Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: Possible involvement of protein kinase C

Hepatology

Volumn 28, Issue 4 I, 1998, Pages 1031-1041

  Roma, Marcelo G ^a   Stone, Vicki ^b   Shaw, Robert ^c   Coleman, Roger ^c  

^a Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^b EDINBURGH NAPIER UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; CALCIMYCIN; CALCIUM; CALMIDAZOLIUM; DEFEROXAMINE; F ACTIN; LEUPEPTIN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C; VASOPRESSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CHOLESTASIS; ENZYME ACTIVITY; ENZYME INHIBITION; FLUORESCENCE MICROSCOPY; LIVER CELL; LIVER FUNCTION; LIVER FUNCTION TEST; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASOPRESSIN BLOOD LEVEL;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ACTINS; ANIMALS; ANTIOXIDANTS; BILE CANALICULI; BUCLADESINE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARBAZOLES; CELLS, CULTURED; CHELATING AGENTS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETON; EGTAZIC ACID; ENZYME ACTIVATION; ENZYME INHIBITORS; IMIDAZOLES; INDOLES; LEUPEPTINS; LIVER; MALE; MICROSCOPY, ELECTRON, SCANNING; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; PYRROLES; RATS; RATS, WISTAR; TIGHT JUNCTIONS; VACUOLES; VASOPRESSINS;

EID: 0031657201     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280418     Document Type: Article

References (18)

1. Exton JH. Role of inositol trisphosphate and diacylglycerol in the regulation of liver function. In: Arias IM, Jacoby WB, Popper H, eds. The Liver: Biology and Pathobiology. New York: Raven, 1988:785-791.
2. Corasanti JG, Smith ND, Gordon ER, Boyer JL. Protein kinase C agonists inhibit bile secretion independently of effects on the microcirculation in the isolated perfused rat liver. HEPATOLOGY 1989;10:8-13.
3. 2+ and on bile secretion in the isolated perfused rat liver. HEPATOLOGY 1992;15:107-116.
4. 2+ on exocytosis in the isolated perfused rat liver. HEPATOLOGY 1994;20:1032-1040.
5. Nathanson MH, Gautam A, Boyer JL. Effect of vasopressin and phorbol dibutyrate on bile secretion in treated rat hepatocyte couplets [Abstract]. Gastroenterology 1990;98:A615.
6. Boyer JL, Soroka CJ. Vesicle targeting to the apical domain regulated bile excretory function in isolated rat hepatocyte couplets. Gastroenterology 1995;109:1600-1611.
7. Lowe PJ, Miyai K, Steinbach JH, Hardison WGM. Hormonal regulation of hepatocyte tight junctional permeability. Am J Physiol 1988;255:G454-G461.
8. Kan KS, Coleman R. The calcium ionophore A23187 increases the tight-junctional permeability in rat liver. Biochem J 1988;256:1039-1041.
9. Llopis J, Kass GEN, Duddy SK, Parrel GC, Gahm A, Orrenius S. Mobilization of the hormone-sensitive calcium pool increases tight junctional permeability in the perfused rat liver. FEBS Lett 1991;280:84-86.
10. Nathanson MH, Gautam A, Ng OC, Boyer JL. Hormonal regulation of paracellular permeability in isolated rat hepatocyte couplets. Am J Physiol 1992;262:G1079-G1086.
11. Burgstahler AD, Nathanson MH. NO modulates the apicolateral cytoskeleton of isolated hepatocytes by a PKC-dependent, cGMP-independent mechanism. Am J Physiol 1995;269:G789-G799.
12. Roma MG, Orsler DJ, Coleman R. Canalicular retention as a marker of tight junctional permeability in isolated hepatocyte couplets: effects of protein kinase modulation and cholestatic agents. Fund Appl Toxicol 1997;37:71-81.
13. Boyer JL. Tight junctions in normal and cholestatic liver: does the paracellular pathway have functional significance? HEPATOLOGY 1983;3:614-617.
14. Phillips MJ, Satir P. The cytoskeleton of the hepatocyte: organization, relationship, and pathology. In: Arias IM, Jacoby WB, Popper H, eds. The Liver: Biology and Pathobiology. New York: Raven, 1988:11-27.
15. Phillips MJ, Oshio C, Miyairi M, Watanabe S, Smith CR. What is actin doing in the liver cell? HEPATOLOGY 1983;3:433-436.
16. Thibault N, Claude JR, Ballet F. Actin filament alteration as a potential marker for cholestasis: a study in isolated rat hepatocyte couplets. Toxicology 1992;73:269-279.
17. Mills CO, Rahman K, Coleman R, Elias E. Cholyllysyl fluorescein synthesis, biliary excretion in vivo and during single pass perfusion in isolated rat liver. Biochim Biophys Acta 1991;1115:151-156.
18. Wilton JC, Coleman R, Lankester DJ, Chipman JK. Stability and optimization of canalicular function in hepatocyte couplets. Cell BiochemFunct 1993;11:179-185.