Hepatitis C virus and its pathogenesis

Seminars in Cancer Biology

Volumn 10, Issue 3, 2000, Pages 233-240

  Shimotohno, Kunitada ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Hepatitis C virus inflammation; Hepatocellular carcinoma; MAP kinase; NFkB

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

APOPTOSIS; CELL PROLIFERATION; CELL TRANSFORMATION; CHRONIC HEPATITIS; CYTOTOXIC T LYMPHOCYTE; HEPATITIS C VIRUS; HUMAN; INFLAMMATION; LIVER CELL CARCINOMA; MITOGENESIS; NONHUMAN; PROTEIN EXPRESSION; REVIEW; VIRUS PATHOGENESIS;

EID: 0033866706     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.2000.0322     Document Type: Article

References (72)

1. Association between high serum alanine aminotransferase levels and more rapid development and higher rate of incidence of hepatocellular carcinoma in patients with hepatitis C virus-associated cirrhosis
2. Hepatitis C virus core protein interacts with 14-3-3 Protein and activates the kinase Raf-1
3. Hepatitis C virus core protein binds to apolipoprotein AII and its secretion is modulated by fibrates
4. Activation of p53 tumor suppressor by hepatitis C virus core protein
5. Hepatitis C virus core protein represses p21WAF1/Cip1/Sid1 promoter activity
6. Hepatitis C virus core protein does not inhibit apoptosis in human hepatoma cells
7. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis
8. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein
9. Suppression of apoptotic cell death by hepatitis C virus core protein
10. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein
11. Steatosis and intrahepatic hepatitis C virus in chronic hepatitis
12. Hepatitis C virus core protein binds to a DEAD box RNA helicase
13. Hepatitis C virus core protein interacts with a human DEAD box protein DDX3
14. Hepatitis C virus core protein interacts with cellular putative RNA helicase
15. Hepatitis C virus core protein regulates cell growth and signal transduction pathway transmitting growth stimuli
16. The core protein of hepatitis C virus induces hepato-cellular carcinoma in transgenic mice
17. Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K
18. Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene
19. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype
20. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor
21. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice
22. Transcriptional repression of p53 promoter by hepatitis C virus core protein
23. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor
24. Hepatitis C virus core protein inhibits human immunodeficiency virus type 1 replication
25. Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation
26. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells
27. Trans-suppression of gene expression by hepatitis C viral core protein
28. Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein
29. Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor
30. Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells
31. Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection
32. Response to retreatment with interferon-alpha plus ribavirin in chronic hepatitis C patients is independent of the NS5A gene nucleotide sequence
33. Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus
34. Long-term response to interferon alpha is unrelated to 'interferon sensitivty determining region' variability in patients with chronic hepatitis C virus-1b infection
35. Mutations in NS5A region of hepatitis C virus genome correlate with presencce of NS5A antibodies and response to interferon therapy for most common European hepatitis C virus genotypes
36. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
37. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
38. HCV NS5A 2209-2248 amino acid substitutions affect serum 2,5AS activities
39. Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase
40. Repression of the PKR protein kinase by the hepatitis C virus NS5A protein: A potential mechanism of interferon resistance
41. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein
42. Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains
43. Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator
44. The amino terminal deletion mutants of hepatitis C virus nonstructural protein NS5A function as transcriptional activators in yeast
45. Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein
46. Hepatitis C virus nonstructural protein NS4B transform NIH3T3 cells in cooperation with the Ha-ras oncogene
47. Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation
48. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
49. The Fas death factor
50. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE- like cysteine proteases
51. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
52. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
53. Suppression of TNF-alpha-induced apoptosis by NF-kappaB.
54. Nuclear factor-kappaB/Rel blocks transforming growth factor beta1-induced apoptosis of murine hepatocyte cell lines
55. An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
56. A role for nuclear factor kappaB in the antiapoptotic function of insulin
57. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappaB.
58. NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAPI and c-IAP2 to suppress caspase-8 activation
59. Differential subcellular localization of hepatitis C virus core gene products
60. Biosynthesis and biochemical properties of the hepatitis C virus core protein
61. Regulated processing of hepatitis C virus core protein is linked to subcellular localization
62. Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted
63. Cell variants showing differential susceptibility to ultraviolet light-induced transformation
64. Tumourigenicity of MTG8, a leukaemia-related gene, in concert with v-Ha-ras gene in BALB/3T3 cells
65. Characterization of cell lines allowing tightly regulated expression of hepatitis C virus core protein
66. Comparison between cytomegalovirus promoter and elongation factor-1 alpha promoter-driven constructs in the establishment of cell lines expressing hepatitis C virus core protein
67. Ets transcription factors: Nuclear effectors of the Ras-MAP-kinase signaling pathway
68. Fas system and apoptosis in viral hepatitis