-
1
-
-
0030891149
-
Cellular import of functional peptides to block intracellular signaling
-
Hawiger J Cellular import of functional peptides to block intracellular signaling. Curr Opin Immunol. 9:1997;189-194.
-
(1997)
Curr Opin Immunol
, vol.9
, pp. 189-194
-
-
Hawiger, J.1
-
2
-
-
0020010267
-
Fluorescent localization of contractile proteins in tissue culture cells
-
Wang K, Feramisco JR, Ash JF Fluorescent localization of contractile proteins in tissue culture cells. Methods Enzymol. 85:1982;514-562.
-
(1982)
Methods Enzymol
, vol.85
, pp. 514-562
-
-
Wang, K.1
Feramisco, J.R.2
Ash, J.F.3
-
3
-
-
0029976805
-
The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes
-
Perlmutter RM, Alberola-Ila J The use of dominant-negative mutations to elucidate signal transduction pathways in lymphocytes. Curr Opin Immunol. 8:1996;285-290.
-
(1996)
Curr Opin Immunol
, vol.8
, pp. 285-290
-
-
Perlmutter, R.M.1
Alberola-Ila, J.2
-
4
-
-
0029006149
-
Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence
-
Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem. 270:1995;14255-14258.
-
(1995)
J Biol Chem
, vol.270
, pp. 14255-14258
-
-
Lin, Y.Z.1
Yao, S.Y.2
Veach, R.A.3
Torgerson, T.R.4
Hawiger, J.5
-
5
-
-
0029999551
-
Identification of a functionally important sequence in the cytoplasmic tail of integrin β3 by using cell-permeable peptide analogs
-
Liu X-Y, Timmons S, Lin Y-Z, Hawiger J Identification of a functionally important sequence in the cytoplasmic tail of integrin β3 by using cell-permeable peptide analogs. Proc Natl Acad Sci USA. 93:1996;11819-11824.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 11819-11824
-
-
Liu, X.-Y.1
Timmons, S.2
Lin, Y.-Z.3
Hawiger, J.4
-
6
-
-
0032482965
-
Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules
-
This paper provides a facile method that expedites synthesis of biologically active cell-permeable peptides by site-specific ligation of two free peptide modules via a nonpeptide thiazolidino linkage.
-
Zhang L, Torgerson TR, Liu X-Y, Timmons S, Colosia AD, Hawiger J, Tam JP Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules. Proc Natl Acad Sci USA. 95:1998;9184-9189. This paper provides a facile method that expedites synthesis of biologically active cell-permeable peptides by site-specific ligation of two free peptide modules via a nonpeptide thiazolidino linkage.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9184-9189
-
-
Zhang, L.1
Torgerson, T.R.2
Liu, X.-Y.3
Timmons, S.4
Colosia, A.D.5
Hawiger, J.6
Tam, J.P.7
-
7
-
-
0031959657
-
Genetic engineering of proteins with cell membrane permeability
-
This report expands application of noninvasive delivery of peptides based on the hydrophobic domains of signal peptides to recombinant fusion proteins that contain gluthione-S-transferase and the src homology 2 domain of the intracellular adaptor protein Grb2. Intracellular delivery of this fusion protein inhibited epidermal growth factor receptor mediated signaling.
-
Rojas M, Donahue JP, Tan Z, Lin Y-Z Genetic engineering of proteins with cell membrane permeability. Nat Biotechnol. 16:1998;370-375. This report expands application of noninvasive delivery of peptides based on the hydrophobic domains of signal peptides to recombinant fusion proteins that contain gluthione-S-transferase and the src homology 2 domain of the intracellular adaptor protein Grb2. Intracellular delivery of this fusion protein inhibited epidermal growth factor receptor mediated signaling.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 370-375
-
-
Rojas, M.1
Donahue, J.P.2
Tan, Z.3
Lin, Y.-Z.4
-
8
-
-
0032574752
-
Penetration and intracellular routing of nucleus-directed peptide-based shuttles (loligomers) in eukaryotic cells
-
Singh D, Kiarash R, Kawamura K, LaCasse EC, Gariépy J Penetration and intracellular routing of nucleus-directed peptide-based shuttles (loligomers) in eukaryotic cells. Biochemistry. 37:1998;5798-5809.
