Intercellular Spread of GFP-VP22

Journal of Gene Medicine

Volumn 1, Issue 4, 1999, Pages 275-279

  Aints, Alar ^a,b   Dilber, M Sirac ^a,b   Smith, C I Edvard ^a,b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Gene therapy; Gene transfer; Green fluorescent protein; Herpes simplex virus; Protein transfer; VP22

Indexed keywords

HERPES; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

GREEN FLUORESCENT PROTEIN; HERPES SIMPLEX VIRUS TYPE 1 PROTEIN VP22; HYBRID PROTEIN; PHOTOPROTEIN; VIRUS PROTEIN;

ACTIVE TRANSPORT; ANIMAL; ARTICLE; CELL FRACTIONATION; CELL LINE; CELL STRAIN COS1; CONFOCAL MICROSCOPY; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MOUSE; RAT;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; COS CELLS; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICE; MICROSCOPY, CONFOCAL; RATS; RECOMBINANT FUSION PROTEINS; SUBCELLULAR FRACTIONS; TRANSFECTION; VIRAL STRUCTURAL PROTEINS;

EID: 0033154929     PISSN: 1099498X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-2254(199907/08)1:4<275::AID-JGM44>3.0.CO;2-M     Document Type: Article

References (10)

1. Elliott GD, Meredith DM. The herpes simplex virus type 1 tegument protein VP22 is encoded by gene UL49. J Gen Virol 1992; 73: 723-726.
2. Elliott G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 1997; 88: 223-233.
3. Phelan A, Elliott G, O'Hare P. Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nat Biotechnol 1998; 16: 440-443.
4. Dilber MS, Phelan A, Aints A, et al. Intercellular delivery of thymidine kinase pro-drug activating enzyme by the herpes simplex virus protein VP22. Gene Ther 1999; 6: 12-21.
5. Elliot G, O'Hare P. Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 1997; 88: 223-233.
6. Elliott G, O'Hare P. Intercellular trafficking of VP22-GFP fusion proteins. Gene Ther 1999; 6: 149-151.
7. Fang B, Xu B, Koch P, et al. Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther 1998; 5: 1420-1424.
8. Boussif O, Lezoualc'h F, Zanta MA, et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethyleneimine. Proc Natl Acad Sci U S A 1995; 92: 7297-7301.
9. Elliott G, O'Hare P. Herpes simplex virus type 1 tegument protein VP22 induces the stabilisation and hyperacetylation of microtubules. J Virol 1998; 72: 6448-6455.
10. Elliott G, Mouzakitis G, O'Hare P. VP16 interacts via its activation domain with VP22, a tegument protein of herpes simplex virus, and is relocated to a novel macromolecular assembly in coexpressing cells. J Virol 1995; 69: 7932-7941.