Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway

Journal of Immunology

Volumn 156, Issue 5, 1996, Pages 1897-1907

  Tachado, Souvenir D ^a   Gerold, Peter ^b   McConville, Malcolm J ^c   Baldwin, Tracey ^a   Quilici, Denis ^a   Schwarz, Ralph T ^b   Schofield, Louis ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALPHOSTIN C; GENISTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; INTERLEUKIN 1; MONOCLONAL ANTIBODY; N(G) METHYLARGININE; NEUTRALIZING ANTIBODY; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE; RECOMBINANT GAMMA INTERFERON; TOXIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; TYRPHOSTIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENDOTHELIUM CELL; ENZYME INDUCTION; LEISHMANIA MEXICANA; MACROPHAGE ACTIVATION; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIBODIES, MONOCLONAL; ARGININE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENDOTHELIUM, VASCULAR; ENZYME INDUCTION; GLYCOLIPIDS; GLYCOSYLPHOSPHATIDYLINOSITOLS; HUMANS; LEISHMANIA MEXICANA; MACROPHAGES; MICE; MICE, INBRED C3H; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; PLASMODIUM FALCIPARUM; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; PROTOZOAN PROTEINS; SIGNAL TRANSDUCTION;

EID: 0030042523     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Aikawa, M., J. W. Barnwell, D. Taylor, M. M. Oo, and R. J. Howard. 1990 The pathology of human cerebral malaria. Am. J. Trop. Med. Hyg. 43:30.
2. Berendt, A. R , G. D. H. Turner, and C. I. Newbold. 1994. Cerebral malaria the sequestration hypothesis. Parasitol. Today 10:412.
3. Ockenhouse, C F., T Tegoshi, Y. Maeno, C. Benjamin, M. Ho, K. E. Kan, Y. Thway, K. Win, M. Aikawa, and R R Lobb. 1992. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. J. Exp Med 176:1183.
4. Clark, I. A., and K. A. Rockett. 1994. The cytokine theory of human cerebral malaria. Parasitol. Today 10:410.
5. Furchgott, R. F , and J. V Zawadzki 1980. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetycholine. Nature 288 373.
6. Newton, C. R J. C., F. J. Kirkham, P. A. Wistanley, G Pasvol, N. Peshu, D A. Warrell, and K. Marsh. 1991. Intracranial pressure in African children with cerebral malaria Lancet 337:573.
7. Snyder, S. H. 1992. Nitric oxide: first in new class of neurotransmitters? Science 257:494.
8. Rockett, K. A., M. M. Awburn, E. J. Rockett, W. B. Cowden, and I A. Clark. 1994 Possible role of nitric oxide in malarial immunosuppression. Parasite Immunol 16:234.
9. Schofield, L., and F. Hackett. 1993. Signal transduction in host cells by glycosylphosphatidylinositol toxin of malaria parasites J. Exp. Med. 177:145.
10. Tachado, S. D , and L Schofield 1994. Glycosyl-phosphatidylinositol toxin of Trypanosoma brucei regulates IL-1 and TNF-α expression in macrophages by protein tyrosine kinase-mediated signal transduction. Biochem. Biophys Res Commun. 205:984.
11. Schofield, L., L. Vivas, P. Gerold, R. T. Schwarz, and S D. Tachado. 1993 Neutralizing monoclonal antibodies to glycosyl-phosphatidylinositol, the dominant TNF-inducing toxin of Plasmodium falciparum. Ann Trop. Med. Parasitol. 87:617.
12. Schofield, L., S. Novakovic, P Gerold, R. T. Schwarz, M. J. McConville and S. D. Tachado. 1996. Glycosyl-phosphatidylinositol toxin of Plasmodium upregulates ICAM-1, VCAM-1, and E-selectin expression in vascular endothelial cells and increases leukocyte and parasite cytoadherence via tyrosine kinase-dependent signal transduction. J. Immunol In press.
13. Ziegler-Heitbrock, H. W., T. Sternsdorf, B. Belohradsky, C. Weber, R. Schreck, P. Bauerle, and M. Strobel. 1993. Pyrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes. J. Immunol 151:6986.
14. Degitz, K., L. Lian-Jie, and S. Caughman. 1991. Cloning and characterization of the 5′ transcriptional regulatory region of the human intercellular adhesion molecule-1 gene. J. Biol. Chem. 266:14024.