-
(1998)
Biochemistry
, vol.37
, pp. 5798-5809
-
-
Singh, D.1
Kiarash, R.2
Kawamura, K.3
Lacasse, E.C.4
Gariépy, J.5
-
9
-
-
0028808099
-
Identification of a renal cell line that constitutively expresses the kidney-specific high-affinity H+/peptide cotransporter
-
Brandsch M, Brandsch C, Prasad PD, Ganapathy V, Hopfer U, Leibach FH Identification of a renal cell line that constitutively expresses the kidney-specific high-affinity H+/peptide cotransporter. FASEB J. 9:1995;1489-1496.
-
(1995)
FASEB J
, vol.9
, pp. 1489-1496
-
-
Brandsch, M.1
Brandsch, C.2
Prasad, P.D.3
Ganapathy, V.4
Hopfer, U.5
Leibach, F.H.6
-
10
-
-
0031953510
-
Intercellular delivery of functional p53 by the herpes virus protein, VP22
-
This report describes use of the Herpes virus protein VP22 as a membrane-permeable vector for intercellular delivery of the proapoptotic p53 protein. The p53-VP22 fusion protein expressed in transfected cells was ferried to nontransfected tumor cells as a result of VP22 membrane-permeable properties. Apoptosis of tumor cells was induced as a result of this intercellular delivery of p53
-
Phelan A, Elliot G, O'Hare P Intercellular delivery of functional p53 by the herpes virus protein, VP22. Nat Biotechnol. 16:1998;440-443. This report describes use of the Herpes virus protein VP22 as a membrane-permeable vector for intercellular delivery of the proapoptotic p53 protein. The p53-VP22 fusion protein expressed in transfected cells was ferried to nontransfected tumor cells as a result of VP22 membrane-permeable properties. Apoptosis of tumor cells was induced as a result of this intercellular delivery of p53.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 440-443
-
-
Phelan, A.1
Elliot, G.2
O'Hare, P.3
-
11
-
-
0031916828
-
The HIV-1 tat nuclear localization sequence confers novel nuclear import properties
-
Efthymiadis A, Briggs LJ, Jans DA The HIV-1 tat nuclear localization sequence confers novel nuclear import properties. J Biol Chem. 273:1998;1623-1628.
-
(1998)
J Biol Chem
, vol.273
, pp. 1623-1628
-
-
Efthymiadis, A.1
Briggs, L.J.2
Jans, D.A.3
-
12
-
-
0032067947
-
Ferrying proteins to the other side
-
Fernandez T, Bayley H Ferrying proteins to the other side. Nat Biotechnol. 16:1998;418-420.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 418-420
-
-
Fernandez, T.1
Bayley, H.2
-
13
-
-
0030666371
-
Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form
-
Rossjohn J, Feil SC, McKinstry WJ, Tweten RK, Parker MW Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell. 89:1997;685-692.
-
(1997)
Cell
, vol.89
, pp. 685-692
-
-
Rossjohn, J.1
Feil, S.C.2
McKinstry, W.J.3
Tweten, R.K.4
Parker, M.W.5
-
14
-
-
0029914034
-
Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo
-
Ballard JD, Collier RJ, Starnbach MN Anthrax toxin-mediated delivery of a cytotoxic T-cell epitope in vivo. Proc Natl Acad Sci USA. 93:1996;12531-12534.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 12531-12534
-
-
Ballard, J.D.1
Collier, R.J.2
Starnbach, M.N.3
-
15
-
-
0025239609
-
Comparison of helix stability in wild-type and mutant LamB signal sequences
-
Bruch MD, Gierasch LM Comparison of helix stability in wild-type and mutant LamB signal sequences. J Biol Chem. 265:1990;3851-3858.
-
(1990)
J Biol Chem
, vol.265
, pp. 3851-3858
-
-
Bruch, M.D.1
Gierasch, L.M.2
-
16
-
-
0025323708
-
The distibution of physical, chemical and conformational properties in signal and nascent peptides
-
Prabhakaran M The distibution of physical, chemical and conformational properties in signal and nascent peptides. Biochem, J. 269:1990;691-696.
