Direct protein transfer to terminally differentiated muscle cells

Journal of Molecular Medicine

Volumn 77, Issue 8, 1999, Pages 609-613

  Derer, Wolfgang ^a,b   Easwaran, Hariharan P ^a   Leonhardt, Heinrich ^a   Cardoso, M Cristina ^a,b   Knopf, Charles W ^c  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b FRANZ VOLHARD CLINIC   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

GFP; Muscle; Protein delivery; Therapy; VP22

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE FUSION; GENE TARGETING; INTRACELLULAR TRANSPORT; MOLECULAR WEIGHT; MUSCLE CELL; NONHUMAN; PROTEIN TRANSPORT;

EID: 0032836142     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001099900036     Document Type: Article

References (13)

1. 1. Verma IM, Somia N (1997) Gene therapy - promises, problems and prospects. Nature 389:239-242
2. 2. Knopf KW, Kaerner HC (1980) Virus-specific basic phosphoproteins associated with herpes simplex virus type a (HSV-1) particles and the chromatin of HSV-1-infected cells. J Gen Virol 46:405-414
3. 3.Elliott GD, Meredith DM (1992) The herpes simplex virus type I tegument protein VP22 is encoded by gene UL49. J Gen Virol 73:723-726
4. 4. Elliott G, O'Hare P (1997) Intercellular trafficking and protein delivery by a herpesvirus structural protein. Cell 88:223-233
5. 5. Phelan A, Elliott G, O'Hare P (1998) Intercellular delivery of functional p53 by the herpesvirus protein VP22. Nature Biotechnol 16:440-443
6. 6. Dilber MS, Phelan A, Aints A et al (1999) Intercellular delivery of thymidine kinase prodrug activating enzyme by the herpes simplex virus protein, VP22. Gene Ther 6:12-21
7. 7. Fang B, Xu B, Koch P et al (1998) Intercellular trafficking of VP22-GFP fusion proteins is not observed in cultured mammalian cells. Gene Ther 5:1420-1424
8. 8. Cardoso MC, Joseph C, Rahn HP et al (1997) Mapping and use of a sequence thin targets DNA ligase I to sites of DNA replication in vivo. J Cell Biol 139:579-587
9. 9. Gluzman Y (1981) SV40-transformed simian cells support the replication of early SV40 mutants. Cell 23:175-182
10. 10. Leonhardt H, Page AW, Weier HU et al (1992) A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei. Cell 71:865-873
11. 11. Elliott G, O'Hare P (1998) Herpes simplex virus type I tegument protein VP22 induces the stabilization and hyperacetylation of microtubules. J Virol 72:6448-6455
12. 12. Elliott G, O'Hare P (1999) Intercellular trafficking of VP22-GFP fusion proteins. Gene Ther 6:149-151
13. 13. Nalbantoglu J, Pari G, Karpati G et al (1999) Expression of the primary coxsackie and adenovirus receptor is downregulated during skeletal muscle maturation and limits the efficacy of adenovirus-mediated gene delivery to muscle cells. Hum Gene Ther 10:1009-1019