Di(2-ethylhexyl) phthalate

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans

Volumn 77, Issue , 2000, Pages 41-148

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Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYLHEXANOL; DRUG METABOLITE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

AIR; ANALYTIC METHOD; CANCER RESEARCH; CARCINOGENICITY; CHEMICAL INDUSTRY; CHEMICAL STRUCTURE; CONFERENCE PAPER; ENVIRONMENTAL EXPOSURE; EXPERIMENTAL ANIMAL; FOOD CONTAMINATION; GENOTOXICITY; HEMODIALYSIS PATIENT; HUMAN; NONHUMAN; OCCUPATIONAL EXPOSURE; PEROXISOME; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; SEDIMENT; SOIL; TOXICOKINETICS; WATER CONTAMINATION;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; CRICETINAE; DIETHYLHEXYL PHTHALATE; DISEASE MODELS, ANIMAL; ENVIRONMENTAL EXPOSURE; HUMANS; MAXIMUM ALLOWABLE CONCENTRATION; MICE; NEOPLASMS; RATS; REPRODUCTION;

EID: 0033788855     PISSN: 02509555     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Conference Paper

References (392)

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4. Effects of di(2-ethylhexyl) phthalate on the gonadal pathophysiology, sperm morphology, and reproductive performance of male rats
5. Effects of parenteral di(2-ethylhexyl)phthalate (DEHP) on gonadal biochemistry, pathology and reproductive performance of mice
6. Absorption, metabolism and excretion of di(2-ethylhexyl) phthalate by rats and mice
7. Metabolism of di(2-ethylhexyl)phthalate
8. Enzymatic hydrolysis of di(2-ethylhexyl) phthalate by lipase
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11. Pharmacokinetics, interactions with macromolecules and species differences in metabolism of DEHP
12. Tests for gene mutational activity in the L5178Y/TK assay system
13. Effect of some phthalate esters in human cells in the comet assay
14. Facts and figures for the chemical industry
15. EU bans phthalates in young children's mouthing toys
16. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
17. Oral toxicity of bis(2-ethylhexyl) phthalate during pregnancy and suckling in Long-Evans rat
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19. The rodent dominant lethal assay: A proposed format for data presentation that alerts to pseudo-dominant lethal effects
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21. Metabolism of DEHP: Effects of prefeeding and dose variation, and comparative studies in rodents and the cynomolgus monkey (CMA studies)
22. Chemical industry voluntary test program for phthalate esters: Health effects studies
23. Oncogenicity testing of 2-ethylhexanol in Fischer 344 rats and B6C3F/mice
24. Global transportation of organic pollutants: Ambient concentrations in the remote marine atmosphere
25. Antifertility effects and dominant lethal assays for mutagenic effects of DEHP
26. Tests with the Salmonella plate-incorporation assay
27. Gap junctional intercellular communication (GJIC) studies on 5 phthalate monoesters in hepatocytes of four species: Implications for cancer risk assessment
28. Peroxisome induction studies on seven phthalate esters
29. Tests with the Syrian hamster embryo cell transformation assay
30. Estimation of the environmental contamination by phthalic acid esters leaching from household wastes
31. Molecular basis of non-responsiveness to peroxisome proliferators: The guinea-pig PPARα is functional and mediates peroxisome proliferator-induced hypolipidaemia
32. Sertoli cell toxicants
33. Airborne di-butyl and di(2-ethylhexyl)phthalate at three New York City air sampling stations
34. Measurement of DNA single-strand breaks by alkaline elution in rat hepatocytes
35. The induction of mitotic gene conversion in the yeast Saccharomyces cerevisiae strain JD1
36. Bis(2-ethylhexyl) phthalate
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38. Use of primary cultures of human hepatocytes in toxicology studies
39. Toxicology of a series of phthalate esters
40. Assays in Aspergillus nidulans for the induction of forward-mutation in haploid strain 35 and for mitotic nondisjunction, haploidization and crossing-over in diploid strain P1
41. Evaluation of the yeast DEL assay with 10 compounds selected by the International Programme on Chemical Safety for the evaluation of short-term tests for carcinogens
42. Migration of plasticizer from poly(vinylchloride) milk tubing
43. Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: Relationship to carcinogenesis and nuclear localization
44. Association of persistent proliferation and oxidative injury with hepatocarcinogenicity in female F-344 rats fed di(2-ethylhexyl) phthalate for 2 years
45. Failure of the peroxisome proliferator WY-14,643 to induce unscheduled DNA synthesis in rat hepatocytes following in vivo treatment
46. Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?
