IMMUNOSTIMULATION; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; PROTOZOAL INFECTION; REVIEW; SIGNAL TRANSDUCTION; VIRULENCE;

EID: 0033902040     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1369-5274(00)00111-9     Document Type: Review

References (73)

1. Immune regulation in parasitic infection and disease
2. Effects of IL-12 on immune response to microbial infections: A key mediator in regulating disease outcome
3. Role of macrophage derived cytokines in the induction and regulation of cell mediated immunity to Toxoplasma gondii
4. Role of natural killer cells in innate resistance to protozoan infection
5. Interleukin 12: A proinflammatory cytokine with regulatory function that bridge innate resistance and adaptive immunity
6. The instructive role of innate immunity in the acquired immune response
7. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
8. Macrophage activation: Lipoarabinomannan from avirulent and virulent strains of Mycobacterium tuberculosis differentially induces the early genes c-fos, KC, JE and tumor necrosis factor-α
9. Interleukin-12 is required for the T-lymphocyte-independent induction of interferon-γ by an intracellular parasite and induces resistance in T-cell deficient hosts
10. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon-γ
11. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
12. Endogenous IFN-gamma is required for resistance to acute Trypanosoma cruzi infection in mice
13. The microbicidal activity of interferon-γ treated macrophages against Trypanosoma cruzi involves an L-arginine dependent, nitrogen oxide-mediated mechanism inhibitable by interleukin-10 and transforming growth factor-β
14. Nitric oxide is involved in the control of Trypanosoma cruzi induced parasitemia and directly kills parasite in vitro
15. IL-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes
16. Interferon-gamma: The major mediator of resistance against Toxoplasma gondii
17. Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii
18. Administration of monoclonal anti-IFN-γ anfibodies in vivo abrogates resistance of C3H/HeN mice to infection with Leishmania major
19. Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine
20. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi
21. The prognostic and pathophysiologic role of pro- and anti-inflammatory cytokines in severe malaria
22. GPI-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi initiate the synthesis of pro-inflammatory cytokines by macrophages
23. Glycoconjugates isolated from Trypanosoma cruzi but not from Leishmania sp. parasite membranes trigger nitric oxide synthesis as well as microbicidal activity by IFN-γ-primed macrophages
24. Highly-purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents
25. Signal transduction in host cells by glycosylphosphatidylinositol toxin of malaria parasites
26. Glycosylphosphatidylinositol toxin of Trypanosoma Brucei regulates IL-1 alpha and TNF-α expression in macrophages by protein tyrosine kinase mediated signal transduction
27. Galactofuranose-containing glycoconjugates of epimastigote and trypomastigote forms of Trypanosoma cruzi
28. Molecular structure of the 'low molecular weight antigen' of Toxoplasma gondii: A glucose α 1-4 N-acetylgalactosamine makers free glycosylphosphatiylinositols highly immunogenic
29. CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells
30. Glycosyl-phosphatidylinositol moiety thatanchors Trypanosoma brucei variant surface glycoprotein to the membrane
31. The structure, biosynthesis and function of glycosyl-phosphatidylinositols in the parasitic protozoa and higher-eukaryotes
32. Mucin like glycoproteins linked to the membrane by GPI-anchor are the major acceptor of sialic acid in a reaction catalyzed by trans-sialidase in metacyclic forms of Trypanosoma cruzi
33. Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi
34. Evidence for glycosylphsophatidylinositol anchoring of Toxoplasma gondii major surface antigens
35. Developmental changes in the glycosylated phosphafidylinositols of Leishmania donovani
36. Structural analysis of GPI membrane anchor of the merozoite surface proteins 1 and 2 of Plasrnodium falciparum
37. The structure, biosynthesis and functions of glycosyl-phosphafidylinositol anchor, and the contributions of Trypanosome research
38. Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway
39. Signal transduction in macrophages by glycocylphosphatidylinositols of Plasmodium, Trypanosoma and Leishmania: Activation of protein tyrosine kinases and protein kinase C by inositolglycan and diacylglycerol moieties
40. The glycosyl-inositol-phosphate and dimyristoylglycerol moieties of the glycosylphosphatidylinositol anchor of the trypanosoma variant-specific surface glycoprotein are distinct macrophage-activating factors
41. GPI-microdomains: A role in signaling via immunoreceptors
42. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
43. The Toll-receptor family and control of innate immunity
44. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
45. Preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a Toll-like receptor 2 and MyD88-dependent signaling pathway
46. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
47. The search for physiological substrates of MAP and SAP kinases in mammalian cells
48. Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-γ and TNF-α in mouse macrophages
49. Regulation of monocyte synthesis by endogenous IL-1 and TNF-α role of the p38 and p42/44 mitogen-activated kinases
50. Differential inhibitory mechanism of cyclic AMP on TNF α and IL-12 synthesis by macrophages exposed to microbial stimuli
51. How do protozoan parasites survive inside macrophages?
52. Leishmania promastigotes selectively inhibit interleukin-12 induction in bone-marrow-derived macrophages from susceptible and resistant mice
53. Cfos and tumor necrosis gene expression in Leishmania donovani - Infected macrophages
54. Inhibitory effects on protein kinase C activity by lipophosphoglycan fragments and glycosylphosphatidylinositol antigens of protozoan parasite Leishmania
55. Effect of glycolipids of Leishmania parasites on human monocyte activity. Inhibition by lipophosphoglycan
56. Leishmania donovani lipophosphoglycan selectively inhibits signal transduction in macrophages
57. Inhibition of macrophage protein kinase C mediated protein phosphorylation by Leishmania donovani lipophosphoglycan
58. Lipophosphoglycan from Leishmania suppresses agonist-induced interleukin 1 β gene expression in human monocytes via a unique promoter sequence
59. Glycoinositolphospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages
60. Regulation of macrophage IL-12 synthesis by Leishmania phosphoglycans
61. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
62. Proapoptotic activity of a Trypanosoma cruzi ceramide-containing glycolipid turned on in macrophages by IFN-γ
63. Modulation of B-lymphocyte and NK cell activities by glycoinositolphospholipid purified from Trypanosoma cruzi
64. Down-regulation of T lymphocyte activation in vitro and in vivo induced by glycoinositolphospholipids from Trypanosoma cruzi. Assignment of the T cell-suppressive determinant to the ceramide domain
65. Costimulatory action of glycoinositolphosphollpids from Trypanosoma cruzi: Increased interleukin 2 secretion and induction of nuclear translocation of the nuclear factor of activated T cells 1
66. Glycoinositolphospholipids purified from Trypanosoma cruzi stimulate Ig production in vitro
67. Fractionation of membrane components from tachyzoite forms of Toxoplasma gondii: Differential recognition by Immunoglobulin (Ig) - M or lgG present in sera from patients with acute or chronic toxoplasmosis
68. Trypanosoma cruzi defined antigens in the serological evaluation of an outbreak of acute Chagas disease in Brazil (Catole do Rocha, Paraiba)
69. Molecular interaction of CD1 b with lipoglycan antigens
70. Natural ligand of mouse CD1 d1: Cellular glycosylphosphatidylinositol
71. Mouse CDl-specific NK1 T cells: Development, specificity, and function
72. Expression of serum amyloid A3 mRNA by inflammatory macrophages exposed to membrane glycoconjugates from Trypanosoma cruzi
73. Kinetics of cytokine gene expression in experimental chagasic cardiomyopathy: A direct correlation between levels of tissue parasitism and chemokine mRNAs expression during infection with Trypanosoma cruzi