An automated method of sample preparation of biofluids using pierceable caps to eliminate the uncapping of the sample tubes during sample transfer

Journal of Biochemical and Biophysical Methods

Volumn 45, Issue 2, 2000, Pages 193-204

  Teitz, Deborah S ^a   Khan, Sanaullah ^a   Powell, Mark L ^a   Jemal, Mohammed ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

Automated sample transfer; LC MS MS; Liquid liquid extraction; Pierceable caps; Sample preparation

Indexed keywords

TERT BUTYL METHYL ETHER;

ARTICLE; AUTOANALYSIS; BODY FLUID; CLINICAL CHEMISTRY; LIQUID LIQUID EXTRACTION; PLASMA; PRIORITY JOURNAL; ROBOTICS; SAMPLING; TECHNIQUE;

BLOOD CHEMICAL ANALYSIS; BODY FLUIDS; CHEMISTRY, ANALYTICAL; CHROMATOGRAPHY, LIQUID; HUMANS; QUALITY CONTROL; ROBOTICS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0034638155     PISSN: 0165022X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-022X(00)00117-2     Document Type: Article

References (11)

1. Jemal M., Xia Y.-Q., Whigan D.B. The use of high-flow high performance liquid chromatography coupled with positive and negative ion electrospray tandem mass spectrometry for quantitative bioanalysis via direct injection of the plasma/serum samples. Rapid Commun. Mass Spectrom. 12:1998;1389-1399.
2. Jemal M., Ouyang Z., Xia Y.-Q., Powell M.L. A versatile system of high-flow high performance liquid chromatography with tandem mass spectrometry for rapid direct-injection analysis of plasma samples for quantitation of a β-lactam drug candidate and its open-ring biotransformation product. Rapid Commun. Mass Spectrom. 13:1999;1462-1471.
3. Studt T. Solving the sample prep bottleneck. Drug Discovery and Development 1999;20-22.
4. Jordan L. Sample preparation perspectives. LC-GC. 11:1993;634-638.
5. Chen X.-H., Franke J.-P., Ensing K., Wijsbeek J., de Zeeuw R.A. Pitfalls and solutions in the development of a fully automated solid-phase extraction method for drug screening purposes in plasma and whole blood. J. Anal. Toxico. 17:1993;421-426.
6. Parker T.D., Wright D.S., Rossi D.T. Design and evaluation of an automated solid-phase extraction method development system for use with biological fluids. Anal. Chem. 68:1996;2437-2441.
7. Allanson J.P., Biddlecombe R.A., Jones A.E., Pleasance S. The use of automated solid phase extraction in the '96 well' format for high throughput bioanalysis using liquid chromatography coupled to tandem mass spectrometry. Rapid Commun. Mass Spectrom. 10:1996;811-816.
8. Plump R.S., Gray R.D.M., Jones C.M. Use of reduced sorbent bed and disk membrane solid-phase extraction for the analysis of pharmaceutical compounds in biological fluids, with applications in the 96-well format. J. Chromatogr. B. 694:1997;123-133.
9. Janiszewski J., Schneider R.P., Hoffmaster K., Swyden M., Wells D., Fouda H. Automated sample preparation using membrane microtiter extraction for bioanalytical mass spectrometry. Rapid Commun. Mass Spectrom. 11:1997;1033-1037.
10. Simpson H., Berthemy A., Buhrman D., Burton R., Newton J., Kealy M., Wells D., Wu D. High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation. Rapid Commun. Mass Spectrom. 12:1998;75-82.
11. Steinborner S., Henion J. Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma. Anal. Chem. 71:1999;2340-2345.