47. Comparison between the organic fraction of suspended matter at a background and urban air station
48. In vivo comparative evaluation of hemodialysis tubing plasticized with DEHP and TEHTM
49. Metabolism and tissue distribution of mono-2-ethylhexyl phthalate in the rat
50. Skin reservoir formation and bioavailability of dermally administered chemicals in hairless guinea pigs
51. Effects of di(2-ethylhexyl) phthalate on peroxisomes of liver, kidney and brain of lactating rats and their pups
52. Occurrence of phthalate esters in Italian packaged foods
53. Contamination of commercial blood products by di-2-ethylhexyl phthalate and mono-2-ethylhexyl phthalate
54. Preliminary findings of the priority pollutant monitoring project of the nationwide urban runoff program
55. Relationship of oxidative damage to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl) phthalate and Wy-14,643
56. Identification of the proximate peroxisome proliferator(s) derived from di(2-ethylhexyl) adipate and species differences in response
57. Tests for mutagenic activity using mutation assays at two loci in the human lymphoblast cell lines TK6 and AHH-I
58. Effects of peroxisome proliferators and 12-O-tetradecanoyl phorbol-13-acetate on intercellular communication and connexin43 in two hamster fibroblast systems
59. Comparative effects of diethylhexyl phthlate or mono-ethylhexyl phthlate on male mouse and rat reproductive organs
60. Tests for chromosome aberrations and aneuploidy in the Chinese hamster fibroblast cell line CH1-L
61. The absorption, metabolism and tissue distribution of di(2-ethylhexyl) phthalate in rats
62. Investigation of the potential for binding of di(2-ethylhexyl) phthalate (DEHP) and di(2-ethylhexyl) adipate (DEHA) to liver DNA in vivo
63. Significance of the surface microlayer to the environmental fate of di(2-ethylhexyl) phthalate predicted from marine microcosms
64. Chronic peroxisome proliferation and hepatomegaly associated with the hepatocellular tumorigenesis of di(2-ethylhexyl) phthalate and the effects of recovery
65. Di(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats
66. Trace organic and heavy metal pollution in the Mississippi River
67. 14C]-DEHP plasticized polyvinyl chloride film in male Fischer 344 rats
68. Two-stage exposure of Syrian-hamster-embryo cells to environmental carcinogens: Superinduction of ornithine decarboxylase correlates with increase of morphological transformation frequency
69. Rapid determination by high performance liquid chromatography of di-2-ethylhexyl phthalate in plasma stored in plastic bags
70. Non-mutagenicity of 4 metabolites of di(2-ethylhexyl) phthalate (DEHP) and 3 structurally related derivatives of di(2-ethylhexyl) adipate (DEHA) in the Salmonella mutagenicity assay
71. Metabolites of the plasticizer di(2-ethylhexyl) phthalate in urine samples of workers in polyvinylchloride processing industries
72. Determination of four metabolites of the plasticizer di(2-ethylhexyl) phthalate in human urine samples
73. Effects of the peroxisome proliferator mono(2-ethylhexyl)phthalate in primary hepatocyte cultures derived from rat, guinea pig, rabbit and monkey. Relationship between interspecies differences in biotransformation and peroxisome proliferating potencies
74. Bacterial mutagenicity testing of urine from rats dosed with 2-ethylhexanol derived plasticizers
75. Tumor-promoting effects of di(2-ethylhexyl) phthalate in JB6 mouse epidermal cells and mouse skin
76. Transfer of di(2-ethylhexyl) phthalate through rat milk and effects on milk composition and the mammary gland
77. Hepatic peroxisome proliferation and hypolipidemic effects of di(2-ethylhexyl) phthalate in neonatal and adult rats
78. Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl) phthalate and the recovery of fertility as adults
79. Alkaline sucrose sedimentation, sister-chromatid exchange and micronucleus assays in CHO cells
80. Genetic toxicology of phthalate esters: Mutagenic and other genotoxic effects
81. A cancer risk assessment of di(2-ethylhexyl) phthalate: Application of the new US EPA Risk Assessment Guidelines
82. Di(2-ethylhexyl) phthalate-induced changes in liver estrogen metabolism and hyperplasia
83. Airborne contaminants in the Great Lakes ecosystem
84. Degradation of bis(2-ethylhexyl)phthalate constituents under methanogenic conditions
85. Influence of water solubility, side-chain degradability and side-chain structure on the degradation of phthalic acid esters under methanogenic conditions
86. Peroxisome proliferation due to di(2-ethylhexyl) phthalate (DEHP): Species differences and possible mechanisms
87. Peroxisome proliferators: Species differences in response of primary hepatocyte cultures
88. Method 5020: Di(2-ethylhexyl) phthalate
89. Lack of DNA damage or lipid peroxidation measured in vivo in the rat liver following treatment with peroxisomal proliferators
90. Tests with the Chinese hamster V79 inhibition of metabolic cooperation assay
91. Guidelines establishing test procedures for the analysis of pollutants under the Clean Water Act. Final Rule and Interim Final rule and Proposed Rule
92. Method 525.2. Determination of organic compounds in drinking water by liquid-solid extraction and capillary column gas chromatography/mass spectrometry [Rev. 2.0]
93. Method 506. Determination of phthalate and adipate esters in drinking water by liquid-liquid extraction or liquid-solid extraction and gas chromatography with photoionization detection [Rev. 1.1]
94. Method 8061A. Phthalate esters by gas chromatography with electron capture detection (GC/ECD) [Rev I]
95. Methods for organic chemical analysis of municipal and industrial wastewater. Method 606 - Phthalate ester
96. Methods for organic chemical analysis of municipal and industrial wastewater. Method 625 - Base/neutrals and acids
97. Method 1625 Revision B - Semivolatile organic compounds by isotope dilution GC/MS
98. Co-recombinogenic and anti-mutagenic effects of diethylhexylphthalate, inactiveness of pentachlorophenol in the spot test with mice
