Ultra-high flow rate capillary liquid chromatography with mass spectrometric detection for the direct analysis of pharmaceuticals in plasma at sub-nanogram per millilitre concentrations

Rapid Communications in Mass Spectrometry

Volumn 13, Issue 16, 1999, Pages 1657-1662

  Ayrton, J ^a   Clare, R A ^a   Dear, G J ^a   Mallett, D N ^a   Plumb, R S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; FLOW RATE; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; PARTICLE SIZE ANALYSIS;

CAPILLARY LIQUID CHROMATOGRAPHY; CAPILLARY SCALE; DIRECT ANALYSIS; LARGER PARTICLE SIZES; MASS SPECTROMETRIC DETECTION; NANOGRAMS; SAMPLE PREPARATION; STATIONARY PHASE; TANDEM-MASS SPECTROMETRY; ULTRA-HIGH FLOW RATES;

PARTICLE SIZE;

EID: 0032777586     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0231(19990830)13:16<1657::AID-RCM694>3.0.CO;2-L     Document Type: Article

References (12)

1. D. F. Hagen, C. G. Markell and G. A. Schmitt, Anal. Chim. Acta 236, 157 (1990).
2. G. Theodoris, I. Papdoyannis, H. Tsoukali-Papadopoulou and G. Vasilikiotis J. Liq. Chromatogr. 18, 1973 (1995).
3. C. Stubbs, M. F. Skinner and I. Kanfer, Chromatographia 29, 31 (1990).
4. C. Chang-yun, L. Hsu and R. R. Walters, J. Liq. Chromatogr. 629, 61 (1993).
5. G. D. Bowers, C. P. Clegg, S. C. Hughes, A. J. Harker and S. Lambert, LC-GC 15, 48 (1997).
6. H. M. Quin and J. J. Takarewski Int. Patent Number WO 97/16724 (1997).
7. J. Ayrton, G. J. Dear, W. J. Leavens, D. N. Mallett and R. S. Plumb, Rapid Commun. Mass Spectrom. 11, 1953 (1997).
8. J. Ayrton, G. J. Dear, W. J. Leavens, D. N. Mallett and R. S. Plumb, J. Chromatogr. A 828, 199 (1998).
9. M. Jemal, Y.-Q. Xia and D. B. Whigan, Rapid Commun. Mass Spectrom. 12, 1389 (1998).
10. D. Zimmer, V. Pickard, W. Czembor and C. Müller, J. Chromatogr. A in press.
11. M. Jemal and Y.-Q. Xia, Rapid Commun. Mass Spectrom. 13, 97 (1999).
12. J. Ayrton, G. J. Dear, W. J. Leavens, D. N. Mallett and R. S. Plumb, J. Chromatogr. B 709, 243 (1998).