15. Whelan, J., P Ghersa, R. van Huijsduijnen, J Gray, G. Chandra, F. Talabot, and J. De Lamarter. 1991. An NF-κB-like factor is essential but not sufficient for cytokine induction of endothelial leukocyte adhesion molecule-1 (ELAM-1) gene transcription. Nucleic Acids Res 19:2645.
16. Neish, A., A. Williams, H. Palmer, M. Whitley, and T. Collins. 1992. Functional analysis of the human vascular cell adhesion 1 promoter. J. Exp. Med. 176:1583.
17. Grili, M., J. J-S. Chiu, and M Lenardo. 1993. NF-κB and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol 143:1.
18. Shu, H., A. Agranoff, E. Nabel, K. Leung, C. Duckett, A. Neish, T. Collins, and G. Nabel. 1993. Differential regulation of vascular cell adhesion molecule-1 gene expression by specific NF-κB subunits in endothelial cells. Mol. Cell Biol. 13: 6283.
19. Xie, Q., and C. Nathan. 1994. The high-output nitric oxide pathway role and regulation. J. Leukocyte Biol. 56:576.
20. Trager, W., and J. Jensen. 1976 Human malaria parasites in continues culture. Science 93:673.
21. Lambros, C., and J. Vanderberg. 1979. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol 65:418
22. Bradford, M 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem 72:248.
23. McConville, M. J., and A. Bacic. 1989. A family of glycoinositol phospholipids from Leishmania major: isolation, characterization, and antigenicity. J. Biol. Chem 264:757.
24. Chaplin, M F 1982. A rapid and sensitive method for the analysis of carbohydrate components in glycoproteins using gas-liquid chromatography. Anal. Biochem. 123:336.
25. Baykov, A., O. Evtushenko, and S. Avaeva. 1988. A malachite green procedure for orthophosphate determination and us use in alkaline phosphatase-based enzyme immunoassay. Anal. Biochem. 171:266.
26. Gerold, P., A. Dieckmann-Schuppert, and R. T Schwarz 1994. Glycosylphosphatidylinositols synthesized by asexual stages of the malarial parasite. Plasmodium falciparum. J. Biol. Chem. 269:2597.
27. Bormann, B. J., C. K. Huang, G. F. Lam, and E. A. Jaffe 1986. Thrombin-induced vimentin in phosphorylation in cultured human umbilical vein endothelial cells. J. Biol. Chem. 161:10471.
28. 15N]nitrate in biologic fluids. Anal Biochem. 126:131.
29. Stuehr, D. J., and C. F. Nathan. 1989. Nitric oxide: a macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells. J. Exp. Med. 169:1543
30. Misko, T. P., R. J. Schilling, D. Salvemini, W. M. Moore, and M G. Currie. 1993. A fluorometric assay for the measurement of nitrite in biologic samples Anal. Biochem 241.11
31. Ding, A., C. F. Nathan, and D. J. Stuehr. 1988. Release of reactive nitrogen intermediates and reactive oxygen intermediate from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407.
32. McConville, M. J., and M. A Ferguson. 1993. The structure, biosynthesis, and function of glycosylated phosphatidylinositols in the parasitic protozoa and higher eukaryotes Biochem. J 294:305.
33. Gerold, P., L. Schofield, M. J Blackman, A. A. Holder, and R. T. Schwarz. 1996. Structural analysis of the glycosyl-phosphatidylinositol membrane anchor of the merozoite surface proteins-1 and -2 of Plasmodium falciparum Mol. Biochem. Parasitol. In press.
34. Huchet, R., M Bruley-Rosset, C. Mathiot, D. Grandjon, and O. Halle-Pannenko. 1993. Involvement of interferon-γ and transforming growth factor-β in graft-vs-host reaction-associated immunosuppression J. Immunol. 150:2517.
35. Grau, G. E., H Heremans, P. F. Piguet, P. Pointaire, P. H. Lambert, A. Billiau, and P. Vassali 1989. Monoclonal antibody against interferon-γ can prevent experimental cerebral malaria and its associated overproduction of tumor necrosis factor. Proc. Natl. Acad Sci. USA 86.5572
36. Wang, W. W , C. P. Jenkinson, J. M. Griscavage, R. M. Kern, N. S. Arabolos, R. E Byrns, S. D. Cederbaum, and L. J. Ignarro. 1995 Co-induction of arginase and nitric oxide synthase in murine macrophages activated by lipopolysaccharide. Biochem. Biophys. Res. Commun 210.1009.
