Secretion of osteopontin by macrophages and its accumulation at tissue surfaces during wound healing in mineralized tissues: A potential requirement for macrophage adhesion and phagocytosis

Anatomical Record

Volumn 245, Issue 2, 1996, Pages 394-409

  Mckee, M D ^a   Nanci, A ^a  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Bone; Cell adhesion; Dentin; Enamel; Immunocytochemistry; Macrophage; Osteopontin; Phagocytosis; Tooth; Ultrastructure; Wound repair

Indexed keywords

ACID PROTEIN; AMELOGENIN; COLLOIDAL GOLD; FIBRONECTIN; INTEGRIN; OSTEOCALCIN; OSTEOPONTIN; SIALOPROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CONTROLLED STUDY; CYTOSKELETON; DENTIN; ELECTRON MICROSCOPY; ENAMEL; EXTRACELLULAR MATRIX; GOLGI COMPLEX; IMMUNOCYTOCHEMISTRY; MACROPHAGE; MALE; MANDIBLE; MINERALIZATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SECRETORY GRANULE; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; WOUND HEALING;

AMELOGENIN; ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CELL ADHESION; DENTAL ENAMEL PROTEINS; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MALE; MICROSCOPY, ELECTRON; OSTEOPONTIN; PHAGOCYTOSIS; PROTEINS; RATS; RATS, WISTAR; SIALOGLYCOPROTEINS; TOOTH; TOOTH GERM; WOUND HEALING;

ANIMALIA;

EID: 0030029816     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0185(199606)245:2<394::AID-AR19>3.0.CO;2-K     Document Type: Article

References (112)

1. Aggeler, J., and Z. Werb 1982 Initial events during phagocytosis by macrophages viewed from outside and inside the cell: Membrane-particle interactions and clathrin. J. Cell Biol., 94:613-623.
2. Arnaout, M.A. 1990 Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood, 75:1037-1050.
3. Aubin, J.E., K. Turksen, and J.N.M. Heersche 1993 Osteoblastic cell lineage. In: Cellular and Molecular Biology of Bone. M. Noda, ed. Academic Press, San Diego, pp. 1-45.
4. Bendayan, M. 1995 Colloidal gold post-embedding immunocytochemistry. Prog. Histochem. Cytochem. 29:1-159.
5. Beninati, S., D.R. Senger, E. Cordella-Miele, A.B. Mukherjee, I. Chackalaparampil, V. Shanmugam, K. Singh, and B.B. Mukherjee 1994 Osteopontin: Its transglutaminase-catalyzed posttranslational modifications and cross-linking to fibronectin. J. Biochem., 115:675-682.
6. Beuth, J., and G. Uhlenbruck 1995 Adhesive properties of bacteria. In: Principles of Cell Adhesion. P.D. Richardson and M. Steiner, eds. CRC Press, Boca Raton, FL, pp. 87-105.
7. Bevilacqua, M.P., D. Amrani, M.W. Mosesson, and C. Bianco 1981 Receptors for cold-insoluble globulin (plasma fibronectin) on human monocytes. J. Exp. Med., 153:42.
8. 1. J. Cell Biol., 127:1129-1137.
9. Boakey, A.L. 1995 Osteopontin and related phosphorylated sialoproteins: Effects on mineralization. Ann. N.Y. Acad. Sci., 760:249-256.
10. Boskey, A.L., M. Maresca, W. Ullrich, S.B. Doty, W.T. Butler, and C.W. Prince 1993 Osteopontin-hydroxyapatite interactions in vitro: Inhibition of hydroxyapatite formation and growth in a gelatin-gel. Bone Miner., 22:147-159.
11. Brown, L.F., B. Berse, L. Van De Water, A. Papadopoulos-Sergiou, C.A. Perruzzi, E.J. Manseau, H.F. Dvorak, and D.R. Senger 1992 Expression and distribution of Osteopontin in human tissues: Widespread association with luminal epithelial surfaces. Mol. Biol. Cell, 3:1169-1180.
12. Butler, W.T. 1991 Sialoproteins of bone and dentin. J. Biol. Buccale, 19:83-89.
13. Butler, W.T. 1995 Structure and functional domains of osteopontin. Ann. N.Y. Acad. Sci., 760:6-11.
14. Chambers, A.F. 1995 Regulation and function of Osteopontin in ras-transformed cells. Ann. N.Y. Acad. Sci., 760:101-108.
