Activation of N-methyl-D-aspartate receptors reverses desensitization of metabotropic glutamate receptor, mGluR5, in native and recombinant systems

Annals of the New York Academy of Sciences

Volumn 868, Issue , 1999, Pages 526-530

  Alagarsamy, S ^a   Rouse, S T ^a   Gereau IV, R W ^b   Heinemann, S F ^b   Smith, Y ^a   Conn, P J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATION CHANNEL; GLUTAMIC ACID; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHATASE; RECEPTOR SUBUNIT;

CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; DESENSITIZATION; ENZYME ACTIVATION; EXCITABILITY; PROTEIN LOCALIZATION; SYNAPSE; SYNAPTIC TRANSMISSION;

EID: 0032970431     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb11321.x     Document Type: Conference Paper

References (7)

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3. Fitzjohn, S.M. et al. 1996. Activation of group I mGluRs potentiates NMDA responses in rat hippocampal slices. Neurosci. Lett. 203: 211-213.
4. Lüthi, A. et al. 1994. Potentiation of a metabotropic glutamatergic response following NMDA receptor activation in rat hippocampus. Pflügers Arch. 427: 197.
5. Challiss, R.A.J. et al. 1994. Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S, 3R-ACPD in neonatal rat cerebral cortex. Br. J. Pharmacol. 112: 231-239.
6. Gereau, R.W. & S.F. Heinemann. 1998. Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5. Neuron 20: 143-151.
7. Wang, J.H. & A. Stelzer. 1994. Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation. Neuroreport 5: 2377-2380.