Treatment of severe ocular-surface disorders with corneal epithelial stem-cell transplantation

New England Journal of Medicine

Volumn 340, Issue 22, 1999, Pages 1697-1703

  Tsubota, Kazuo ^a,b   Satake, Yoshiyuki ^a   Kaido, Minako ^a   Shinozaki, Naoshi ^a   Shimmura, Shigeto ^a,b   Bissen Miyajima, Hiroko ^a,b   Shimazaki, Jun ^a  

^a TOKYO DENTAL COLLEGE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETAMETHASONE; CYCLOSPORIN A; DEXAMETHASONE; HYALEIN; HYALURONIC ACID; SANBETAZONE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLINDNESS; CLINICAL ARTICLE; CORNEA EDEMA; CORNEA EPITHELIUM; DRUG EFFICACY; DRUG SAFETY; FEMALE; GRAFT REJECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; STEM CELL TRANSPLANTATION; SURGICAL TECHNIQUE; VISUAL ACUITY;

ADULT; CELL TRANSPLANTATION; CORNEAL DISEASES; CORNEAL TRANSPLANTATION; EPITHELIUM, CORNEAL; EYE INJURIES; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSION; MALE; MIDDLE AGED; POSTOPERATIVE CARE; POSTOPERATIVE COMPLICATIONS; STEM CELL TRANSPLANTATION; TREATMENT FAILURE; VISUAL ACUITY;

EID: 0033519715     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199906033402201     Document Type: Article

References (19)

1. Puangsricharern V, Tseng S. Cytologic evidence of corneal diseases with limbal stem cell deficiency. Ophthalmology 1995;102:1476-85.
2. Kenyon KR, Tseng SC. Limbal autograft transplantation for ocular surface disorders. Ophthalmology 1989;96:709-22.
3. Tsai R, Tseng S. Human allograft limbal transplantation for corneal surface reconstruction. Cornea 1994;13:389-400.
4. Pfister R. Corneal stem cell disease: concepts, categorization, and treatment by auto- and homotransplantation of limbal stem cells. CLAO J 1994;20:64-72.
5. Tsubota K, Toda I, Saito H, Shinozaki N, Shimazaki J. Reconstruction of the corneal epithelium by limbal allograft transplantation for severe ocular surface disorders. Ophthalmology 1995;102:1486-96.
6. Kin JC, Tseng SC. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 1995;14:473-84.
7. Tsubota K, Satake Y, Ohyama M, et al. Surgical reconstruction of the ocular surface in advanced ocular cicatricial pemphigoid and Stevens-Johnson syndrome. Am J Ophthalmol 1996;122:38-52.
8. Tsubota K, Satake Y, Shimazaki J. Treatment of severe dry eye. Lancet 1996;348:123.
9. Holland EJ, Schwartz GS. The evolution of epithelial transplantation for severe ocular surface disease and a proposed classification system. Cornea 1996;15:549-56.
10. Swift GJ, Aggarwal RK, Davis GJ, Coster DJ, Williams KA. Survival of rabbit limbal stem cell allografts. Transplantation 1996;62:568-74.
11. Williams KA, Brereton HM, Aggarwal R, et al. Use of DNA polymorphisms and the polymerase chain reaction to examine the survival of a human limbal stem cell allograft. Am J Ophthalmol 1995;120:342-50.
12. Kinoshita S, Kiritoshi A, Ohji M, Ohashi Y, Manabe R. Disappearance of palisades of Vogt in ocular surface diseases. Jpn J Clin Ophthalmol 1986; 40:363-6.
13. Shimazaki J, Yang HY, Tsubota K. Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns. Ophthalmology 1997;104:2068-76.
14. Tsubota K, Goto E, Fujita H, et al. Treatment of dry eye by autologous serum application in Sjögren's syndrome. Br J Ophthalmol 1999;83:390-5.
15. Tsubota K, Yamada M, Urayama K. Spectacle side panels and moist inserts for the treatment of dry-eye patients. Cornea 1994;13:197-201.
16. Kinoshita S, Friend J, Thoft RA. Sex chromatin of donor corneal epithelium in rabbits. Invest Ophthalmol Vis Sci 1981;21:434-41.
17. Dohlman CH. On the fate of the corneal graft. Acta Ophthalmol 1957;35:286-302.
18. Beck RW, Cleary PA, Anderson MM Jr, et al. A randomized, controlled trial of corticosteroids in the treatment of acute optic neuritis. N Engl J Med 1992;326:581-8.
19. Shimazaki J, Kaido M, Shinozaki N, et al. Long term survival of the donor-derived cells after limbal allograft transplantation: implications of stem cell transplantation of the corneal epithelium. Invest Ophthalmol Vis Sci (in press).