15. Chen, Y., B.S. Bal, and J.P. Gorski 1992 Calcium and collagen binding properties of Osteopontin, bone sialoprotein, and bone acidic glycoprotein-75 from bone. J. Biol. Chem. 267:24871-24878.
16. Church, D.B., and K.J. Schlegel 1985 Immune deficiency disorders. In: Immunology III. J.A. Bellanti, ed. W.B. Saunders, Philadelphia, pp. 471-498.
17. Couchman, J.R., and A. Woods 1995 Transmembrane signaling generated by cell-extracellular matrix interactions. Kidney Int., (Suppl. 47) 49:S8-S11.
18. Crocker, P.R., S. Kelm, C. Dubois, B. Martin, A.S. McWilliam, D.M. Shotton, J.C. Paulson, and S. Gordon 1991 Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages. EMBO J., 10:1661-1669.
19. Denhardt, D.T., and A.F. Chambers 1994 Overcoming obstacles to metastasis - Defenses against host defenses: Osteopontin (OPN) as a shield against attack by cytotoxic host cells. J. Cell. Biochem., 56:48-51.
20. Denhardt, D.T., and X. Guo 1993 Osteopontin: A protein with diverse functions. FASEB J., 7:1475-1482.
21. Doran, J.E., A.R. Mansberger, and A.C. Reese 1980 Cold insoluble globulin-enhanced phagocytosis of gelatinized targets by macrophage monolayers: A model system. J. Reticuloendothel. Soc., 27: 471.
22. Fadok, V.A., J.S. Savill, C. Haslett, D.L. Bratton, D.E. Doherty, P.A. Campbell, and P.M. Henson 1992 Different populations of macrophages use either the vitronectin receptor or the phosphotidylserine receptor to recognize and remove apoptotic cells. J. Immunol., 149:4029-4035.
23. 1: Regulation of the functional response by soluble fibronectin. J. Cell Biol., 121:155-162.
24. Fearon, D.T. and K.F. Austen 1980 The alternative pathway of complement: A system for host resistance to microbial infection. N. Engl. J. Med., 303:259-263.
25. Fisher, L.W., J.T. Stubbs, and M.F. Young 1995 Antisera and cDNA probes to human and certain animal model bone matrix noncollagenous proteins. Acta Orthop. Scand., 266(Suppl.):1-5.
26. Fitzpatrick, L.A., A. Severson, W.D. Edwards, and R.T. Ingram 1994 Diffuse calcification in human coronary arteries. Association of osteopontin with atherosclerosis. J. Clin. Invest., 94:1597-1604.
27. Giachelli, C.M., N. Bae, M. Almeida, D.T. Denhardt, C.E. Alpers, and S.M. Schwarte 1993 Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J. Clin. Invest., 92:1686-1696.
28. Giachelli, C.M., S.M. Schwartz, and L. Liaw 1995 Molecular and cellular biology of osteopontin: Potential role in cardiovascular disease. Trends Cardiovasc. Med., 5:88-95.
29. Gorski, J.P. 1992 Acidic phosphoproteins from bone matrix: A structural rationalization of their role in biomineralization. Calcif. Tissue Int., 50:391-396.
30. Gorski, J.P., D. Griffin, G. Dudley, C. Stanford, R. Thomas, C. Huang, E. Lai, B. Karr, and M. Solursh 1990 Bone acidic glycoprotein-75 is a major synthetic product of osteoblastic cells and localized as 75- and/or 50-kDa forms in mineralized phases of bone and growth plate and in serum. J. Biol. Chem., 265:14956-14963.
31. Gorski, J.P., E. Kremer, J. Ruiz-Perez, G.E. Wise, and A. Artigues 1995 Conformational analyses on soluble and surface bound osteopontin. Ann. N.Y. Acad. Sci., 760:12-23.
32. Griffin, F.M.J., J.A. Griffin, J.E. Leider, and S.C. Silverstein 1975 Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane. J. Exp. Med., 142:1263-1282.
33. Griffin, F.M.J., J.A. Griffin, and S.C. Silverstein 1976 Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgG-coated bone marrow-derived lymphocytes. J. Exp. Med., 144:788-809.
34. Groot, C.G., J.K. Danes, J. Blok, A. Hoogendijk, and P.V. Hauschka 1986 Light and electron microscopic demonstration of osteocalcin antigenicity in embryonic and adult rat bone. Bone, 7:379-385.