99. Phthalate esters in rivers of the greater Manchester area, U.K.
100. Exposure from occupational versus other sources
101. Food and drugs
102. Organic compounds as contaminants of the Elbe River and its tributaries. Part II: GC/MS screening for contaminants of the Elbe water
103. Testing of known carcinogens and noncarcinogens in the Syrian hamster embryo (SHE) micronucleus test in vitro: Correlations with in vivo micronucleus formation and cell transformation
104. The Drosophila reversion assay using the unstable zeste-white somatic eye color system
105. Phthalate esters and their effect on the liver
106. Effects of prolonged administration of phthalate ester on the liver
107. Effects of prolonged treatment with phthalate ester on rat liver
108. Tests for the induction of mutations to ouabain or 6-thioguanine resistance in mouse lymphoma L5178Y cells
109. Di(2-ethylhexyl) phthalate: Lack of initiating activity in the liver of female F-344 rats
110. Comparison of responses of base-specific Salmonella tester strains with the traditional strains for identifying mutagens: The results of a validation study
111. A truncated human peroxisome proliferator-activated receptor α splice variant with dominant negative activity
112. Characterization of leachates from hazardous waste landfills
113. Accumulation of phthalate ester plasticizers in Lake Constance sediment
114. Plasticizers in food
115. Phthalate ester plasticizers: A new class of marine pollutant
116. Phthalate esters, PCB and DDT residues in the Gulf of Mexico atmosphere
117. Phthalic acid esters
118. The fate of environmental contaminants in the food chain
119. Testicular atrophy produced by phthalate esters
120. Aspects of the testicular toxicity of phthalate esters
121. Short-term toxicity study of di(2-ethylhexyl) phthalate in rats
122. Peroxisome proliferation in cultured rat hepatocytes produced by clofibrate and phthalate ester metabolites
123. Peroxisomal effects of phthalate esters in primary cultures of rat hepatocytes
124. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketonazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
125. Assessment of the safety of chemicals administered intravenously in the neonatal rat
126. Analysis of phthalates in baby foods
127. Investigation on the presence of aromatic hydrocarbons, polycyclic aromatic hydrocarbons, persistent organochlorine compounds, phthalates and the breathable fraction of atmospheric particulates in the air of Rieti urban area
128. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells
129. Can nongenotoxic carcinogens be detected with the lacI transgenic mouse mutation assay?
130. 32P-postlabeling analysis of peroxisome proliferator-DNA adduct formation in rat liver in vivo and hepatocytes in vitro
131. Promoting effect of the peroxisome proliferator, clofibrate, but not di(2-ethylhexyl) phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine
132. Hepatic ploidy, nuclearity, and distribution of DNA synthesis: A comparison of nongenotoxic hepatocarcinogens with noncarcinogenic liver mitogens
133. Suppression of apoptosis and induction of DNA synthesis in vitro by the phthalate plasticisers monoethylhexylphthalate (MEHP) and diisononylphthalate (DINP): A comparison of rat and human hepatocytes in vitro
134. Species differences in response to diethylhexylphthalate (DEHP): Suppression of apoptosis, induction of DNA synthesis and PPARα-mediated gene expression
135. Assays for enhanced DNA viral transformation of primary Syrian hamster embryo (SHE) cells
136. Characteristics of the hepatocarcinogenesis caused by dehydroepiandrosterone, a peroxisome proliferator, in male F-344 rats
137. Phthalate ester effects on rat Sertoli cell function in vitro: Effects of phthalate side chain and age of animal
138. Differential prenatal toxicity of branched phthalate esters in rats
139. An in-vitro model for peroxisome proliferation utilizing primary hepatocytes in sandwich culture
140. Organic contaminants and characteristics of sediments from Oso Bay, South Texas, USA
141. Measurement of water solubilities, octanol/water partition coefficients and vapour pressures of commercial phthalate esters
142. A single amino acid change in the mouse peroxisome proliferator-activated receptor alpha alters transcriptional responses to peroxisome proliferators
143. Hepatocarcinogenic potential of di(2-ethylhexyl) phthalate in rodents and its implications on human risk
144. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
145. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
146. Comparative distribution, excretion and metabolism of di(2-ethylhexyl) phthalate in rats, dogs and miniature pigs
147. Incidence and mortality pattern of malignancy and factors affecting the risk of malignancy in dialysis patients
148. Tests for genetic activity in the yeast Saccharomyces cerevisiae: Study of forward and reverse mutation, mitotic recombination and illegitimate mating induction
149. Evaluation of short-term tests for carcinogenicity. Report of the International Programme on Chemical Safety's collaborative study on in vitro assays
150. Chromosome tests with 134 compounds on Chinese hamster cells in vitro - A screening for chemical carcinogens
151. The in vitro chromosomal aberration test using Chinese hamster lung (CHL) fibroblast cells in culture
152. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
153. The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs
154. Enhancing effect of various hepatocinogens on induction of preneoplastic glutathione S-transferase placental form positive loci in rats - An approach for a new medium-term bioassay system
155. Plasticizers from plastic devices: Extraction, metabolism and accumulation by biological systems
156. Migration of a phthalate ester plasticizer from polyvinyl chloride blood bags into stored human blood and its localization in human tissues
157. Effects of plasticizer di(2-ethylhexyl) phthalate (DEHP) on reproductive function of mice
158. Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexyl phthalate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB)
159. Phthalate esters in marine sediments around Taiwan
160. The human peroxisome proliferator-activated receptor (PPAR) subtype NUC1 represses the activation of hPPAR α and thyroid hormone receptors
161. Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat
162. Diethyl phthalate: A perspective
163. Extracorporeal membrane oxygenation exposes infants to the plasticizer, di(2-ethylhexyl) phthalate
164. Enhancement of the DNA damaging activity of N-nitrosodimethylamine by di(2-ethylhexyl) phthalate in somatic cells in vivo of Drosophila melanogaster
165. Peroxisome proliferation due to di(2-ethylhexyl) adipate, 2-ethylhexanol and 2-ethylhexanic acid
166. Concentrations and transformations of hazardous air pollutants
167. Evaluation of di(2-ethylhexyl) phthalate and its major metabolites in the Ames test and L5178Y mouse lymphoma mutagenicity assay
168. Di(2-ethylhexyl) phthlate: Short-term repeated toxicity study including fertility assessment
169. Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute
170. The carcinogenicity of di(2-ethylhexyl) phthalate (DEHP) in perspective
171. Comparative chronic toxicities and carcinogenic potentials of 2-ethylhexyl-containing compounds in rats and mice
172. Effect of di(2-ethylhexyl) phthalate on DNA repair and lipid peroxidation in rat hepatocytes and on metabolic cooperation in Chinese hamster V-79 cells
173. Subchronic toxicity of di(2-ethylhexyl) phthalate in common marmosets: Lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasia
174. Promoting effect of peroxisome proliferators in two-stage rat renal tumorigenesis
175. Peroxisome proliferation: Current mechanisms relating to nongenotoxic carcinogenesis
176. Mechanisms of hepatocarcinogenicity of peroxisome-proliferating drugs and chemicals
177. Studies on the hepatic effects of orally administered di(2-ethylhexyl) phthalate in the rat
178. Comparative studies on di(2-ethylhexyl) phthalate-induced hepatic peroxisome proliferation in the rat and hamster
179. Hepatic effects of phthalate esters and related compounds - In vivo and in vitro correlations
180. Effect of prolonged administration of clofibric acid and di(2-ethylhexyl) phthalate on hepatic enzyme activities and lipid peroxidation in the rat
181. Reproductive effects of four phthalic acid esters in the mouse
182. Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter
183. Phthalate esters: The question of safety
184. Phthalate esters: The question of safety - An update
185. Assays for the induction of morphological transformation in C3H/10T-1/2 cells in culture with and without S9-mediated metabolic activation
186. A toxicological investigation of some acute, short-term, and chronic effects of administering di-2-ethylhexyl phthalate (DEHP) and other phthalate esters
187. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
188. The Fas system is a key regulator of germ cell apoptosis in the testes
189. Interaction of some peroxisome proliferators with the mouse liver peroxisome proliferator-activated receptor (PPAR): A molecular modelling and quantitative structure-activity relationship (QSAR) study
190. Bis(2-ethylhexyl) phthalate concentrations in the serum of hemodialysis patients
191. Mutation tests with Salmonella using 8-azaguanine resistance as the genetic marker
192. Induction of sister chromatid exchanges by direct and indirect mutagens in human lymphocytes, co-cultured with intact rat liver cells. Effect of enzyme induction and preservation of the liver cells by freezing in liquid nitrogen
193. Urine phthalate determinations as an index of occupational exposure to phthalic anhydride and di(2-ethylhexyl) phthalate
194. Phytotoxicological effects of di(2-ethylhexyl) phthalate and di-n-butyl-phthalate on higher plants in laboratory and field experiments
195. Assays for forward mutation in Schizosaccharomyces pombe strain P1
196. Investigation of the potential for binding of di(2-ethylhexyl) phthalate (DEHP) to rat liver DNA in vivo
197. Inhibition of gap-junctional intercellular communication between Chinese hamster lung fibroblasts by di(2-ethylhexyl) phthalate (DEHP) and trisodium nitrilotriacetate monohydrate (NTA)
198. Inhibition of metabolic cooperation between Chinese hamster V79 cells by tumor promoters and other chemicals
199. Studies on the toxicity and skin effects of compounds used in the rubber and plastics industries. II. Plasticizers
200. Trans-Activation of PPARα and PPARγ by structurally diverse environmental chemicals
201. Relationship of hepatic peroxisome proliferation and replicative DNA synthesis to the hepatocarcinogenicity of the peroxisome proliferators di(2-ethylhexyl) phthalate and [4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid (Wy-14,643) in rats
202. Effects of the peroxisome proliferator di(2-ethylhexyl) phthalate on enzymes in rat liver and on carcinogen-induced liver altered foci in comparison to the promoter phenobarbital
203. Mutation tests on Salmonella typhimurium by the preincubation method
204. Assays for morphological transformation and mutation to ouabain resistance of Balb/c-3T3 cells in culture
205. Bis(2-ethylhexyl)phthalate: Evaluation of risks to health from environmental exposure in Canada
206. Approach to assessment of risk to human health for priority substances under the Canadian Environmental Protection Act
207. Tests for genetic activity in the yeast Saccharomyces cerevisiae using strains D7-144, XV185-14c and RM52
208. Studies by the National Toxicology Program on di(2-ethylhexyl) phthalate
209. Developmental toxicity in rats after inhalation exposure of di-2-ethylhexylphthalate (DEHP)
210. The fate of leached di(2-ethylhexyl) phthalate in patients undergoing CAPD treatment
211. Uraemic pruritus and exposure to di(2-ethylhexyl) phthalate (DEHP) in haemodialysis patients
212. Intercellular communication in colonies of Syrian hamster embryo cells and the susceptibility for morphological transformation
213. Morphological transformation and catalase activity of Syrian hamster embryo cells treated with hepatic peroxisome proliferators, TPA and nickel sulphate
214. Identification of the proximate peroxisome proliferator(s) derived from di(2-ethylhexyl) phthalate
215. Inhibition of peroxisome proliferator signaling pathways by thyroid hormone receptor. Competitive binding to the response element
216. The orphan nuclear hormone receptor LXR α interacts with the peroxisome proliferator-activated receptor and inhibits peroxisome proliferator signaling