37. Paul, A., R. H. Pendrigh, and R. Plevin. 1995. Protein kinase C and tyrosine kinase pathways regulate lipopolysaccharide-induced nitric oxide synthase activity in RAW 246.7 murine macrophages. Br. J Pharmacol. 114 363.
38. Sen, R., and D. Baltimore. 1986. Inducibility of κ immunoglobulin enhancer-binding protein by a post-translational mechanism. Cell 47:921.
39. Severn, A., M. J. Wakelam, and F. Y. Liew. 1992. The role of protein kinase C in the induction of nitric oxide synthesis by murine macrophages. Biochem. Biophys. Res. Commun. 188:997.
40. Baeuerle, P A. 1991. The inducible transcription factor NF-κB: regulation by distinct protein subunits. Biochim Biophys. Acta 1072:63.
41. Sherman, M. P., E E. Aeberhard, V. Z. Wong, J. M. Griscavage, and L J. Ignarro 1993. Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys Res. Commun. 191:1301
42. Belohradsky, B., C. Weber, A. Wedel, R. Schreck, P. Baeuerle, and M. Strobel. 1993. Pyrrolidine dithiocarbamate inhibits NF-κB mobilization and TNF production in human monocytes. J. Immunol. 151:6986.
43. Schreck, R., B. Meier, D. N. Mannel, W. Droge, and P. Baeuerle. 1992. Dithiocarbamates as potent inhibitors of nuclear factor-κB activation in intact cells. J. Exp. Med. 175.1181.
44. Esslinger, C. W , S. Picot, and P Ambroise-Thomas. 1994. Intra-erythrocytic Plasmodium falciparum induces up-regulation of intercellular adhesion molecule-1 on human endothelial cells in vitro. Scan. J. Immunol. 39.229.
45. Clark, I. A., K. A. Rockett, and W. B. Cowden 1991. Proposed link between cytokines, nitric oxide, and human cerebral malaria. Parasitol. Today 7:205.
46. Brown, D. 1993. The tyrosine kinase connection, how GPI-anchored proteins activate T cells. Curr. Opin. Immunol. 5:349.
47. Stefanova, I., V. Horejse, W. K. Ansotegui, and H. Stockinger. 1991. GPI-anchored cell-surface molecules complexed to protein tyrosine kinases. Science 254:1016
48. Jun, C. D., B. M. Choi, H. M. Kim, and H. T. Chung. 1995. Involvement of protein kinase C during taxol-induced activation of murine peritoneal macrophages. J. Immunol. 154:6541.
49. Berridge, M. J 1984 Inositol trisphosphate and diacyglycerol second messengers. Biochem. J. 220:345
50. Proudfoot, L., C. A. O'Donnell, and F. Y. Liew. 1995. Glycoinositophospholipids of Leishmania major inhibit nitric oxide synthesis and reduce leishmanicidal activity in murine macrophages. Eur. J. Immunol. 25:745.
51. McNeely, T., G. Rosen, M Londner, and S. J. Turco. 1989. Inhibitory effects on protein kinase C activity by lipophosphoglycan fragments and glycosylphosphatidylinositol antigens of the protozoan parasite Leishmania. Biochem. J. 259:601.
52. Descoteaux, A., S. J. Turco, D. L. Sacks, and G. Matlashewski. 1991. Leishmania donovani lipophosphoglycan selectively inhibits signal transduction in macrophages. J. Immunol 146:2747.
53. Reiner, S L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major Annu. Rev. Immunol. 13:151.
54. Turco, S. J., and A Descoteaux. 1992. The lipophosphoglycan of Leishmania parasites. Annu Rev. Microbiol. 46:65.
55. Schofield, L., P. Gerold, R. T. Schwarz, and S. D Tachado. 1994. Signal transduction in host cells mediated by glycosyl-phosphatidylinositol of the parasitic protozoa, or why do the parasitic protozoa have so many GPI molecules. Brazilian J. Med. Biol. Res. 27:249
56. Bierhaus, A , Ch. J. Hemmer, N. Mackman, R. Kutob, R Ziegler, M Dietrich, and P. Nawroth. 1995. Antiparasitic treatment of patients with Plasmodium falciparum malaria reduces the ability of patient serum to induce tissue factor by decreasing NF-κB activation. Thromb. Haemost. 73 39.
57. Orthner, C., G M. Rodgers, and L. A. Fitzgerald. 1995 Pyrrolidine dithiocarbamate abrogates tissue factor expression by endothelial cells: evidence implicating nuclear factor-κB in TF induction by diverse agonists Blood 86:436.