The fate of leached di(2-ethylhexyl)phthalate in patients undergoing CAPD treatment

Peritoneal Dialysis International

Volumn 16, Issue 1, 1996, Pages 58-62

  Mettang, Thomas ^a,c   Thomas, Stefan ^a   Kiefer, Thomas ^a   Fischer, Frank Peter ^a   Kuhlmann, Ulrich ^a   Wodarz, Roman ^b   Rettenmeier, Albert W ^b  

^a ROBERT BOSCH HOSPITAL   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c ROBERT BOSCH GMBH   (Germany)

Author keywords

di(2 ethylhexyl) phthalate; Phthalates; Plasticizer; Uremia

Indexed keywords

2 ETHYLHEXANOL; PHTHALIC ACID; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CLINICAL ARTICLE; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; CONTROLLED STUDY; DIALYSATE; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

EID: 0030059316     PISSN: 08968608     EISSN: None     Source Type: Journal    
DOI: 10.1177/089686089601600114     Document Type: Article

References (15)

1. Ljunggren L. Plasticizer migration from blood lines in hemodialysis. Artif Organs 1984; 8:99-102.
2. Jaeger RJ, Rubin JR. Plasticizers from plastic devices: extraction, metabolism and accumulation in biological systems. Science 1970; 170:46.
3. Pollack GM, Buchanan JF, Slaughter RL, Kohli RK, Shen DD. Circulating concentrations of di(2-ethylhexyl)phthalate and its de-esterified phthalic acid products following plasticizer exposure in patients receiving hemodialysis. Toxicol Appl Pharmacol 1985; 79:257-67.
4. Gibson TP, Briggs WA, Boone BJ. Delivery of di(2-ethylhexyl)phthalate to patients during hemodialysis. J Lab Clin Med 1976; 87:519-24.
5. Kluwe WM, McGonnell EE, Huff JE, Haseman JK, Douglas JF, Hartwell WV. Carcinogenicity testing of phthalate esters and related compounds by the National Toxicology Program and the National Cancer Institute. Environ Health Perspect 1982; 45:129-33.
6. Reddy JK, Lalwani ND. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit Rev Toxicol 1984; 12:1-58.
7. Tomita I, Nakamura Y, Yagi Y, Tutikawa K. Teratogenicity/fetotoxicity of DEHP in mice. Environ Health Perspect 1982; 45:71-6.
8. Labow RS, Barry YA, Tocchi M, Keon WJ. The effect of mono(2-ethylhexyl)phthalate on an isolated perfused rat heart-lung preparation. Environ Health Perspect 1990; 89:189-93.
9. Hillman LS, Goodwin SL, Sherman WR. Identification and measurement of plasticizer in neonatal tissues after umbilical catheters and blood products. N Engl J Med 1975; 292:381-6.
10. Nässberger L, Arbin A, Östelius J. Exposure of patients to phthalates from polyvinyl chloride tubes and bags during dialysis. Nephron 1987; 45:286-90.
11. Schmid P, Schlatter CH. Excretion and metabolism of di(2-ethylhexyl)phthalate in man. Xenobiotica 1985; 15:251-6.
12. Draviam EJ, Pearson KH, Kerkay J. Human metabolism of bis(2-ethylhexyl)phthalate. Anal Lett 1982; 15:1729-50.
13. Crocker JFS, Safe SH, Acott P. Effects of chronic phthalate exposure to the kidney. J Toxicol Environ Health 1988; 23:433-44.
14. Oishi S, Hiraga K. Testicular atrophy induced by phthalate acid esters: effect on testosterone and zinc concentrations. Toxicol Appl Pharmacol 1980; 53:35.
15. Fracasso A, Coli U, Landini S, et al. Plasticizer from plastic devices: effect on peritoneal membrane. In: La Greca G, Chiaramonte S, Fabris A, Feriani M, Ronco C, eds. Peritoneal dialysis. Wichtig: Milano, 1988:57-60.