217. Effects of tiadenol and di(2-ethylhexyl) phthalate on the metabolism of phosphatidylcholine and phosphatidylethanolamine in the liver of rats: Comparison with clofibric acid
218. Effects of chronic di(2-ethylhexyl) phthalate intake on the secretion and removal rate of triglyceride-rich lipoproteins in rats
219. A multidisciplinary approach to toxicological screening: III. Neurobehavioral toxicity
220. Evaluation studies on the in vitro rat hepatocyte micronucleus assay
221. Phthalic acid esters, total DDTs and polychlorinated biphenyls in marine samples from Galveston Bay, Texas
222. Di-n-hexyl phthalate (DHP), a newly identified contaminant in Atlantic herring (Clupea harengus larengus) and Atlantic mackerel (Scomber scombus)
223. Assays for the induction of gene mutations at the thymidine kinase locus in L5178Y mouse lymphoma cells in culture
224. Toxic effect of systemic administration of low doses of the plasticizer di(2-ethylhexyl) phthalate [DEHP] in rats
225. A multidisciplinary approach to toxicological screening. II. Developmental toxicity
226. Nonadditive developmental toxicity in mixtures of trichloroethylene, di(2-ethylhexyl) phthalate, and heptachlor in a 5 x 5 x 5 design
227. Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis
228. Diethylhexyl phthalate
229. Diethylhexyl phthalate, juvenile exposure, mouse
230. Phthalate ester exposure - Air levels and health of workers processing polyvinylchloride
231. Mutagenicity tests on organic contaminants in city water and related compounds. I. Bacterial mutagenicity tests
232. Tests for the induction of sister-chromatid exchanges in human peripheral lymphocytes in culture
233. Tests for the induction of forward mutation at the thymidine kinase locus of L5178Y mouse lymphoma cells in culture
234. Air contaminants
235. Promoting activity of di(2-ethylhexyl) phthalate in rat liver foci bioassay
236. Residential exposure to plasticizers and its possible role in the pathogenesis of asthma
237. Reversibility of testicular atrophy induced by di(2-ethylhexyl) phthalate in rats
238. Enhancement of fatty acyl-CoA oxidizing activity in rat liver peroxisomes by di(2-ethylhexyl) phthalate
239. Studies into the transfer and migration of phthalate esters from aluminum foil-paper laminates to butter and margarine
240. The occurrence of phthalate ester and di-2-ethylhexyl adipate plasticizers in Canadian packaging and food sampled in 1985-1989: A survey
241. Interaction of the peroxisome proliferator-activated receptor α with the retinoid X receptor α unmasks a cryptic peroxisome proliferator response element that overlaps an ARP-1-binding site in the CYP4A6 promoter
242. Peroxisome proliferator activated receptor-α expression in human liver
243. Hepatic mixed function oxidases and cytochrome P-450 contents in rat pups exposed to di(2-ethylhexyl) phthalate through mother's milk
244. Effect of di(2-ethylhexyl) phthalate (DEHP) on spermatogenesis in adult rats
245. Effect of testosterone on the testicular atrophy caused by di(2-ethylhexyl) phthalate (DEHP)
246. Testicular toxicity of di(2-ethylhexyl) phthalate in developing rats
247. Tests for the effects on mitosis and the mitotic spindle in Chinese hamster primary liver cells (CHI-L) in culture
248. The detection of mitotic gene conversion, point mutation and mitotic segregation using the yeast Saccharomyces cerevisiae strain D7
249. Toxic potential of the plasticizer di(2-ethylhexyl) phthalate in the context of its disposition and metaboloism in primates and man
250. Di-2-ethylhexyl phalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) accumulation in whole blood and red cell concentrates
251. DEHP in the vicinity of an industrial area in Finland
252. Role of PPAR α in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643
253. Di(ethylhexyl) phthalate induces a functional zinc deficiency that is independent of peroxisome proliferator-activated receptor
254. Survey of di(2-ethylhexyl) phthalate plasticizer contamination of retail Danish milks
255. Phthalate ester concentration variations in dated sediment cores from the Chesapeake Bay
256. Genotoxicity studies of di(2-ethylhexyl) phthalate and its metabolites in CHO cells
257. Exposure of newborn infants to di(2-ethylhexyl) phthalate and 2-ethyl hexanoic acid following exchange transfusion with polyvinyl chloride catheters
258. Circulating concentrations of di(2-ethylhexyl) phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis
259. Subchronic oral toxicity of di-n-octyl phthalate and di(2-ethylhexyl) phthalate in the rat
260. Lack of hepatic promotional activity by the peroxisomal proliferating hepatocarcinogen di(2-ethylhexyl) phthalate
261. Phthalate ester speciation in estuarine water, suspended particulates and sediments
262. Tests for the induction of chromosome aberrations, polyploidy and sister-chromatic exchanges in rat liver (RL4) cells
263. Tests for the induction of DNA-repair synthesis in primary cultures of adult rat hepatocytes
264. Absence of liver effects in cynomolgus monkeys treated with peroxisomal proliferators
265. Cytogenetic evaluation of di(2-ethylhexyl) phthalate and its major metabolites in Fischer 344 rats
