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Volumn 6, Issue 7, 1999, Pages 673-682

Bax antisense oligonucleotides reduce axotomy-induced retinal ganglion cell death in vivo by reduction of Bax protein expression

Author keywords

Apoptosis; Cell death; Gene transfer; Neuroprotection; Rat; Retina

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; FLUORESCEIN; PROTEIN BAX;

EID: 0032783006     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400538     Document Type: Article
Times cited : (88)

References (47)
  • 2
    • 0028310855 scopus 로고
    • Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats
    • Berkelaar M, Clarke DB, Wang YC, Bray GM and Aguayo AJ (1994) Axotomy results in delayed death and apoptosis of retinal ganglion cells in adult rats. J. Neurosci. 14: 4368-4374
    • (1994) J. Neurosci. , vol.14 , pp. 4368-4374
    • Berkelaar, M.1    Clarke, D.B.2    Wang, Y.C.3    Bray, G.M.4    Aguayo, A.J.5
  • 3
    • 0031239774 scopus 로고    scopus 로고
    • c-Jun protein is expressed in degenerating retinal ganglion cells after optic nerve lesion in the rat
    • Isenmann S and Bähr M (1997) c-Jun protein is expressed in degenerating retinal ganglion cells after optic nerve lesion in the rat. Exp. Neurol. 147: 28-36
    • (1997) Exp. Neurol. , vol.147 , pp. 28-36
    • Isenmann, S.1    Bähr, M.2
  • 4
    • 0030851891 scopus 로고    scopus 로고
    • Upregulation of bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat
    • Isenmann S, Wahl C, Krajewski S, Reed JC and Bähr M (1997) Upregulation of Bax Protein in Degenerating Retinal Ganglion Cells precedes Apoptotic Cell Death after Optic Nerve Lesion in the Rat. Eur. J. Neurosci. 9: 1763-1772
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 1763-1772
    • Isenmann, S.1    Wahl, C.2    Krajewski, S.3    Reed, J.C.4    Bähr, M.5
  • 5
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai ZN, Milliman CL and Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 6
    • 0345286251 scopus 로고    scopus 로고
    • Bcl-2 deficient mice undergo a rapid wave of retinal ganglion cell degeneration following the period of naturally occuring cell death
    • in press
    • Cellerino A, Michaelidis T, Barski JJ, Bähr M, Thoenen H and Meyer M (1999) Bcl-2 deficient mice undergo a rapid wave of retinal ganglion cell degeneration following the period of naturally occuring cell death. NeuroReport in press
    • (1999) NeuroReport
    • Cellerino, A.1    Michaelidis, T.2    Barski, J.J.3    Bähr, M.4    Thoenen, H.5    Meyer, M.6
  • 7
    • 0030008918 scopus 로고    scopus 로고
    • Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2
    • Bonfanti L, Strettoi E, Chierzi S, Cenni MC, Liu XH, Martinou JC, Maffei L and Rabacchi SA (1996) Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J. Neurosci. 16: 4186-4194
    • (1996) J. Neurosci. , vol.16 , pp. 4186-4194
    • Bonfanti, L.1    Strettoi, E.2    Chierzi, S.3    Cenni, M.C.4    Liu, X.H.5    Martinou, J.C.6    Maffei, L.7    Rabacchi, S.A.8
  • 8
    • 0029738162 scopus 로고    scopus 로고
    • Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice
    • Cenni MC, Bonfanti L, Martinou JC, Ratto GM, Strettoi E and Maffei L (1996) Long-term survival of retinal ganglion cells following optic nerve section in adult bcl-2 transgenic mice. Eur. J. Neurosci. 8: 1735-1745
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1735-1745
    • Cenni, M.C.1    Bonfanti, L.2    Martinou, J.C.3    Ratto, G.M.4    Strettoi, E.5    Maffei, L.6
  • 9
    • 0031828871 scopus 로고    scopus 로고
    • Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice
    • Mosinger Ogilvie J, Deckwerth TL, Knudson CM and Korsmeyer SJ (1998) Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. Invest. Ophthalmol. Vis. Sci. 39: 1713-1720
    • (1998) Invest. Ophthalmol. Vis. Sci. , vol.39 , pp. 1713-1720
    • Mosinger Ogilvie, J.1    Deckwerth, T.L.2    Knudson, C.M.3    Korsmeyer, S.J.4
