The peroxisome proliferator (PP) response element upstream of the human acyl CoA oxidase gene is inactive among a sample human population: Significance for species differences in response to PPs

Carcinogenesis

Volumn 20, Issue 3, 1999, Pages 369-372

  Woodyatt, N J ^a   Lambe, K G ^a   Myers, K A ^a   Tugwood, J D ^a   Roberts, R A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A OXIDASE; DNA FRAGMENT; PEROXISOME PROLIFERATOR;

ARTICLE; CELL STRAIN 3T3; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; LIVER BIOPSY; LIVER CARCINOGENESIS; PEROXISOME; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; SPECIES DIFFERENCE;

EID: 0032995560     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.3.369     Document Type: Article

References (35)

1. Ashby, J., Brady, A., Elcombe, C.R., Elliot, B.M., Ishmael, J., Odum, J., Tugwood, J.D., Kettle, S. and Purchase, I.F.H. (1994) Mechanistically-based human hazard assessment of peroxisome-proliferator-induced hepatocarcinogenesis. Hum. Exp. Toxicol., 13, S1-S117.
2. Bruccoleri, A., Gallucci, R., Germolec, D.R., Blackspear, P. Simeonova, P., Thurman, R.G. and Luster, M.I. (1997) Induction of early-immediate genes by tumor necrosis factor-alpha contribute to liver repair following chemical-induced hepatotoxicity. Hepatology, 25, 133-141.
3. Bentley, P., Calder, I., Elcombe, C., Grasso, P., Wiegand, H.G. and Stringer, D.A. (1992) Hepatic Peroxisome Proliferation. ECETOC Monograph 17.
4. Chevalier, S. and Roberts, R.A. (1998) Perturbation of rodent hepatocyte growth control by nongenotoxic hepatocarcinogens: mechanisms and lack of relevance for human health. Oncol. Rep., 5, 1319-1327.
5. Pilot, H. (1998) Hepatocyte death in hepatocarcinogenesis. Hepatology, 28, 1-5.
6. Moody, D.E., Reddy, J.K., Lake, B.G., Popp, J.A. and Reese, D.H. (1991) Peroxisome proliferation and non-genotoxic carcinogenesis: commentary on a symposium. Fundam. Appl. Toxicol., 6, 233-248.
7. Issemann, I. and Green, S. (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 347, 645-650.
8. Lee, S.S.-T., Pineau, T., Drago, J., Lee, E.J., Owens, J.O., Kroetz, D.L., Fernandez-Salguero, P.M., Westphal, H. and Gonzalez, F.J. (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleitrophic effects of peroxisome proliferators. Mol. Cell. Biol., 15, 3012-3022.
9. Gonzalez, F.J. (1997) Recent update on the PPAR alpha-null mouse. Biochimie, 79, 139-144.
10. Evans, R.M. (1988) The steroid and thyroid hormone receptor superfamily. Science, 240, 889-895.
11. Tugwood, J.D., Issemann, I., Anderson, R.G., Bundell, K.R., McPheat, W.L. and Green, S. (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J., 11, 433-439.
12. Aldridge, T.C., Tugwood, J.D. and Green, S. (1995) Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem. J., 306, 473-479.
13. Osumi, T., Ishii, N., Miyazawa, S. and Hashimoto, T. (1987) Isolation and structural characterization of the rat acyl CoA oxidase gene. J. Biol. Chem., 262, 8138-8143.
14. Kliewer, S.A., Umesono, K., Noonan, D.J., Heyman, R.A. and Evans, R.M. (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature, 358, 771-774.
15. Gulick, T., Cresci, S., Caira, T., Moore, D.D. and Kelly, D.P. (1994) The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc. Natl Acad. Sci. USA, 91, 11012-11016.
16. Hanefeld, M., Hemmer, C. and and Kadner, E. (1983) Relationship between morphological changes and lipid lowering action of p-chlorophenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man. Atherosclerosis, 46, 239-246.
17. Williams, G.M. and Perrone, C. (1995) Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens. In Reddy, J.K., Suga, T., Mannaerts, G.P., Lazarow, P.B. and Subramani, S. (eds) Peroxisomes: Biology and Role in Toxicology and Disease, Vol. 804. New York Academy of Sciences, New York, NY, pp. 554-572.
