Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: A correlation with cell polarity in HepG2 cells

Journal of Cell Biology

Volumn 138, Issue 2, 1997, Pages 307-321

  Zegers, Mirjam M P ^a   Hoekstra, Dick ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C; SPHINGOLIPID;

ARTICLE; CELL MEMBRANE TRANSPORT; CELL POLARITY; CORRELATION FUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL;

4-CHLORO-7-NITROBENZOFURAZAN; ACTINS; BILE CANALICULI; BIOLOGICAL TRANSPORT; CARCINOMA, HEPATOCELLULAR; CARRIER PROTEINS; CELL MEMBRANE; CELL POLARITY; CERAMIDES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLUORESCENT DYES; HUMANS; MICROFILAMENT PROTEINS; MICROFILAMENTS; PROTEIN KINASE C; SPHINGOLIPIDS; SPHINGOMYELINS; STAUROSPORINE; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0030845928     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.138.2.307     Document Type: Article

References (50)

1. Ali, N., and W.H. Evans. 1990. Priority targeting of glycosyl-phosphatidylinositol-anchored proteins to the bile-canalicular (apical) plasma membrane of hepatocytes. Biochem. J. 271:193-199.
2. Apodaca, G., L.A. Katz, and K.E. Mostov. 1994. Receptor-mediated endocytosis of IgA in MDCK cells via apical recycling endosomes. J. Cell Biol. 125:67-86.
3. Babia, T., J.W. Kok, and D. Hoekstra. 1994. The use of fluorescent lipid analogues to study endocytosis of glycosphingolipids. In Receptor Research Methods. B. Grcenstein, editor. Harwood Academic Publishing. London. 155-174.
4. Barroso, M., and E.S. Sztul. 1994. Basolateral to apical trancytosis in polarized cells is indirect and involves BFA and trimeric G protein sensitive passage through the apical endosome. J. Cell Biol. 124:83-100.
5. Bartles, J.R., H.M. Feracci, B. Stieger, and A.L. Hubbard. 1987. Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation. J. Cell Biol. 105:1241-1251.
6. - exchanger in rat hepatocytes. Proc. Natl. Acad. Sci. USA. 91:792-796.
7. Bligh, E.G., and W.J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917.
8. s, in transcytosis of the polymeric immunoglobulin receptor. J. Biol. Chem. 268:25824-25835.
9. Boyer, J.L., and C.J. Soroka. 1995. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterology. 109:1600-1611.
10. Brewer, C.B., and M.G. Roth. 1995. Polarized exocytosis in MDCK cells is regulated by phosphorylation. J. Cell Sci. 108:789-796.
11. Brignoni, M., E.J. Podesta, P. Mele, M.L. Rodriguez, D.E. Vega-Salas, and P.J.I. Salas. 1994. Exocytosis of the Vacuolar Apical Compartment (VAC) in Madin-Darby canine kidney epithelial cells: cAMP is involved as second messenger. Exp. Cell Res. 205:171-178.
12. Brignoni, M., O.P. Pignatoro, M.L. Rodriguez, A. Alvarez, D.E. VegaSalas, E. Rodriquez-Boulan, and P.J.I. Salas. 1995. Cyclic AMP modulates the rate of 'constitutive' exocytosis of apical membrane proteins in Madin-Darby canine kidney cells. J. Cell Sci. 108:1931-1943.
13. Cardone, M.H., B.L. Smith, W. Song, D. Mochly-Rosen, and K.E. Mostov. 1994. Phorbol myristate acetate-mediated stimulation of transcytosis and apical recycling in MDCK cells. J. Cell Biol. 124:717-727.
14. Chiu, J.H., C.P. Hu, W.Y. Lui, J.L. Szencheng, and C. Chang. 1990. The formation of bile canaliculi in human hepatoma cell lines. Hepatology. 11:834-842.
15. Corasanti, J.G., N.D. Smith, E.R. Gordon, and J.L. Boyer. 1989. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. Hepatology. 10:8-13.
16. Deckert, M., M. Ticchioni, and A. Bernard. 1996. Endocytosis of GPI-anchored proteins in human lymphocytes: role of glycolipid-based domains, actin cytoskeleton, and protein kinases. J. Cell Biol. 133:791-799.
17. Eker, P., P.K. Holm, B. van Deurs, and K. Sandvig. 1994. Selective regulation of apical endocytosis in polarized Madin-Darby canine kidney cells by mastoporan and cAMP. J. Biol. Chem. 269:18607-18615.
18. Fabre, M., and A. Garcia de Herreros. 1993. Phorbol ester-induced scattering of HT-29 human intestinal cancer cells is associated with down-modulation of E-cadherin. J. Cell Sci. 106:513-522.
19. Garcia de Herreros, A., M. Fabre, E. Battle, C. Balague, and F.X. Real. 1993. The tumor promoter 12-O-tetradecanoylphorbol-13-acetate blocks differentiation of HT-29 human colon cancer cells. J. Cell Sci. 106:1165-1172.
20. Hansen, S.H., and J.E. Casanova. 1994. Gsα stimulates transcytosis and apical secretion in MDCK cells through cAMP and protein kinase A. J. Cell Biol. 126:677-687.
21. Hayakawa, T., R. Bruck, O.C. Ng, and J.L. Boyer. 1990. DBcAMP stimulates vesicle transport and HRP excretion in isolated perfused rat liver. Am. J. Physiol. 259:G727-G735.
22. Hoekstra, D., and J.W. Kok. 1992. Trafficking of glycosphingolipids in eukaryotic cells; sorting and recycling of lipids. Biochim. Biophys. Acta. 1113:277-294.
23. Kishimoto, Y. 1975. A facile synthesis of ceramides. Chem. Phys. Lipids. 15:33-36.
24. Kok, J.W., T. Babia, and D. Hoekstra. 1991. Sorting of sphingolipids in the endocytic pathway of HT29 cells. J. Cell Biol. 114:231-239.
25. Koval, M., and R.E. Pagano. 1989. Lipid recycling between the plasma membrane and intracellular compartments: transport and metabolism of fluorescent sphingomyelin analogues in cultured fibroblasts. J. Cell Biol. 108:2169-2181.
26. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:680-685.
27. Maurice, M., M.J. Schell, B. Lardeux, and A.L. Hubbard. 1994. Biosynthesis and intracellular transport of a bile canalicular plasma membrane protein: studies in vivo and in the perfused rat liver. Hepatology. 19:648-655.
28. Mays, R.W., K.A. Beck, and W.J. Nelson. 1994. Organization and function of the cytoskeleton in polarized epithelial cells: a component of the protein sorting machinery. Curr. Opin. Cell Biol. 6:16-24.
29. Pagano, R.E., O.C. Martin, H.C. Kang, and R.P. Haugland. 1991. A novel fluorescent ceramide analog for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursor. J. Cell Biol. 113:1267-1279.
30. Peterson, G.L. 1977. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83:346-356.
31. s class of heterotrimeric G protein. Nature (Lond.). 362:456-458.
32. Pimplikar, S.W., and K. Simons. 1994. Activators of piotein kinase A stimulate apical but not basolateral transport in epithelial Madin-Darby canine kidney cells. J. Biol. Chem. 269:19054-19059.
33. Remy, L., C. Chalvet, J.P. Ripert, and A. Gerolami. 1989. Intracellular lumina and bile canaliculi in rat hepatocytes in vitro - a cytochemical study. Acta Histochem. 85:87-92.
34. Rigotti, A., R. Marzolo, and F. Nervi. 1994. Lipid transport from the hepatocyte into the bile. In Cell Lipids. D. Hoekstra, editor. Academic Press, San Diego, CA. 579-615.
