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of outstanding interest. Interesting study documenting a role for IL-12 in resistance to T. cruzi. The authors shown that the induction of IL-12 by this parasite is stage-specific, that trypomastigotes but not epimastigotes are active and, in contrast to Toxoplasma gondii or Listeria monocytogenes, that live organisms are required to elicit the monokine response.
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52
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Human natural killer cells produce abundant macrophage inflammatory protein-1 alpha in response to monocyte-derived cytokines
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of outstanding interest. Provocative study suggesting that NK cells may contribute to the activation and recruitment of inflammatory cells via the production of chemokines.
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Bluman EM, Bartynski KJ, Avalos BR, Caligiur MA. Human natural killer cells produce abundant macrophage inflammatory protein-1 alpha in response to monocyte-derived cytokines. of outstanding interest J Clin Invest. 97:1996;2722-2727 Provocative study suggesting that NK cells may contribute to the activation and recruitment of inflammatory cells via the production of chemokines.
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Bluman, E.M.1
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53
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of special interest. Comprehensive review of the practical uses of IL-12 in immunotherapy against infectious disease. The author highlights protozoan infections in which IL-12 treatment has proven beneficial in immunocompromised mice.
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Gazzinelli RT. Molecular and cellular basis of interleukin 12 activity in prophylaxis and therapy against infectious diseases. of special interest Mol Med Today. 2:1996;258-267 Comprehensive review of the practical uses of IL-12 in immunotherapy against infectious disease. The author highlights protozoan infections in which IL-12 treatment has proven beneficial in immunocompromised mice.
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Gazzinelli, R.T.1
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54
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0027140444
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Natural and acquired resistance to Leishmania: Cellular activation by Leishmania aethiopica of mononuclear cells from unexposed individuals is through the stimulation of natural killer (NK) cells
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Akuffo H, Maasho K, Howe R. Natural and acquired resistance to Leishmania: cellular activation by Leishmania aethiopica of mononuclear cells from unexposed individuals is through the stimulation of natural killer (NK) cells. Clin Exp Immunol. 94:1993;516-521.
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Akuffo, H.1
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55
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of special interest. Evidence that NK cell lytic activity is enhanced in the peripheral blood of patients with cutaneous and mucosal leishmaniasis and that both IL-10 and transforming growth factor (TGF)-β can inhibit this response.
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Barral-Netto M, Barral A, Brodskyn C, Carvalho EM, Reed SG. Cytotoxicity in human mucosal and cutaneous leishmaniasis. of special interest Parasite Immunol. 17:1995;21-28 Evidence that NK cell lytic activity is enhanced in the peripheral blood of patients with cutaneous and mucosal leishmaniasis and that both IL-10 and transforming growth factor (TGF)-β can inhibit this response.
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Sharma, S.D.1
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57
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IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis
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of special interest. Direct evidence supporting a central role for IL-12 in directing both innate and adaptive immune responses against Leishmania major is provided. Both resistant and susceptible mice are shown to produce IL-12 within the first few days of infection. Inhibition of IL-12 function in the latter animals is attributed to the regulatory activities of IL-4, IL-10 and TGF-β.
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Scharton-Kersten T, Afonso LCC, Wysocka M, Trinchieri G, Scott P. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. of special interest J Immunol. 154:1995;5320-5330 Direct evidence supporting a central role for IL-12 in directing both innate and adaptive immune responses against Leishmania major is provided. Both resistant and susceptible mice are shown to produce IL-12 within the first few days of infection. Inhibition of IL-12 function in the latter animals is attributed to the regulatory activities of IL-4, IL-10 and TGF-β.
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58
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of special interest. Demonstration that the induction of IL-12 by T. gondii is IFN-γ independent in vivo. The parasite induced NK cell cytolytic response is characterized as requiring IL-12 but only partially dependent upon IFN-γ.
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Scharton-Kersten TM, Wynn TA, Denkers EY, Bala S, Grunvald E, Hieny S, Gazzinelli RT, Sher A. In the absence of endogenous IFN-γ mice develop unimpaired IL-12 responses to Toxoplasma gondii while failing to control acute infection. of special interest J Immunol. 157:1996;4045-4054 Demonstration that the induction of IL-12 by T. gondii is IFN-γ independent in vivo. The parasite induced NK cell cytolytic response is characterized as requiring IL-12 but only partially dependent upon IFN-γ.
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Scharton-Kersten, T.M.1
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59
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A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12
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of outstanding interest. First description of a defined parasite moiety with IL-12-inducing properties. Intriguingly, the protein is homologous to the eukaryotic ribosomal protein, elF4A.