-
(1990)
Biochem, J
, vol.269
, pp. 691-696
-
-
Prabhakaran, M.1
-
17
-
-
0025721096
-
Hydrophobic content and lipid interactions of wild-type and mutant OmpA signal peptides correlate with their in vivo function
-
Hoyt DW, Gierasch LM Hydrophobic content and lipid interactions of wild-type and mutant OmpA signal peptides correlate with their in vivo function. Biochemistry. 30:1991;10155-10163.
-
(1991)
Biochemistry
, vol.30
, pp. 10155-10163
-
-
Hoyt, D.W.1
Gierasch, L.M.2
-
18
-
-
0026722528
-
The role of the N region in signal sequence and signal-anchor function
-
Andrews DW, Young JC, Mirels LF, Czarnota GJ The role of the N region in signal sequence and signal-anchor function. J Biol Chem. 267:1992;7761-7769.
-
(1992)
J Biol Chem
, vol.267
, pp. 7761-7769
-
-
Andrews, D.W.1
Young, J.C.2
Mirels, L.F.3
Czarnota, G.J.4
-
19
-
-
0032400997
-
Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50
-
This paper demonstrates that the cell-permeable SN50 peptide carrying the nuclear localization sequence (NLS) of the NF-κB p50 inhibits inducible nuclear import of NF-κB and three other transcription factors involved in the cellular response to immunological and inflammatory stress. Inhibition of nuclear import of transcription factors was paralleled by saturable binding of the SN50 peptide to the cytoplasmic NLS-binding protein complex. Attenuation of gene expression regulated by the transcription factors that were blocked by the SN50 peptide was demonstrated.
-
Torgerson TR, Colosia AD, Donahue JP, Lin Y-Z, Hawiger J Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50. J Immunol. 161:1998;6084-6092. This paper demonstrates that the cell-permeable SN50 peptide carrying the nuclear localization sequence (NLS) of the NF-κB p50 inhibits inducible nuclear import of NF-κB and three other transcription factors involved in the cellular response to immunological and inflammatory stress. Inhibition of nuclear import of transcription factors was paralleled by saturable binding of the SN50 peptide to the cytoplasmic NLS-binding protein complex. Attenuation of gene expression regulated by the transcription factors that were blocked by the SN50 peptide was demonstrated.
-
(1998)
J Immunol
, vol.161
, pp. 6084-6092
-
-
Torgerson, T.R.1
Colosia, A.D.2
Donahue, J.P.3
Lin, Y.-Z.4
Hawiger, J.5
-
20
-
-
0025747497
-
Alpha-2,8-polysialic acid is the neuronal surface receptor of antennapedia homeobox peptide
-
Joliot AH, Triller A, Volovitch M, Pernelle C, Prochiantz A Alpha-2,8-polysialic acid is the neuronal surface receptor of antennapedia homeobox peptide. New Biol. 3:1991;1121-1134.
-
(1991)
New Biol
, vol.3
, pp. 1121-1134
-
-
Joliot, A.H.1
Triller, A.2
Volovitch, M.3
Pernelle, C.4
Prochiantz, A.5
-
21
-
-
0029982569
-
Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent
-
Derossi D, Calvet S, Trembleau A, Brunissen A, Chassaing G, Prochiantz A Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent. J Biol Chem. 271:1996;18188-18193.
-
(1996)
J Biol Chem
, vol.271
, pp. 18188-18193
-
-
Derossi, D.1
Calvet, S.2
Trembleau, A.3
Brunissen, A.4
Chassaing, G.5
Prochiantz, A.6
-
22
-
-
0027970448
-
Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae
-
Fra AM, Williamson E, Simons K, Parton RG Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae. J Biol Chem. 269:1994;30745-30748.
-
(1994)
J Biol Chem
, vol.269
, pp. 30745-30748
-
-
Fra, A.M.1
Williamson, E.2
Simons, K.3
Parton, R.G.4
-
23
-
-
0025949412
-
Nuclear targeting sequences-a consensus?
