Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery

Investigative Ophthalmology and Visual Science

Volumn 38, Issue 11, 1997, Pages 2224-2233

  Hoffman, Lisa M ^a   Maguire, Albert M ^a   Bennett, Jean ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Adenovirus; CTLA4; Gene therapy; Immune privilege; Mice

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; IMMUNOGLOBULIN G;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TRANSFER; GENETIC STABILITY; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; TRANSGENE;

ADENOVIRIDAE; ANIMALS; ANTERIOR EYE SEGMENT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; BETA-GALACTOSIDASE; CYTOMEGALOVIRUS; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HISTOCYTOCHEMISTRY; IMMUNITY, CELLULAR; IMMUNOCONJUGATES; IMMUNOENZYME TECHNIQUES; IMMUNOGLOBULIN G; IMMUNOSUPPRESSIVE AGENTS; LAC OPERON; MICE; MICE, MUTANT STRAINS; RETINA; T-LYMPHOCYTES; TRANSGENES;

EID: 0030874508     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Kay MA. Hepatic gene therapy: Persistent expression of human alpha 1-antitrypsin in mice after direct gene delivery in vivo. Hum Gene Ther. 1992;3:641-647.
2. Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA. 1994;91:6196-6200.
3. Kozarsky KF, Jooss K, Donahee M, Strauss JF, Wilson JM. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nat Genet. 1996; 10:54-62.
4. Engelhardt JF, Yang Y, Stratford-Perricaudet LD, et al. Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with El-deleted adenoviruses. Nat Genet. 1993;4:27-34.
5. Simon RH, Engelhardt JF, Yang Y, et al. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Toxicity study. Hum Gene Ther. 1993;4: 771-780.
6. Akli S, Caillaud C, Vigne E, et al. Transfer of a foreign gene into the brain using adenovirus vectors. Nat Genet. 1993;3:224-228.
7. Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nat Genet. 1993;3:219-223.
8. Kaplitt MG, Leone R, Samulski RJ, et al. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet. 1994;8:148-154.
9. Setoguchi Y, Jaffe HA, Danel C, Crystal RG. Ex vivo and in vivo gene transfer to the skin using replication-deficient recombinant adenovirus. J Invest Dermatol. 1994;102:415-421.
10. Ragot T, Vincent N, Chafey P, et al. Efficient adenovirus-mediated transfer of a human minidystrophin gene to skeletal muscle of max mice. Nature. 1993; 361:647-650.
11. Bennett J, Wilson J, Sun D, Forbes B, Maguire A. Adenovirus vector-mediated in vivo gene transfer into adult murine retina. Invest Ophthalmol Vis Sci. 1994; 35:2535-2542.
12. Li T, Adamian M, Roof DJ, et al. In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector. Invest Ophthalmol Vis Sci. 1994;35:2543-2549.
13. Bennett J, Tanabe T, Sun D, et al. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy. Nat Med. 1996;2:649-654.
14. Yang Y, Nunes FA, Berencsi K, Furth EE, Gonczol E, Wilson JM. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA. 1994;91:4407-4411.
15. Yang Y, Ertl HCJ, Wilson JM. MHC Class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses. Immunity. 1994;1:433-442.
16. Tripathy SK, Black HB, Goldwasser E, Leiden JM. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nat Med. 1996; 2:545-550.
17. Barr D. Strain related variations in adenovirally mediated transgene expression in mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains. Gene Therapy 1995; 2:151-155.
18. Jiang LQ, Jorquera M, Streilein JW. Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Invest Ophthalmol Vis Sci. 1993;34: 3347-3354.
19. Ar'Rajab A, Davidson IJ, Harris RB, Sentementes JT. Immune privilege of the testis for islet xenotransplantation (rat to mouse). Cell Transplant. 1994;3:493-498.
20. Yang Y, Li Q, Ertl HC, Wilson JM. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J Virol. 1995;69:2004-2015.
21. Atherton SS, Pesicka GA, Streilein JW. Retinitis and deviant immune responses following intravitreal inoculation of HSV-1. Invest Ophthalmol Vis Sci. 1987;28: 859-866.
22. Niederkorn JY, Streilein JW. Intracamerally induced concomitant immunity. J Immunol. 1983;131:2587-2594.
23. Jiang LQ, Jorquera M, Streilein JW. Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Invest Ophthalmol Vis Sci. 1993;34: 3347-3354.
24. Budenz D, Bennett J, Alonso L, Maguire A. In vivo gene transfer into murine trabecular meshwork and corneal endothelial cells. Invest Ophthalmol Vis Sci. 1995;36:2211-2215.
25. Linsley PS, Wallace PM, Johnson J el al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science. 1992;257:792-795.
26. Kay MA, Holterman A-X, Meuse L, et al. Long-term hepatic adenovirus-mediated gene expression in mice following CTLA4Ig administration. Nat Genet. 1995; 11:191-197.
27. Bennett J, Pakola S, Zeng Y, Maguire AM. Humoral response after administration of E1-deleted adenoviruses: Immune privilege of the subretinal space. Hum Gene Ther. 1996;7:1763-1769.
28. Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science. 1995;270:1189-1192.