Catch VP22: The hitch-hiker's ride to gene therapy?

Gene Therapy

Volumn 6, Issue 1, 1999, Pages 4-5

  Murphy, Anthea L ^a   Murphy, Stephen J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS FUSION PROTEIN; VIRUS PROTEIN;

ADENOVIRUS; CANCER THERAPY; GENE THERAPY; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; PRIORITY JOURNAL; PROTEIN TARGETING; SHORT SURVEY; SUICIDE GENE;

GANCICLOVIR; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; NEOPLASMS; SIMPLEXVIRUS; VIRAL STRUCTURAL PROTEINS;

ADENOVIRIDAE; HERPES; HUMAN HERPESVIRUS 1;

EID: 0032898522     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300849     Document Type: Short Survey

References (7)

1. Dilber MS, Phelan A, Aints A, Mohamed AJ, Elliott G, Smith CIE, O'Hare P. Intercellular delivery of thymidine kinase pro-drug activating enzyme by the herpes simplex virus protein VP22. Gene Therapy 1999; 6: 12-21.
2. Dargan D. The structure and assembly of herpes viruses. In: Harris JR, Horne RW (eds) Viral structure. New York: Academic Press, 1986, pp 359-437.
3. Elliott G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 1997; 88: 223-233.
4. Fang B, Xu B, Koch P, Roth JA. Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Therapy 1998; 5: 1420-1424.
5. Elliott G, O'Hare P. Intercellular trafficking of VP22-GFP fusion proteins. Gene Therapy 1999; 6: 149-151.
6. Vrionis FD, Wu JK, Qi P, Waltzman M, Cherington V, Spray DC. The bystander effect exerted by tumor cells expressing the herpes simplex virus thymidine kinase (HSVtk) gene is dependent on connexin expression and cell communication via gap junctions. Gene Therapy 1997; 4: 577-585.
7. Phelan A, Elliott G, O'Hare P. Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nature Biotechnology 1998; 16: 440-443.