Species differences in response to diethylhexylphthalate: Suppression of apoptosis, induction of DNA synthesis and peroxisome proliferator activated receptor alpha-mediated gene expression

Archives of Toxicology

Volumn 74, Issue 2, 2000, Pages 85-91

  Hasmall, Susan C ^a   James, Neil H ^a   Macdonald, Neil ^a   Soames, Anthony R ^a   Roberts, Ruth A ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Diethylhexylphthalate; Hepatocarcinogenesis; Human; Peroxisome proliferation; Species differences

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; FATTY ACID OXIDATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REPORTER GENE; SPECIES DIFFERENCE; TRANSCRIPTION REGULATION;

3T3 CELLS; ANIMALS; APOPTOSIS; BETA-GALACTOSIDASE; DIETHYLHEXYL PHTHALATE; DNA; DNA REPLICATION; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION; GENES, REPORTER; GUINEA PIGS; HUMANS; IN SITU NICK-END LABELING; LIVER; MALE; MICE; MICROBODIES; NAFENOPIN; OXIDATION-REDUCTION; PEROXISOME PROLIFERATORS; RATS; RATS, INBRED F344; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SPECIES SPECIFICITY; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; CAVIA PORCELLUS; RODENTIA; SUS SCROFA;

EID: 0034065023     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050657     Document Type: Article

References (54)