35. Hartwig, J.H., H.L. Yin, and T.P. Stossel 1980 Contractile proteins and the mechanism of phagocytosis in macrophages. In: Mononuclear Phagocytes. Functional Aspects, Part II. R. van Furth, ed. Martinus Nijhoff, The Hague, pp. 971-996.
36. 3 integrin. J. Bone Miner. Res., 7:335-343.
37. Hill, H.R., N.H. Augustine, P.A. Williams, E.J. Brown, and J.F. Bohnsack 1993 Mechanism of fibronectin enhancement of group B streptococcal phagocytosis by human neutrophils and culture-derived macrophages. Cell, 61:2334-2339.
38. Hirota, S., M. Imakita, K. Kohri, A. Ito, E. Morii, S. Adachi, H.-M. Kim, Y. Kitamura, C. Yutani, and S. Nomura 1993 Expression of osteopontin messenger RNA by macrophages in atherosclerotic plaques: A possible association with calcification. Am. J. Pathol., 143:1003-1008.
39. Hirota, S., A. Ito, J. Nagoshi, M. Takeda, A. Kurata, Y. Takatsuka, K. Kohri, S. Nomura, and Y. Kitamura 1995 Expression of bone matrix protein messenger ribonucleic acids in human breast cancers: Possible involvement of osteopontin in development of calcifying foci. Lab. Invest., 72:64-69.
40. Horton, M.A. 1995 Interactions of connective tissue cells with the extracellular matrix. Bone, 17(Suppl.):51S-53S.
41. Hoyer, J.R. 1994 Uropontin in urinary calcium stone formation. Miner. Electrolyte Metab., 20:385-392.
42. Hruska, K.A., F. Rolnick, R.L. Duncan, M. Medhora, and K. Yamakawa 1993 Signal transduction in osteoblasts and osteoclasts. In: Cellular and Molecular Biology of Bone. M. Noda, ed. Academic Press, San Diego, pp. 413-444.
43. Hruska, K.A., M. Chellaiah, F. Rolnick, K. Yamakawa, and A. Gupta 1995 Recent progress in signal transduction related to bone remodeling and aging. Calcif. Tissue Int., 56(Suppl. 1):S35-S38.
44. 3 and αvβ5 on human monocytes and T lymphocytes facilitates adenovirus-mediated gene delivery. J. Virol., 69:2257-2263.
45. Hunter, G.K., C.L. Kyle, and H.A. Goldberg 1994 Modulation of crystal formation by bone phosphoproteins: Structural specificity of the osteopontin-mediated inhibition of hydroxyapatite formation. Biochem. J., 300:723-728.
46. Hynes, R.O. 1992 Integrins: Versatility, modulation, and signaling in cell adhesion. Cell, 69:11-25.
47. Ikeda, T., T. Shirasawa, Y. Esaki, S. Yoshiki, and K. Hirokawa 1993 Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta. J. Clin. Invest., 92:2814-2820.
48. Isberg, R.R. and J.M. Leong 1990 Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell, 60:861-871.
49. Isberg, R.R., and G. Tran Van Nhieu 1994 Binding and internalization of microorganisms by integrin receptors. Trends Microbiol., 2:10-14.
50. Ishibashi, Y., S. Claus, and D.A. Relman 1994 Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18). J. Exp. Med., 180:1225-1233.
51. Jaconi, M.E.E., J.M. Theler, W. Schlegel, R.D. Appel, S.D. Wright, and P.D. Lew 1991 Multiple elevations of cytosolic-free calcium in human neutrophils: Initiation by adherence receptors of the integrin family. J. Cell Biol., 112:1249-1257.
52. Kawaguchi, H., M.D. McKee, H. Okamoto, and A. Nanci 1993 Tissue response to hydroxyapatite implanted in an alveolar bone defect: Immunocytochemical and lectin-gold characterization of the hydroxyapatite-bone interface. Cells Mater., 3:337-350.
53. Kido, J., C. Kasahara, K. Ohishi, S. Nishikawa, H. Ishida, K. Yamashita, S. Kitamura, K. Kohri, and T. Nagata 1995 Identification of osteopontin in human dental calculus matrix. Arch. Oral Biol., 40:967-972.
54. Kohri, K., S. Nomura, Y. Kitamura, T. Nagata, K. Yoshioka, M. Iguchi, T. Yamate, T. Umekawa, Y. Suzuki, H. Sinohara, and T. Kurita 1993 Structure and expression of the mRNA encoding urinary stone protein (osteopontin). J. Biol. Chem., 268:15180-15184.
55. 3 in smooth muscle cell migration to osteopontin in vitro. J. Clin. Invest., 95:713-724.
56. Lipscomb, M.F., J.M. Onofrio, E.J. Nash, A.K. Pierce, and G.B. Toews 1983 Morphological study of the role of phagocytes in the clearance of Staphylococcus aureus from the lung. J. Reticuloendothel. Soc., 33:429-442.
57. Marquette, D., J. Molnar, K. Yamada, D. Schlesinger, S. Darby, and P. Van Alten 1981 Phagocytosis promoting activity of avian plasma and fibroblastic cell surface fibronectins. Mol. Cell. Biochem., 36:147.
58. McKee, M.D., and H. Warshawsky 1984 In vivo experimentation on rat incisor enamel organs through a surgical window. Anat. Rec., 210:693-705.
59. McKee, M.D., and H. Warshawsky 1986 Response of the rat incisor dental tissues to penetration of the labial alveolar bone in preparation of a surgical window. J. Biol. Buccale, 14:39-51.
60. McKee, M.D., and A. Nanci 1993 Ultrastructural, cytochemical and immunocytochemical studies on bone and its interfaces. Cells Mater., 3:219-243.
61. McKee, M.D., and A. Nanci 1995a Osteopontin and the bone remodeling sequence: Colloidal-gold immunocytochemistry of an interfacial extracellular matrix protein. Ann. N.Y. Acad. Sci., 760: 177-189.
62. McKee, M.D., and A. Nanci 1995b Post-embedding colloidal-gold immunocytochemistry of non-collagenous extracellular matrix proteins in mineralized tissues. Microsc. Res. Tech., 31:44-62.
63. McKee, M.D., and A. Nanci 1996a Osteopontin: An interfacial extracellular matrix protein in mineralized tissues. Connect. Tissue Res. (in press).
64. McKee, M.D., and A. Nanci 1996b Osteopontin at mineralized tissue interfaces in bone, teeth and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover and repair. Microsc. Res. Tech., 33:141-164.
65. McKee, M.D., M.J. Glimcher, and A. Nanci 1992 High-resolution immunolocalization of osteopontin and osteocalcin in bone and cartilage during endochondral ossification in the chicken tibia. Anat. Rec., 234:479-492.
66. 2HS-glycoprotein) proteins in rat bone. J. Bone Miner. Res., 8:485-496.
67. McKee, M.D., A. Nanci, and S.R. Khan 1995 Ultrastructural immunodetection of osteopontin and osteocalcin as major matrix components of renal calculi. J. Bone Miner. Res., 10:1913-1929.
68. Miyazaki, Y., M. Setoguchi, S. Yoshida, Y. Higuchi, S. Akizuki, and S. Yamamoto 1990 The mouse osteopontin gene: Expression in monocytic lineages and complete nucleotide sequence. J. Biol. Chem., 265:14432.
69. 2HS-glycoprotein. Bone Miner., 13:1-21.
70. Murry, C.E., C.M. Giachelli, S.M. Schwartz, and R. Vracko 1994 Macrophages express osteopontin during repair of myocardial necrosis. Am. J. Pathol., 145:1450-1462.
71. Nanci, A., H.C. Slavkin, and C.E. Smith 1987 Application of high-resolution immunocytochemistry to the study of the secretory, resorptive, and degradative functions of ameloblasts. Adv. Dent. Res., 1:148-161.
72. Nanci, A., G.F. McCarthy, C. Clokie, H. Warshawsky, S. Zalzal, and M.D. McKee 1994 Tissue response to titanium implants in the rat tibia: Ultrastructural, immunocytochemical and lectin-cytochemical characterization of the bone-titanium interface. Cells Mater., 4:1-30.
73. Nanci, A., J. Hashimoto, S. Zalzal, and C.E. Smith 1996a Transient accumulation of phosphorylated and short-lived glycosylated enamel proteins at interrod and rod growth sites. Adv. Dent. Res. (in press).
74. Nanci, A., S. Zalzal, Y. Gotoh, and M.D. McKee 1996b Ultrastructural and immunocytochemical characterization of cultured primary rat calvarial osteoblasts. Microsc Res. Tech., 33:214-231.
75. Nasu, K., T. Ishida, M. Setoguchi, Y. Higuchi, S. Akizuki, and S. Yamamoto 1995 Expression of wild-type and mutated rabbit osteopontin in Escherichia coli, and their effects on adhesion and migration of P388D1 cells. Biochem. J., 307:257-265.
76. Ng-Sikorski, J., R. Andersson, M. Patarroyo, and T. Andersson 1991 Calcium signaling capacity of the CD11b/CD18 integrin on human neutrophils. Exp. Cell Res., 195:504-508.
77. North, R.J. 1968 The uptake of particulate antigens. J. Reticuloendothel. Soc., 5:203-229.
78. O'Brien, E.R., M.R. Garvin, D.K. Stewart, T. Hinohara, J.B. Simpson, S.M. Schwartz, and C.M. Giachelli 1994 Osteopontin is synthesized by macrophage, smooth muscle, and endothelial cells in primary and restenotic human coronary atherosclerotic plaques. Arterioscler. Thromb., 14:1648-1656.
79. Osdoby, P., M. Krukowski, and P. Collin-Osdoby 1992 Experimental systems for studying osteoclast biology. In: Biology and Physiology of the Osteoclast. B.R. Rifkin and C.V. Gay, eds. CRC Press, Boca Raton, FL, pp. 1-32.
80. Pacifia, R., J. Roman, R. Kimble, R. Civitelli, C.M. Brownfield, and C. Bizzarri 1994 Ligand binding to monocyte α5β1 integrin activates the α2β1 receptor via the α5 subunit cytoplasmic domain and protein kinase C. J. Immunol., 153:2222-2233.
81. Patarca, R., G.J. Freeman, R.P. Singh, F.Y. Wei, T. Durfee, F. Blattner, D.C. Regnier, C.A. Kozak, B.A. Mock, H.C. Morse, T.R. Jerrells, and H. Cantor 1989 Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. J. Exp. Med., 170: 145-161.
82. Patarca, R., R. A. Saavedra, and H. Cantor 1993 Molecular and cellular basis of genetic resistance to bacterial infection: The role of the early T-lymphocyte activation-1/osteopontin gene. Crit. Rev. Immunol., 13:225-246.
83. Pichler, R., C. Giachelli, B. Young, C.E. Alpers, W.G. Couser, and R.J. Johnson 1995 The pathogenesis of tubulointerstitial disease associated with glomerulonephritis: The glomerular cytokine theory. Miner. Electrolyte Metab., 21:317-327.
84. Pommier, C.G., S. Inada, L.F. Fries, T. Takahashi, M.M. Frank, and EJ. Brown 1983 Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes. J. Exp. Med., 157:1844-1854.
85. Prince, C.W., D. Dickie, and C.L. Krumdieck 1991 Osteopontin, a substrate for transglutaminase and factor XIII activity. Biochem. Biophys. Res. Commun., 177:1205-1210.
86. Rabinovitch, M. 1970 Phagocytic recognition. In: Mononuclear Phagocytes. R. van Furth, ed. Blackwell Scientific, Oxford, pp. 219-313.
87. Rabinovitch, M. 1995 Professional and non-professional phagocytes: An introduction. Trends Cell Biol., 5:85-88.
88. Reinholt, F.P., K. Hultenby, Å. Oldberg, and D. Heinegård 1990 Osteopontin: A possible anchor of osteoclasts to bone. Proc. Natl. Acad. Sci. U.S.A., 87:4473-4475.
89. Ritter, N.M., M.C. Farach-Carson, and W.T. Butler 1992 Evidence for the formation of a complex between osteopontin and osteocalcin. J. Bone Miner. Res., 7:877-885.
90. 3 potentiate bone resorption. J. Biol. Chem., 268:9901-9907.
91. Savill, J., I. Dransfield, N. Hogg, and C. Haslett 1990 Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature, 343:170-173.
92. Senger, D.R., C.A. Perruzzi, C.F. Gracey, A. Papadopoulos, and D.G. Tenen 1988 Secreted phosphoproteins associated with neoplastic transformation: Close homology with plasma proteins cleaved during blood coagulation. Cancer Res., 48:5770-5774.
93. Senger, D.R., L.F. Brown, C.A. Perruzzi, A. Papadopoulos-Sergiou, and L. Van De Water 1995 Osteopontin at the tumor/host interface: Functional regulation by thrombin-cleavage and consequences for cell adhesion. Ann. N.Y. Acad. Sci., 760:83-100.