-
Dingwall C, Laskey RA Nuclear targeting sequences-a consensus? Trends Biochem Sci. 16:1991;478-481.
-
(1991)
Trends Biochem Sci
, vol.16
, pp. 478-481
-
-
Dingwall, C.1
Laskey, R.A.2
-
24
-
-
0028287515
-
Putative nuclear localization signals (NLS) in protein transcription factors
-
Boulikas T Putative nuclear localization signals (NLS) in protein transcription factors. J Cell Biol. 55:1994;32-58.
-
(1994)
J Cell Biol
, vol.55
, pp. 32-58
-
-
Boulikas, T.1
-
25
-
-
0028559537
-
Cytosolic factors in nuclear transport: What's importin?
-
Powers MA, Forbes DJ Cytosolic factors in nuclear transport: what's importin? Cell. 79:1994;931-934.
-
(1994)
Cell
, vol.79
, pp. 931-934
-
-
Powers, M.A.1
Forbes, D.J.2
-
26
-
-
0031938280
-
Nuclear factor-κB contributes to excitotoxin-induced apoptosis in rat striatum
-
Qin ZH, Wang Y, Nakai M, Chase TN Nuclear factor-κB contributes to excitotoxin-induced apoptosis in rat striatum. Mol Pharmacol. 53:1998;33-42.
-
(1998)
Mol Pharmacol
, vol.53
, pp. 33-42
-
-
Qin, Z.H.1
Wang, Y.2
Nakai, M.3
Chase, T.N.4
-
27
-
-
0032498545
-
A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: Role in integrin alpha2 gene expression and tissue remodeling
-
Xu J, Zutter MM, Santoro SA, Clark RA A three-dimensional collagen lattice activates NF-kappaB in human fibroblasts: role in integrin alpha2 gene expression and tissue remodeling. J Cell Biol. 9:1998;709-719.
-
(1998)
J Cell Biol
, vol.9
, pp. 709-719
-
-
Xu, J.1
Zutter, M.M.2
Santoro, S.A.3
Clark, R.A.4
-
28
-
-
17944384904
-
Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κB activation
-
Kilgore KS, Schmid E, Shanley TP, Flory CM, Maheswari V, Tramontini NL, Cohen H, Ward PA, Friedl HP, Warren JS Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-κB activation. Am J Pathol. 150:1997;2019-2031.
-
(1997)
Am J Pathol
, vol.150
, pp. 2019-2031
-
-
Kilgore, K.S.1
Schmid, E.2
Shanley, T.P.3
Flory, C.M.4
Maheswari, V.5
Tramontini, N.L.6
Cohen, H.7
Ward, P.A.8
Friedl, H.P.9
Warren, J.S.10
-
29
-
-
0032530948
-
Nuclear translocation of upstream stimulating factor 2 (USF2) in activated mast cells: A possible role in their survival
-
Frenkel S, Kay G, Nechushtan H, Razin E Nuclear translocation of upstream stimulating factor 2 (USF2) in activated mast cells: a possible role in their survival. J Immunol. 161:1998;2881-2887.
-
(1998)
J Immunol
, vol.161
, pp. 2881-2887
-
-
Frenkel, S.1
Kay, G.2
Nechushtan, H.3
Razin, E.4
-
30
-
-
0028987936
-
Integrins and signal transduction pathways: The road taken
-
Clark EA, Brugge JS Integrins and signal transduction pathways: the road taken. Science. 268:1995;233-239.
-
(1995)
Science
, vol.268
, pp. 233-239
-
-
Clark, E.A.1
Brugge, J.S.2
-
31
-
-
0029861248
-
Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor
-
Rojas M, Yao SY, Lin YZ Controlling epidermal growth factor (EGF)-stimulated Ras activation in intact cells by a cell-permeable peptide mimicking phosphorylated EGF receptor. J Biol Chem. 271:1996;27456-27461.
-
(1996)
J Biol Chem
, vol.271
, pp. 27456-27461
-
-
Rojas, M.1
Yao, S.Y.2
Lin, Y.Z.3
|