18. Hasmall, S.C., James, N.H., Saomes, A. and Roberts, R.A. (1999) The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea pig liver in vivo nor in human hepatocytes in vitro. Arch. Toxicol., 71, in press.
19. Schoonjans, K., Staels, B. and Auwerx, J. (1996) Role of the peroxisome proliferator activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res., 37, 905-925.
20. Barber, E.D., Astill, B.D., Moran, E.J., Schneider, B.F., Gray, T.J.B., Lake, B.G. and Evans, J.G. (1987) Peroxisome induction studies on seven phthalate esters. Toxicol. Ind. Health, 3, 130.
21. Varanasi, U., Chu, R., Huang, Q., Castellon, R., Yeldandi, A.V. and Reddy, J.K. (1996) Identification of a peroxisome proliferator-responsive element upstream of the human peroxisomal fatty acyl coenzyme A oxidase gene. J. Biol. Chem., 271, 2147-2155.
22. Varanasi, U., Chu, R., Chu, S., Espinosa, R., LeBeau, M.M. and Reddy, J.K. (1994) Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis and chromosomal localization. Proc. Natl Acad. Sci. USA, 91, 3107-3111.
23. Ausubel, F., Brent, R., Kingston, R., Moore, D., Seidman, J., Smith, J. and Struhl, K. (1995) Preparation and analysis of DNA. In Chanda, V. (ed.) Current Protocols in Molecular Biology, Vol. 2. John Wiley & Sons, New York, NY.
24. Roberts, R.A., James, N.H., Woodyatt, N., Macdonald, N. and Tugwood, J. (1998) Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPARα). Carcinogenesis, 19, 43-48.
25. Duclos, S., Bride, J., Ramirez, L.C. and Bournot, P. (1997) Peroxisome proliferation and beta-oxidation in Fao and MH-1C-1 rat hepatoma cells, HepG2 human hepatoblastoma cells and cultured human hepatocytes: effects of ciprofibrate. Eur. J. Cell Biol., 72, 314-323.
26. Bar-Tana, J. (1998) PPARα activation and its consequence in humans. Toxicol. Lett., 95, 5.
27. Hertz, R., Bishara-Shieban, J. and Bar-Tana, J. (1995) Mode of action of peroxisome proliferators as hypolipidemic drugs. J. Biol. Chem., 270, 13470-13475.
28. Issemann, I., Prince, R.A., Tugwood, J.D. and Green, S. (1993) The peroxisome proliferator-activated receptor: retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. J. Mol. Endocrinol., 11, 37-47.
29. Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G. and Wahli, W. (1993) Positive regulation of the peroxisomal-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol. Cell, 77, 67-76.
30. Auwerx, J. (1992) Regulation of gene expression by fatty acids and fibric acid derivatives: an integrative role for PPARs. Hormone Res., 38, 269-277.
31. Vu-Dac, N., Chopin-Delannoy, S., Gervois, P., Bonnelye, E., Martin, G., Fruchart, J.-C., Laudet, V. and Staels, B. (1998) The nuclear receptors PPAR-alpha and Rev-erb-alpha mediate the species specific regulation of apolipoprotein A1 expression by fibrates. J. Biol. Chem., 273, 25713-25722.
32. Gonzalez, F.J. (1997) The role of peroxisome proliferator activated receptor alpha in peroxisome proliferation, physiological homeostasis and chemical carcinogenesis. In American Institute for Cancer Research (eds) Dietary Fat and Cancer. Plenum Press, New York, NY, pp. 109-125.
33. Sher, T., Yi, H.F., McBride, W. and Gonzalez, F.J. (1993) cDNA cloning, chromosomal mapping and functional characterisation of the human peroxisome proliferator-activated receptor. Biochemistry, 32, 5598-5604.
34. Tugwood, J.D., Aldridge, T.C., Lambe, K.L., Macdonald, N. and Woodyatt, N.J. (1996) PPARS: structures and function. In Reddy, J.K., Suga, T., Mannaerts, G.P., Lazarow, P.B. and Subramani, S. (eds) Peroxisomes: Biology and Role in Toxicology and Disease. Vol. 804. New York Academy of Sciences, NY, pp. 252-265.
35. Palmer, C.N.A., Hsu, M.-H., Griffin, K.J., Raucy, J.L. and Johnson, E.F. (1998) Peroxisome proliferator activated receptor alpha expression in human liver. Mol. Pharmacol., 53, 14-22.