266. Absence of γ-glutamyl transpeptidase activity in neoplastic lesions induced in the liver of male F-344 rats by di(2-ethylhexyl) phthalate, a peroxisome proliferator
267. Quantitative analysis of hepatocellular lesions induced by di(2-ethylhexyl) phthalate in F-344 rats
268. Analysis of water and sediment from the Nueces Estuary/ Corpus Christi Bay (Texas) for selected organic pollutants
269. Di(2-ethylhexyl) phthalate: An industrial plasticizer induces hypolipidemia and enhances hepatic catalase and carnitine acetyltransferase activities in rat and mice
270. Comparison of hepatic peroxisome proliferative effect and its implication for hepatocarcinogenicity of phthalate esters, di(2-ethylhexyl) phthalate, and di(2-ethylhexyl) adipate with a hypolipidemic drug
271. Mutation tests with Salmonella using the plate-incorporation assay
272. Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP) in rats and marmosets: Extrapolation of effects in rodents to man
273. Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes
274. Trace-level analysis of phthalate esters in surface water and suspended particulate matter by means of capillary gas chromatography with electron-capture and mass-selective detection
275. Teratogenicity of di(2-ethylhexyl) phthlate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine
276. Activation of some aromatic amines to mutagenic products by prostaglandin endoperoxide synthetase
277. The accumulation of mono-2-ethylhexylphthalate (MEHP) during storage of whole blood and plasma
278. Distribution of di(2-ethylhexyl) phthalate and products in blood components
279. Di(2-ethylhexyl) phthalate as plasticizer in PVC respiratory tubing systems: Indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants
280. Fate in humans of the plasticizer, di-2-ethylhexyl phthalate, arising from transfusion of platelets stored in vinyl plastic bags
281. Analysis for phthalate esters in environmental samples: Separation from PCBs and pesticides using dual column liquid chromatography
282. Lack of di(2-ethylhexyl) phthalate activity in the C3H/10T1/2 cell transformation system
283. Tests with the Syrian hamster embryo (SHE) cell transformation assay
284. Di-2-ethylhexyl phthalate (DEHP) content of blood or blood components stored in plastic bags
285. Testicular effects of di(2-ethylhexyl) phthalate (DEHP): Histochemical and histopathological alterations
286. Various short-term and two long term studies with the plasticizer di(2-ethylhexyl) phthalate in the Syrian golden hamster
287. Excretion and metabolism of di(2-ethylhexyl) phthalate in man
288. Analysis of phthalate in sediments from Dutch rivers by means of high performance liquid chromatography
289. In vitro absorption of some ophthalate diesters through human and rat skin
290. Acute and subacute toxicity of di(2-ethylhexyl) phthalate with note upon its metabolism
291. Levels of di(2-ethylhexyl) phthalate and total phthalate esters in milk, cream, butter and cheese
292. Assessment of the teratogenicity of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl)phthalate in mice
293. Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice
294. Exposure to di(2-ethylhexyl) phthalate in infants receiving extracorporeal membrane oxygenation
295. Metabolic and peroxisome proliferation studies with di(2-ethylhexyl) phthalate in rats and monkeys
296. Effect of di(2-ethylhexyl) phthalate administration on rat sperm count and on sperm metabolic energetics
297. Teratogenicity of phthalate esters in rats
298. Mutagenic and antifertility sensitivities of mice to di-2-ethylhexyl phthalate(DEHP) and dimethoxyethyl phthalate (DMEP)
299. 14C-diethyl phthalate in rats
300. Exposure of newborn infants to plasticizers: Plasma levels of di(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate during exchange transfusion
301. Dispositions of di- and mono-(2-ethylhexyl) phthalate in newborn infants subjected to exchange transfusions
302. Non-linearities in the pharmacokinetics of di(2-ethylhexyl) phthalate and metabolites in male rats
303. Kinetics of di(2-ethylhexyl) phthalate in immature and mature rats and effect on testis
304. Effects of di(2-ethylhexyl) phthalate and five of its metabolites on rat testis in vivo and in vitro
305. Age-dependent response of the rat testes to di(2-ethylhexyl) phthalate
306. Metabolism of mono-(2-ethylhexyl) phthalate in fetal, neonatal and adult rat liver
307. Correlation of the carcinogenic potential of di(2-ethylhexyl) phthalate (DEHP) with induced hyperplasia rather than with genotoxic activity
308. Biochemical alterations in rat fetal liver following in utero exposure to di(2-ethylhexyl) phthalate (DEHP)
309. Regulation of apo A-1 gene expression by fibrates
310. Assessment of priority pollutant concentrations in the United States using STORET data base
311. The environmental fate of phthalate esters: A literature review
312. Migration of di(2-ethylhexyl) phthalate from PVC child articles into saliva and saliva stimulant
313. Effects of bis(2-ethylhexyl) phthalate on chromosomes of human leukocytes and human fetal lung cells
