Identification of osteopontin as a novel ligand for the integrin α8β1 and potential roles for this integrin-ligand interaction in kidney morphogenesis

Molecular Biology of the Cell

Volumn 9, Issue 6, 1998, Pages 1425-1435

  Denda, Sumiko ^a,b   Reichardt, Louis F ^a   Müller, Ulrich ^a,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b SHISEIDO RESEARCH CENTER   (Japan)

^c FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; OSTEOPONTIN;

ANIMAL TISSUE; ARTICLE; CELL INTERACTION; KIDNEY DEVELOPMENT; LIGAND BINDING; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

ANIMALIA;

EID: 0031813775     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.6.1425     Document Type: Article

References (41)

1. Aufderheide, E., Chiquet-Ehrismann, R., and Ekblom, P. (1987). Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme. J. Cell Biol. 105, 599-608.
2. Bossy, B., Bossy-Wetzel, E., and Reichardt, L.F. (1991). Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos. EMBO J. 10, 2375-2385.
3. Chen, T., Zhang, Q., McCulloch, C.A.G., and Sodek, J. (1991). Immunohistochemical localization of bone sialoprotein in foetal procine bone tissues: comparisons with secreted phosphoprotein 1 (SPP-1, osteopontin) and SPARC (osteonectin). Histochem. J. 23, 281-289.
4. Cheng, H.-J., and Flanagan, J.G. (1994). Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases. Cell 79, 157-168.
5. Clover, J., Dodds, R.A., and Gowen, M. (1992). Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture. J. Cell Sci. 203, 267-271.
6. DeFreitas, M.F., Yoshida, C.K., Frazier, W.A., Mendrick, D.L., Kypta, R.M., and Reichardt, L.F. (1995). Identification of integrin alpha 3 beta 1 as a neuronal thrombospondin receptor mediating neurite outgrowth. Neuron 25, 333-343.
7. Denda, S., Müller, U., Crossin, K.L., Erickson, H.P., and Reichardt, L.F. (1998). Utilization of a soluble integrin-alkaline phophatase chimera to characterize integrin alpha 8 beta 1 receptor interactions with tenascin: murine alpha 8 beta 1 binds to the RGD site in tenascin-C fragments, but not to native tenascin-C. Biochemistry 37, 5464-5474.
8. Denhardt, D.T., and Guo, X. (1993). Osteopontin: a protein with diverse functions. FASEB J. 7, 1475-1482.
9. Ekblom, P. (1981). Formation of basement membranes in the embryonic kidney: an immunohistological study. J. Cell Biol. 92, 1-10.
10. Flanagan, J.G., and Leder, P. (1990). The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell 63, 185-194.
11. George, E.L., Georges-Labouesse, E.N., Patel-King, R.S., Rayburm, H., and Hynes, R.O. (1993). Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119, 1079-1091.
12. Gorski, J.P., Griffin, D., Dudley, G., Stanford, C., Thomas, R., Huang, C., Lai, E., Karr, B., and Solursh, M. (1990). Bone acidic glycoprotein-75 is a major synthetic product of osteoblastic cells and localized as 75- and/or 50-kDa forms in mineralized phases of bone and growth plate and in serum. J. Biol. Chem. 265, 14956-14963.
13. Grano, M., Zigrino, P., Colucci, S., Zambonin, G., Trusolino, L., Serra, M., Baldini, N., Teti, A., Marchisio, P.C., and Zallone, A.Z. (1994). Adhesion properties and integrin expression of cultured human osteoclast-like cells. Exp. Cell Res. 212, 209-218.
14. Grzesik, W.J., and Robey, P.G. (1994). Bone matrix RGD glycoproteins: immunolocalization and interaction with human primary osteoblastic bone cells in vitro. J. Bone Miner. Res. 9, 487-496.
15. Hall, D.E., Reichardt, L.F., Crowley, E., Holley, B., Moezzi, H., Sonnenberg, A., and Damsky, C.H. (1990). The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin. J. Cell Biol. 110, 2175-2184.
16. Hildebrand, J.D., Schaller, M.D., and Parsons, J.T. (1995). Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol. Biol. Cell 6, 637-647.
17. 2+ suppresses cell adhesion to osteopontin by attenuating binding affinity for integrin alpha v beta 3. J. Biol. Chem. 270, 9917-9925.
18. Hynes, R.O. (1992). Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
