Nitric oxide and guanosine 3',5'-cyclic monophosphate stimulate bile secretion in isolated rat hepatocyte couplets, but not in isolated bile duct units

Hepatology

Volumn 28, Issue 6, 1998, Pages 1621-1628

  Trauner, Michael ^a,b   Mennone, Albert ^b   Gigliozzi, Alessandro ^b   Fraioli, Flavia ^b   Boyer, James L ^b  

^a UNIVERSITY OF GRAZ   (Austria)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BUCLADESINE; CYCLIC GMP; DIBUTYRYL CYCLIC GMP; N ACETYL S NITROSOPENICILLAMINE; N(G) METHYLARGININE; NITRIC OXIDE; SECRETIN;

ANIMAL CELL; ARTICLE; BILE SECRETION; CELL PH; CELL POLARITY; CELL VIABILITY; HORMONAL REGULATION; INTRAHEPATIC BILE DUCT; ION EXCHANGE; LIVER CELL; LIVER PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TELEVISION CAMERA;

EID: 0031793979     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280623     Document Type: Article

References (6)

1. Nathanson MH, Boyer JL. Mechanisms and regulation of bile formation. HEPATOLOGY 1991;14:551-566.
2. Dufour JF, Turner T, Arias IM. Nitric oxide blocks bile canalicular contraction by inhibiting inositol triphosphate-dependent calcium mobilization. Gastroenterology 1995:108:841-849.
3. 2+-independent mechanism. Am J Physiol 1995;269:G789-G799.
4. Trauner M, Nathanson MH, Mennone A, Rydberg SA, Boyer JL. Nitric oxide donors stimulate bile flow and glutathione disulfide excretion independent of guanosine 3′,5′-cyclic monophosphate in the isolated perfused rat liver. HEPATOLOGY 1997;25:263-269.
5. Myers NC, Gruene S, Jameson HL, Anwer MS. Cyclic GMP stimulates bile acid independent bile formation and biliary bicarbonate excretion. Am J Physiol 1996;270:G418-G424.
6. St-Pierre M, Dufour JFJ, Arias IM. Stimulation of bile acid independent bile flow with bromo-cyclic guanosine monophosphate. HEPATOLOGY 1996;24:1487-1491.