Antigen specific T lymphocyte activation

Reviews in Immunogenetics

Volumn 2, Issue 2, 2000, Pages 164-174

  Judd, B A ^a   Koretzky, G A ^a  

^a Room 427 BRBII ^*  (United States)

Author keywords

Adapter molecule; Glycolipid enriched microdomains (GEMs); PTK; TCR

Indexed keywords

ANTIGEN; GLYCOLIPID; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANTIGEN RECOGNITION; COMPLEX FORMATION; EFFECTOR CELL; ENZYME ACTIVATION; IMMUNE RESPONSE; NONHUMAN; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMAL; APOPTOSIS; HUMAN; LYMPHOCYTE ACTIVATION; MICE; PROTEIN-TYROSINE KINASE; PROTO-ONCOGENE PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0033776435     PISSN: 13981714     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

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10. The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
11. CD4 and CD8 recognition of class II and class I molecules of the major histocompatibility complex
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15. CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases
16. Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines
17. Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor
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20. Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway
21. The PH superfold: A structural scaffold for multiple functions
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33. Inositol phosphates and cell signalling
34. Protein kinase C and T cell activation
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37. Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import
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44. Positive and negative selection invoke distinct signaling pathways
45. Phosphoinositide kinases
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48. Signaling by distinct classes of phosphoinositide 3-kinases
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50. Pleckstrin homology domains of tec family protein kinases
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52. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
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56. LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
57. Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells
58. The p85 subunit of phosphatidylinositol 3-kinase associates with the Fc receptor gamma-chain and linker for activitor of T cells (LAT) in platelets stimulated by collagen and convulxin
59. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
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63. LAT palmitoylation: Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation
64. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway
65. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
66. Essential role of LAT in T cell development
67. Localization of LAT in glycolipid-enriched microdomains is required for T cell activation
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69. Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity
70. Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function
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78. Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production
79. Uncoupling of nonreceptor tyrosine kinases from PLC-gammal in an SLP-76-deficient T cell
80. Impaired viability and profound block in thymocyte development in mice lacking the adaptor protein SLP-76
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83. Cutting edge: SLP-76 cooperativity with FYB/FYN-T in the up-regulation of TCR-driven IL-2 transcription requires SLP-76 binding to FYB at Tyr595 and Tyr651
84. Functional rafts in cell membranes
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86. Membrane compartmentation is required for efficient T cell activation
87. Three-dimensional segregation of supramolecular activation clusters in T cells
88. The immunological synapse: A molecular machine controlling T cell activation
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91. CD28 and apoptosis
92. CTLA-4 is a second receptor for the B cell activation antigen B7
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94. Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft versus-host disease induced by fully major histocompatibility complex-disparate donor grafts
95. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
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101. A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells
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111. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G
112. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins
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114. Activation-induced apoptosis in lymphocytes
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118. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
119. FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex
120. Involvement of MACH, a novel MORT1/FADD-interacting protease, in FAS/APO-1- and TNF receptor-induced cell death
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123. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
124. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity