Itk and Fyn make independent contributions to T cell activation

Journal of Experimental Medicine

Volumn 186, Issue 12, 1997, Pages 2069-2073

  Liao, X Charlene ^a,d   Littman, Dan R ^b,c   Weiss, Arthur ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; ENZYME DEFICIENCY; FLOW CYTOMETRY; GENOTYPE; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 0031468126     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.12.2069     Document Type: Article

References (14)

1. Wange, R.L., and L.E. Samelson. 1996. Complex complexes: signaling at the TCR. Immunity. 5:197-205.
2. Weiss, A., and D.R. Littman. 1994. Signal transduction by lymphocyte antigen receptors. Cell. 76:263-274.
3. Qian, D., and A. Weiss. 1997. T cell antigen receptor signal transduction. Curr. Opin. Cell Biol. 9:205-212.
4. Desiderio, S., and J.D. Silicano. 1994. The Itk/Btk/Tec family of protein-tyrosine kinases. Chem. Immunol. 59:191-210.
5. Liao, X.C., and D.R. Littman. 1995. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Immunity. 3:757-769.
6. Rawlings, D.J., A.M. Scharenberg, H. Park, M.I. Wahl, S. Lin, R.M. Kato, A.-C. Fluckiger, O.N. Witte, and J.-P. Kinet. 1996. Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science. 271:822-825.
7. Alexandropoulos, K., G. Cheng, and D. Baltimore. 1995. Proline-rich sequences that bind to Src homology 3 domains with individual specificities. Proc. Natl. Acad. Sci. USA. 92:3110-3114.
8. lck. Nature. 357:161-164.
9. fyn. Cell. 70:751-763.
10. fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell. 70:741-750.
11. van Oers, N.S.C., D. Lowin-Kropf, D. Finlay, K. Connolly, and A. Weiss. 1996. αβ T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases. Immunity. 5:429-436.
12. Groves, T., P. Smiley, M.P. Cooke, K. Forbush, R.M. Perlmutter, and C.J. Guidos. 1996. Fyn can partially substitute for Lck in T lymphocyte development. Immunity. 5:417-428.
13. Tanaka, Y., L. Arbouin, A. Gillet, S.-Y. Lin, A. Magnan, B. Malissen, and M. Malissen. 1995. Early T-cell development in CD3-deficient mice. Immunol. Rev. 148:172-199.
14. Qian, D., S. Lev, N.S.C. van Oers, I. Dikic, J. Schlessinger, and A. Weiss. 1997. Tyrosine phosphorylation of Pyk2 is selectively regulated by Fyn during TCR signaling. J. Exp. Med. 185:1253-1259.