1. Aldridge TC, Tugwood JD, Green S (1995) Identification and characterization of DNA elements implicated in the regulation of CYP4A1 transcription. Biochem J 306: 473-479
2. Ashby J, Brady A, Elcombe CR, Elliot BM, Ishmael J, Odum J, Tugwood JD, Kettle S, Purchase IFH (1994) Mechanistically-based human hazard assessment of peroxisome-proliferator-induced hepatocarcinogenesis. Hum Exp Toxicol 13 [Suppl 2]: S1-S117
3. Auwerx J (1992) Regulation of gene expression by fatty acids and fibric acid derivatives: an integrative role for PPARs. Horm Res 38: 269-277
4. Barber ED, Astill BD, Moran EJ, Schneider BF, Gray TJB, Lake BG, Evans JG (1987) Peroxisome induction studies on seven phthalate esters. Toxicol Ind Health 3: 7-24
5. Bentley P, Calder I, Elcombe C, Grasso P, Wiegand HG, Stringer DA (1992) Hepatic peroxisome proliferation. European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) Brussels. Monograph No. 17
6. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
7. Bronfman M, Inestosa NC, Leighton F (1979) Fatty acid oxidation by human liver peroxisomes. Biochem Biophys Res Commun 88: 1030-1036
8. Chevalier S, Roberts RA (1998) Perturbation of rodent hepatocyte growth control by nongenotoxic hepatocarcinogens: mechanisms and lack of relevance for human health. Oncol Reports 5: 1319-1327
9. Eldridge SR, Goldsworthy TL, Popp JA, Butterworth BE (1992) Mitogenic stimulation of hepatocellular proliferation in rodents following 1,4-dichlorobenzene administration. Carcinogenesis 13: 409-415
10. Evans RM (1988) The steroid and thyroid hormone receptor superfamily. Science 240: 889-895
11. Flecknell P (1996) Laboratory animal anaesthesia. Academic Press, London
12. Goldsworthy TL, Conolly RB, Fransson-Steen R (1996) Apoptosis and cancer risk assessment. Mutat Res 365: 71-90
13. Goll V, Alexandre E, Viollon-Abadie C, Nicod L, Jaeck D, Richert L (1999) Comparison of the effects of various peroxisome proliferators on peroxisomal enzyme activities, DNA synthesis and apoptosis in rat and human hepatocyte cultures. Toxicol Appl Pharmacol 160: 21-32
14. Gonzalez F (1997) The Role of peroxisome proliferator activated receptor alpha in peroxisome proliferation, physiological homeostasis and chemical carcinogenesis. In: Dietary fat and cancer: genetic and molecular interactions (Proceedings of Seventh Annual Conference of AICR held in Washington, D.C., August 28-30, 1996). Edited by American Institute for Cancer Research, Washington, DC, USA. New York. Adv Exp Med Bio. 422: 109-125
15. Gulick T, Cresci S, Caira T, Moore DD, Kelly DP (1994) The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci 91: 11012-11016
16. Hanefeld M, Hemmer C, Kadner E (1983) Relationship between morphological changes and lipid lowering action of p-chlorophenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man. Atherosclerosis 46: 239-246
17. Hasmall S, James N, Macdonald N, West D, Chevalier S, Cosulich S, Roberts R (1999) Suppression of apoptosis and induction of DNA synthesis in vitro by the phthalate plasticizers monoethylhexylphthalate (MEHP) and diisononylphthalate (DINP): a comparison of rat and human hepatocytes in vitro. Arch Toxicol 73: 451-456
18. Hasmall S, Roberts R (1999) The perturbation of apoptosis and mitosis by drugs and xenobiotics. Pharmacol Ther 82: 63-70
19. Hasmall SC, James NH, Soames A, Roberts RA (1998) The peroxisome proliferator nafenopin does not suppress hepatocyte apoptosis in guinea pig liver in vivo nor in human hepatocytes in vitro. Arch Toxicol 71: 777-783
20. Hertz R, Bishara-Shieban J, Bar-Tana J (1995) Mode of action of peroxisome proliferators as hypolipidemic drugs. J Biol Chem 270: 13470-13475
21. Huber W, Grasl-Kraup B, Schulte-Hermann R (1996) Hepatocarcinogenic potential of di-(2-ethylhexyl) phthalate in rodents and its impications for human risk assessment. Crit Rev Toxicol 26: 365-481
22. Issemann I, Green S (1990) Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347: 645-650
23. James NH, Molloy CA, Soames AR, French NJ, Roberts RA (1992) An in vitro model of rodent hepatocarcinogenesis. Exp Cell Res 203: 407-419
24. James NH, Roberts RA (1996) Species differences in response to peroxisome proliferators correlate in vitro with induction of DNA synthesis rather than with suppression of apoptosis. Carcinogenesis 17: 1623-1632
25. James NH, Soames AR, Roberts RA (1998) Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexylphlathate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB). Arch Toxicol 72: 784-790
26. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B (1997) DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements: importance of the 5′-flanking region. J Biol Chem 272: 40-51
27. Kliewer SA, Umesono K, Noonan DJ, Heyman RA, Evans RM (1992) Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature 358: 771-774
28. Koop C (1999) A blue ribbon panel report: a scientific evaluation of health effects of two plasticizers used in medical devices and toys. American Council on Science and Health, New York
29. Lake BG, Evans JG, Gray TJB, Korosi SA, North CJ (1989) Comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, Syrian hamster, guinea pig and marmoset. Toxicol Appl Pharmacol 99: 148-160
30. Lambe K, Macdonald N, Woodyatt N, Chevalier S, Roberts R (1999) Species differences in sequence and activity of the peroxisome proliferator response element (PPRE) within the acyl CoA oxidase gene promoter. Toxicol Lett 110: 119-127
31. Lee SS-T, Pineau T, Drago J, Lee EJ, Owens JO, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ (1995) Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleitrophic effects of peroxisome proliferators. Mol Cell Biol 15: 3012-3022
32. Mitchell A, Lhuguenot J-C, Bridges J, Elcombe C (1985) Identification of the proximate peroxisome proliferators derived from di(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol 80: 23-32
33. Moody DE, Reddy JK, Lake BG, Popp JA, Reese DH (1991) Peroxisome proliferation and non-genotoxic carcinogenesis: commentary on a symposium. Fund Appl Toxicol 6: 233-248
34. Mukherjee R, Jow L, Noonan D, McDonnell DP (1994) Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem 51: 157-166
35. Osumi T, Ishii N, Miyazawa S, Hashimoto T (1987) Isolation and structural characterization of the rat acyl CoA oxidase gene. J Biol Chem 262: 8138-8143
36. Peters JM, Cattley RC, Gonzalez FJ (1997) Role of PPAR alpha in the mechanism of action of the nongenotoxic carcinogen and peroxisome proliferator Wy-14,643. Carcinogenesis 18: 2029-2033
37. Popp JA, Marsman DS, Cattley RC, Conway JG (1989) Hepatocarcinogenicity and peroxisome proliferation. CIIT Activities 9: 1-9
38. National Toxicology Program (1982) Carcinogenesis bioassay of di(ethylhexyl)phthalate (CAS No. 117-81-7) in F344 rats and B6C3F1 mice (feed study). National Toxicology Program: 82-1773
39. Reddy J, Rao M (1977) Malignant tumors in rats fed nafenopin, a hepatic peroxisome proliferator. J Natl Cancer Inst 59: 1645-1650
40. Roberts R, James N, Hasmall S, Holden P, Lambe K, Macdonald N, West D, Whitcome D, Woodyatt N (2000) Apoptosis and proliferation in nongenotoxic carcinogenesis: species differences and role of PPARalpha. Toxicol Lett (in press)
41. Roberts RA, (1999) Peroxisome proliferators: mechanisms of adverse effects in rodents and molecular basis for species differences. Arch Toxicol 73: 413-418
42. Roberts RA, James NH, Woodyatt N, Macdonald N, Tugwood J (1998) Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPARα). Carcinogenesis 19: 43-48
43. Roberts RA, Soames AR, Gill JH, James NH, Wheeldon EB (1995) Non-genotoxic hepatocarcinogens stimulate DNA synthesis and their withdrawal induces apoptosis, but in different discrete hepatocyte populations. Carcinogenesis 16: 1693-1698
44. Schoonjans K, Staels B, Auwerx J (1996) Role of the peroxisome proliferator activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res 37: 905-925
45. Schulte-Hermann R, Grasl-Kraupp B, Bursch W (1995) Apoptosis and hepatocarcinogenesis. In: Liver regeneration and carcinogenesis. Academic Press Inc, New York, pp 141-178
46. Sher T, Yi HF, McBride W, Gonzalez FJ (1993) cDNA cloning, chromosomal mapping and functional characterisation of the human peroxisome proliferator-activated receptor. Biochemistry 32: 5598-5604
47. Soames A, Cliffe S, Pate I, Foster J (1999) Quantitative analysis of the lobular distribution of S-phase in rat liver following dietary administration of Di(2-ethylhexyl)phthalate. Toxicol Pathol 27: 436-440
48. Soames AR, Lavender D, Foster JR, Williams SM, Wheeldon EB (1994) Image analysis of bromodeoxyuridine (BrdU) staining for measurement of S-phase in rat and mouse liver. J Histochem Cytochem 42: 939-944
49. Tucker MJ, Orton TC (1992) Comparative toxicology of hypolipidaemic fibrates. Taylor & Francis, London
50. Tugwood JD, Issemann I, Anderson RG, Bundell KR, McPheat WL, Green S (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. EMBO J 11: 433-439
51. Vu-Dac N, Chopin-Delannoy S, Gervois P, Bonnelye E, Martin G, Fruchart J-C, Laudet V, Staels B (1998) The nuclear receptors PPAR-alpha and Rev-erb-alpha mediate the species specific regulation of apolipoprotein A1 expression by fibrates. J Biol Chem 273: 25713-25722
52. Ward J, Peters J, Perella C, Gonzalez F (1998) Receptor and nonreceptor-mediated organ specific toxicity of DEHP in PPAR-alpha null mice. Toxicol Pathol 26: 240-246
53. Williams GM, Perrone C (1995) Mechanism-based risk assessment of peroxisome proliferating rodent hepatocarcinogens. In: Reddy JK, Suga T, Mannaerts GP, Lazarow PB, Subramani S (eds) Peroxisomes: biology and role in toxicology and disease. The New York Academy of Sciences, New York, 804: 554-572
54. Woodyatt N, Lambe K, Myers K, Tugwood J, Roberts R (1999) The peroxisome proliferator (PP) response element (PPRE) upstream of the human acyl CoA oxidase gene is inactive in a sample human population: significance for species differences in response to PPs. Carcinogenesis 20: 369-375