Potential use of non-classical pathways for the transport of macromolecular drugs

Expert Opinion on Investigational Drugs

Volumn 9, Issue 9, 2000, Pages 2039-2050

  Kueltzo, L A ^a   Middaugh, C R ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Antennapedia; Gene delivery; Non classical transport; Protein delivery; Tat; VP22

Indexed keywords

CHAPERONE; DRUG VEHICLE; FIBROBLAST GROWTH FACTOR; PEPTIDE; POLYANION; PROTEIN; PROTEOGLYCAN; SIGNAL PEPTIDE; TOXIN; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR; VIRUS PROTEIN;

BIOPHYSICS; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; GENE TARGETING; INTERNALIZATION; LIPID BILAYER; MACROMOLECULE; MEMBRANE TRANSPORT; MICELLE; PROTEIN SECRETION; PROTEIN TRANSPORT; REVIEW;

EID: 0033849876     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.9.9.2039     Document Type: Review

References (107)

1. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus
2. A nuclear localization signal can enhance both the nuclear transport and expression of 1 kb DNA
3. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence
4. Secretion of mammalian proteins that lack a signal sequence
5. Tat-mediated delivery of heterologous proteins into cells
6. Rab3A and Rab3B carboxy-terminal peptides are both potent and specific inhibitors of prolactin release by rat cultured anterior pituitary cells
7. Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro
8. Intercellular trafficking and protein delivery by a herpesvirus structural protein
9. The herpes simplex virus Type 1 tegument protein VP22 is encoded by gene UL49
10. Can VP22 resurrect gene therapy?
11. Catch VP22: The hitch-hiker's ride to gene therapy?
12. Phosphorylation of the herpes simplex virus Type 1 tegument protein VP22
13. An amino acid sequence shared by the herpes simplex virus 1 a regulatory proteins 0, 4, 22 and 27 predicts the nucleotidylation of the U(L)21, U(L)31, U(L)47 and U(L)49 gene products
14. Virus-specific basic phosphoproteins associated with herpes simplex virus type a (HSV-1) particles and the chromatin of HSV-1-infected cells
15. Herpes simplex virus type 1 tegument protein VP22 induces the stabilization and hyperacetylation of microtubules
16. Direct protein transfer to terminally differentiated muscle cells
17. Intercellular spread of GFP-VP22
18. Intercellular delivery of functional p53 by the herpesvirus protein VP22
19. Quantification of VP22-GFP spread by direct fluorescence in 15 commonly used cell lines
20. Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22
21. Structural interactions of fibroblast growth factor receptor with its ligands
22. Acidic and basic fibroblast growth factors
23. Keratinocyte growth factor: A unique player in epithelial repair processes
24. Heat shock induces the release of fibroblast growth factor 1 from NIH 3T3 cells
25. The 27-kDa heat shock protein facilitates basic fibroblast growth factor release from endothelial cells
26. The extravesicular domain of synaptotagmin-1 is released with the latent fibroblast growth factor-1 homodimer in response to heat shock
27. Effect of a-crystallin and GroEL on the aggregation and refolding of acidic fibroblast growth factor
28. The characterization, stabilization and formulation of acidic fibroblast growth factor
29. Uptake and intracellular transport of acidic fibroblast growth factor: Evidence for free and cytoskeleton-anchored fibroblast growth factor receptors
30. Role of the nuclear localization sequence in fibroblast growth factor-1-stimultaed mitogenic pathways
31. Characterization of the nuclear translocation of acidic fibroblast growth factor
32. Analysis of endogenous and exogenous nuclear translocation of fibroblast growth factor-1 in NIH 3T3 cells
33. Biochemical analysis of the arginine methylation of high molecular weight fibroblast growth factor-2
34. Basic fibroblast growth factor-Pseudomonas exotoxin chimeric proteins; comparison with acidic fibroblast growth factor-Pseudomonas exotoxin
35. Cytotoxic activity of chimeric proteins composed of acidic fibroblast growth factor and Pseudomonas exotoxin on a variety of cell types
36. In vivo activities of acidic fibroblast growth factor-Pseudomonas exotoxin fusion proteins
37. Tight folding of acidic fibroblast growth factor prevents its translocation to the cytosol with diphtheria toxin as vector
38. A functional fibroblast growth factor-1 immunoglobulin fusion protein
39. Multifaceted activities of the HIV-1 transactivator of transcription, Tat
40. Endocytosis and targeting of exogenous HIV-1 Tat protein
41. Cellular uptake of the Tat protein from human immunodeficiency virus
42. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
43. In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA
44. Release, uptake and effects of extracellular human immunodeficiency virus Type 1 Tat protein on cell growth and viral transactivation
45. Endosomolytic activity of cationic liposomes enhances the delivery of human immunodeficiency virus-1 trans-activator protein (TAT) to mammalian cells
46. Cationic liposome-mediated uptake of human immunodeficiency virus Type 1 Tat protein into cells
47. In vivo protein transduction: Delivery of a biologically active protein into the mouse
48. Protein therapy-delivery guaranteed
49. Antennapedia homeobox as a signal for the cellular internalization and nuclear addressing of a small exogenous peptide
50. Getting hydrophilic compounds into cells: Lessons from homeopeptides
51. Homeodomain-derived peptides. In and out of the cells
52. Cell internalization of the third helix of the Antennapedia homeodomain is receptor-independent
53. The third helix of the Antennapedia Homeodomain translocates through biological membranes
54. Trojan peptides: The penetratin system for intracellular delivery
55. Inhibition of cancer cell growth and c-Myc transcriptional activity by a c-Myc helix 1-type peptide fused to an internalization sequence
56. Cell-penetrating peptides
57. Cellular import of functional peptides to block intracellular signaling
58. Noninvasive intracellular delivery of functional peptides and proteins
59. Transcription factor hoxa-5 is taken up by cells in culture and conveyed to their nuclei
60. A short region of its homeodomain is necessary for engrailed nuclear export and secretion
61. Identification of a signal sequence necessary for the unconventional secretion of engrailed homeoprotein
62. Novel cell permeable motif derived from the PreS2-domain of hepatitis-B virus surface antigens
63. Cell penetration by transportan
64. Cellular uptake of an alpha-helical amphipathic model peptide with the potential to deliver polar compounds into the cell interior non- endocytically
65. Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo
66. Translocation of the catalytic domain of diphtheria toxin across planar phospholipid bilayers by its own T domain
67. Intranuclear delivery of an antiviral peptide mediated by the B subunit of Escherichia coli heat-labile enterotoxin
68. Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo
69. Characterization of membrane translocation by anthrax protective antigen
70. Common principles of protein translocation across membranes
71. Nucleocytoplasmic transport
72. Caveolins, a family of scaffolding proteins for organizing 'preassembled signaling complexes' at the plasma membrane
73. Chaperone-mediated protein folding
74. How chaperones protect virgin proteins
75. Do molecular chaperones have to be proteins?
76. Lipid-assisted protein folding
77. The structure of human acidic fibroblast growth factor and its interaction with heparin
78. Effect of polyanions on the refolding of human acidic fibroblast growth factor
79. Regulation of basic fibroblast growth factor binding and activity by cell density and heparan sulfate
80. Conformational lability of herpes virus protein VP22
81. Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation and size
82. Multiple interactions of HIV-1 Tat protein with size-defined heparin oligosaccharides
83. The basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonists
84. HIV-tat protein is a heparin-binding angiogenic growth factor
85. Molten globule and protein folding
86. The 'molten globule' state is involved in the translocation of proteins across membranes?
87. HtrA heat shock protease interacts with phospholipid membranes and undergoes conformational changes
88. Interaction of partially unfolded forms of Torpedo acetylcholinesterase with liposomes
89. Colicin Ia inserts into negatively charged membranes at low pH with a tertiary but little secondary structural change
90. A 'molten-globule' membrane-insertion intermediate of the pore-forming domain of colicin A
91. Partially structured self-associating states of acidic fibroblast growth factor
92. Interaction of diphtheria toxin T domain with molten globule-like proteins and its implications for translocation
93. Interaction of partially structured states of acidic fibroblast growth factor with phospholipid membranes
94. Conformational and associative behaviours of the third helix of antennapedia homeodomain in membrane-mimetic environments
95. Structure-activity relationship of truncated and substituted analogues of the intracellular delivery vector penetratin
96. An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery
97. Interbilayer lipid mixing induced by the human immunodeficiency virus type-1 fusion peptide on large unilamellar vesicles: The nature of the nonlamellar intermediates
98. Amphiphilic α-helices and lipid interactions
99. Specificity of helix-induction by 2,2,2-trifluoroethanol in polypeptides
100. Conformational and topological requirements of cell-permeable peptide function
101. Unusual routes of protein secretion: The easy way out
102. Unusual protein secretion and translocation pathways in yeast: Implication of ABC transporters
103. Polypeptide import and degradation by isolated lysosomes
104. Intrinsically unstructured proteins: Re-assessing the protein structure-function paradigm
105. Evidence for a lipochaperonin: Association of active protein-folding GroESL oligomers with lipids can stabilize membranes under heat shock conditions
106. Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
107. Introduction of exogenous antigens into the MHC class I processing and presentation pathway by Drosophila antennapedia homeodomain primes cytotoxic T cells in vivo