  • 11
    • 0025272049 scopus 로고
    • Lipofection of cDNAs in the embryonic vertebrate central nervous system
    • Holt CE, Garlick N and Cornel E (1990) Lipofection of cDNAs in the embryonic vertebrate central nervous system. Neuron 4: 203-214
    • (1990) Neuron , vol.4 , pp. 203-214
    • Holt, C.E.1    Garlick, N.2    Cornel, E.3
  • 13
    • 0030014899 scopus 로고    scopus 로고
    • Polyethylenimine-mediated DNA transfection of peripheral and central neurons in primary culture: probing Ca2+ channel structure and function with antisense oligonucleotides
    • Lambert RC, Maulet Y, Dupont JL, Mykita S, Craig P, Volsen S and Feltz A (1996) Polyethylenimine-mediated DNA transfection of peripheral and central neurons in primary culture: probing Ca2+ channel structure and function with antisense oligonucleotides. Mol. Cell. Neurosci. 7: 239-246
    • (1996) Mol. Cell. Neurosci. , vol.7 , pp. 239-246
    • Lambert, R.C.1    Maulet, Y.2    Dupont, J.L.3    Mykita, S.4    Craig, P.5    Volsen, S.6    Feltz, A.7
  • 15
    • 0031983648 scopus 로고    scopus 로고
    • Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat
    • Isenmann S, Stoll G, Schroeter M, Krajewski S, Reed JC and Bähr M (1998b) Differential regulation of Bax, Bcl-2, and Bcl-X proteins in focal cortical ischemia in the rat. Brain Pathol. 8: 49-63
    • (1998) Brain Pathol. , vol.8 , pp. 49-63
    • Isenmann, S.1    Stoll, G.2    Schroeter, M.3    Krajewski, S.4    Reed, J.C.5    Bähr, M.6
  • 16
    • 0030709339 scopus 로고    scopus 로고
    • In vivo neurotrophic effects of GDNF on retinal ganglion cells
    • Klöcker N, Bräunling F, Isenmann S and Bähr M (1997) In vivo neurotrophic effects of GDNF on retinal ganglion cells. NeuroReport 8: 3439-3442
    • (1997) NeuroReport , vol.8 , pp. 3439-3442
    • Klöcker, N.1    Bräunling, F.2    Isenmann, S.3    Bähr, M.4
  • 17
    • 0032130217 scopus 로고    scopus 로고
    • Protection of axotomized rat retinal ganglion cells by adenovirally administered BDNF in vivo
    • Isenmann S, Klöcker N, Gravel C and Bähr M (1998a) Protection of axotomized rat retinal ganglion cells by adenovirally administered BDNF in vivo. Eur. J. Neurosci. 10: 2751-2756
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 2751-2756
    • Isenmann, S.1    Klöcker, N.2    Gravel, C.3    Bähr, M.4
  • 18
    • 0028324822 scopus 로고
    • Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells
    • Mansour Robaey S, Clarke DB, Wang YC, Bray GM and Aguayo AJ (1994) Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc. Natl. Acad. Sci. USA 91: 1632-1636
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 1632-1636
    • Mansour Robaey, S.1    Clarke, D.B.2    Wang, Y.C.3    Bray, G.M.4    Aguayo, A.J.5
  • 19
    • 0029979673 scopus 로고    scopus 로고
    • Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative study
    • Peinado Ramon P, Salvador M, Villegas Peres MP and Vidal Sanz M (1996) Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative study. Invest. Ophthalmol. Vis. Sci. 37: 489-500
    • (1996) Invest. Ophthalmol. Vis. Sci. , vol.37 , pp. 489-500
    • Peinado Ramon, P.1    Salvador, M.2    Villegas Peres, M.P.3    Vidal Sanz, M.4
  • 21
    • 0030462236 scopus 로고    scopus 로고
    • Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal γ-aminobutyric acid transmission in the conscious rat
    • Sommer W, Rimondini R, O'Connor W, Hansson AC, Ungerstedt U and Fuxe K (1996) Intrastriatally injected c-fos antisense oligonucleotide interferes with striatonigral but not striatopallidal γ-aminobutyric acid transmission in the conscious rat. Proc. Natl. Acad. Sci. USA 93: 14134-14139
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14134-14139
    • Sommer, W.1    Rimondini, R.2    O'Connor, W.3    Hansson, A.C.4    Ungerstedt, U.5    Fuxe, K.6
  • 22
    • 0031900833 scopus 로고    scopus 로고
    • The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain
    • Sommer W, Cui X, Erdmann B, Wiklund L, Bricca C, Heilig M and Fuxe K (1998) The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain. Antisense Ncl. Acid Drug Development 8: 75-85
    • (1998) Antisense Ncl. Acid Drug Development , vol.8 , pp. 75-85
    • Sommer, W.1    Cui, X.2    Erdmann, B.3    Wiklund, L.4    Bricca, C.5    Heilig, M.6    Fuxe, K.7
  • 23
    • 0032584228 scopus 로고    scopus 로고
    • Prolonged delivery of brain-derived neurotrophic factors by adenovirus-infected muller cells temporarily rescues injured retinal ganglion cells
    • DiPolo A, Aigner LJ, Dunn RJ, Bray GM and Aguayo AJ (1998) Prolonged delivery of brain-derived neurotrophic factors by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc. Natl. Acad. Sci. USA 95: 3978-3983
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3978-3983
    • Dipolo, A.1    Aigner, L.J.2    Dunn, R.J.3    Bray, G.M.4    Aguayo, A.J.5
  • 25
    • 0027207494 scopus 로고
    • Antisense oligonucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischemic infarctions
    • Wahlestedt C, Golanov E, Yamamoto S, Yee F, Ericson H, Yoo H, Inturrisi CE and Reis DJ (1993) Antisense oligonucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischemic infarctions. Nature 363: 260-263
    • (1993) Nature , vol.363 , pp. 260-263
    • Wahlestedt, C.1    Golanov, E.2    Yamamoto, S.3    Yee, F.4    Ericson, H.5    Yoo, H.6    Inturrisi, C.E.7    Reis, D.J.8
  • 26
    • 0028180462 scopus 로고
    • Antisense oligonucleotide strategies in neuropharmacology (1994)
    • Wahlestedt C (1994) Antisense oligonucleotide strategies in neuropharmacology (1994). Trends Pharmacol. Sci. 15: 42-46
    • (1994) Trends Pharmacol. Sci. , vol.15 , pp. 42-46
    • Wahlestedt, C.1
  • 29
    • 7844230217 scopus 로고    scopus 로고
    • Rescue of retinal ganglion cells from axotomy-induced apoptosis through trk oncogene transfer
    • Garcia-Valenzuela E and Sharma SC (1998) Rescue of retinal ganglion cells from axotomy-induced apoptosis through trk oncogene transfer. NeuroReport 9: 3165-3170
    • (1998) NeuroReport , vol.9 , pp. 3165-3170
    • Garcia-Valenzuela, E.1    Sharma, S.C.2
  • 31
    • 0027298897 scopus 로고
    • Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: Implications for therapeutic application within the central nervous system
    • Whitesell L, Geselowitz D, Chavany C, Fahmy B, Walbridge S, Alger JR and Neckers LM (1993) Stability, clearance, and disposition of intraventricularly administered oligodeoxynucleotides: implications for therapeutic application within the central nervous system. Proc. Natl. Acad. Sci. USA 90: 4665-4669
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 4665-4669
    • Whitesell, L.1    Geselowitz, D.2    Chavany, C.3    Fahmy, B.4    Walbridge, S.5    Alger, J.R.6    Neckers, L.M.7
  • 34
    • 0031051716 scopus 로고    scopus 로고
    • Infusions of tyrosine hydroxylase antisense oligodeoxynucleotides into substantia nigra of the rat - Effects on tyrosine hydroxylase mrna and protein content, striatal dopamine release and behaviour
    • Skutella T, Schwarting RKW, Huston JP, Sillaber I, Probst JC, Holsboer F and Spanagel R (1997) Infusions of tyrosine hydroxylase antisense oligodeoxynucleotides into substantia nigra of the rat - effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour. Eur. J. Neurosci. 9: 210-220
    • (1997) Eur. J. Neurosci. , vol.9 , pp. 210-220
    • Skutella, T.1    Schwarting, R.K.W.2    Huston, J.P.3    Sillaber, I.4    Probst, J.C.5    Holsboer, F.6    Spanagel, R.7
  • 35
    • 0033557658 scopus 로고    scopus 로고
    • Suppression of postischemic hippocampal nerve growth factor expression by a c-fos antisense oligodeoxynucleotide
    • Cui JK, Hsu CY and Liu PK (1999) Suppression of postischemic hippocampal nerve growth factor expression by a c-fos antisense oligodeoxynucleotide. J. Neurosci. 19: 1335-1344
    • (1999) J. Neurosci. , vol.19 , pp. 1335-1344
    • Cui, J.K.1    Hsu, C.Y.2    Liu, P.K.3