19. Jones, K.R., Farinas, I., Backus, C., and Reichardt, L.F. (1994). Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76, 989-999.
20. Klein, G., Langegger, M., Timple, R., and Ekblom, P. (1988). Role of laminin A chain in the development of epithelial cell polarity. Cell 55, 331-341.
21. Lenter, M., Uhlig, H., Hamann, A., Jeno, P., Imhof, B., and Vestweber, D. (1993). A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1. Proc. Natl. Acad. Sci. USA 90, 9051-9055.
22. Mackie, E.J., and Tucker, R.P. (1992). Tenascin in bone morphogenesis: expression by osteoblasts and cell type-specific expression of splice variants. J. Cell Sci. 103, 765-771.
23. Mark, M.P., Buttler, W.T., Prince, C.W., Finkelman, R.D., and Ruch, J.-V. (1988). Developmental expression of 44-kDa bone phosphoprotein (osteopontin) and bone γ-carboxyglutamic acid (Gla)-containing protein (osteocalcin) in calcifying tissues of rat. Differentiation 37, 123-136.
24. Mendrick, D.L., and Kelly, D.M. (1993). Temporal expression of VLA-2 and modulation of its ligand specificity by rat glomerular epithelial cells in vitro. Lab. Invest. 69, 690-702.
25. Müller, U., Bossy, B., Venstrom, K., and Reichardt, L.F. (1995). Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin. Mol. Biol. Cell 6, 433-448.
26. Müller, U., Wang, D., Denda, S., Meneses, J.J., Pedersen, R.A., and Reichardt, L.F. (1997). Integrin alpha 8 beta 1 is critically important for epithelial-mesenchymal interactions during kidney morphogenesis. Cell 88, 603-613.
27. Nemir, M., DeVouge, M.W., and Mukherjee, B.B. (1989). Normal rat kidney cells secrete both phosphorylated and nonphosphorylated forms of osteopontin showing different physiological properties. J. Biol. Chem. 264, 18202-18208.
28. Rogers, S.N., Padanilam, B.J., Hruska, K.A., Giachelli, C.M., and Hammerman, M.R. (1997) Metanephric osteopontin regulates nephrogenesis in vitro. Am. J. Physiol. 272, F469-F476.
29. Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T., and Aizawa, S. (1992). Mice develop normally without tenascin. Genes Dev. 6, 1821-1831.
30. Sariola, H., Aufderheide, E., Bernhard, H., Henke-Fahle, S., Dippold, W., and Ekblom, P. (1988). Antibodies to cell surface ganglioside Gd3 perturb inductive epithelial-mesenchymal interactions. Cell 54, 235-245.
31. Schnapp, L.M., Hatch, N., Ramos, D.M., Klimanskaya, I.V., Sheppard, D., and Pytela, R. (1995). The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J. Biol. Chem. 270, 23196-23202.
32. Seiffert, D. (1996). Detection of vitronectin in mineralized bone matrix. J. Histochem. Cytochem. 44, 275-280.
33. Seiffert, D., Iruela-Arispe, M.L., Sage, E.H., and Loskutoff, D.J. (1995). Distribution of vitronectin mRNA during murine development. Dev. Dyn. 203, 71-79.
34. Shiraga, H. et al. (1992). Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. Proc. Natl. Acad. Sci. USA 89, 426-430.
35. Sonnenberg, A. (1993). Integrins and their ligands. Curr. Top. MiCrobiol. Immunol. 184, 7-35.
36. Stern, D.N., Glimcher, M.J., and Saavedra, R.A. (1995). Localization of osteopontin during mouse development. Ann. NY Acad. Sci. 760, 367-370.
37. Talts, J.F., Eng, H., Zhang, H-Y., Faissner, A., and Ekblom, P. (1997). Characterization of monoclonal antibodies against tenascin-C: no apparent effect on kidney development in vitro. Int. J. Dev. Biol. 41, 39-48.
38. Varnum-Finney, B., Venstrom, K., Müller, U., Kypta, R., Backus, C., Chiquet, M., and Reichardt, L.F. (1995). The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C. Neuron 14, 1213-1222.
39. Wolfsberg, T.G., Primakoff, P., Myles, D.G., and White, J.M. (1995). ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J. Cell Biol. 131, 275-278.
40. Yang, J.T., Rayburn, H., and Hynes, R.O. (1993). Embryonic mesodermal defects in alpha 5 integrin-deficient mice. Development 129, 1093-1105.
41. Zheng, X., Saunders, T.L., Camper, S.A., Samuelson, L.C., and Ginsburg, D. (1995). Vitronectin is not essential for normal mammalian development and fertility. Proc. Natl. Acad. Sci. USA 92, 12426-12430.