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Skeiky YAW, Guderian JA, Benson DR, Bacelar O, Carvalho EM, Kubin M, Badaro R, Trinchieri G, Reed SG. A recombinant Leishmania antigen that stimulates human peripheral blood mononuclear cells to express a Th1-type cytokine profile and to produce interleukin 12. of outstanding interest J Exp Med. 181:1995;1527-1537 First description of a defined parasite moiety with IL-12-inducing properties. Intriguingly, the protein is homologous to the eukaryotic ribosomal protein, elF4A.
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Skeiky, Y.A.W.1
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63
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Biochemical characterization and protein kinase C dependency of monokine inducing activities in Toxoplasma gondii
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of special interest. Description of biochemical properties of a soluble IL-12-inducing activity in T. gondii.
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Grunvald E, Chiramonte M, Hieny S, Wysocka M, Trinchieri G, Vogel SN, Gazzinelli RT, Sher A. Biochemical characterization and protein kinase C dependency of monokine inducing activities in Toxoplasma gondii. of special interest Infect Immun. 64:1996;2010 Description of biochemical properties of a soluble IL-12-inducing activity in T. gondii.
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Grunvald, E.1
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64
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Hunter CA, Chizzonite R, Remington JS. IL-1β is required for IL-12 to induce production of IFN-γ by NK cells. J Immunol. 155:1995;4347-4354.
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65
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+ T cells, actively contribute to the induced resistance.
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+ T cells, actively contribute to the induced resistance.
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66
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CR3-dependent resistance to acute Toxoplasma gondii infection in mice
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of outstanding interest. A novel paper describing the role of the type 3 complement receptor in the induction of NK cell responses by T. gondii in vivo.
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Johnson LL, Gibson GW, Sayles PC. CR3-dependent resistance to acute Toxoplasma gondii infection in mice. of outstanding interest Infect Immun. 64:1996;1998-2003 A novel paper describing the role of the type 3 complement receptor in the induction of NK cell responses by T. gondii in vivo.
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Effects of IL-12 on immune responses to microbial infections: A key mediator in regulating disease outcome
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of outstanding interest. A detailed review on the beneficial and detrimental effects of IL-12 on immunity to a number of infectious agents with an emphasis on the regulation of NK cell activation and effector functions.
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Biron CA, Gazzinelli RT. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. of outstanding interest Curr Opin Immunol. 7:1995;485-496 A detailed review on the beneficial and detrimental effects of IL-12 on immunity to a number of infectious agents with an emphasis on the regulation of NK cell activation and effector functions.
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Biron, C.A.1
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68
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Cloning of a new cytokine that induces IFN-gamma production by T cells
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Okamura H, Tsutsui H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 378:1995;88-92.
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Okamura, H.1
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69
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Mapping the epitope recognized by non-specific cytotoxic cells: Determination of the fine specificity using synthetic peptides
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0028987734
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Transforming growth factor-beta inhibits interleukin-12-induced production of interferon-gamma by natural killer cells: A role for transforming growth factor-beta in the regulation of T cell-independent resistance to Toxoplasma gondii
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of special interest. An important paper demonstrating that TGF-β antagonizes the protective effects of IL-12 in immunodeficient mice infected with T. gondii. In vitro analyses indicate that TGF-β directly inhibits NK cell function.
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Hunter CA, Bermudez L, Beernink H, Waegell W, Remington JS. Transforming growth factor-beta inhibits interleukin-12-induced production of interferon-gamma by natural killer cells: a role for transforming growth factor-beta in the regulation of T cell-independent resistance to Toxoplasma gondii. of special interest Eur J Immunol. 25:1995;994-1000 An important paper demonstrating that TGF-β antagonizes the protective effects of IL-12 in immunodeficient mice infected with T. gondii. In vitro analyses indicate that TGF-β directly inhibits NK cell function.
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72
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+ T cells and accompanied by overproduction of IL-12, IFN-gamma, and TNF-alpha
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of outstanding interest. The unexpected lethality of T. gondii in IL-10 knockout mice is attributed to an exaggerated type I cytokine response rather than unchecked parasite replication. The study argues that IL-10 is required for the down-modulation of T. gondii-induced cell-mediated immunity and illustrates the potent regulatory effects of this cytokine in vivo.
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+ T cells and accompanied by overproduction of IL-12, IFN-gamma, and TNF-alpha. of outstanding interest J Immunol. 157:1996;798-805 The unexpected lethality of T. gondii in IL-10 knockout mice is attributed to an exaggerated type I cytokine response rather than unchecked parasite replication. The study argues that IL-10 is required for the down-modulation of T. gondii-induced cell-mediated immunity and illustrates the potent regulatory effects of this cytokine in vivo.
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