  • 37
    • 0032528118 scopus 로고    scopus 로고
    • Enforced dimerisation of Bax results in its translocation, mitochondrial dysfunction and apoptosis
    • Gross A, Jockel J, Wie MC and Korsmeyer SJ (1998) Enforced dimerisation of Bax results in its translocation, mitochondrial dysfunction and apoptosis. EMBO J. 17: 3878-3885
    • (1998) EMBO J. , vol.17 , pp. 3878-3885
    • Gross, A.1    Jockel, J.2    Wie, M.C.3    Korsmeyer, S.J.4
  • 38
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR and Reed JC (1998) Mitochondria and apoptosis. Science 281: 1309-1312
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 39
    • 0032080856 scopus 로고    scopus 로고
    • Physiological and induced neuronal death are not affected in NSE-bax transgenic mice
    • Bernard R, Dieni S, Rees S and Bernard O (1998) Physiological and induced neuronal death are not affected in NSE-bax transgenic mice. J. Neurosci. Res. 52: 247-259
    • (1998) J. Neurosci. Res. , vol.52 , pp. 247-259
    • Bernard, R.1    Dieni, S.2    Rees, S.3    Bernard, O.4
  • 40
    • 0031438851 scopus 로고    scopus 로고
    • Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: A phenotype indistinguishable from bax deletion
    • Easton RM, Deckwerth TL, Parsadanian AS and Johnson EM (1997) Analysis of the mechanism of loss of trophic factor dependence associated with neuronal maturation: A phenotype indistinguishable from Bax deletion J. Neurosci. 17: 9656-9666
    • (1997) J. Neurosci. , vol.17 , pp. 9656-9666
    • Easton, R.M.1    Deckwerth, T.L.2    Parsadanian, A.S.3    Johnson, E.M.4
  • 41
    • 0031845159 scopus 로고    scopus 로고
    • Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation
    • DeckwerthTL, Easton RM, Knudson CM, Korsmeyer SJ and Johnson EM (1998) Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Exp. Neurol. 52: 150-162
    • (1998) Exp. Neurol. , vol.52 , pp. 150-162
    • Easton, R.M.1    Knudson, C.M.2    Korsmeyer, S.J.3    Johnson, E.M.4
  • 43
    • 0032191380 scopus 로고    scopus 로고
    • Lentiviruses as gene transfer agents for delivery to non-dividing cells
    • Naldini L (1998) Lentiviruses as gene transfer agents for delivery to non-dividing cells. Curr. Opin. Biotechnol. 9: 457-463
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 457-463
    • Naldini, L.1
  • 44
    • 0025161168 scopus 로고
    • The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur-transfer agent
    • Jyer RP, Phillips LR, Egan W, Reagan JB and Beaucage SL (1990) The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur-transfer agent. J. Org. Chem. 55: 4693-4698
    • (1990) J. Org. Chem. , vol.55 , pp. 4693-4698
    • Jyer, R.P.1    Phillips, L.R.2    Egan, W.3    Reagan, J.B.4    Beaucage, S.L.5
  • 45
    • 0024300829 scopus 로고
    • Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes
    • Stamatatos L, Leventis R, Zuckermann ML and Silvius JR (1988) Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes. Biochemistry 27: 3917-3925
    • (1988) Biochemistry , vol.27 , pp. 3917-3925
    • Stamatatos, L.1    Leventis, R.2    Zuckermann, M.L.3    Silvius, J.R.4
  • 46
    • 0029799791 scopus 로고    scopus 로고
    • A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: Polyethylenimine
    • Abdallah B, Hassan A, Benoist C, Goula D, Behr JP and Demeneix BA (1996) A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Human Gene Ther. 7: 1947-1954
    • (1996) Human Gene Ther. , vol.7 , pp. 1947-1954
    • Abdallah, B.1    Hassan, A.2    Benoist, C.3    Goula, D.4    Behr, J.P.5    Demeneix, B.A.6
  • 47
    • 0027294922 scopus 로고
    • Flunarizine enhances rat retinal ganglion cell survival after axotomy
    • Eschweiler GW and Bähr M (1993) Flunarizine enhances rat retinal ganglion cell survival after axotomy. J. Neural. Sci. 116: 34-40
    • (1993) J. Neural. Sci. , vol.116 , pp. 34-40
    • Eschweiler, G.W.1    Bähr, M.2


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