314. Physicochemical aspects of the extraction in blood and the disposition in rats of di(2-ethylhexyl) phthalate plasticizer
315. + ATPase loci in two different mouse lymphoma cell lines in culture
316. Assay for the carcinogenicity of chemical agents using enhancement of anchorage-independent survival of retrovirus-infected Fischer rat embryo cells
317. Relationship between hepatic peroxisome proliferation and 8-hydroxydeoxyguanosine formation in liver DNA of rats following long-term exposure to three peroxisome proliferators; di(2-ethylhexyl) phthalate, aluminum clofibrate and simfibrate
318. Significant increase of 8-hydroxyguanosine in liver DNA of rats following short-term exposure to the peroxisome proliferators di(2-ethylhexyl) phthalate and di(2-ethylhexyl) adipate
319. Lack of induction of hepatic DNA damage on long-term administration of peroxisome proliferators in male F-344 rats
320. Residue levels of phthalate esters in water and sediment samples from the Klang River Basin
321. Altered development of testis of rat exposed to di(2-ethylhexyl)
322. Effect of in utero exposure to di(2-ethylhexyl) phthalate on rat testes
323. The influence of low protein diet on the testicular toxicity of di(2-ethylhexyl) phthalate
324. Disposition of orally administered di(2-ethylhexyl) phthalate and mono-(2-ethylhexyl) phthalate in the rat
325. Mortality study in workers exposed to di-2-ethylhexyl phthalate (DOP)
326. Biological effects of di(2-ethylhexyl) phthalate and other phthalic acid esters
327. Determination of phthalates in aquatic environments
328. Phthalate esters in the Swedish atmosphere
329. Teratogenicity/fetotoxicity of DEHP in mice
330. Mutagenic/carcinogenic potential of DEHP and MEHP
331. Fetotoxic effects of mono-2-ethylhexyl phthalate (MEHP) in mice
332. Phthalic acid and derivatives
333. Chromosomal study on human leucocytes cultures treated with phthalate acid ester
334. Ability of peroxisome proliferators to induce cell transformation, chromosome aberrations and peroxisome proliferation in cultured Syrian hamster embryo cells
335. Peroxisome proliferator-activated receptors: Structures and function
336. A peroxisome proliferator-activated receptor-alpha (PPARα) cDNA cloned from guinea-pig liver encodes a protein with similar properties to the mouse PPARα: Implications for species differences in responses to peroxisome proliferators
337. An evaluation of the effects of diethylhexyl phthalate (DEHP) on mitotically capable cells in blood packs
338. Developmental toxicity evaluation of dietary di(2-ethylhexyl) phthalate in Fischer 344 rats and CD-I mice
339. Air impurities in the PVC plastics processing industry
340. Cytochrome P450-mediated metabolism of tumour promoters modifies the inhibition of intercellular communication: A modified assay for tumour promotion
341. Determination of 2-ethyl-1-hexanol as contaminant in drinking water
342. The Drosophila somatic recombination and mutation assay (SRM) using the white-coral somatic eye color system
343. Diethylhexylphthalate as an environmental contaminant - A review
344. Dissimilar patterns of promotion by di(2-ethylhexyl) phthalate and phenobarbital of hepatocellular neoplasia initiated by diethylnitrosamine in B6C3F1 mice
345. Di(2-ethylhexyl) phthalate but not phenobarbital promotes N-nitrosodiethylamine-initiated hepatocellular proliferative lesions after short-term exposure in male B6C3F1 mice
346. Tumor-initiating and promoting activities of di(2-ethylhexyl) phthalate in vivo and in vitro
347. Receptor and nonreceptor-mediated organ-specific toxicity of di(2-ethylhexyl) phthalate (DEHP) in peroxisome proliferator-activated receptor α-null mice
348. Promotion of hepatocellular foci and adenomas by di(2-ethylhexyl) phthalate and phenobarbital in C3H/HeNCr mice following exposure to N-nitrosodiethylamine at 15 days of age
349. The potential health effects of phthalate esters in children's toys: A review and risk assessment
350. Tests with the rat hepatocyte primary culture/DNA-repair test
351. Lack of rapid initiating, promoting or sequential syncarcinogenic effects of di(2-ethylhexyl) phthalate in rat liver carcinogenesis
352. The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: Significance for species differences in response to PPs
353. Somatic mutation and recombination test in wings of Drosophila melanogaster
354. Teratogenic potential of di- and mono-(2-ethylhexyl) phthalate in mice
355. Chemical mutagenesis testing in Drosophila. IV. Results of 45 coded compounds tested for the National Toxicology Program
356. Mutagenicity study of nine monoalkyl phthalates and a dialkyl phthalate using Salmonella typhimurium and Escherichia coli
357. Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters
358. Tests with a preincubation modification of the Salmonella/microsome assay
359. Mutagenicity testing of di(2-ethylhexyl) phthalate and related chemicals in Salmonella
360. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
361. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments