A versatile system of high-flow high performance liquid chromatography with tandem mass spectrometry for rapid direct-injection analysis of plasma samples for quantitation of a β-lactam drug candidate and its open-ring biotransformation product

Rapid Communications in Mass Spectrometry

Volumn 13, Issue 14, 1999, Pages 1462-1471

  Jemal, Mohammed ^a   Ouyang, Zheng ^a   Xia, Yuan Qing ^a   Powell, Mark L ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIRECT INJECTION; DRUG PRODUCTS; EFFLUENTS; FORMIC ACID; MASS SPECTROMETERS; MASS SPECTROMETRY; PURIFICATION; QUALITY CONTROL;

ANALYTICAL COLUMNS; BIOANALYTICAL METHODS; BIOTRANSFORMATION PRODUCT; DIRECT INJECTION ANALYSIS; DRUG CANDIDATES; HIGH FLOW; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY WITH TANDEM MASS SPECTROMETRY (LCMS/MS); PLASMA SAMPLES; VERSATILE SYSTEM;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0032798341     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0231(19990730)13:14<1462::AID-RCM668>3.0.CO;2-Z     Document Type: Article

References (6)

1. H. M. Quin and J. J. Takarewski, International Patent Number WO97/16724.
2. Brochure on the 2300 HTLC System from Cohesive Technologies, Inc, PB#105928.
3. J. Ayrton, G. J. Dear, W. J. Leavens, D. N. Mallet and R. S. Plumb, Rapid Commun. Mass Spectrom. 11, 1953 (1997).
4. M. Jemal, Y. Q. Xia and D. B. Whigan, Rapid Commun. Mass Spectrom. 12, 1389 (1998).
5. I. Fu, E. J. Woolf and B. K. Matuszewski, J. Pharm. Biomed. Anal. 18, 347 (1998).
6. M. Jemal and Y. Q. Xia, Rapid Commun. Mass Spectrom. 13, 97 (1999).