Tumourigenicity of MTG8, a leukaemia-related gene, in concert with v- Ha-ras gene in BALB/3T3 cells

British Journal of Haematology

Volumn 101, Issue 4, 1998, Pages 737-742

  Sueoka, Eisaburo ^a   Sueoka, Naoko ^a   Okabe, Sachiko ^a   Komori, Atsumasa ^a   Suganuma, Masami ^a   Kozu, Tomoko ^a   Fujiki, Hirota ^a  

^a SAITAMA CANCER CENTER   (Japan)

Author keywords

Acute myeloid leukaemia; AML1 MTG8(ETO) fused gene; Carcinogenesis; Cell transformation; V Ha ras gene

Indexed keywords

COMPLEMENTARY DNA; GENE PRODUCT; MESSENGER RNA; RAS PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL STRAIN 3T3; CELL TRANSFORMATION; CONTROLLED STUDY; GENE FUSION; GENE OVEREXPRESSION; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE; ONCOGENE H RAS; PRIORITY JOURNAL; SUBCUTANEOUS TISSUE;

3T3 CELLS; ACUTE DISEASE; ANIMALS; BLOTTING, WESTERN; CELL TRANSFORMATION, NEOPLASTIC; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA-BINDING PROTEINS; GENES, RAS; HUMANS; LEUKEMIA, MYELOID; MICE; MICE, NUDE; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 0031858792     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1998.00757.x     Document Type: Article

References (26)

1. Bos, J.L. (1989) ras Oncogenes in human cancer: a review. Cancer Research, 49, 4682-4689.
2. Bos, J.L., Toksoz, D., Marshall, C.J., Verlaan-de Vries, M., Veeneman, G.H., van der Eb, A.J., van Boom, J.H., Janssen, J.W.G. & Steenvoorden, A.C.M. (1985) Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia. Nature, 315, 726-730.
3. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
4. Era, T., Asou, N., Kunisada, T., Yamasaki, H., Asou, H., Kamada, N., Nishikawa, S.I., Yamaguchi, K. & Takatsuki, K. (1995) Identification of two transcripts of AML1/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells. Genes, Chromosomes and Cancer, 13, 25-33.
5. Erickson, P., Gao, J., Chang, K.S., Look, T., Whisenant, E., Raimondi, S., Lasher, R., Trujillo, J., Rowley, J. & Drabkin, H. (1992) Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt. Blood, 80, 1825-1831.
6. Feinstein, P.G., Kornfeld, K., Hogness, D.S. & Mann, R.S. (1995) Identification of homeotic target genes in Drosophila melanogaster including nervy, a proto-oncogene homologue. Genetics, 140, 573-586.
7. Hawley, R.G., Fong, A.Z.C., Ngan, B.-Y. & Hawley, T.S. (1995) Hematopoietic transforming potential of activated ras in chimeric mice. Oncogene, 11, 1113-1123.
8. Hiebert, S.W., Sun, W., Davis, J.N., Golub, T., Shurtleff, S., Buijs, A., Downing, J.R., Grosveld, G., Roussel, M.F., Gilliland, D.G., Lenny, N. & Meyers, S. (1996) The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription. Molecular and Cellular Biology, 16, 1349-1355.
9. Kozu, T., Komori, A., Sueoka, E., Fujiki, H., Kaneko, Y., Matsui, T., Uehara, T., Seino, Y. & Ishii, M. (1997) Significance of MTG8 in leukemogenesis. Leukemia, 11, 297-298.
10. Kozu, T., Miyoshi, H., Shimizu, K., Maseki, N., Kaneko, Y., Asou, H., Kamada, N. & Ohki, M. (1993) Junctions of the AML1/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction. Blood, 82, 1270-1276.
11. Meyers, S., Lenny, N. & Hiebert, S.W. (1995) The t(8;21) fusion protein interferes with AML-1B-dependent transcriptional activation. Molecular and Cellular Biology, 15, 1974-1982.
12. Miller, A.D., Miller, D.G., Garcia, J.V. & Lynch, C.M. (1993) Use of retroviral vectors for gene transfer and expression. Methods in Enzymology, 217, 581-599.
13. Miyoshi, H., Kozu, T., Shimizu, K., Enomoto, K., Maseki, N., Kaneko, Y., Kamada, N. & Ohki, M. (1993) The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript. EMBO Journal, 12, 2715-2721.
14. Nishio, K., Sugimoto, Y., Nakagawa, K., Niimi, S., Fujiwara, Y., Bungo, M., Kasahara, K., Fujiki, H. & Saijo, N. (1990) Cross-resistance to tumour promoters in human cancer cell lines resistant to adriamycin or cisplatin. British Journal of Cancer, 62, 415-419.
15. β proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Molecular and Cellular Biology, 14, 5558-5568.
16. Okuda, T., van Deursen, J., Hiebert, S.W., Grosveld, G. & Downing, J.R. (1996) AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell, 84, 321-330.
17. Rowley, J.D. (1984) Biological implications of consistent chromosome rearrangements in leukemia and lymphoma. Cancer Research, 44, 3159-3168.
18. Sakai, A. & Sato, M. (1989) Improvement of carcinogen identification in BALB/3T3 cell transformation by application of a two-stage method. Method Research, 214, 285-296.
19. Sanchez, I., Hughes, R.T., Mayer, B.J., Yee, K., Woodgett, J.R., Avruch, J., Kyriakis, J.M. & Zon, L.I. (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-jun. Nature, 372, 794-798.
20. Sasaki, K., Mizusawa, H. & Ishidate, M. (1988) Isolation and characterization of ras-transfected BALB/3T3 clone showing morphological transformation by 12-O-tetradecanoyl-phorbol-13-acetate. Japanese Journal of Cancer Research, 79, 921-930.
21. Tanaka, T., Mitani, K., Kurokawa, M., Ogawa, S., Tanaka, K., Nishida, J., Yazaki, Y., Shibata, Y. & Hirai, H. (1995) Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias. Molecular and Cellular Biology, 15, 2383-2392.
22. Wang, J., Wang, M. & Liu, J.M. (1997) Transforming properties of the ETO gene, fusion partner in t(8;21) leukemias. Cancer Research, 57, 2951-2955.
23. Yan, M., Dai, T., Deak, J.C., Kyriakis, J.M., Zon, L.I., Woodgett, J.R. & Templeton, D.J. (1994) Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature, 372, 798-800.
24. Yergeau, D., Hetherington, C.L., Wang, Q., Zhang, P., Sharpe, A.H., Binder, M., Marin-Padilla, M., Tenen, D.G., Speck, N.A. & Zhang, D.-E. (1997) Embrionic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nature Genetics, 15, 303-306.
25. Zent, C.S., Mathieu, C., Claxton, D.F., Zhang, D.E., Tenen, D.G., Rowley, J.D. & Nucifora, G. (1996) The chimeric genes AML1/MDS1 and AML1/EAP inhibit AML1B activation at the CSF1R promoter, but only AML1/MDS1 has tumor-promoter properties. Proceedings of the National Academy of Sciences of the United States of America, 93, 1044-1048.
26. Zhang, D.E., Fujioka, K., Hetherington, C.J., Shapiro, L.H., Chen, H.M., Look, A.T. & Tenen, D.G., (1994) Identification of a region which directs the monocytic activity of the colony-stimulating factor 1 (macrophage colony-stimulating factor) receptor promoter and binds PEBP2/CBF (AML1). Molecular and Cellular Biology, 14, 8085-8095.