Activation of p53 tumor suppressor by hepatitis C virus core protein

Virology

Volumn 264, Issue 1, 1999, Pages 134-141

  Lu, Wen ^a   Lo, Shih yen ^a   Chen, Min ^a   Wu, Kai jin ^b   Fung, Yuen Kai T ^b   Ou, Jing hsiung ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORE PROTEIN; PROTEIN P53; STRUCTURAL PROTEIN; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; HEP 2 CELL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE; VIRUS CORE; VIRUS GENE; VIRUS PATHOGENESIS;

HEPATITIS C VIRUS; RNA VIRUSES;

EID: 0033544419     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1999.9979     Document Type: Article

References (34)

1. Bressac B., Galvin K. M., Liang T. J., Isselbacher K. J., Wands J. R., Ozturk M. Abnormal structure and expression of p53 gene in human hepatocellular carcinoma. Proc. Natl. Acad. Sci. USA. 87:1990;1973-1977.
2. Chang J., Yang S.-H., Cho Y.-G., Hwang S.-B., Hahn Y. S., Sung Y. C. Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene. J. Virol. 72:1998;3060-3065.
3. Crary G. S., Albercht J. H. Expression of cyclin-dependent kinase inhibitor p21 in human liver. Hepatology. 28:1998;738-743.
4. French S. W. Ethanol and hepatocellular injury. Hepat. Chronic Liver Dis. 16:1996;289-306.
5. Friedman S. L., Shaulian E., Littlewood T., Resnitzky D., Oren M. Resistance to p53-mediated growth arrest and apoptosis in Hep3B hepatoma cells. Oncogene. 15:1997;63-70.
6. Gu W., Roeder R. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell. 90:1997;595-606.
7. Guo W., Bell K. D., Ou J.-H. Characterization of the hepatitis B virus EnhI enhancer and X promoter complex. J. Virol. 65:1991;6686-6692.
8. Hachiya M., Chumakov A., Miller C. W., Akashi M., Said J., Koeffler H. P. Mutant p53 proteins behave in a dominant, negative fashion in vivo. Anticancer Res. 14:1994;1853-1860.
9. Jiang M. C., Yang-Yen H. F., Lin J. K., Yen J. J. Differential regulation of p53, c-Myc, Bcl-2 and Bax protein expression during apoptosis induced by widely divergent stimuli in human hepatoblastoma cells. Oncogene. 13:1996;609-616.
10. Kawamura T., Furusaka A., Koziel M. J., Chung R., Wang T. C., Schmidt E. V., Liang T. J. Transgenic expression of hepatitis C virus structural proteins in mouse. Hepatology. 25:1997;1014-1021.
11. Kim D. W., Harada T., Saito I., Miyamura T. An efficient expression vector for stable expression in human liver cells. Gene. 134:1993;307-308.
12. Ko L. J., Prives C. p53: Puzzle and paradigm. Genes Dev. 10:1996;1054-1072.
13. Liu Q., Tackney C., Bhat R. A., Prince A. M., Zhang P. Regulated processing of hepatitis C virus core protein is linked to subcellular localization. J. Virol. 71:1997;657-662.
14. Lo S.-Y., Masiarz F., Hwang S. B., Lai M. M. C., Ou J.-H. Differential subcellular localization of hepatitis C virus core gene products. Virology. 213:1995;455-461.
15. Lo S.-Y., Ou J. H. Expression and dimerization of hepatitis C virus core protein in E. coli. Methods Mol. Med. 19:1998;325-330.
16. Lo S.-Y., Selby M. J., Ou J.-H. Interaction between hepatitis C virus core protein and E1 envelope protein. J. Virol. 70:1996;5177-5182.
17. Moriya K., Fujie H., Shintani Y., Yotsuyanagi H., Tsutsumi T., Ishibashi K., Matsuura Y., Kimura S., Miyamura T., Koike K. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nature Med. 4:1998;1065-1067.
18. Muller M., Strand S., Hug H., Heinemann E.-M., Walczak H., Hofmann W. J., Stremmel W., Krammer P. H., Galle P. R. Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involved activation of wild-type p53. J. Clin. Invest. 99:1997;403-413.
19. Pasquinelli C., Shoenberger J. M., Chung J., Chang K.-M., Guidotti L. G., Selby M., Berger K., Lesniewski R., Houghton M., Chisari F. V. Hepatitis C virus core and E2 protein expression in transgenic mice. Hepatology. 25:1997;719-727.
20. Ponchel F., Puisieux A., Tabone E., Michot J. P., Froschl G., Morel A. P., Frebourg T., Bontaiere B., Oberhammer F., Ozturk M. Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis. Cancer Res. 54:1994;2064-2068.
21. Ray R. B., Lagging L. M., Meyer K., Ray R. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotypes. J. Virol. 70:1996a;4438-4443.
22. Ray R. B., Lagging L. M., Meyer K., Steele R., Ray R. Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein. Virus Res. 37:1995;209-220.
23. Ray R. B., Meyer K., Ray R. Suppression of apoptotic cell death by hepatitis C virus core protein. Virology. 226:1996b;176-182.
24. Ray R. B., Steele R., Meyer K., Ray R. Transcriptional repression of p53 promoter by hepatitis C virus core protein. J. Biol. Chem. 272:1997;10983-10986.
25. waf1/Cip1/Sid1 promoter activity. Gene. 208:1998;331-336.
26. Ruggieri A., Harada T., Matsuura Y., Miyamura T. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology. 229:1997;68-76.
27. Searle P. F., Stuart G. W., Palmiter R. D. Building a metal-responsive promoter with synthetic regulatory elements. Mol. Cell. Biol. 5:1985;1480-1488.
28. INK4a. Cell. 88:1997;593-602.
29. Shih C.-M., Chen C.-M., Chen S.-Y., Lee Y.-H. W. Modulation of the trans-suppression activity of hepatitis C virus core protein by phosphorylation. J. Virol. 69:1995;1160-1171.
30. Shrivastava A., Manna S. K., Ray R., Aggarwal B. B. Ectopic expression of hepatitis C virus core protein differentially regulates nuclear transcription factors. J. Virol. 72:1998;9722-9728.
31. Thompson E. B. The many roles of c-myc in apoptosis. Annu. Rev. Physiol. 60:1998;575-600.
32. Yasui K., Wakita T., Tsukiyama-Kohara K., Funahashi S.-I., Ichikawa M., Kajita T., Moradpour D., Wands J. R., Kohara M. The native form and maturation process of hepatitis C virus core protein. J. Virol. 72:1998;6048-6055.
33. Yeh C.-T., Ou J.-H. Phosphorylation of hepatitis B virus precore and core proteins. J. Virol. 65:1991;2327-2331.
34. Zhu N., Khoshnan A., Schneider R., Matsumoto M., Dennert G., Ware C., Lai M. M. C. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J. Virol. 72:1998;3691-3697.