35. Rodriquez-Boulan, E., and S.K. Powell. 1992. Polarity of epithelial and neuronal cells. Annu. Rev. Cell Biol. 8:395-427.
36. Ruegg, U.T., and G.M. Burgess. 1989. Staurosporine, K-252 and UCN-01; potent but nonspecific inhibitors of protein kinases. Trends Pharmacol. Sci. 10:218-220.
37. Saucan, L., and G.E. Palade. 1992. Differential colchicine effects on the transport of membrane and secretory proteins in rat hepatocytes in vivo: bipolar secretion of albumin. Hepatology. 15:714-721.
38. Schell, M.J., M. Maurice, B. Stieger, and A.L. Hubbard. 1992. 5′ nucleotidase is sorted to the apical domain of hepatocytes via an indirect route. J. Cell Biol. 119:1173-1182.
39. Smart, E.J., D.C. Foster, Y.S. Ying, B.A. Kamen, and R.G.W. Anderson. 1994. Protein kinase C activators inhibit receptor-mediated potocytosis by preventing internalization of caveolea. J. Cell Biol. 124:307-313.
40. Sormunen, R., S. Eskelinen, and V.P. Lehto. 1993. Bile canaliculus formation in cultured HepG2 cells. Lab. Invest. 68:652-662.
41. Terry, T.L., and W.J. Gallin. 1994. Effects of fetal calf serum and disruption of cadherin function on the formation of bile canaliculi between hepatocvtes. Exp. Cell Res. 214:642-653.
42. Towbin, H., T. Staehalin, and J. Gordon. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedures and some applications. Proc. Natl. Acad. Sci. USA. 76:4350-4354.
43. van't Hof, W., and G. van Meer. 1990. Generation of lipid polarity in intestinal epithelial (Caco-2) cells: sphingolipid synthesis in the Golgi complex and sorting before vesicular traffic to the plasma membrane. J. Cell Biol. 111:977-986.
44. van Genderen, I., and G. van Meer. 1995. Differential targeting of glucosylceramide and galactosylceramide analogues after synthesis but not during transcytosis in Madin-Darby canine kidney cells. J. Cell Biol. 131:645-654.
45. van IJzendoorn, S.C.D., M.M.P. Zegers, J.W. Kok, and D. Hoekstra. 1997. Segregation of glucosylceramide and sphingomyelin in the apical to basolateral transcytotic route in HepG2 cells. J. Cell Biol. 137:347-357.
46. van Meer, G., E.H.K. Steltzer, R.W. Wijnaendts-van-Resandt, and K. Simons. 1987. Sorting of sphingolipids in epithelial (Madin-Darby canine kidney) cells. J. Cell Biol. 105:1623-1635.
47. Vega-Salas, D.E., P.J.I. Salas, and E. Rodriquez-Boulan. 1987. Modulation of the expression of an apical plasma membrane protein of Madin-Darby canine kidney epithelial cells: cell-cell interactions control the appearance of a novel intracellular storage compartment. J. Cell Biol. 104:1249-1259.
48. Vega-Salas, D.E., P.J.I. Salas, and E. Rodriquez-Boulan. 1988. Exocytosis of vacuolar apical compartment (VAC): a cell-cell contact controlled mechanism for the establishment of the apical plasma membrane domain in epithelial cells. J. Cell Biol. 107:1717-1728.
49. Wilton, J.C., G.M. Matthews, R.D. Burgoyne, C.O. Mills, J.K. Chipman, and R. Coleman. 1994. Fluorescent choleretic and cholestatic bile salts take different paths across the hepatocyte: transcytosis of glycolithocholate leads to an extensive redistribution of annexin II. J. Cell Biol. 127: 401-410.
50. Zaal, K.J.M., J.W. Kok, R. Sormunen, S. Eskelinen, and D. Hoekstra. 1993. Intracellular sites involved in the biogenesis of bile canaliculi in hepatic cells. Eur. J. Cell Biol. 63:10-19.