94. Shakibaei, M., B. Zimmermann, and M. Scheller 1993 Endocytosis of integrin α5β1 (fibronectin receptor) of mouse peritoneal macrophages in vitro: An immunoelectron microscopic study. J. Struct. Biol., 111:180-189.
95. Shanahan, C.M., N.R.B. Cary, J.C. Metcalfe, and P.L. Weissberg 1994 High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J. Clin. Invest., 93:2393-2402.
96. Shiraga, H., W. Min, W.J. VanDusen, M.D. Clayman, D. Miner, C.H. Terrell, J.R. Sherbotie, J.W. Foreman, C. Przysiecki, E.G. Neilson, and J.R. Hoyer 1992 Inhibition of calcium oxalate crystal growth in vitro by uropontin: Another member of the aspartic acid-rich protein superfamily. Proc. Natl. Acad. Sci. U.S.A., 89: 426-430.
97. Singh, K., D. Deonarine, V. Shanmugam, D.R. Senger, A.B. Mukherjee, P.-L. Chang, C.W. Prince, and B.B. Mukhenee 1993 Calcium-binding properties of osteopontin derived from non-osteogenic sources. J. Biochem., 114:702-707.
98. Singh, R.P., R. Patarca, J. Schwartz, P. Singh, and H. Cantor 1990 Definition of a specific interaction between the early T lymphocyte activation 1 (Eta-1) protein and murine macrophages in vitro and its effect upon macrophages in vivo. J. Exp. Med., 171:1931-1942.
99. Sodek, J., J. Chen, S. Kasugai, T. Nagata, Q. Zhang, M.D. McKee, and A. Nanci 1992 Elucidating the functions of bone sialoprotein and osteopontin in bone formation. In: Chemistry and Biology of Mineralized Tissues. H. Slavkin and P. Price, eds. Elsevier Science Publishers, Amsterdam, pp. 297-306.
100. Sorensen, E.S., L.K. Rasmussen, L. Moller, P.H. Jensen, P. Hojrup, and T.E. Petersen 1994 Localization of transglutaminase-reactive glutamine residues in bovine osteopontin. Biochem. J., 304:13-16.
101. Sporn, S.A., D.F. Eierman, C.E. Johnson, J. Morris, G. Martin, M. Ladner, and S. Haskill 1990 Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair. J. Immunol., 144:4434-4441.
102. Thorens, B., J.-J. Mermod, and P. Vassalli 1987 Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation. Cell, 48:671-679.
103. Trotter, J.A. 1981 The organization of actin in spreading macrophages. Exp. Cell Res., 132:235-248.
104. Tuan, R.S. 1993 Analysis of gene expression in skeletal tissues by in situ hybridization. Bone, 14:309-314.
105. Van Oss, C.J., and C.F. Gillman 1972 Phagocytosis as a surface phenomenon. I. Contact angles and phagocytosis of non-opsonized bacteria. J. Reticuloendothel. Soc., 12:283-292.
106. Van Strijp, J.A.G., D.G. Russell, E. Tuomanen, E.J. Brown, and S.D. Wright 1993 Ligand specificity of purified complement receptor type 3 (CD11b/CD18, Mac-1, αMβ2): Indirect effects of an Arg-Gly-Asp sequence. J. Immunol., 151:3324-3336.
107. Veis, A. 1993 Mineral-matrix interactions in bone and dentin. J. Bone Miner. Res., 8:S493-S497.
108. Verbrugh, H.A., P.K. Peterson, D.E. Smith, B.Y.T. Nguyen, J.R. Hoidal, B.J. Wilkinson, J. Verhoef, and L.T. Furcht 1981 Human fibronectin binding to staphylococcal surface protein and its relative inefficiency in promoting phagocytosis by human polymorphonuclear leukocytes, monocytes, and alveolar macrophages. Infect. Immunol., 33:811.
109. Weber, G.F., S. Ashkar, M.J. Glimcher, and H. Cantor 1996 Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science 271:509-512.
110. Worcester, E.M., S.S. Blumenthal, A.M. Beshensky, and D.L. Lewand 1992 The calcium oxalate crystal growth inhibitor protein produced by mouse kidney cortical cells in culture is osteopontin. J. Bone Miner. Res., 7:1029-1036.
111. Wright, S.D., L.S. Craigmyle, and S.C. Silverstein 1983 Fibronectin and serum amyloid P component stimulate C3b- and C3bi-mediated phagocytosis in cultured human monocytes. J. Exp. Med., 158:1338-1343.
112. 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. J. Biol. Chem., 270:9550-9557.